mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MPHOSPH8
Gene summary
Basic gene Info.Gene symbolMPHOSPH8
Gene nameM-phase phosphoprotein 8
SynonymsHSMPP8|TWA3|mpp8
CytomapUCSC genome browser: 13q12.11
Type of geneprotein-coding
RefGenesNM_017520.3,
DescriptionM-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM
Modification date20141207
dbXrefs MIM : 611626
HGNC : HGNC
Ensembl : ENSG00000196199
HPRD : 13682
Vega : OTTHUMG00000016498
ProteinUniProt: Q99549
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MPHOSPH8
BioGPS: 54737
PathwayNCI Pathway Interaction Database: MPHOSPH8
KEGG: MPHOSPH8
REACTOME: MPHOSPH8
Pathway Commons: MPHOSPH8
ContextiHOP: MPHOSPH8
ligand binding site mutation search in PubMed: MPHOSPH8
UCL Cancer Institute: MPHOSPH8
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for MPHOSPH8

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E60E60QBLCA1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for MPHOSPH8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E60E60Q-0.91966095
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MPHOSPH8 from PDB

Top
Differential gene expression and gene-gene network for MPHOSPH8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MPHOSPH8 and the right PPI network was created from samples without mutations in the LBS of MPHOSPH8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for MPHOSPH8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for MPHOSPH8
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MPHOSPH8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3qo2AE60
IIIPeptide ligand (THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3qo2BE60
IIIPeptide ligand (ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3qo2CE60
IIIPeptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3qo2DE60
IIIPeptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3r93AE60
IIIPeptide ligand (ARG,THR,LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3r93BE60
IIIPeptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3r93CE60
IIIPeptide ligand (LYS,GLN,THR,ALA,ARG,LYS,SER,THR,GLY,GLY,LYS,ALA)3r93DE60
IIIPeptide ligand (TYR,GLU,PRO,SER,THR,THR,ALA,ARG,LYS,VAL,GLY,ARG)3svmAE60


Top
Conservation information for LBS of MPHOSPH8
Multiple alignments for Q99549 in multiple species
LBSAA sequence# speciesSpecies
C99VHLEDCKEVLL2Mus musculus, Rattus norvegicus
C99IHLEDCKEVLL1Homo sapiens
D57EEDGEDVFEVE3Homo sapiens, Mus musculus, Rattus norvegicus
D87GYTSDDDTWEP2Homo sapiens, Rattus norvegicus
D87GYTSEDDTWEP1Mus musculus
D98EVHLEDCKEVL2Mus musculus, Rattus norvegicus
D98EIHLEDCKEVL1Homo sapiens
E101LEDCKEVLLEF3Homo sapiens, Mus musculus, Rattus norvegicus
E56SEEDGEDVFEV3Homo sapiens, Mus musculus, Rattus norvegicus
E60GEDVFEVERIL2Mus musculus, Rattus norvegicus
E60GEDVFEVEKIL1Homo sapiens
E91DDDTWEPEIHL1Homo sapiens
E91EDDTWEPEVHL1Mus musculus
E91DDDTWEPEVHL1Rattus norvegicus
E97PEVHLEDCKEV2Mus musculus, Rattus norvegicus
E97PEIHLEDCKEV1Homo sapiens
F59DGEDVFEVERI2Mus musculus, Rattus norvegicus
F59DGEDVFEVEKI1Homo sapiens
H95WEPEVHLEDCK2Mus musculus, Rattus norvegicus
H95WEPEIHLEDCK1Homo sapiens
I94TWEPEVHLEDC2Mus musculus, Rattus norvegicus
I94TWEPEIHLEDC1Homo sapiens
K100HLEDCKEVLLE3Homo sapiens, Mus musculus, Rattus norvegicus
K81YKVRWKGYTSD2Homo sapiens, Rattus norvegicus
K81YKVRWKGYTSE1Mus musculus
L96EPEVHLEDCKE2Mus musculus, Rattus norvegicus
L96EPEIHLEDCKE1Homo sapiens
P92DDTWEPEVHLE2Mus musculus, Rattus norvegicus
P92DDTWEPEIHLE1Homo sapiens
T89TSDDDTWEPEI1Homo sapiens
T89TSEDDTWEPEV1Mus musculus
T89TSDDDTWEPEV1Rattus norvegicus
V102EDCKEVLLEFR3Homo sapiens, Mus musculus, Rattus norvegicus
V58EDGEDVFEVER2Mus musculus, Rattus norvegicus
V58EDGEDVFEVEK1Homo sapiens
V61EDVFEVERILD2Mus musculus, Rattus norvegicus
V61EDVFEVEKILD1Homo sapiens
W80LYKVRWKGYTS3Homo sapiens, Mus musculus, Rattus norvegicus
Y83VRWKGYTSDDD2Homo sapiens, Rattus norvegicus
Y83VRWKGYTSEDD1Mus musculus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas