mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPL16
Gene summary
Basic gene Info.Gene symbolMRPL16
Gene namemitochondrial ribosomal protein L16
SynonymsL16mt|MRP-L16
CytomapUCSC genome browser: 11q12.1
Type of geneprotein-coding
RefGenesNM_017840.3,
Description39S ribosomal protein L16, mitochondrial
Modification date20141207
dbXrefs MIM : 611829
HGNC : HGNC
Ensembl : ENSG00000166902
HPRD : 14743
Vega : OTTHUMG00000167410
ProteinUniProt: Q9NX20
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPL16
BioGPS: 54948
PathwayNCI Pathway Interaction Database: MRPL16
KEGG: MRPL16
REACTOME: MRPL16
Pathway Commons: MRPL16
ContextiHOP: MRPL16
ligand binding site mutation search in PubMed: MRPL16
UCL Cancer Institute: MRPL16
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MRPL16

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R227G225SCOAD1
I72D71NLUAD1
R227R227QTHCA1
M104R106CUCEC1
R227R227WUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MRPL16
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M104R106C-1.2160011
R227R227Q-1.0104356
R227R227W-0.71920874
R227G225S-0.6050766
I72D71N-0.53173948
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPL16 from PDB

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Differential gene expression and gene-gene network for MRPL16
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPL16 and the right PPI network was created from samples without mutations in the LBS of MRPL16. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MRPL16
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MRPL16
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPL16 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yNI72 M104 R227


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Conservation information for LBS of MRPL16
Multiple alignments for Q9NX20 in multiple species
LBSAA sequence# speciesSpecies
G100GYLHWGHFEMM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G137TRKGVGQRMGG2Mus musculus, Rattus norvegicus
G137TRKSVGHRMGG1Homo sapiens
G137TRKGMGQRMGG1Bos taurus
G141VGQRMGGGKGA2Mus musculus, Rattus norvegicus
G141VGHRMGGGKGA1Homo sapiens
G141MGQRMGGGKGA1Bos taurus
G142GQRMGGGKGAI3Mus musculus, Rattus norvegicus, Bos taurus
G142GHRMGGGKGAI1Homo sapiens
G143QRMGGGKGAID3Mus musculus, Rattus norvegicus, Bos taurus
G143HRMGGGKGAID1Homo sapiens
G145MGGGKGAIDHY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H101YLHWGHFEMMR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H181LNQVAHKLPFP3Mus musculus, Rattus norvegicus, Bos taurus
H181LDQVAHKLPFA1Homo sapiens
I72KNLSDIRGPST1Homo sapiens
I72KNLKDIRGPST1Mus musculus
I72KNLKDIRGPSA1Rattus norvegicus
I72KNLRDIRGPST1Bos taurus
K134KPITRKGVGQR2Mus musculus, Rattus norvegicus
K134KPITRKSVGHR1Homo sapiens
K134KAITRKGMGQR1Bos taurus
K144RMGGGKGAIDH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K182NQVAHKLPFPA3Mus musculus, Rattus norvegicus, Bos taurus
K182DQVAHKLPFAA1Homo sapiens
K228MLGIRKVLSPY2Homo sapiens, Bos taurus
K228MFGIRKFLSPY2Mus musculus, Rattus norvegicus
K244GRYWGKFYMPK2Mus musculus, Rattus norvegicus
K244GKYWGKFYMPK1Homo sapiens
K244GRYWGKFYMPE1Bos taurus
K67VRREPKNLKDI2Mus musculus, Rattus norvegicus
K67VRREPKNLSDI1Homo sapiens
K67VRREPKNLRDI1Bos taurus
L183QVAHKLPFPAK3Mus musculus, Rattus norvegicus, Bos taurus
L183QVAHKLPFAAK1Homo sapiens
L69REPKNLKDIRG2Mus musculus, Rattus norvegicus
L69REPKNLSDIRG1Homo sapiens
L69REPKNLRDIRG1Bos taurus
M104WGHFEMMRLTI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M140GVGQRMGGGKG2Mus musculus, Rattus norvegicus
M140SVGHRMGGGKG1Homo sapiens
M140GMGQRMGGGKG1Bos taurus
N68RREPKNLKDIR2Mus musculus, Rattus norvegicus
N68RREPKNLSDIR1Homo sapiens
N68RREPKNLRDIR1Bos taurus
P184VAHKLPFPAKA3Mus musculus, Rattus norvegicus, Bos taurus
P184VAHKLPFAAKA1Homo sapiens
P232RKVLSPYDLTH2Homo sapiens, Bos taurus
P232RKFLSPYDLTQ2Mus musculus, Rattus norvegicus
P66KVRREPKNLKD2Mus musculus, Rattus norvegicus
P66KVRREPKNLSD1Homo sapiens
P66KVRREPKNLRD1Bos taurus
Q178QGFLDQVAHKL1Homo sapiens
Q178KGILNQVAHKL1Mus musculus
Q178KRVLNQVAHKL1Rattus norvegicus
Q178QGILNQVAHKL1Bos taurus
R111RLTINRFMDPK3Mus musculus, Rattus norvegicus, Bos taurus
R111RLTINRSMDPK1Homo sapiens
R139KGVGQRMGGGK2Mus musculus, Rattus norvegicus
R139KSVGHRMGGGK1Homo sapiens
R139KGMGQRMGGGK1Bos taurus
R227NMLGIRKVLSP2Homo sapiens, Bos taurus
R227NMFGIRKFLSP2Mus musculus, Rattus norvegicus
R63LVPKVRREPKN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R64VPKVRREPKNL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R73NLSDIRGPSTE1Homo sapiens
R73NLKDIRGPSTE1Mus musculus
R73NLKDIRGPSAE1Rattus norvegicus
R73NLRDIRGPSTE1Bos taurus
S231IRKVLSPYDLT2Homo sapiens, Bos taurus
S231IRKFLSPYDLT2Mus musculus, Rattus norvegicus
V229LGIRKVLSPYD2Homo sapiens, Bos taurus
V229FGIRKFLSPYD2Mus musculus, Rattus norvegicus
Y233KFLSPYDLTQK2Mus musculus, Rattus norvegicus
Y233KVLSPYDLTHK1Homo sapiens
Y233KVLSPYDLTHR1Bos taurus
Y96ALGGGYLHWGH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus


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