mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RNF111
Gene summary
Basic gene Info.Gene symbolRNF111
Gene namering finger protein 111
CytomapUCSC genome browser: 15q21
Type of geneprotein-coding
DescriptionArkadiaE3 ubiquitin-protein ligase Arkadia
Modification date20141207
dbXrefs MIM : 605840
Ensembl : ENSG00000157450
HPRD : 09318
Vega : OTTHUMG00000132716
ProteinUniProt: Q6ZNA4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RNF111
BioGPS: 54778
PathwayNCI Pathway Interaction Database: RNF111
Pathway Commons: RNF111
ContextiHOP: RNF111
ligand binding site mutation search in PubMed: RNF111
UCL Cancer Institute: RNF111
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for RNF111

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RNF111
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RNF111 from PDB

Differential gene expression and gene-gene network for RNF111
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RNF111 and the right PPI network was created from samples without mutations in the LBS of RNF111. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RNF111
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RNF111
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RNF111 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of RNF111
Multiple alignments for Q6ZNA4 in multiple species
LBSAA sequence# speciesSpecies
C942DTEEKCTICLS3Homo sapiens, Xenopus tropicalis, Mus musculus
C945EKCTICLSILE3Homo sapiens, Xenopus tropicalis, Mus musculus
C960VRRLPCMHLFH3Homo sapiens, Xenopus tropicalis, Mus musculus
C968LFHQVCVDQWL3Homo sapiens, Xenopus tropicalis, Mus musculus
C979ITNKKCPICRV3Homo sapiens, Xenopus tropicalis, Mus musculus
C982KKCPICRVDIE2Homo sapiens, Mus musculus
C982KKCPICRVDID1Xenopus tropicalis
H962RLPCMHLFHQV3Homo sapiens, Xenopus tropicalis, Mus musculus
H965CMHLFHQVCVD3Homo sapiens, Xenopus tropicalis, Mus musculus

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