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mutLBSgeneDB |
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| Gene summary for PPIC |
 Gene summary |
| Basic gene Info. | Gene symbol | PPIC |
| Gene name | peptidylprolyl isomerase C (cyclophilin C) | |
| Synonyms | CYPC | |
| Cytomap | UCSC genome browser: 5q23.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000943.4, | |
| Description | PPIase Ccyclophilin Cparvulinpeptidyl-prolyl cis-trans isomerase Crotamase C | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 123842 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000168938 | ||
| HPRD : 00459 | ||
| Vega : OTTHUMG00000128921 | ||
| Protein | UniProt: P45877 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PPIC | |
| BioGPS: 5480 | ||
| Pathway | NCI Pathway Interaction Database: PPIC | |
| KEGG: PPIC | ||
| REACTOME: PPIC | ||
| Pathway Commons: PPIC | ||
| Context | iHOP: PPIC | |
| ligand binding site mutation search in PubMed: PPIC | ||
| UCL Cancer Institute: PPIC | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PPIC |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K159 | G158S | LAML | 1 | L156 | L156V | OV | 1 | E68 | V67A | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PPIC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L156 | L156V | -1.3205514 | E68 | V67A | -1.1872 | K159 | G158S | -0.95215598 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PPIC from PDB |
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| Differential gene expression and gene-gene network for PPIC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PPIC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PPIC |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00172 | L-Proline | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PPIC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2esl | F | E68 | III | Peptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA) | 2esl | A | K159 | III | Peptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA) | 2esl | D | K159 | III | Peptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA) | 2esl | A | L156 | III | Peptide ligand (DAL,MLE,MLE,MVA,BMT,ABA,SAR,MLE,VAL,MLE,ALA) | 2esl | E | L156 |
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| Conservation information for LBS of PPIC |
| Multiple alignments for P45877 in multiple species |
| LBS | AA sequence | # species | Species | A135 | GWVSMANAGPD | 3 | Homo sapiens, Mus musculus, Bos taurus | A135 | GRLSMANRGKD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A137 | VSMANAGPDTN | 3 | Homo sapiens, Mus musculus, Bos taurus | A137 | LSMANRGKDTN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E68 | VPKTVENFVAL | 3 | Homo sapiens, Mus musculus, Bos taurus | E68 | CPKTAKNFYKL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E77 | ALATGEKG-YG | 3 | Homo sapiens, Mus musculus, Bos taurus | E77 | KLSTTTNSKKG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F147 | NGSQFFITLT- | 3 | Homo sapiens, Mus musculus, Bos taurus | F147 | NGSQFFITTTE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F94 | RVIKDFMIQGG | 3 | Homo sapiens, Mus musculus, Bos taurus | F94 | RVIPNFMVQGG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G106 | ITTGDGTGGVS | 1 | Homo sapiens | G106 | FTDGTGVGGKS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G106 | FTARDGTGGMS | 1 | Mus musculus | G106 | FTRGDGTGGIS | 1 | Bos taurus | G138 | SMANAGPDTNG | 3 | Homo sapiens, Mus musculus, Bos taurus | G138 | SMANRGKDTNG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H160 | WLDGKHVVFGK | 3 | Homo sapiens, Mus musculus, Bos taurus | H160 | WLDGKHVVFGQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K159 | TWLDGKHVVFG | 3 | Homo sapiens, Mus musculus, Bos taurus | K159 | SWLDGKHVVFG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L156 | -KPTWLDGKHV | 3 | Homo sapiens, Mus musculus, Bos taurus | L156 | EEASWLDGKHV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N136 | WVSMANAGPDT | 3 | Homo sapiens, Mus musculus, Bos taurus | N136 | RLSMANRGKDT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P139 | MANAGPDTNGS | 3 | Homo sapiens, Mus musculus, Bos taurus | P139 | MANRGKDTNGS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q145 | DTNGSQFFITL | 3 | Homo sapiens, Mus musculus, Bos taurus | Q145 | DTNGSQFFITT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q97 | KDFMIQGGDFT | 2 | Mus musculus, Bos taurus | Q97 | KDFMIQGGDIT | 1 | Homo sapiens | Q97 | PNFMVQGGDFT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R89 | GSKFHRVIKDF | 2 | Homo sapiens, Bos taurus | R89 | GSTFHRVIPNF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R89 | GSIFHRVIKDF | 1 | Mus musculus | T107 | TTGDGTGGVSI | 1 | Homo sapiens | T107 | TDGTGVGGKSI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T107 | TARDGTGGMSI | 1 | Mus musculus | T107 | TRGDGTGGISI | 1 | Bos taurus | W155 | T-KPTWLDGKH | 3 | Homo sapiens, Mus musculus, Bos taurus | W155 | TEEASWLDGKH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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