mutLBSgeneDB |
Gene summary for MPHOSPH8 |
Gene summary |
Basic gene Info. | Gene symbol | MPHOSPH8 |
Gene name | M-phase phosphoprotein 8 | |
Synonyms | HSMPP8|TWA3|mpp8 | |
Cytomap | UCSC genome browser: 13q12.11 | |
Type of gene | protein-coding | |
RefGenes | NM_017520.3, | |
Description | M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM | |
Modification date | 20141207 | |
dbXrefs | MIM : 611626 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196199 | ||
HPRD : 13682 | ||
Vega : OTTHUMG00000016498 | ||
Protein | UniProt: Q99549 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MPHOSPH8 | |
BioGPS: 54737 | ||
Pathway | NCI Pathway Interaction Database: MPHOSPH8 | |
KEGG: MPHOSPH8 | ||
REACTOME: MPHOSPH8 | ||
Pathway Commons: MPHOSPH8 | ||
Context | iHOP: MPHOSPH8 | |
ligand binding site mutation search in PubMed: MPHOSPH8 | ||
UCL Cancer Institute: MPHOSPH8 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MPHOSPH8 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E60 | E60Q | BLCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MPHOSPH8 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E60 | E60Q | -0.91966095 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MPHOSPH8 from PDB |
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Differential gene expression and gene-gene network for MPHOSPH8 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MPHOSPH8 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MPHOSPH8 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MPHOSPH8 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3qo2 | A | E60 | III | Peptide ligand (THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3qo2 | B | E60 | III | Peptide ligand (ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3qo2 | C | E60 | III | Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3qo2 | D | E60 | III | Peptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3r93 | A | E60 | III | Peptide ligand (ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3r93 | B | E60 | III | Peptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3r93 | C | E60 | III | Peptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA) | 3r93 | D | E60 | III | Peptide ligand (TYR,GLU,PRO,SER,THR,THR,ALA,ARG,LYS,VAL,GLY,ARG) | 3svm | A | E60 |
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Conservation information for LBS of MPHOSPH8 |
Multiple alignments for Q99549 in multiple species |
LBS | AA sequence | # species | Species | C99 | VHLEDCKEVLL | 2 | Mus musculus, Rattus norvegicus | C99 | IHLEDCKEVLL | 1 | Homo sapiens | D57 | EEDGEDVFEVE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D87 | GYTSDDDTWEP | 2 | Homo sapiens, Rattus norvegicus | D87 | GYTSEDDTWEP | 1 | Mus musculus | D98 | EVHLEDCKEVL | 2 | Mus musculus, Rattus norvegicus | D98 | EIHLEDCKEVL | 1 | Homo sapiens | E101 | LEDCKEVLLEF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E56 | SEEDGEDVFEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E60 | GEDVFEVERIL | 2 | Mus musculus, Rattus norvegicus | E60 | GEDVFEVEKIL | 1 | Homo sapiens | E91 | DDDTWEPEIHL | 1 | Homo sapiens | E91 | EDDTWEPEVHL | 1 | Mus musculus | E91 | DDDTWEPEVHL | 1 | Rattus norvegicus | E97 | PEVHLEDCKEV | 2 | Mus musculus, Rattus norvegicus | E97 | PEIHLEDCKEV | 1 | Homo sapiens | F59 | DGEDVFEVERI | 2 | Mus musculus, Rattus norvegicus | F59 | DGEDVFEVEKI | 1 | Homo sapiens | H95 | WEPEVHLEDCK | 2 | Mus musculus, Rattus norvegicus | H95 | WEPEIHLEDCK | 1 | Homo sapiens | I94 | TWEPEVHLEDC | 2 | Mus musculus, Rattus norvegicus | I94 | TWEPEIHLEDC | 1 | Homo sapiens | K100 | HLEDCKEVLLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K81 | YKVRWKGYTSD | 2 | Homo sapiens, Rattus norvegicus | K81 | YKVRWKGYTSE | 1 | Mus musculus | L96 | EPEVHLEDCKE | 2 | Mus musculus, Rattus norvegicus | L96 | EPEIHLEDCKE | 1 | Homo sapiens | P92 | DDTWEPEVHLE | 2 | Mus musculus, Rattus norvegicus | P92 | DDTWEPEIHLE | 1 | Homo sapiens | T89 | TSDDDTWEPEI | 1 | Homo sapiens | T89 | TSEDDTWEPEV | 1 | Mus musculus | T89 | TSDDDTWEPEV | 1 | Rattus norvegicus | V102 | EDCKEVLLEFR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V58 | EDGEDVFEVER | 2 | Mus musculus, Rattus norvegicus | V58 | EDGEDVFEVEK | 1 | Homo sapiens | V61 | EDVFEVERILD | 2 | Mus musculus, Rattus norvegicus | V61 | EDVFEVEKILD | 1 | Homo sapiens | W80 | LYKVRWKGYTS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y83 | VRWKGYTSDDD | 2 | Homo sapiens, Rattus norvegicus | Y83 | VRWKGYTSEDD | 1 | Mus musculus |
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