mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for WDYHV1
Gene summary
Basic gene Info.Gene symbolWDYHV1
Gene nameWDYHV motif containing 1
CytomapUCSC genome browser: 8q24.13
Type of geneprotein-coding
DescriptionN-terminal Gln amidaseWDYHV motif-containing protein 1nt(Q)-amidaseprotein N-terminal glutamine amidohydrolaseprotein NH2-terminal glutamine deamidase
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000156795
HPRD : 07653
Vega : OTTHUMG00000165093
ProteinUniProt: Q96HA8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_WDYHV1
BioGPS: 55093
PathwayNCI Pathway Interaction Database: WDYHV1
Pathway Commons: WDYHV1
ContextiHOP: WDYHV1
ligand binding site mutation search in PubMed: WDYHV1
UCL Cancer Institute: WDYHV1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for WDYHV1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for WDYHV1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for WDYHV1 from PDB

Differential gene expression and gene-gene network for WDYHV1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of WDYHV1 and the right PPI network was created from samples without mutations in the LBS of WDYHV1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for WDYHV1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for WDYHV1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of WDYHV1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (SER,THR,ALA)3c9qAD79 Y80

Conservation information for LBS of WDYHV1
Multiple alignments for Q96HA8 in multiple species
LBSAA sequence# speciesSpecies
A189---WGAVYTLS2Homo sapiens, Rattus norvegicus
A189---NTTVMDEP1Caenorhabditis elegans
A189SQKLGVVVSHT1Arabidopsis thaliana
A189SSKHGVVINET1Oryza sativa subsp. japonica
A189---PGSVYSLS1Drosophila melanogaster
A189---PGAVYDLL1Anopheles gambiae
A189---YGEVYSLS1Danio rerio
A189---WGAVYTLP1Mus musculus
A189---WGAVYSLP1Bos taurus
C26Y--SSCYCEEN2Homo sapiens, Rattus norvegicus
C26Y--VSCYCEEN2Drosophila melanogaster, Anopheles gambiae
C26Y--NSCYCEEN2Mus musculus, Bos taurus
C26Y--QSCYCEEN1Caenorhabditis elegans
C26FQHTPYYCEEN1Arabidopsis thaliana
C26FTHTPYYCEEN1Oryza sativa subsp. japonica
C26Y--TSCYCEEN1Danio rerio
D43YIKNHDQYPLE2Homo sapiens, Bos taurus
D43YIKTHNQYLLE2Mus musculus, Rattus norvegicus
D43KIDDKNGI---1Caenorhabditis elegans
D43TLCENGVAEAT1Arabidopsis thaliana
D43ELIRSGISDPA1Oryza sativa subsp. japonica
D43QVKRTRPEELS1Drosophila melanogaster
D43QVKKTYPSELP1Anopheles gambiae
D43YIKNQRHCPLE1Danio rerio
D79GPVIWDYHVVL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D79GHVLWDYHVIA1Caenorhabditis elegans
D79GVVLWDYHVIC1Arabidopsis thaliana
D79GFVLWDYHVIC1Oryza sativa subsp. japonica
D79QVVIWDYHVFF1Drosophila melanogaster
D79KLVIWDYHVFF1Anopheles gambiae
D79EPVIWDYHVIL1Danio rerio
F200EFTHRFGSKNC1Homo sapiens
F200ELFQLFSK---1Caenorhabditis elegans
F200QLQDLFTKLP-1Arabidopsis thaliana
F200ILPEFFSRLPG1Oryza sativa subsp. japonica
F200EFVQNFYKSPH1Drosophila melanogaster
F200HFVQQFYKPPD1Anopheles gambiae
F200DFVKHFGVK--1Danio rerio
F200EFVHRFSSKTY1Mus musculus
F200EFVHRFSSKNY1Rattus norvegicus
F200EFVHRFSSQNY1Bos taurus
H42EYIKNHDQYPL2Homo sapiens, Bos taurus
H42EYIKTHNQYLL2Mus musculus, Rattus norvegicus
H42EKIDDKNGI--1Caenorhabditis elegans
H42KTLCENGVAEA1Arabidopsis thaliana
H42KELIRSGISDP1Oryza sativa subsp. japonica
H42EQVKRTRPEEL1Drosophila melanogaster
H42EQVKKTYPSEL1Anopheles gambiae
H42EYIKNQRHCPL1Danio rerio
I77GDGPVIWDYHV2Homo sapiens, Bos taurus
I77ENGPVIWDYHV2Mus musculus, Rattus norvegicus
I77INGHVLWDYHV1Caenorhabditis elegans
I77ADGVVLWDYHV1Arabidopsis thaliana
I77GDGFVLWDYHV1Oryza sativa subsp. japonica
I77DDQVVIWDYHV1Drosophila melanogaster
I77DEKLVIWDYHV1Anopheles gambiae
I77GDEPVIWDYHV1Danio rerio
M149SDRSHMKDSSG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M149SDRRHMRRPDG2Drosophila melanogaster, Anopheles gambiae
M149SDRSHMLSKNG1Caenorhabditis elegans
M149SDRRHMKEPDG1Arabidopsis thaliana
M149SDRSHMKDHAG1Oryza sativa subsp. japonica
M149SDRSHMKDSDG1Danio rerio
R199SEFTHRFGSKN1Homo sapiens
R199PELFQLFSK--1Caenorhabditis elegans
R199TQLQDLFTKLP1Arabidopsis thaliana
R199TILPEFFSRLP1Oryza sativa subsp. japonica
R199SEFVQNFYKSP1Drosophila melanogaster
R199LHFVQQFYKPP1Anopheles gambiae
R199SDFVKHFGVK-1Danio rerio
R199PEFVHRFSSKT1Mus musculus
R199SEFVHRFSSKN1Rattus norvegicus
R199PEFVHRFSSQN1Bos taurus
W78DGPVIWDYHVV2Homo sapiens, Bos taurus
W78NGPVIWDYHVV2Mus musculus, Rattus norvegicus
W78NGHVLWDYHVI1Caenorhabditis elegans
W78DGVVLWDYHVI1Arabidopsis thaliana
W78DGFVLWDYHVI1Oryza sativa subsp. japonica
W78DQVVIWDYHVF1Drosophila melanogaster
W78EKLVIWDYHVF1Anopheles gambiae
W78DEPVIWDYHVI1Danio rerio
Y51EEC--YAVFIS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y51-----FAIIIS1Caenorhabditis elegans
Y51TCSDLFVVFIS1Arabidopsis thaliana
Y51AGTNLYAVFIS1Oryza sativa subsp. japonica
Y51SKC--YAVFVS1Drosophila melanogaster
Y51PKC--YAVFVS1Anopheles gambiae
Y51EEV--YAVFIS1Danio rerio
Y80PVIWDYHVVLL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y80HVLWDYHVIAI1Caenorhabditis elegans
Y80VVLWDYHVICV1Arabidopsis thaliana
Y80FVLWDYHVICI1Oryza sativa subsp. japonica
Y80VVIWDYHVFFI1Drosophila melanogaster
Y80LVIWDYHVFFM1Anopheles gambiae
Y80PVIWDYHVILL1Danio rerio

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