mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRMT6
Gene summary
Basic gene Info.Gene symbolPRMT6
Gene nameprotein arginine methyltransferase 6
SynonymsHRMT1L6
CytomapUCSC genome browser: 1p13.3
Type of geneprotein-coding
RefGenesNM_018137.2,
DescriptionHMT1 hnRNP methyltransferase-like 6heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6histone-arginine N-methyltransferase PRMT6protein arginine N-methyltransferase 6
Modification date20141207
dbXrefs MIM : 608274
HGNC : HGNC
Ensembl : ENSG00000198890
HPRD : 10505
Vega : OTTHUMG00000010964
ProteinUniProt: Q96LA8
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRMT6
BioGPS: 55170
PathwayNCI Pathway Interaction Database: PRMT6
KEGG: PRMT6
REACTOME: PRMT6
Pathway Commons: PRMT6
ContextiHOP: PRMT6
ligand binding site mutation search in PubMed: PRMT6
UCL Cancer Institute: PRMT6
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0016571histone methylation19405910
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine17898714
GO:0034970histone H3-R2 methylation17898714
GO:0043985histone H4-R3 methylation18079182
GO:0045892negative regulation of transcription, DNA-templated18079182


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Ligand binding site mutations for PRMT6

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E155E155QBLCA1
L343I341MHNSC1
G138G138RLUAD1
R351R351PLUAD1
V237I236MLUAD1
L162L162MSTAD1
M60I61NSTAD1
W203E202AUCEC1
Y324L322FUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PRMT6
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V237I236M-1.4385832
W203E202A-1.0802328
M60I61N-1.0177709
Y324L322F-0.95356255
L162L162M-0.85573556
G138G138R-0.76878358
E155E155Q-0.52095902
R351R351P-0.44669618
L343I341M-0.088328242
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRMT6 from PDB

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Differential gene expression and gene-gene network for PRMT6
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRMT6 and the right PPI network was created from samples without mutations in the LBS of PRMT6. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PRMT6
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PRMT6
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRMT6 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
36S2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5- YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE4qppAL162 L343 R351
36S2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5- YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE4qppBL162 L343 R351
36S2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5- YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE4qppCL162 L343 R351
SAHS-ADENOSYL-L-HOMOCYSTEINE4hc4AM60
SAHS-ADENOSYL-L-HOMOCYSTEINE4qppAM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4qppBM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4qppCM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4y2hAM60 E155
49KN-{[5-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]METHYL}-N- METHYLETHANE-1,2-DIAMINE4y2hAM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4y2hBM60 E155
49KN-{[5-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]METHYL}-N- METHYLETHANE-1,2-DIAMINE4y2hBM60 E155
49LN,N'-DIMETHYL-N-({3-[4-({TRANS-3-[2-(TETRAHYDRO-2H- PYRAN-4-YL)ETHOXY]CYCLOBUTYL}OXY)PHENYL]-1H-PYRAZOL-4- YL}METHYL)ETHANE-1,2-DIAMINE4y30AM60 E155
49LN,N'-DIMETHYL-N-({3-[4-({TRANS-3-[2-(TETRAHYDRO-2H- PYRAN-4-YL)ETHOXY]CYCLOBUTYL}OXY)PHENYL]-1H-PYRAZOL-4- YL}METHYL)ETHANE-1,2-DIAMINE4y30BM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE5e8rAM60 E155
5L6N-METHYL-N-({4-[4-(PROPAN-2-YLOXY)PHENYL]-1H-PYRROL-3- YL}METHYL)ETHANE-1,2-DIAMINE5e8rAM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE5e8rBM60 E155
5L6N-METHYL-N-({4-[4-(PROPAN-2-YLOXY)PHENYL]-1H-PYRROL-3- YL}METHYL)ETHANE-1,2-DIAMINE5e8rBM60 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4y30AM60 G138 E155
SAHS-ADENOSYL-L-HOMOCYSTEINE4y30BM60 G138 E155
IIIPeptide ligand (UNK,UNK,UNK,UNK,UNK)4qppCW203 V237
IIIPeptide ligand (UNK,UNK,UNK,UNK,UNK)4qppBW203 V237 Y324


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Conservation information for LBS of PRMT6
Multiple alignments for Q96LA8 in multiple species
LBSAA sequence# speciesSpecies
A113VYAVEASAIWQ2Homo sapiens, Mus musculus
A113VYAVDASDIAV1Arabidopsis thaliana
A113VYAVDASDIAL1Oryza sativa subsp. japonica
A113VYAVEASSMSQ1Xenopus tropicalis
A113VYAVEASDIWQ1Bos taurus
A91VLDVGAGTGIL4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
A91VVDVGCGTGIL1Arabidopsis thaliana
A91VLDVGCGTGVL1Oryza sativa subsp. japonica
C50QLYYECYSDVS2Homo sapiens, Mus musculus
C50VAYFHSYAHVG1Arabidopsis thaliana
C50MAYFKAYSHIG1Oryza sativa subsp. japonica
C50CEYFQCYSDVS1Xenopus tropicalis
C50QLYYQCYSDVS1Bos taurus
E112RVYAVEASAIW2Homo sapiens, Mus musculus
E112RVYAVDASDIA2Arabidopsis thaliana, Oryza sativa subsp. japonica
E112AVYAVEASSMS1Xenopus tropicalis
E112RVYAVEASDIW1Bos taurus
E141LPGPVETVELP3Homo sapiens, Mus musculus, Bos taurus
E141LHGRVEDVEID1Arabidopsis thaliana
E141LHGRIEDVEIE1Oryza sativa subsp. japonica
E141LNSSVESAEIP1Xenopus tropicalis
E155DAIVSEWMGYG2Homo sapiens, Mus musculus
E155DVIISEWMGYM2Arabidopsis thaliana, Oryza sativa subsp. japonica
E155DAIVSEWMGYA1Xenopus tropicalis
E155DAIVSEWMGCG1Bos taurus
E164YGLLHESMLSS2Homo sapiens, Mus musculus
E164YMLLYESMLGS2Arabidopsis thaliana, Oryza sativa subsp. japonica
E164YALMYESMLPS1Xenopus tropicalis
E164CGLLHESMLSS1Bos taurus
E264ARAGLEQELEA2Mus musculus, Bos taurus
E264SRAGLEQELEA1Homo sapiens
E264CKTIKIQELDS1Arabidopsis thaliana
E264CYTIQAPELET1Oryza sativa subsp. japonica
E264NVCTQE-EVRN1Xenopus tropicalis
E59VSVHEEMIADR2Homo sapiens, Bos taurus
E59VGIHEEMIKDR1Arabidopsis thaliana
E59IGVHEEMLKDH1Oryza sativa subsp. japonica
E59VSVHEEMIADT1Xenopus tropicalis
E59VSVHEEMIADQ1Mus musculus
G138VHVLPGPVETV3Homo sapiens, Mus musculus, Bos taurus
G138VIVLHGRVEDV1Arabidopsis thaliana
G138VIVLHGRIEDV1Oryza sativa subsp. japonica
G138VKVLNSSVESA1Xenopus tropicalis
G90TVLDVGAGTGI4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
G90VVVDVGCGTGI1Arabidopsis thaliana
G90VVLDVGCGTGV1Oryza sativa subsp. japonica
G92LDVGAGTGILS4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
G92VDVGCGTGILS1Arabidopsis thaliana
G92LDVGCGTGVLS1Oryza sativa subsp. japonica
H163GYGLLHESMLS2Homo sapiens, Mus musculus
H163GYMLLYESMLG2Arabidopsis thaliana, Oryza sativa subsp. japonica
H163GYALMYESMLP1Xenopus tropicalis
H163GCGLLHESMLS1Bos taurus
H233RCLMGHSEIVV3Homo sapiens, Mus musculus, Bos taurus
H233QCAF--EEPSV1Arabidopsis thaliana
H233QCAF--MEPSV1Oryza sativa subsp. japonica
H233SCIM-NKEMAV1Xenopus tropicalis
H317FHPATHWKQAL2Homo sapiens, Mus musculus
H317ESPPTHWQQTI1Arabidopsis thaliana
H317EDAPTHWQQTL1Oryza sativa subsp. japonica
H317YGEETHWKQTL1Xenopus tropicalis
H317FHPVTHWKQAL1Bos taurus
H57SDVSVHEEMIA4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
H57AHVGIHEEMIK1Arabidopsis thaliana
H57SHIGVHEEMLK1Oryza sativa subsp. japonica
I95GAGTGILSIFC3Homo sapiens, Mus musculus, Bos taurus
I95GCGTGILSIFC1Arabidopsis thaliana
I95GCGTGVLSIFC1Oryza sativa subsp. japonica
I95GAGTGILSVFS1Xenopus tropicalis
L162MGYGLLHESML2Homo sapiens, Mus musculus
L162MGYMLLYESML2Arabidopsis thaliana, Oryza sativa subsp. japonica
L162MGYALMYESML1Xenopus tropicalis
L162MGCGLLHESML1Bos taurus
L267GLEQELEAGVG3Homo sapiens, Mus musculus, Bos taurus
L267IKIQELDS-VT1Arabidopsis thaliana
L267IQAPELET-IT1Oryza sativa subsp. japonica
L267TQE-EVRN-LH1Xenopus tropicalis
L343SGEITLLPSRD1Homo sapiens
L343EGSVTLSQSKE1Arabidopsis thaliana
L343EGSVTISQSQQ1Oryza sativa subsp. japonica
L343TGDVTLSPSDI1Xenopus tropicalis
L343SGEITLLPSPD1Mus musculus
L343SGEITLLPSQD1Bos taurus
L344GEITLLPSRDN1Homo sapiens
L344GSVTLSQSKEN1Arabidopsis thaliana
L344GSVTISQSQQH1Oryza sativa subsp. japonica
L344GDVTLSPSDIN1Xenopus tropicalis
L344GEITLLPSPDN1Mus musculus
L344GEITLLPSQDH1Bos taurus
L353DNPRRLRVLLR1Homo sapiens
L353ENKRFMNIHLE1Arabidopsis thaliana
L353QHARFLNICLK1Oryza sativa subsp. japonica
L353INPRHLRVLLN1Xenopus tropicalis
L353DNPRRLRILLR1Mus musculus
L353DHHRHLRVLLR1Bos taurus
L46RERDQLYYECY1Homo sapiens
L46TDFDVAYFHSY1Arabidopsis thaliana
L46TDYDMAYFKAY1Oryza sativa subsp. japonica
L46TEQDCEYFQCY1Xenopus tropicalis
L46SERDQLYYECY1Mus musculus
L46RERDQLYYQCY1Bos taurus
L96AGTGILSIFCA3Homo sapiens, Mus musculus, Bos taurus
L96CGTGILSIFCA1Arabidopsis thaliana
L96CGTGVLSIFCA1Oryza sativa subsp. japonica
L96AGTGILSVFSV1Xenopus tropicalis
M157IVSEWMGYGLL2Homo sapiens, Mus musculus
M157IISEWMGYMLL2Arabidopsis thaliana, Oryza sativa subsp. japonica
M157IVSEWMGYALM1Xenopus tropicalis
M157IVSEWMGCGLL1Bos taurus
M166LLHESMLSSVL3Homo sapiens, Mus musculus, Bos taurus
M166LLYESMLGSVI2Arabidopsis thaliana, Oryza sativa subsp. japonica
M166LMYESMLPSVI1Xenopus tropicalis
M200ISD-QMLEWRL2Homo sapiens, Mus musculus
M200ISHPDRYSHSI1Arabidopsis thaliana
M200ITNSHRYQDSV1Oryza sativa subsp. japonica
M200VND-LIVESRL1Xenopus tropicalis
M200ISD-QMLELRL1Bos taurus
M60SVHEEMIADRV2Homo sapiens, Bos taurus
M60GIHEEMIKDRA1Arabidopsis thaliana
M60GVHEEMLKDHV1Oryza sativa subsp. japonica
M60SVHEEMIADTV1Xenopus tropicalis
M60SVHEEMIADQV1Mus musculus
N349LPSRDNPRRLR1Homo sapiens
N349SQSKENKRFMN1Arabidopsis thaliana
N349SQSQQHARFLN1Oryza sativa subsp. japonica
N349SPSDINPRHLR1Xenopus tropicalis
N349LPSPDNPRRLR1Mus musculus
N349LPSQDHHRHLR1Bos taurus
P139HVLPGPVETVE3Homo sapiens, Mus musculus, Bos taurus
P139IVLHGRVEDVE1Arabidopsis thaliana
P139IVLHGRIEDVE1Oryza sativa subsp. japonica
P139KVLNSSVESAE1Xenopus tropicalis
P345EITLLPSRDNP1Homo sapiens
P345SVTLSQSKENK1Arabidopsis thaliana
P345SVTISQSQQHA1Oryza sativa subsp. japonica
P345DVTLSPSDINP1Xenopus tropicalis
P345EITLLPSPDNP1Mus musculus
P345EITLLPSQDHH1Bos taurus
P350PSRDNPRRLRV1Homo sapiens
P350QSKENKRFMNI1Arabidopsis thaliana
P350QSQQHARFLNI1Oryza sativa subsp. japonica
P350PSDINPRHLRV1Xenopus tropicalis
P350PSPDNPRRLRI1Mus musculus
P350PSQDHHRHLRV1Bos taurus
Q239SEIVVQGLSGE2Homo sapiens, Bos taurus
Q239EEPSVESISGE1Arabidopsis thaliana
Q239MEPSVETISGE1Oryza sativa subsp. japonica
Q239KEMAVNLVSPE1Xenopus tropicalis
Q239SEIVVQDLSGE1Mus musculus
R204QMLEWRLGFWS2Homo sapiens, Mus musculus
R204DRYSHSIDFWR1Arabidopsis thaliana
R204HRYQDSVYFWQ1Oryza sativa subsp. japonica
R204LIVESRLDFWS1Xenopus tropicalis
R204QMLELRLSFWS1Bos taurus
R351SRDNPRRLRVL1Homo sapiens
R351SKENKRFMNIH1Arabidopsis thaliana
R351SQQHARFLNIC1Oryza sativa subsp. japonica
R351SDINPRHLRVL1Xenopus tropicalis
R351SPDNPRRLRIL1Mus musculus
R351SQDHHRHLRVL1Bos taurus
R352RDNPRRLRVLL1Homo sapiens
R352KENKRFMNIHL1Arabidopsis thaliana
R352QQHARFLNICL1Oryza sativa subsp. japonica
R352DINPRHLRVLL1Xenopus tropicalis
R352PDNPRRLRILL1Mus musculus
R352QDHHRHLRVLL1Bos taurus
R43RTKRERDQLYY1Homo sapiens
R43PPCTDFDVAYF1Arabidopsis thaliana
R43PPCTDYDMAYF1Oryza sativa subsp. japonica
R43--RTEQDCEYF1Xenopus tropicalis
R43RTKSERDQLYY1Mus musculus
R43RTRRERDQLYY1Bos taurus
R66IADRVRTDAYR2Homo sapiens, Bos taurus
R66IKDRARTETYR1Arabidopsis thaliana
R66LKDHVRTNTYR1Oryza sativa subsp. japonica
R66IADTVRTNAYK1Xenopus tropicalis
R66IADQVRTEAYR1Mus musculus
S114YAVEASAIWQQ2Homo sapiens, Mus musculus
S114YAVDASDIAVQ1Arabidopsis thaliana
S114YAVDASDIALQ1Oryza sativa subsp. japonica
S114YAVEASSMSQL1Xenopus tropicalis
S114YAVEASDIWQQ1Bos taurus
S168HESMLSSVLHA3Homo sapiens, Mus musculus, Bos taurus
S168YESMLGSVITA1Arabidopsis thaliana
S168YESMLGSVIFA1Oryza sativa subsp. japonica
S168YESMLPSVIYA1Xenopus tropicalis
S169ESMLSSVLHAR3Homo sapiens, Mus musculus, Bos taurus
S169ESMLGSVITAR1Arabidopsis thaliana
S169ESMLGSVIFAR1Oryza sativa subsp. japonica
S169ESMLPSVIYAR1Xenopus tropicalis
V140VLPGPVETVEL3Homo sapiens, Mus musculus, Bos taurus
V140VLHGRVEDVEI1Arabidopsis thaliana
V140VLHGRIEDVEI1Oryza sativa subsp. japonica
V140VLNSSVESAEI1Xenopus tropicalis
V237GHSEIVVQGLS2Homo sapiens, Bos taurus
V237--EEPSVESIS1Arabidopsis thaliana
V237--MEPSVETIS1Oryza sativa subsp. japonica
V237-NKEMAVNLVS1Xenopus tropicalis
V237GHSEIVVQDLS1Mus musculus
V56YSDVSVHEEMI4Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus
V56YAHVGIHEEMI1Arabidopsis thaliana
V56YSHIGVHEEML1Oryza sativa subsp. japonica
W156AIVSEWMGYGL2Homo sapiens, Mus musculus
W156VIISEWMGYML2Arabidopsis thaliana, Oryza sativa subsp. japonica
W156AIVSEWMGYAL1Xenopus tropicalis
W156AIVSEWMGCGL1Bos taurus
W203-QMLEWRLGFW2Homo sapiens, Mus musculus
W203PDRYSHSIDFW1Arabidopsis thaliana
W203SHRYQDSVYFW1Oryza sativa subsp. japonica
W203-LIVESRLDFW1Xenopus tropicalis
W203-QMLELRLSFW1Bos taurus
W318HPATHWKQALL2Homo sapiens, Mus musculus
W318SPPTHWQQTIV1Arabidopsis thaliana
W318DAPTHWQQTLL1Oryza sativa subsp. japonica
W318GEETHWKQTLL1Xenopus tropicalis
W318HPVTHWKQALL1Bos taurus
Y159SEWMGYGLLHE2Homo sapiens, Mus musculus
Y159SEWMGYMLLYE2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y159SEWMGYALMYE1Xenopus tropicalis
Y159SEWMGCGLLHE1Bos taurus
Y324KQALLYLNEPV3Homo sapiens, Mus musculus, Bos taurus
Y324QQTIVYFYDPI1Arabidopsis thaliana
Y324QQTLLYLFEPI1Oryza sativa subsp. japonica
Y324KQTLLYLDEEV1Xenopus tropicalis
Y47ERDQLYYECYS2Homo sapiens, Mus musculus
Y47DFDVAYFHSYA1Arabidopsis thaliana
Y47DYDMAYFKAYS1Oryza sativa subsp. japonica
Y47EQDCEYFQCYS1Xenopus tropicalis
Y47ERDQLYYQCYS1Bos taurus
Y48RDQLYYECYSD2Homo sapiens, Mus musculus
Y48FDVAYFHSYAH1Arabidopsis thaliana
Y48YDMAYFKAYSH1Oryza sativa subsp. japonica
Y48QDCEYFQCYSD1Xenopus tropicalis
Y48RDQLYYQCYSD1Bos taurus
Y51LYYECYSDVSV2Homo sapiens, Mus musculus
Y51AYFHSYAHVGI1Arabidopsis thaliana
Y51AYFKAYSHIGV1Oryza sativa subsp. japonica
Y51EYFQCYSDVSV1Xenopus tropicalis
Y51LYYQCYSDVSV1Bos taurus


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