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mutLBSgeneDB |
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| Gene summary for WDYHV1 |
 Gene summary |
| Basic gene Info. | Gene symbol | WDYHV1 |
| Gene name | WDYHV motif containing 1 | |
| Synonyms | C8orf32 | |
| Cytomap | UCSC genome browser: 8q24.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001283024.1, NM_001283027.1,NM_018024.2, | |
| Description | N-terminal Gln amidaseWDYHV motif-containing protein 1nt(Q)-amidaseprotein N-terminal glutamine amidohydrolaseprotein NH2-terminal glutamine deamidase | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000156795 | ||
| HPRD : 07653 | ||
| Vega : OTTHUMG00000165093 | ||
| Protein | UniProt: Q96HA8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WDYHV1 | |
| BioGPS: 55093 | ||
| Pathway | NCI Pathway Interaction Database: WDYHV1 | |
| KEGG: WDYHV1 | ||
| REACTOME: WDYHV1 | ||
| Pathway Commons: WDYHV1 | ||
| Context | iHOP: WDYHV1 | |
| ligand binding site mutation search in PubMed: WDYHV1 | ||
| UCL Cancer Institute: WDYHV1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for WDYHV1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D79 | D79V | BRCA | 1 | A189 | A189T | COAD | 1 | Y80 | Y80F | OV | 1 | Y51 | E49V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for WDYHV1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y80 | Y80F | -1.1770252 | D79 | D79V | -1.0143942 | Y51 | E49V | -0.77109614 | A189 | A189T | -0.75422002 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for WDYHV1 from PDB |
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| Differential gene expression and gene-gene network for WDYHV1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for WDYHV1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for WDYHV1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of WDYHV1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (SER,THR,ALA) | 3c9q | A | D79 Y80 | CO3 | CARBONATE | 4w79 | A | Y51 | CO3 | CARBONATE | 3c9q | A | Y51 A189 | CO3 | CARBONATE | 4w79 | A | Y51 A189 |
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| Conservation information for LBS of WDYHV1 |
| Multiple alignments for Q96HA8 in multiple species |
| LBS | AA sequence | # species | Species | A189 | ---WGAVYTLS | 2 | Homo sapiens, Rattus norvegicus | A189 | ---NTTVMDEP | 1 | Caenorhabditis elegans | A189 | SQKLGVVVSHT | 1 | Arabidopsis thaliana | A189 | SSKHGVVINET | 1 | Oryza sativa subsp. japonica | A189 | ---PGSVYSLS | 1 | Drosophila melanogaster | A189 | ---PGAVYDLL | 1 | Anopheles gambiae | A189 | ---YGEVYSLS | 1 | Danio rerio | A189 | ---WGAVYTLP | 1 | Mus musculus | A189 | ---WGAVYSLP | 1 | Bos taurus | C26 | Y--SSCYCEEN | 2 | Homo sapiens, Rattus norvegicus | C26 | Y--VSCYCEEN | 2 | Drosophila melanogaster, Anopheles gambiae | C26 | Y--NSCYCEEN | 2 | Mus musculus, Bos taurus | C26 | Y--QSCYCEEN | 1 | Caenorhabditis elegans | C26 | FQHTPYYCEEN | 1 | Arabidopsis thaliana | C26 | FTHTPYYCEEN | 1 | Oryza sativa subsp. japonica | C26 | Y--TSCYCEEN | 1 | Danio rerio | D43 | YIKNHDQYPLE | 2 | Homo sapiens, Bos taurus | D43 | YIKTHNQYLLE | 2 | Mus musculus, Rattus norvegicus | D43 | KIDDKNGI--- | 1 | Caenorhabditis elegans | D43 | TLCENGVAEAT | 1 | Arabidopsis thaliana | D43 | ELIRSGISDPA | 1 | Oryza sativa subsp. japonica | D43 | QVKRTRPEELS | 1 | Drosophila melanogaster | D43 | QVKKTYPSELP | 1 | Anopheles gambiae | D43 | YIKNQRHCPLE | 1 | Danio rerio | D79 | GPVIWDYHVVL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D79 | GHVLWDYHVIA | 1 | Caenorhabditis elegans | D79 | GVVLWDYHVIC | 1 | Arabidopsis thaliana | D79 | GFVLWDYHVIC | 1 | Oryza sativa subsp. japonica | D79 | QVVIWDYHVFF | 1 | Drosophila melanogaster | D79 | KLVIWDYHVFF | 1 | Anopheles gambiae | D79 | EPVIWDYHVIL | 1 | Danio rerio | F200 | EFTHRFGSKNC | 1 | Homo sapiens | F200 | ELFQLFSK--- | 1 | Caenorhabditis elegans | F200 | QLQDLFTKLP- | 1 | Arabidopsis thaliana | F200 | ILPEFFSRLPG | 1 | Oryza sativa subsp. japonica | F200 | EFVQNFYKSPH | 1 | Drosophila melanogaster | F200 | HFVQQFYKPPD | 1 | Anopheles gambiae | F200 | DFVKHFGVK-- | 1 | Danio rerio | F200 | EFVHRFSSKTY | 1 | Mus musculus | F200 | EFVHRFSSKNY | 1 | Rattus norvegicus | F200 | EFVHRFSSQNY | 1 | Bos taurus | H42 | EYIKNHDQYPL | 2 | Homo sapiens, Bos taurus | H42 | EYIKTHNQYLL | 2 | Mus musculus, Rattus norvegicus | H42 | EKIDDKNGI-- | 1 | Caenorhabditis elegans | H42 | KTLCENGVAEA | 1 | Arabidopsis thaliana | H42 | KELIRSGISDP | 1 | Oryza sativa subsp. japonica | H42 | EQVKRTRPEEL | 1 | Drosophila melanogaster | H42 | EQVKKTYPSEL | 1 | Anopheles gambiae | H42 | EYIKNQRHCPL | 1 | Danio rerio | I77 | GDGPVIWDYHV | 2 | Homo sapiens, Bos taurus | I77 | ENGPVIWDYHV | 2 | Mus musculus, Rattus norvegicus | I77 | INGHVLWDYHV | 1 | Caenorhabditis elegans | I77 | ADGVVLWDYHV | 1 | Arabidopsis thaliana | I77 | GDGFVLWDYHV | 1 | Oryza sativa subsp. japonica | I77 | DDQVVIWDYHV | 1 | Drosophila melanogaster | I77 | DEKLVIWDYHV | 1 | Anopheles gambiae | I77 | GDEPVIWDYHV | 1 | Danio rerio | M149 | SDRSHMKDSSG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M149 | SDRRHMRRPDG | 2 | Drosophila melanogaster, Anopheles gambiae | M149 | SDRSHMLSKNG | 1 | Caenorhabditis elegans | M149 | SDRRHMKEPDG | 1 | Arabidopsis thaliana | M149 | SDRSHMKDHAG | 1 | Oryza sativa subsp. japonica | M149 | SDRSHMKDSDG | 1 | Danio rerio | R199 | SEFTHRFGSKN | 1 | Homo sapiens | R199 | PELFQLFSK-- | 1 | Caenorhabditis elegans | R199 | TQLQDLFTKLP | 1 | Arabidopsis thaliana | R199 | TILPEFFSRLP | 1 | Oryza sativa subsp. japonica | R199 | SEFVQNFYKSP | 1 | Drosophila melanogaster | R199 | LHFVQQFYKPP | 1 | Anopheles gambiae | R199 | SDFVKHFGVK- | 1 | Danio rerio | R199 | PEFVHRFSSKT | 1 | Mus musculus | R199 | SEFVHRFSSKN | 1 | Rattus norvegicus | R199 | PEFVHRFSSQN | 1 | Bos taurus | W78 | DGPVIWDYHVV | 2 | Homo sapiens, Bos taurus | W78 | NGPVIWDYHVV | 2 | Mus musculus, Rattus norvegicus | W78 | NGHVLWDYHVI | 1 | Caenorhabditis elegans | W78 | DGVVLWDYHVI | 1 | Arabidopsis thaliana | W78 | DGFVLWDYHVI | 1 | Oryza sativa subsp. japonica | W78 | DQVVIWDYHVF | 1 | Drosophila melanogaster | W78 | EKLVIWDYHVF | 1 | Anopheles gambiae | W78 | DEPVIWDYHVI | 1 | Danio rerio | Y51 | EEC--YAVFIS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | Y51 | -----FAIIIS | 1 | Caenorhabditis elegans | Y51 | TCSDLFVVFIS | 1 | Arabidopsis thaliana | Y51 | AGTNLYAVFIS | 1 | Oryza sativa subsp. japonica | Y51 | SKC--YAVFVS | 1 | Drosophila melanogaster | Y51 | PKC--YAVFVS | 1 | Anopheles gambiae | Y51 | EEV--YAVFIS | 1 | Danio rerio | Y80 | PVIWDYHVVLL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | Y80 | HVLWDYHVIAI | 1 | Caenorhabditis elegans | Y80 | VVLWDYHVICV | 1 | Arabidopsis thaliana | Y80 | FVLWDYHVICI | 1 | Oryza sativa subsp. japonica | Y80 | VVIWDYHVFFI | 1 | Drosophila melanogaster | Y80 | LVIWDYHVFFM | 1 | Anopheles gambiae | Y80 | PVIWDYHVILL | 1 | Danio rerio |
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