mutLBSgeneDB |
Gene summary for DUS2 |
Gene summary |
Basic gene Info. | Gene symbol | DUS2 |
Gene name | dihydrouridine synthase 2 | |
Synonyms | DUS2L|SMM1|URLC8 | |
Cytomap | UCSC genome browser: 16q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001271762.1, NM_001271763.1,NM_017803.4, | |
Description | SMM1 homologdihydrouridine synthase 2-like, SMM1 homologtRNA-dihydrouridine(20) synthase [NAD(P)+]-likeup-regulated in lung cancer protein 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609707 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167264 | ||
HPRD : 08624 | ||
Vega : OTTHUMG00000137538 | ||
Protein | UniProt: Q9NX74 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUS2 | |
BioGPS: 54920 | ||
Pathway | NCI Pathway Interaction Database: DUS2 | |
KEGG: DUS2 | ||
REACTOME: DUS2 | ||
Pathway Commons: DUS2 | ||
Context | iHOP: DUS2 | |
ligand binding site mutation search in PubMed: DUS2 | ||
UCL Cancer Institute: DUS2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006469 | negative regulation of protein kinase activity | 18096616 | GO:0060548 | negative regulation of cell death | 18096616 |
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Ligand binding site mutations for DUS2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | V20 | R21L | LUAD | 1 | G216 | G216V | LUAD | 1 | E43 | L44P | SKCM | 1 | H183 | V182I | THCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for DUS2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E43 | L44P | -1.1787514 | H183 | V182I | -1.1267951 | V20 | R21L | -0.72012311 | G216 | G216V | -0.59259412 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for DUS2 from PDB |
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Differential gene expression and gene-gene network for DUS2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for DUS2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for DUS2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of DUS2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FNR | REDUCED FMN | 4xp7 | A | V20 E43 H183 G216 | FMN | FLAVIN MONONUCLEOTIDE | 4wfs | A | V20 E43 H183 G216 |
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Conservation information for LBS of DUS2 |
Multiple alignments for Q9NX74 in multiple species |
LBS | AA sequence | # species | Species |
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