mutLBSgeneDB |
Gene summary for TRMT61B |
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Basic gene Info. | Gene symbol | TRMT61B |
Gene name | tRNA methyltransferase 61B | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p23.2 | |
Type of gene | protein-coding | |
RefGenes | NM_017910.3, | |
Description | potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61Bpotential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61BtRNA (adenine(58)-N(1))-methyltransferase, mitochondrialtRNA methyltransferase 61 homolog B | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000171103 | ||
HPRD : 07935 | ||
Vega : OTTHUMG00000128433 | ||
Protein | UniProt: Q9BVS5 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRMT61B | |
BioGPS: 55006 | ||
Pathway | NCI Pathway Interaction Database: TRMT61B | |
KEGG: TRMT61B | ||
REACTOME: TRMT61B | ||
Pathway Commons: TRMT61B | ||
Context | iHOP: TRMT61B | |
ligand binding site mutation search in PubMed: TRMT61B | ||
UCL Cancer Institute: TRMT61B | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0051260 | protein homooligomerization | 23097428 | GO:0070901 | mitochondrial tRNA methylation | 23097428 |
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Ligand binding site mutations for TRMT61B |
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LBS | AAchange of nsSNV | Cancer type | # samples | T230 | P232Q | LUAD | 1 | V279 | V279L | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TRMT61B |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T230 | P232Q | -1.4983137 | V279 | V279L | -1.0812155 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for TRMT61B |
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Phenotype information for TRMT61B |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TRMT61B |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of TRMT61B |
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LBS | AA sequence | # species | Species |
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