mutLBSgeneDB |
Gene summary for STEAP3 |
Gene summary |
Basic gene Info. | Gene symbol | STEAP3 |
Gene name | STEAP family member 3, metalloreductase | |
Synonyms | AHMIO2|STMP3|TSAP6|dudlin-2 | |
Cytomap | UCSC genome browser: 2q14.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001008410.1, NM_018234.2,NM_182915.2, | |
Description | 1010001D01Rikdudlin 2dudulin 2dudulin-2hTSAP6hpHydemetalloreductase STEAP3pHydesix transmembrane prostate protein 3six-transmembrane epithelial antigen of prostate 3tumor suppressor pHydetumor suppressor-activated pathway protein 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609671 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115107 | ||
HPRD : 10285 | ||
Vega : OTTHUMG00000131402 | ||
Protein | UniProt: Q658P3 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STEAP3 | |
BioGPS: 55240 | ||
Pathway | NCI Pathway Interaction Database: STEAP3 | |
KEGG: STEAP3 | ||
REACTOME: STEAP3 | ||
Pathway Commons: STEAP3 | ||
Context | iHOP: STEAP3 | |
ligand binding site mutation search in PubMed: STEAP3 | ||
UCL Cancer Institute: STEAP3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0009306 | protein secretion | 15319436 |
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Ligand binding site mutations for STEAP3 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | S58 | V56E | HNSC | 1 | R59 | R59C | SKCM | 1 | I149 | I149S | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for STEAP3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | I149 | I149S | -1.5365368 | S58 | V56E | -0.39803349 | R59 | R59C | -0.36153668 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for STEAP3 from PDB |
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Differential gene expression and gene-gene network for STEAP3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for STEAP3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for STEAP3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of STEAP3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 2vq3 | A | S58 R59 I149 | NAP | NADP ZWITTERION | 2vq3 | B | S58 R59 I149 |
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Conservation information for LBS of STEAP3 |
Multiple alignments for Q658P3 in multiple species |
LBS | AA sequence | # species | Species | A151 | FNVISAWALQA | 2 | Mus musculus, Rattus norvegicus | A151 | FNVISAWTLQA | 1 | Homo sapiens | A90 | EVIFVAVFREH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D38 | ILGSGDFARSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F39 | LGSGDFARSLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F92 | IFVAVFREHYS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G35 | KVGILGSGDFA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G37 | GILGSGDFARS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H95 | AVFREHYSSLC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I149 | KAFNVISAWAL | 2 | Mus musculus, Rattus norvegicus | I149 | KAFNVISAWTL | 1 | Homo sapiens | N116 | LVDVSNPTEKE | 2 | Mus musculus, Rattus norvegicus | N116 | LVDVSNPTEQE | 1 | Homo sapiens | N147 | VVKAFNVISAW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R59 | VVVGSRNPKRT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S115 | ILVDVSNPTEK | 2 | Mus musculus, Rattus norvegicus | S115 | ILVDVSNPTEQ | 1 | Homo sapiens | S150 | AFNVISAWALQ | 2 | Mus musculus, Rattus norvegicus | S150 | AFNVISAWTLQ | 1 | Homo sapiens | S36 | VGILGSGDFAR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S58 | SVVVGSRNPKR | 2 | Mus musculus, Rattus norvegicus | S58 | KVVVGSRNPKR | 1 | Homo sapiens | V114 | KILVDVSNPTE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V91 | VIFVAVFREHY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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