mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPP2R4
Gene summary
Basic gene Info.Gene symbolPPP2R4
Gene nameprotein phosphatase 2A activator, regulatory subunit 4
SynonymsPP2A|PR53|PTPA
CytomapUCSC genome browser: 9q34
Type of geneprotein-coding
RefGenesNM_001193397.1,
NM_001271832.1,NM_021131.4,NM_178000.2,NM_178001.2,
NM_178003.2,NM_178002.1,
DescriptionPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2A, regulatory subunit B' (PR 53)serine/threonine-protein phosphatase 2A activatorserine/threonine-protein phosphatase 2A regulatory subunit
Modification date20141222
dbXrefs MIM : 600756
HGNC : HGNC
Ensembl : ENSG00000119383
HPRD : 02858
Vega : OTTHUMG00000020774
ProteinUniProt: Q15257
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPP2R4
BioGPS: 5524
PathwayNCI Pathway Interaction Database: PPP2R4
KEGG: PPP2R4
REACTOME: PPP2R4
Pathway Commons: PPP2R4
ContextiHOP: PPP2R4
ligand binding site mutation search in PubMed: PPP2R4
UCL Cancer Institute: PPP2R4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006200ATP catabolic process16916641
GO:0032515negative regulation of phosphoprotein phosphatase activity16916641
GO:0032516positive regulation of phosphoprotein phosphatase activity16916641
GO:0035307positive regulation of protein dephosphorylation16916641
GO:0035308negative regulation of protein dephosphorylation16916641
GO:0043065positive regulation of apoptotic process17333320
GO:0043666regulation of phosphoprotein phosphatase activity16916641


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Ligand binding site mutations for PPP2R4

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
G243G243VLUSC1
G240G240SSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPP2R4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G240G240S-0.9402112
G243G243V-0.56154101
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPP2R4 from PDB

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Differential gene expression and gene-gene network for PPP2R4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPP2R4 and the right PPI network was created from samples without mutations in the LBS of PPP2R4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPP2R4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0242656Disease Progression1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPP2R4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPP2R4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PPP2R4
Multiple alignments for Q15257 in multiple species
LBSAA sequence# speciesSpecies
A239YRMEPAGSQGV3Homo sapiens, Mus musculus, Bos taurus
A239YWLEPAGSHGV3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A239YYLEPAGSHGV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A239YTLEPAGSHGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A332IRMYKAECLEK3Homo sapiens, Mus musculus, Bos taurus
A332RRMFVSEVLKK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A332IKMYRAEVLGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A332VKMYKAEVLQK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A332IKMYKAEVLSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A332VKMYKAEVLGK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D185NSTRIDYGTGH3Homo sapiens, Mus musculus, Bos taurus
D185NRTRIDYGSGH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D185NRKRIDYGSGH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D185DRSRIDYGSGH1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D185NKRRIDYGSGH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D185DCKRIDYGSGH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D249VWGLDDFQFLP3Homo sapiens, Mus musculus, Bos taurus
D249VWGLDDYHFLP3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D249VWGLDDYQFLP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D249VWGLDDFHFLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E333RMYKAECLEKF3Homo sapiens, Mus musculus, Bos taurus
E333RMFVSEVLKKL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E333KMYRAEVLGKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E333KMYKAEVLQKL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E333KMYKAEVLSKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E333KMYKAEVLGKL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G187TRIDYGTGHEA3Homo sapiens, Mus musculus, Bos taurus
G187KRIDYGSGHEL2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G187TRIDYGSGHEL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G187SRIDYGSGHEL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G187RRIDYGSGHEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G189IDYGSGHELNF4Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii
G189IDYGTGHEAAF3Homo sapiens, Mus musculus, Bos taurus
G189IDYGSGHELYF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G240RMEPAGSQGVW3Homo sapiens, Mus musculus, Bos taurus
G240WLEPAGSHGVW3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G240YLEPAGSHGVW1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G240TLEPAGSHGVW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G243PAGSHGVWGLD5Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cere
G243PAGSQGVWGLD3Homo sapiens, Mus musculus, Bos taurus
G325SKVNQGLIRMY3Homo sapiens, Mus musculus, Bos taurus
G325EKIEGGMRRMF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G325SKVNEGMIKMY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G325SKVAEGMVKMY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G325SKVAEGMIKMY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G325TKVSEGMVKMY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H343FPVIQHFKFGS3Homo sapiens, Mus musculus, Bos taurus
H343LPVMQHFLFGS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H343LPIMQHYLFGH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H343LPIMQHFYFGY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H343LPIMQHFYFSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H343LPIMQHFFFSR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I313NQLWNISAVPS3Homo sapiens, Mus musculus, Bos taurus
I313PMLDDISSAKN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I313PMIDDISAVKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I313PMLDDISGVKR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I313PMLDDISGVKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I313PMLDDISGVRS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K321VPSWSKVNQGL3Homo sapiens, Mus musculus, Bos taurus
K321AKNWEKIEGGM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K321VKTWSKVNEGM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K321VKRWSKVAEGM1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K321VKTWSKVAEGM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K321VRSWTKVSEGM1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L326KVNQGLIRMYK3Homo sapiens, Mus musculus, Bos taurus
L326KIEGGMRRMFV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L326KVNEGMIKMYR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L326KVAEGMVKMYK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L326KVAEGMIKMYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L326KVSEGMVKMYK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M329QGLIRMYKAEC3Homo sapiens, Mus musculus, Bos taurus
M329EGMVKMYKAEV2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M329GGMRRMFVSEV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M329EGMIKMYRAEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M329EGMIKMYKAEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P238TYRMEPAGSQG3Homo sapiens, Mus musculus, Bos taurus
P238KYWLEPAGSHG3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P238TYYLEPAGSHG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P238FYTLEPAGSHG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P339CLEKFPVIQHF3Homo sapiens, Mus musculus, Bos taurus
P339VLKKLPVMQHF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P339VLGKLPIMQHY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P339VLQKLPIMQHF1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P339VLSKLPIMQHF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P339VLGKLPIMQHF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q242EPAGSHGVWGL5Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cere
Q242EPAGSQGVWGL3Homo sapiens, Mus musculus, Bos taurus
Q342KFPVIQHFKFG3Homo sapiens, Mus musculus, Bos taurus
Q342KLPVMQHFLFG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q342KLPIMQHYLFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q342KLPIMQHFYFG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q342KLPIMQHFYFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q342KLPIMQHFFFS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R183VGNSTRIDYGT3Homo sapiens, Mus musculus, Bos taurus
R183FGNRTRIDYGS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R183FGNRKRIDYGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R183WGDRSRIDYGS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R183WGNKRRIDYGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R183WGDCKRIDYGS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R328NQGLIRMYKAE3Homo sapiens, Mus musculus, Bos taurus
R328EGGMRRMFVSE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R328NEGMIKMYRAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R328AEGMVKMYKAE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R328AEGMIKMYKAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R328SEGMVKMYKAE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S241LEPAGSHGVWG5Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cere
S241MEPAGSQGVWG3Homo sapiens, Mus musculus, Bos taurus
T188RIDYGSGHELN4Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii
T188RIDYGTGHEAA3Homo sapiens, Mus musculus, Bos taurus
T188RIDYGSGHELY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V322PSWSKVNQGLI3Homo sapiens, Mus musculus, Bos taurus
V322KNWEKIEGGMR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V322KTWSKVNEGMI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V322KRWSKVAEGMV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V322KTWSKVAEGMI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V322RSWTKVSEGMV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V340LEKFPVIQHFK3Homo sapiens, Mus musculus, Bos taurus
V340LKKLPVMQHFL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V340LGKLPIMQHYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V340LQKLPIMQHFY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V340LSKLPIMQHFY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V340LGKLPIMQHFF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)


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