mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPP2CA
Gene summary
Basic gene Info.Gene symbolPPP2CA
Gene nameprotein phosphatase 2, catalytic subunit, alpha isozyme
SynonymsPP2Ac|PP2CA|PP2Calpha|RP-C
CytomapUCSC genome browser: 5q31.1
Type of geneprotein-coding
RefGenesNM_002715.2,
DescriptionPP2A-alphaprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprotein phosphatase 2A catalytic subunit, alpha isoformreplication protein Cserine/threonine protein phosphatase 2A, catalytic subunit, alpha isoformserine/threonine-prote
Modification date20141222
dbXrefs MIM : 176915
HGNC : HGNC
HPRD : 08912
ProteinUniProt: P67775
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPP2CA
BioGPS: 5515
PathwayNCI Pathway Interaction Database: PPP2CA
KEGG: PPP2CA
REACTOME: PPP2CA
Pathway Commons: PPP2CA
ContextiHOP: PPP2CA
ligand binding site mutation search in PubMed: PPP2CA
UCL Cancer Institute: PPP2CA
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PPP2CA

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L243M245LKIRC1
H191G193CLUAD1
Q122R121TOV1
Y127V126AUCEC1
R268R268HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPP2CA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y127V126A-1.8569844
R268R268H-1.2696825
H191G193C-0.91470416
L243M245L-0.71317428
Q122R121T-0.64624691
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPP2CA from PDB

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Differential gene expression and gene-gene network for PPP2CA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPP2CA and the right PPI network was created from samples without mutations in the LBS of PPP2CA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPP2CA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004096Asthma1Biomarker
umls:C0018799Heart Diseases1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPP2CA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00163Vitamin ESmall molecule
ExperimentalDB025062,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidSmall molecule
ExperimentalDB06905(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPP2CA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nymCQ122 Y127 H191
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)3dw8CQ122 Y127 H191
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)3dw8FQ122 Y127 H191
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2iaeFQ122 Y127 H191 L243
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nppFQ122 Y127 H191 L243
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nylFQ122 Y127 H191 L243
XT1DINOPHYSISTOXIN-13k7vCQ122 Y127 H191 L243
XT2DINOPHYSISTOXIN-23k7wCQ122 Y127 H191 L243
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2iaeCQ122 Y127 H191 L243 R268
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2ie3CQ122 Y127 H191 L243 R268
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE4lacCY127
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nylCY127 H191
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nppCY127 H191 L243
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)2nymFY127 H191 L243
IIIPeptide ligand (DAL,LEU,ACB,ARG,1ZN,FGA,DAM)3fgaCY127 H191 L243
OKAOKADAIC ACID2ie4CY127 H191 L243 R268


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Conservation information for LBS of PPP2CA
Multiple alignments for P67775 in multiple species
LBSAA sequence# speciesSpecies
A216ISPRGAGYTFG11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
C266SAPNYCYRCGN11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
C269NYCYRCGNQAA6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
C269NYCYRCGNMAA5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D57VTVCGDIHGQF6Schizosaccharomyces pombe (strain 972 / ATCC 24843), Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D57VTVCGDVHGQF5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
D85YLFMGDYVDRG11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
F260NVVTIFSAPNY6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
F260NVVTVFSAPNY5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
G215GISPRGAGYTF11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
H118ILRGNHESRQI11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
H167QIFCLHGGLSP5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
H167QVFCLHGGLSP5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H167RIFCLHGGLSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H191LQEVPHEGPMC5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
H191IQEVPHEGPMC5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H191VQEVPHEGPIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H241LVSRAHQLVME5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
H241LISRAHQLVME5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H241LIARAHQLVME1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H59VCGDVHGQFHD5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
H59VCGDIHGQFYD5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
H59VCGDIHGQFHD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I123HESRQITQVYG11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
L243SRAHQLVMEGY6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Arabidopsis thaliana
L243SRAHQLVMEGF4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
L243ARAHQLVMEGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N117TILRGNHESRQ11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
P190RLQEVPHEGPM5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
P190RIQEVPHEGPM5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
P190RVQEVPHEGPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P213GWGISPRGAGY11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
Q122NHESRQITQVY11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
R214WGISPRGAGYT11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
R268PNYCYRCGNQA6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
R268PNYCYRCGNMA5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R89GDYVDRGYYSV10Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R89GDYVDRGYHSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V189DRLQEVPHEGP5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
V189DRIQEVPHEGP5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
V189DRVQEVPHEGP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W200MCDLLWSDPDD10Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
W200ICDLLWSDPDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y127QITQVYGFYDE11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
Y265FSAPNYCYRCG11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis th
Y267APNYCYRCGNQ6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Bos taurus, Drosophila melanogaster
Y267APNYCYRCGNM5Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana


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