mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RFK
Gene summary
Basic gene Info.Gene symbolRFK
Gene nameriboflavin kinase
SynonymsRIFK
CytomapUCSC genome browser: 9q21.13
Type of geneprotein-coding
RefGenesNM_018339.5,
Description0610038L10RikATP:riboflavin 5'-phosphotransferaseflavokinase
Modification date20141207
dbXrefs MIM : 613010
HGNC : HGNC
Ensembl : ENSG00000135002
HPRD : 17969
Vega : OTTHUMG00000020040
ProteinUniProt: Q969G6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RFK
BioGPS: 55312
PathwayNCI Pathway Interaction Database: RFK
KEGG: RFK
REACTOME: RFK
Pathway Commons: RFK
ContextiHOP: RFK
ligand binding site mutation search in PubMed: RFK
UCL Cancer Institute: RFK
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for RFK

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P26I25VBRCA1
D122D122VPRAD1
D122I123TSTAD1
K107K107NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RFK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
P26I25V-1.5739579
K107K107N-1.5371141
D122I123T-0.75230831
D122D122V-0.095301993
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RFK from PDB

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Differential gene expression and gene-gene network for RFK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RFK and the right PPI network was created from samples without mutations in the LBS of RFK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RFK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RFK
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00140RiboflavinSmall molecule
ExperimentalDB03247Riboflavin MonophosphateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RFK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of RFK
Multiple alignments for Q969G6 in multiple species
LBSAA sequence# speciesSpecies
A28LGIPTANFPEQ2Homo sapiens, Mus musculus
A28LGIPTANLPVD2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A28LGIPTANVPID1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A28LGIPTANVPIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A28LGIPTANVPIE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A28LGIPTANLSTK1Arabidopsis thaliana
A28LGIPTANFPLE1Drosophila melanogaster
A28LGIPTANISED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D122SAIQGDIEEAK2Homo sapiens, Mus musculus
D122ADIHTDIEIAK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D122EDINIDIRTAQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D122EDIHTDIKIAS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D122AKIHEDREVAE1Arabidopsis thaliana
D122AAIRGDIEQAK1Drosophila melanogaster
D122EDIHTDIRVAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D122KDINTDCDVAR1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D122ADIHFDCEVAR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D89HTFKEDFYGEI2Homo sapiens, Mus musculus
D89HKFSDNFYGAQ1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D89HDFKNDFYGAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D89NDFEEDFYGAK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D89HDFTEDFYGEE1Arabidopsis thaliana
D89HDFNCDLYGQT1Drosophila melanogaster
D89ERQGEDFYEEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D89HKFTADFYDAP1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D89GEFAADFYGVG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E79TKKSMETHIMH1Homo sapiens
E79KNKTVELHIIH1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E79DFKTMELHIIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E79SKKTVELHILN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E79KEKTIEPWLLH1Arabidopsis thaliana
E79KEKSVETHMLH1Drosophila melanogaster
E79VKKSMETHIIH1Mus musculus
E79KLRSAEVHLIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E79TERSAEVHILH1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
E79TVRSAEVHVLG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F109RPEKNFDSLES2Homo sapiens, Mus musculus
F109RPELNYTTKEA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F109RPELDYTTKDA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F109RPEANFSSLES1Arabidopsis thaliana
F109RPERSFDSLES1Drosophila melanogaster
F109RPELNYAGLDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F109RDEKNYDSLEA1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F109RNEKDYSGLEA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F16QVVRGFGRGSK2Homo sapiens, Mus musculus
F16DVIAGFGRGSA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F16DIVCGFGRGSA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F16DIVAGFGRGSA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F16PVIKGFGRGSK1Arabidopsis thaliana
F16EIVRGFGRGSK1Drosophila melanogaster
F16KVVHGFGRGSK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F16KVISGFGRGSK1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F16EVISGFGRGSK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F86HIMHTFKEDFY1Homo sapiens
F86HIIHKFSDNFY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F86HIIHDFKNDFY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F86HILNDFEEDFY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F86WLLHDFTEDFY1Arabidopsis thaliana
F86HMLHDFNCDLY1Drosophila melanogaster
F86HIIHTFKEDFY1Mus musculus
F86HLIERQGEDFY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F86HILHKFTADFY1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F86HVLGEFAADFY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F90TFKEDFYGEIL2Homo sapiens, Mus musculus
F90KFSDNFYGAQI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F90DFKNDFYGARV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F90DFEEDFYGAKI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F90DFTEDFYGEEL1Arabidopsis thaliana
F90DFNCDLYGQTL1Drosophila melanogaster
F90RQGEDFYEEIM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F90KFTADFYDAPM1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F90EFAADFYGVGM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G15GQVVRGFGRGS2Homo sapiens, Mus musculus
G15VDVIAGFGRGS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G15CDIVCGFGRGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G15VDIVAGFGRGS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G15GPVIKGFGRGS1Arabidopsis thaliana
G15GEIVRGFGRGS1Drosophila melanogaster
G15GKVVHGFGRGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G15GKVISGFGRGS1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
G15GEVISGFGRGS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G17VVRGFGRGSKQ2Homo sapiens, Mus musculus
G17VISGFGRGSKE2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G17VIAGFGRGSAE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G17IVCGFGRGSAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G17IVAGFGRGSAE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G17VIKGFGRGSKV1Arabidopsis thaliana
G17IVRGFGRGSKE1Drosophila melanogaster
G17VVHGFGRGSKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G19RGFGRGSKQLG2Homo sapiens, Mus musculus
G19AGFGRGSAELG2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G19SGFGRGSKELG2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G19CGFGRGSAELG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G19KGFGRGSKVLG1Arabidopsis thaliana
G19RGFGRGSKELG1Drosophila melanogaster
G19HGFGRGSKELG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H84ETHIMHTFKED1Homo sapiens
H84ELHIIHKFSDN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H84ELHIIHDFKND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H84ELHILNDFEED1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H84EPWLLHDFTED1Arabidopsis thaliana
H84ETHMLHDFNCD1Drosophila melanogaster
H84ETHIIHTFKED1Mus musculus
H84EVHLIERQGED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H84EVHILHKFTAD1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
H84EVHVLGEFAAD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I119SLISAIQGDIE2Homo sapiens, Mus musculus
I119ALIADIHTDIE1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I119ALIEDINIDIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I119ALIEDIHTDIK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I119SLIAKIHEDRE1Arabidopsis thaliana
I119SLIAAIRGDIE1Drosophila melanogaster
I119KLIEDIHTDIR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I119ALVKDINTDCD1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I119ALIADIHFDCE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I46DISTGIYYGWA1Homo sapiens
I46QLDTGVYFGWC1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I46DLDLGVYFGFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I46EMATGVYFGWA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I46EHPSGVYFGWA1Arabidopsis thaliana
I46SLPTGAYYGWA1Drosophila melanogaster
I46DVSTGIYYGWA1Mus musculus
I46YRDSGVYFGYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I46SISSGVYYGWA1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I46NIDSGIYFGWA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I82SMETHIMHTFK1Homo sapiens
I82TVELHIIHKFS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I82TMELHIIHDFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I82TVELHILNDFE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I82TIEPWLLHDFT1Arabidopsis thaliana
I82SVETHMLHDFN1Drosophila melanogaster
I82SMETHIIHTFK1Mus musculus
I82SAEVHLIERQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I82SAEVHILHKFT1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I82SAEVHVLGEFA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K107YLRPEKNFDSL2Homo sapiens, Mus musculus
K107YIRPELDYTTK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K107HIRPELNYTTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K107YIRPELNYTTK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K107YIRPEANFSSL1Arabidopsis thaliana
K107YLRPERSFDSL1Drosophila melanogaster
K107YIRPELNYAGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K107FIRDEKNYDSL1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K107FIRNEKDYSGL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K21FGRGSKELGIP4Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K21FGRGSAELGIP3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K21FGRGSKQLGIP2Homo sapiens, Mus musculus
K21FGRGSKVLGIP1Arabidopsis thaliana
L115DSLESLISAIQ2Homo sapiens, Mus musculus
L115TTKDALIADIH1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L115TTKEALIEDIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L115TTKEALIEDIH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L115SSLESLIAKIH1Arabidopsis thaliana
L115DSLESLIAAIR1Drosophila melanogaster
L115AGLDKLIEDIH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L115DSLEALVKDIN1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L115SGLEALIADIH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L23RGSKELGIPTA4Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L23RGSAELGIPTA3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L23RGSKQLGIPTA2Homo sapiens, Mus musculus
L23RGSKVLGIPTA1Arabidopsis thaliana
N29GIPTANFPEQV2Homo sapiens, Mus musculus
N29GIPTANVPIDD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N29GIPTANVPINQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N29GIPTANVPIEQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N29GIPTANLSTKD1Arabidopsis thaliana
N29GIPTANFPLEV1Drosophila melanogaster
N29GIPTANISEDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N29GIPTANLPVDA1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N29GIPTANLPVDD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N68VSIGWNPYYKN2Homo sapiens, Mus musculus
N68LSVGWNPFYQN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N68LSVGKNPFYGN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N68LSVGWNPFYNN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N68MSIGWNPYFNN1Arabidopsis thaliana
N68LSIGWNPFYNN1Drosophila melanogaster
N68MSVGWNPYYKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N68MSIGYNPFYNN1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N68MSIGYNPFYKN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P26AELGIPTANVP3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P26KQLGIPTANFP2Homo sapiens, Mus musculus
P26KELGIPTANLP2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P26KVLGIPTANLS1Arabidopsis thaliana
P26KELGIPTANFP1Drosophila melanogaster
P26KELGIPTANIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P69SIGWNPYYKNT1Homo sapiens
P69SVGWNPFYQNK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P69SVGKNPFYGND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P69SVGWNPFYNNS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P69SIGWNPYFNNK1Arabidopsis thaliana
P69SIGWNPFYNNK1Drosophila melanogaster
P69SIGWNPYYKNV1Mus musculus
P69SVGWNPYYKNK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P69SIGYNPFYNNT1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
P69SIGYNPFYKNT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R104IVGYLRPEKNF2Homo sapiens, Mus musculus
R104FLGYIRPELDY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R104ILGHIRPELNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R104FLGYIRPELNY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R104IVGYIRPEANF1Arabidopsis thaliana
R104IVGYLRPERSF1Drosophila melanogaster
R104VLGYIRPELNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R104ILGFIRDEKNY1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R104ITGFIRNEKDY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R14-GQVVRGFGRG2Homo sapiens, Mus musculus
R14FVDVIAGFGRG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R14YCDIVCGFGRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R14YVDIVAGFGRG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R14-GPVIKGFGRG1Arabidopsis thaliana
R14-GEIVRGFGRG1Drosophila melanogaster
R14-GKVVHGFGRG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R14-GKVISGFGRG1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R14-GEVISGFGRG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R18VRGFGRGSKQL2Homo sapiens, Mus musculus
R18ISGFGRGSKEL2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R18IAGFGRGSAEL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R18VCGFGRGSAEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R18VAGFGRGSAEL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R18IKGFGRGSKVL1Arabidopsis thaliana
R18VRGFGRGSKEL1Drosophila melanogaster
R18VHGFGRGSKEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S20GFGRGSKELGI4Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S20GFGRGSAELGI3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S20GFGRGSKQLGI2Homo sapiens, Mus musculus
S20GFGRGSKVLGI1Arabidopsis thaliana
S64HKMVVSIGWNP2Homo sapiens, Mus musculus
S64LPVVLSVGWNP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S64LPMVLSVGKNP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S64FPIVLSVGWNP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S64FKMVMSIGWNP1Arabidopsis thaliana
S64HKMVLSIGWNP1Drosophila melanogaster
S64FPMVMSVGWNP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S64FPMVMSIGYNP1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
S64YPMVMSIGYNP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T27ELGIPTANVPI3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T27QLGIPTANFPE2Homo sapiens, Mus musculus
T27ELGIPTANLPV2Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T27VLGIPTANLST1Arabidopsis thaliana
T27ELGIPTANFPL1Drosophila melanogaster
T27ELGIPTANISE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T80KKSMETHIMHT1Homo sapiens
T80NKTVELHIIHK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T80FKTMELHIIHD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T80KKTVELHILND1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T80EKTIEPWLLHD1Arabidopsis thaliana
T80EKSVETHMLHD1Drosophila melanogaster
T80KKSMETHIIHT1Mus musculus
T80LRSAEVHLIER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T80ERSAEVHILHK1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
T80VRSAEVHVLGE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V12CR-GQVVRGFG2Homo sapiens, Mus musculus
V12TSFVDVIAGFG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V12TDYCDIVCGFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V12TEYVDIVAGFG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V12IG-GPVIKGFG1Arabidopsis thaliana
V12AG-GEIVRGFG1Drosophila melanogaster
V12FE-GKVVHGFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V12ME-GKVISGFG1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
V12ME-GEVISGFG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V62-VHKMVVSIGW2Homo sapiens, Mus musculus
V62AVLPVVLSVGW1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V62SVLPMVLSVGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V62GVFPIVLSVGW1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V62-VFKMVMSIGW1Arabidopsis thaliana
V62-VHKMVLSIGW1Drosophila melanogaster
V62-VFPMVMSVGW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V62-VFPMVMSIGY1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
V62QIYPMVMSIGY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y70IGWNPYYKNTK1Homo sapiens
Y70VGWNPFYQNKN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y70VGKNPFYGNDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y70VGWNPFYNNSK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y70IGWNPYFNNKE1Arabidopsis thaliana
Y70IGWNPFYNNKE1Drosophila melanogaster
Y70IGWNPYYKNVK1Mus musculus
Y70VGWNPYYKNKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y70IGYNPFYNNTE1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y70IGYNPFYKNTV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y71GWNPYYKNTKK1Homo sapiens
Y71GWNPFYQNKNK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y71GKNPFYGNDFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y71GWNPFYNNSKK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y71GWNPYFNNKEK1Arabidopsis thaliana
Y71GWNPFYNNKEK1Drosophila melanogaster
Y71GWNPYYKNVKK1Mus musculus
Y71GWNPYYKNKLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y71GYNPFYNNTER1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y71GYNPFYKNTVR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y91FKEDFYGEILN2Homo sapiens, Mus musculus
Y91FSDNFYGAQIK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y91FKNDFYGARVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y91FEEDFYGAKIK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y91FTEDFYGEELR1Arabidopsis thaliana
Y91FNCDLYGQTLK1Drosophila melanogaster
Y91QGEDFYEEIMR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y91FTADFYDAPMR1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y91FAADFYGVGMR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)


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