mutLBSgeneDB |
Gene summary for 55110 |
Gene summary |
Basic gene Info. | Gene symbol | 55110 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: P61326 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_55110 | |
BioGPS: 55110 | ||
Pathway | NCI Pathway Interaction Database: 55110 | |
KEGG: 55110 | ||
REACTOME: 55110 | ||
Pathway Commons: 55110 | ||
Context | iHOP: 55110 | |
ligand binding site mutation search in PubMed: 55110 | ||
UCL Cancer Institute: 55110 | ||
Assigned class in mutLBSgeneDB |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for 55110 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for 55110 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R82 | R82Q | -1.4737802 | D66 | D66N | -1.0225694 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for 55110 from PDB |
Top |
Differential gene expression and gene-gene network for 55110 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for 55110 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for 55110 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of 55110 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ILE,ARG,ASN,LYS,ASP,ARG,PRO,ALA,MET,GLN,LEU,TYR,GLN,PRO,GLY) | 2xb2 | C | D66 | III | Peptide ligand (HIS,LEU,ASP,ASP,ASP,GLU,ASP,ARG,LYS,ASN,PRO,ALA,TYR,ILE,PRO,ARG,LYS,GLY,LEU,PHE,PHE,GLU,HIS,ASP,LEU,ARG,GLY,GLN) | 2j0s | C | R82 |
Top |
Conservation information for LBS of 55110 |
Multiple alignments for P61326 in multiple species |
LBS | AA sequence | # species | Species | D66 | KRIIDDSEITK | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | F17 | GHKGKFGHEFL | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | G15 | YVGHKGKFGHE | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | H13 | RYYVGHKGKFG | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | K16 | VGHKGKFGHEF | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | K41 | NNSNYKNDVMI | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | L107 | SKIGSLIDVNQ | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | R82 | WPPPDRVGRQE | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | V83 | PPPDRVGRQEL | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | Y40 | ANNSNYKNDVM | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |