mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STEAP3
Gene summary
Basic gene Info.Gene symbolSTEAP3
Gene nameSTEAP family member 3, metalloreductase
SynonymsAHMIO2|STMP3|TSAP6|dudlin-2
CytomapUCSC genome browser: 2q14.2
Type of geneprotein-coding
RefGenesNM_001008410.1,
NM_018234.2,NM_182915.2,
Description1010001D01Rikdudlin 2dudulin 2dudulin-2hTSAP6hpHydemetalloreductase STEAP3pHydesix transmembrane prostate protein 3six-transmembrane epithelial antigen of prostate 3tumor suppressor pHydetumor suppressor-activated pathway protein 6
Modification date20141207
dbXrefs MIM : 609671
HGNC : HGNC
Ensembl : ENSG00000115107
HPRD : 10285
Vega : OTTHUMG00000131402
ProteinUniProt: Q658P3
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STEAP3
BioGPS: 55240
PathwayNCI Pathway Interaction Database: STEAP3
KEGG: STEAP3
REACTOME: STEAP3
Pathway Commons: STEAP3
ContextiHOP: STEAP3
ligand binding site mutation search in PubMed: STEAP3
UCL Cancer Institute: STEAP3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0009306protein secretion15319436


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Ligand binding site mutations for STEAP3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S58V56EHNSC1
R59R59CSKCM1
I149I149SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STEAP3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I149I149S-1.5365368
S58V56E-0.39803349
R59R59C-0.36153668
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STEAP3 from PDB

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Differential gene expression and gene-gene network for STEAP3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STEAP3 and the right PPI network was created from samples without mutations in the LBS of STEAP3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STEAP3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STEAP3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STEAP3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAPNADP ZWITTERION2vq3AS58 R59 I149
NAPNADP ZWITTERION2vq3BS58 R59 I149


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Conservation information for LBS of STEAP3
Multiple alignments for Q658P3 in multiple species
LBSAA sequence# speciesSpecies
A151FNVISAWALQA2Mus musculus, Rattus norvegicus
A151FNVISAWTLQA1Homo sapiens
A90EVIFVAVFREH3Homo sapiens, Mus musculus, Rattus norvegicus
D38ILGSGDFARSL3Homo sapiens, Mus musculus, Rattus norvegicus
F39LGSGDFARSLA3Homo sapiens, Mus musculus, Rattus norvegicus
F92IFVAVFREHYS3Homo sapiens, Mus musculus, Rattus norvegicus
G35KVGILGSGDFA3Homo sapiens, Mus musculus, Rattus norvegicus
G37GILGSGDFARS3Homo sapiens, Mus musculus, Rattus norvegicus
H95AVFREHYSSLC3Homo sapiens, Mus musculus, Rattus norvegicus
I149KAFNVISAWAL2Mus musculus, Rattus norvegicus
I149KAFNVISAWTL1Homo sapiens
N116LVDVSNPTEKE2Mus musculus, Rattus norvegicus
N116LVDVSNPTEQE1Homo sapiens
N147VVKAFNVISAW3Homo sapiens, Mus musculus, Rattus norvegicus
R59VVVGSRNPKRT3Homo sapiens, Mus musculus, Rattus norvegicus
S115ILVDVSNPTEK2Mus musculus, Rattus norvegicus
S115ILVDVSNPTEQ1Homo sapiens
S150AFNVISAWALQ2Mus musculus, Rattus norvegicus
S150AFNVISAWTLQ1Homo sapiens
S36VGILGSGDFAR3Homo sapiens, Mus musculus, Rattus norvegicus
S58SVVVGSRNPKR2Mus musculus, Rattus norvegicus
S58KVVVGSRNPKR1Homo sapiens
V114KILVDVSNPTE3Homo sapiens, Mus musculus, Rattus norvegicus
V91VIFVAVFREHY3Homo sapiens, Mus musculus, Rattus norvegicus


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