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mutLBSgeneDB |
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| Gene summary for NMRK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | NMRK1 |
| Gene name | nicotinamide riboside kinase 1 | |
| Synonyms | C9orf95|NRK1|bA235O14.2 | |
| Cytomap | UCSC genome browser: 9q21.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001127603.1, NM_017881.2,NR_023352.1, | |
| Description | NRK 1RNK 1nicotinic acid riboside kinase 1nmR-K 1ribosylnicotinamide kinase 1ribosylnicotinic acid kinase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608704 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106733 | ||
| HPRD : 09868 | ||
| Vega : OTTHUMG00000020034 | ||
| Protein | UniProt: Q9NWW6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NMRK1 | |
| BioGPS: 54981 | ||
| Pathway | NCI Pathway Interaction Database: NMRK1 | |
| KEGG: NMRK1 | ||
| REACTOME: NMRK1 | ||
| Pathway Commons: NMRK1 | ||
| Context | iHOP: NMRK1 | |
| ligand binding site mutation search in PubMed: NMRK1 | ||
| UCL Cancer Institute: NMRK1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for NMRK1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F100 | F100V | COAD | 1 | K172 | T171K | KICH | 1 | F100 | E98K | LUSC | 1 | L177 | D176G | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NMRK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K172 | T171K | -1.4046067 | L177 | D176G | -1.0700276 | F100 | E98K | -0.85745467 | F100 | F100V | -0.39519583 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NMRK1 from PDB |
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| Differential gene expression and gene-gene network for NMRK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NMRK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NMRK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NMRK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NMN | NICOTINAMIDE MONONUCLEOTIDE | 2qg6 | A | F100 | TIZ | TIAZOFURIN | 2ql6 | A | F100 | TIZ | TIAZOFURIN | 2ql6 | B | F100 | TIZ | TIAZOFURIN | 2ql6 | C | F100 | TIZ | TIAZOFURIN | 2ql6 | D | F100 | TIZ | TIAZOFURIN | 2ql6 | E | F100 | TIZ | TIAZOFURIN | 2ql6 | F | F100 | TIZ | TIAZOFURIN | 2ql6 | G | F100 | TIZ | TIAZOFURIN | 2ql6 | H | F100 | TIZ | TIAZOFURIN | 2ql6 | I | F100 | TIZ | TIAZOFURIN | 2ql6 | J | F100 | TIZ | TIAZOFURIN | 2ql6 | K | F100 | TIZ | TIAZOFURIN | 2ql6 | L | F100 | TIZ | TIAZOFURIN | 2ql6 | M | F100 | TIZ | TIAZOFURIN | 2ql6 | N | F100 | TIZ | TIAZOFURIN | 2ql6 | O | F100 | TIZ | TIAZOFURIN | 2ql6 | P | F100 | NMN | NICOTINAMIDE MONONUCLEOTIDE | 2qsz | A | F100 | NNR | N-RIBOSYLNICOTINAMIDE | 2qt0 | A | F100 | NNR | N-RIBOSYLNICOTINAMIDE | 2qt1 | A | F100 | ADP | ADP | 2ql6 | A | K172 | ADP | ADP | 2ql6 | B | K172 | ADP | ADP | 2ql6 | C | K172 | ADP | ADP | 2ql6 | D | K172 | ADP | ADP | 2ql6 | E | K172 | ADP | ADP | 2ql6 | F | K172 | ADP | ADP | 2ql6 | G | K172 | ADP | ADP | 2ql6 | H | K172 | ADP | ADP | 2ql6 | I | K172 | ADP | ADP | 2ql6 | J | K172 | ADP | ADP | 2ql6 | K | K172 | ADP | ADP | 2ql6 | L | K172 | ADP | ADP | 2ql6 | M | K172 | ADP | ADP | 2ql6 | N | K172 | ADP | ADP | 2ql6 | O | K172 | ADP | ADP | 2ql6 | P | K172 | ADP | ADP | 2qsy | A | K172 L177 | ANP | AMP-PNP | 2qt0 | A | K172 L177 |
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| Conservation information for LBS of NMRK1 |
| Multiple alignments for Q9NWW6 in multiple species |
| LBS | AA sequence | # species | Species | D36 | SVISQDDFFKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D56 | GFLQYDVLEAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E174 | DGTRSEEDLFS | 2 | Mus musculus, Rattus norvegicus | E174 | DGTKSEEDLFL | 1 | Homo sapiens | F100 | LIIEGFLLFNY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F39 | SQDDFFKPESE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G15 | GVTNGGKTTLA | 2 | Mus musculus, Rattus norvegicus | G15 | GVTNSGKTTLA | 1 | Homo sapiens | K16 | VTNGGKTTLAK | 2 | Mus musculus, Rattus norvegicus | K16 | VTNSGKTTLAK | 1 | Homo sapiens | K172 | YLDGTRSEEDL | 2 | Mus musculus, Rattus norvegicus | K172 | YLDGTKSEEDL | 1 | Homo sapiens | L177 | RSEEDLFSQVY | 2 | Mus musculus, Rattus norvegicus | L177 | KSEEDLFLQVY | 1 | Homo sapiens | N13 | IGGVTNGGKTT | 2 | Mus musculus, Rattus norvegicus | N13 | ISGVTNSGKTT | 1 | Homo sapiens | Q135 | STRVYEPPDPP | 2 | Mus musculus, Rattus norvegicus | Q135 | STRVYQPPDSP | 1 | Homo sapiens | R128 | EECKRRRSTRV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R129 | ECKRRRSTRVY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R132 | RRRSTRVYEPP | 2 | Mus musculus, Rattus norvegicus | R132 | RRRSTRVYQPP | 1 | Homo sapiens | S14 | GGVTNGGKTTL | 2 | Mus musculus, Rattus norvegicus | S14 | SGVTNSGKTTL | 1 | Homo sapiens | S173 | LDGTRSEEDLF | 2 | Mus musculus, Rattus norvegicus | S173 | LDGTKSEEDLF | 1 | Homo sapiens | T12 | GIGGVTNGGKT | 2 | Mus musculus, Rattus norvegicus | T12 | GISGVTNSGKT | 1 | Homo sapiens | T17 | TNSGKTTLAKN | 1 | Homo sapiens | T17 | TNGGKTTLAKS | 1 | Mus musculus | T17 | TNGGKTTLAKN | 1 | Rattus norvegicus | T18 | NSGKTTLAKNL | 1 | Homo sapiens | T18 | NGGKTTLAKSL | 1 | Mus musculus | T18 | NGGKTTLAKNL | 1 | Rattus norvegicus | Y134 | RSTRVYEPPDP | 2 | Mus musculus, Rattus norvegicus | Y134 | RSTRVYQPPDS | 1 | Homo sapiens | Y55 | NGFLQYDVLEA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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