mutLBSgeneDB |
Gene summary for 55110 |
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Basic gene Info. | Gene symbol | 55110 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: P61326 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_55110 | |
BioGPS: 55110 | ||
Pathway | NCI Pathway Interaction Database: 55110 | |
KEGG: 55110 | ||
REACTOME: 55110 | ||
Pathway Commons: 55110 | ||
Context | iHOP: 55110 | |
ligand binding site mutation search in PubMed: 55110 | ||
UCL Cancer Institute: 55110 | ||
Assigned class in mutLBSgeneDB |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for 55110 |
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LBS | AAchange of nsSNV | Cancer type | # samples |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for 55110 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R82 | R82Q | -1.4737802 | D66 | D66N | -1.0225694 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for 55110 |
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Phenotype information for 55110 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for 55110 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ILE,ARG,ASN,LYS,ASP,ARG,PRO,ALA,MET,GLN,LEU,TYR,GLN,PRO,GLY) | 2xb2 | C | D66 | III | Peptide ligand (HIS,LEU,ASP,ASP,ASP,GLU,ASP,ARG,LYS,ASN,PRO,ALA,TYR,ILE,PRO,ARG,LYS,GLY,LEU,PHE,PHE,GLU,HIS,ASP,LEU,ARG,GLY,GLN) | 2j0s | C | R82 |
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Conservation information for LBS of 55110 |
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LBS | AA sequence | # species | Species | D66 | KRIIDDSEITK | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | F17 | GHKGKFGHEFL | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | G15 | YVGHKGKFGHE | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | H13 | RYYVGHKGKFG | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | K16 | VGHKGKFGHEF | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | K41 | NNSNYKNDVMI | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | L107 | SKIGSLIDVNQ | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | R82 | WPPPDRVGRQE | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | V83 | PPPDRVGRQEL | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus | Y40 | ANNSNYKNDVM | 5 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Gallus gallus |
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