mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPIC
Gene summary
Basic gene Info.Gene symbolPPIC
Gene namepeptidylprolyl isomerase C (cyclophilin C)
CytomapUCSC genome browser: 5q23.2
Type of geneprotein-coding
DescriptionPPIase Ccyclophilin Cparvulinpeptidyl-prolyl cis-trans isomerase Crotamase C
Modification date20141222
dbXrefs MIM : 123842
Ensembl : ENSG00000168938
HPRD : 00459
Vega : OTTHUMG00000128921
ProteinUniProt: P45877
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPIC
BioGPS: 5480
PathwayNCI Pathway Interaction Database: PPIC
Pathway Commons: PPIC
ContextiHOP: PPIC
ligand binding site mutation search in PubMed: PPIC
UCL Cancer Institute: PPIC
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PPIC
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PPIC
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPIC from PDB

Differential gene expression and gene-gene network for PPIC
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPIC and the right PPI network was created from samples without mutations in the LBS of PPIC. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PPIC
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PPIC
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00172L-ProlineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPIC go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PPIC
Multiple alignments for P45877 in multiple species
LBSAA sequence# speciesSpecies
A135GWVSMANAGPD3Homo sapiens, Mus musculus, Bos taurus
A135GRLSMANRGKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A137VSMANAGPDTN3Homo sapiens, Mus musculus, Bos taurus
A137LSMANRGKDTN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E68VPKTVENFVAL3Homo sapiens, Mus musculus, Bos taurus
E68CPKTAKNFYKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E77ALATGEKG-YG3Homo sapiens, Mus musculus, Bos taurus
E77KLSTTTNSKKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F147NGSQFFITLT-3Homo sapiens, Mus musculus, Bos taurus
F147NGSQFFITTTE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F94RVIKDFMIQGG3Homo sapiens, Mus musculus, Bos taurus
F94RVIPNFMVQGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G106ITTGDGTGGVS1Homo sapiens
G106FTDGTGVGGKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G106FTARDGTGGMS1Mus musculus
G106FTRGDGTGGIS1Bos taurus
G138SMANAGPDTNG3Homo sapiens, Mus musculus, Bos taurus
G138SMANRGKDTNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H160WLDGKHVVFGK3Homo sapiens, Mus musculus, Bos taurus
H160WLDGKHVVFGQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K159TWLDGKHVVFG3Homo sapiens, Mus musculus, Bos taurus
K159SWLDGKHVVFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L156-KPTWLDGKHV3Homo sapiens, Mus musculus, Bos taurus
L156EEASWLDGKHV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N136WVSMANAGPDT3Homo sapiens, Mus musculus, Bos taurus
N136RLSMANRGKDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P139MANAGPDTNGS3Homo sapiens, Mus musculus, Bos taurus
P139MANRGKDTNGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q145DTNGSQFFITL3Homo sapiens, Mus musculus, Bos taurus
Q145DTNGSQFFITT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q97KDFMIQGGDFT2Mus musculus, Bos taurus
Q97KDFMIQGGDIT1Homo sapiens
Q97PNFMVQGGDFT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R89GSKFHRVIKDF2Homo sapiens, Bos taurus
R89GSTFHRVIPNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R89GSIFHRVIKDF1Mus musculus
T107TTGDGTGGVSI1Homo sapiens
T107TDGTGVGGKSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T107TARDGTGGMSI1Mus musculus
T107TRGDGTGGISI1Bos taurus
W155T-KPTWLDGKH3Homo sapiens, Mus musculus, Bos taurus
W155TEEASWLDGKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

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