mutLBSgeneDB |
Gene summary for MRPL16 |
Gene summary |
Basic gene Info. | Gene symbol | MRPL16 |
Gene name | mitochondrial ribosomal protein L16 | |
Synonyms | L16mt|MRP-L16 | |
Cytomap | UCSC genome browser: 11q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_017840.3, | |
Description | 39S ribosomal protein L16, mitochondrial | |
Modification date | 20141207 | |
dbXrefs | MIM : 611829 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166902 | ||
HPRD : 14743 | ||
Vega : OTTHUMG00000167410 | ||
Protein | UniProt: Q9NX20 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MRPL16 | |
BioGPS: 54948 | ||
Pathway | NCI Pathway Interaction Database: MRPL16 | |
KEGG: MRPL16 | ||
REACTOME: MRPL16 | ||
Pathway Commons: MRPL16 | ||
Context | iHOP: MRPL16 | |
ligand binding site mutation search in PubMed: MRPL16 | ||
UCL Cancer Institute: MRPL16 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MRPL16 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R227 | G225S | COAD | 1 | I72 | D71N | LUAD | 1 | R227 | R227Q | THCA | 1 | M104 | R106C | UCEC | 1 | R227 | R227W | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MRPL16 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | M104 | R106C | -1.2160011 | R227 | R227Q | -1.0104356 | R227 | R227W | -0.71920874 | R227 | G225S | -0.6050766 | I72 | D71N | -0.53173948 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MRPL16 from PDB |
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Differential gene expression and gene-gene network for MRPL16 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MRPL16 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MRPL16 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MRPL16 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3j7y | N | I72 M104 R227 |
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Conservation information for LBS of MRPL16 |
Multiple alignments for Q9NX20 in multiple species |
LBS | AA sequence | # species | Species | G100 | GYLHWGHFEMM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G137 | TRKGVGQRMGG | 2 | Mus musculus, Rattus norvegicus | G137 | TRKSVGHRMGG | 1 | Homo sapiens | G137 | TRKGMGQRMGG | 1 | Bos taurus | G141 | VGQRMGGGKGA | 2 | Mus musculus, Rattus norvegicus | G141 | VGHRMGGGKGA | 1 | Homo sapiens | G141 | MGQRMGGGKGA | 1 | Bos taurus | G142 | GQRMGGGKGAI | 3 | Mus musculus, Rattus norvegicus, Bos taurus | G142 | GHRMGGGKGAI | 1 | Homo sapiens | G143 | QRMGGGKGAID | 3 | Mus musculus, Rattus norvegicus, Bos taurus | G143 | HRMGGGKGAID | 1 | Homo sapiens | G145 | MGGGKGAIDHY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H101 | YLHWGHFEMMR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H181 | LNQVAHKLPFP | 3 | Mus musculus, Rattus norvegicus, Bos taurus | H181 | LDQVAHKLPFA | 1 | Homo sapiens | I72 | KNLSDIRGPST | 1 | Homo sapiens | I72 | KNLKDIRGPST | 1 | Mus musculus | I72 | KNLKDIRGPSA | 1 | Rattus norvegicus | I72 | KNLRDIRGPST | 1 | Bos taurus | K134 | KPITRKGVGQR | 2 | Mus musculus, Rattus norvegicus | K134 | KPITRKSVGHR | 1 | Homo sapiens | K134 | KAITRKGMGQR | 1 | Bos taurus | K144 | RMGGGKGAIDH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K182 | NQVAHKLPFPA | 3 | Mus musculus, Rattus norvegicus, Bos taurus | K182 | DQVAHKLPFAA | 1 | Homo sapiens | K228 | MLGIRKVLSPY | 2 | Homo sapiens, Bos taurus | K228 | MFGIRKFLSPY | 2 | Mus musculus, Rattus norvegicus | K244 | GRYWGKFYMPK | 2 | Mus musculus, Rattus norvegicus | K244 | GKYWGKFYMPK | 1 | Homo sapiens | K244 | GRYWGKFYMPE | 1 | Bos taurus | K67 | VRREPKNLKDI | 2 | Mus musculus, Rattus norvegicus | K67 | VRREPKNLSDI | 1 | Homo sapiens | K67 | VRREPKNLRDI | 1 | Bos taurus | L183 | QVAHKLPFPAK | 3 | Mus musculus, Rattus norvegicus, Bos taurus | L183 | QVAHKLPFAAK | 1 | Homo sapiens | L69 | REPKNLKDIRG | 2 | Mus musculus, Rattus norvegicus | L69 | REPKNLSDIRG | 1 | Homo sapiens | L69 | REPKNLRDIRG | 1 | Bos taurus | M104 | WGHFEMMRLTI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M140 | GVGQRMGGGKG | 2 | Mus musculus, Rattus norvegicus | M140 | SVGHRMGGGKG | 1 | Homo sapiens | M140 | GMGQRMGGGKG | 1 | Bos taurus | N68 | RREPKNLKDIR | 2 | Mus musculus, Rattus norvegicus | N68 | RREPKNLSDIR | 1 | Homo sapiens | N68 | RREPKNLRDIR | 1 | Bos taurus | P184 | VAHKLPFPAKA | 3 | Mus musculus, Rattus norvegicus, Bos taurus | P184 | VAHKLPFAAKA | 1 | Homo sapiens | P232 | RKVLSPYDLTH | 2 | Homo sapiens, Bos taurus | P232 | RKFLSPYDLTQ | 2 | Mus musculus, Rattus norvegicus | P66 | KVRREPKNLKD | 2 | Mus musculus, Rattus norvegicus | P66 | KVRREPKNLSD | 1 | Homo sapiens | P66 | KVRREPKNLRD | 1 | Bos taurus | Q178 | QGFLDQVAHKL | 1 | Homo sapiens | Q178 | KGILNQVAHKL | 1 | Mus musculus | Q178 | KRVLNQVAHKL | 1 | Rattus norvegicus | Q178 | QGILNQVAHKL | 1 | Bos taurus | R111 | RLTINRFMDPK | 3 | Mus musculus, Rattus norvegicus, Bos taurus | R111 | RLTINRSMDPK | 1 | Homo sapiens | R139 | KGVGQRMGGGK | 2 | Mus musculus, Rattus norvegicus | R139 | KSVGHRMGGGK | 1 | Homo sapiens | R139 | KGMGQRMGGGK | 1 | Bos taurus | R227 | NMLGIRKVLSP | 2 | Homo sapiens, Bos taurus | R227 | NMFGIRKFLSP | 2 | Mus musculus, Rattus norvegicus | R63 | LVPKVRREPKN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R64 | VPKVRREPKNL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R73 | NLSDIRGPSTE | 1 | Homo sapiens | R73 | NLKDIRGPSTE | 1 | Mus musculus | R73 | NLKDIRGPSAE | 1 | Rattus norvegicus | R73 | NLRDIRGPSTE | 1 | Bos taurus | S231 | IRKVLSPYDLT | 2 | Homo sapiens, Bos taurus | S231 | IRKFLSPYDLT | 2 | Mus musculus, Rattus norvegicus | V229 | LGIRKVLSPYD | 2 | Homo sapiens, Bos taurus | V229 | FGIRKFLSPYD | 2 | Mus musculus, Rattus norvegicus | Y233 | KFLSPYDLTQK | 2 | Mus musculus, Rattus norvegicus | Y233 | KVLSPYDLTHK | 1 | Homo sapiens | Y233 | KVLSPYDLTHR | 1 | Bos taurus | Y96 | ALGGGYLHWGH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus |
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