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mutLBSgeneDB |
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| Gene summary for ACPP |
 Gene summary |
| Basic gene Info. | Gene symbol | ACPP |
| Gene name | acid phosphatase, prostate | |
| Synonyms | 5'-NT|ACP-3|ACP3 | |
| Cytomap | UCSC genome browser: 3q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099.4, NM_001134194.1,NM_001292037.1, | |
| Description | 5'-nucleotidaseTMPaseecto-5'-nucleotidaseprostatic acid phosphataseprostatic acid phosphotasethiamine monophosphatase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 171790 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000014257 | ||
| HPRD : 01378 | ||
| Vega : OTTHUMG00000159650 | ||
| Protein | UniProt: P15309 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACPP | |
| BioGPS: 55 | ||
| Pathway | NCI Pathway Interaction Database: ACPP | |
| KEGG: ACPP | ||
| REACTOME: ACPP | ||
| Pathway Commons: ACPP | ||
| Context | iHOP: ACPP | |
| ligand binding site mutation search in PubMed: ACPP | ||
| UCL Cancer Institute: ACPP | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0046085 | adenosine metabolic process | 18940592 |
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| Ligand binding site mutations for ACPP |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R43 | R43W | BRCA | 2 | R43 | R43W | SKCM | 1 | H44 | G45R | SKCM | 1 | R47 | R47Q | SKCM | 1 | D211 | D211N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ACPP |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R43 | R43W | -1.5802703 | R47 | R47Q | -0.96288319 | D211 | D211N | -0.57389854 | H44 | G45R | -0.42669584 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ACPP from PDB |
| PDB ID | PDB title | PDB structure | 1CVI | CRYSTAL STRUCTURE OF HUMAN PROSTATIC ACID PHOSPHATASE |  |
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| Differential gene expression and gene-gene network for ACPP |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ACPP |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ACPP |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03390 | N-Propyl-Tartramic Acid | Small molecule |  |
| Experimental | DB03577 | Alpha-Benzyl-Aminobenzyl-Phosphonic Acid | Small molecule |  |
| Approved | DB06688 | Sipuleucel-T | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ACPP go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ACPP |
| Multiple alignments for P15309 in multiple species |
| LBS | AA sequence | # species | Species | D211 | WSKVYDPLFCE | 2 | Bos taurus, Mus musculus | D211 | WSKVYDPLYCE | 1 | Homo sapiens | D211 | WSRLYDPLYCE | 1 | Rattus norvegicus | D290 | MYSAHDTTVSG | 3 | Homo sapiens, Bos taurus, Mus musculus | D290 | MYSAYDTTVSG | 1 | Rattus norvegicus | E338 | NETQNEPYPLT | 2 | Mus musculus, Rattus norvegicus | E338 | NETQHEPYPLM | 1 | Homo sapiens | E338 | NETRYEPHPLT | 1 | Bos taurus | F203 | HGQDLFGIWSK | 1 | Homo sapiens | F203 | HDQDLLGIWSK | 1 | Bos taurus | F203 | DDQDLFGIWSK | 1 | Mus musculus | F203 | EDQDLFEIWSR | 1 | Rattus norvegicus | H289 | IMYSAHDTTVS | 2 | Homo sapiens, Bos taurus | H289 | VMYSAHDTTVS | 1 | Mus musculus | H289 | IMYSAYDTTVS | 1 | Rattus norvegicus | H337 | RNETQNEPYPL | 2 | Mus musculus, Rattus norvegicus | H337 | RNETQHEPYPL | 1 | Homo sapiens | H337 | RNETRYEPHPL | 1 | Bos taurus | H44 | TLVFRHGDRSP | 2 | Homo sapiens, Bos taurus | H44 | TLVFRHGDRGP | 2 | Mus musculus, Rattus norvegicus | I50 | GDRSPIDTFPT | 1 | Homo sapiens | I50 | GDRSPIETFPN | 1 | Bos taurus | I50 | GDRGPIETFPT | 1 | Mus musculus | I50 | GDRGPIETFPN | 1 | Rattus norvegicus | R111 | STDVDRTLMSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R111 | STDIDRTLMSA | 1 | Bos taurus | R43 | VTLVFRHGDRS | 2 | Homo sapiens, Bos taurus | R43 | VTLVFRHGDRG | 2 | Mus musculus, Rattus norvegicus | R47 | FRHGDRGPIET | 2 | Mus musculus, Rattus norvegicus | R47 | FRHGDRSPIDT | 1 | Homo sapiens | R47 | FRHGDRSPIET | 1 | Bos taurus | S207 | LFGIWSKVYDP | 2 | Homo sapiens, Mus musculus | S207 | LLGIWSKVYDP | 1 | Bos taurus | S207 | LFEIWSRLYDP | 1 | Rattus norvegicus | T291 | YSAHDTTVSGL | 3 | Homo sapiens, Bos taurus, Mus musculus | T291 | YSAYDTTVSGL | 1 | Rattus norvegicus | Y155 | EDQLLYLPFRN | 2 | Homo sapiens, Bos taurus | Y155 | EDRLLYLPFRD | 2 | Mus musculus, Rattus norvegicus | Y340 | TQNEPYPLTLP | 2 | Mus musculus, Rattus norvegicus | Y340 | TQHEPYPLMLP | 1 | Homo sapiens | Y340 | TRYEPHPLTLP | 1 | Bos taurus |
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