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mutLBSgeneDB |
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| Gene summary for RNLS |
 Gene summary |
| Basic gene Info. | Gene symbol | RNLS |
| Gene name | renalase, FAD-dependent amine oxidase | |
| Synonyms | C10orf59|RENALASE | |
| Cytomap | UCSC genome browser: 10q23.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031709.2, NM_018363.3, | |
| Description | MAO-Calpha-NAD(P)H oxidase/anomerasemonoamine oxidase-Crenalase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609360 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000184719 | ||
| HPRD : 07742 | ||
| Vega : OTTHUMG00000018692 | ||
| Protein | UniProt: Q5VYX0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RNLS | |
| BioGPS: 55328 | ||
| Pathway | NCI Pathway Interaction Database: RNLS | |
| KEGG: RNLS | ||
| REACTOME: RNLS | ||
| Pathway Commons: RNLS | ||
| Context | iHOP: RNLS | |
| ligand binding site mutation search in PubMed: RNLS | ||
| UCL Cancer Institute: RNLS | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RNLS |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M11 | M11I | PRAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RNLS |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M11 | M11I | -0.38446725 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RNLS from PDB |
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| Differential gene expression and gene-gene network for RNLS |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RNLS |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RNLS |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RNLS go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FAD | FAD | 3qj4 | A | M11 | FAD | FAD | 3qj4 | B | M11 |
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| Conservation information for LBS of RNLS |
| Multiple alignments for Q5VYX0 in multiple species |
| LBS | AA sequence | # species | Species | A60 | TADLGAQYITC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C327 | SNFDGCITSAL | 1 | Homo sapiens | C327 | SNFNGCISSAL | 1 | Mus musculus | C327 | ----------- | 1 | Rattus norvegicus | D317 | LACGGDGFTQS | 1 | Homo sapiens | D317 | LVCGGDGFTHS | 1 | Mus musculus | D317 | LI--------- | 1 | Rattus norvegicus | F324 | FTQSNFDGCIT | 1 | Homo sapiens | F324 | FTHSNFNGCIS | 1 | Mus musculus | F324 | ----------- | 1 | Rattus norvegicus | G41 | AEDSGGRMTTA | 1 | Homo sapiens | G41 | GGDIGGRMITA | 1 | Mus musculus | G41 | AGDIGGRMTTA | 1 | Rattus norvegicus | G59 | CTADLGAQYIT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G8 | RVLVVGAGLTG | 2 | Mus musculus, Rattus norvegicus | G8 | QVLIVGAGMTG | 1 | Homo sapiens | H130 | EVYFRHRVTQI | 1 | Homo sapiens | H130 | EVSLKHCVTQI | 1 | Mus musculus | H130 | EVFLRQCVTQI | 1 | Rattus norvegicus | H245 | PSLVIHTTVPF | 1 | Homo sapiens | H245 | PSVVIQTTVPF | 1 | Mus musculus | H245 | PLLVVHTTVPF | 1 | Rattus norvegicus | M11 | VVGAGLTGSLC | 2 | Mus musculus, Rattus norvegicus | M11 | IVGAGMTGSLC | 1 | Homo sapiens | M161 | LVILTMPAPQI | 2 | Mus musculus, Rattus norvegicus | M161 | LIVLTMPVPEI | 1 | Homo sapiens | N323 | GFTQSNFDGCI | 1 | Homo sapiens | N323 | GFTHSNFNGCI | 1 | Mus musculus | N323 | ----------- | 1 | Rattus norvegicus | P162 | VILTMPAPQIL | 2 | Mus musculus, Rattus norvegicus | P162 | IVLTMPVPEIL | 1 | Homo sapiens | Q292 | KWRHSQVTNAA | 1 | Homo sapiens | Q292 | KWTYSQVTSSV | 1 | Mus musculus | Q292 | KWRYSQVTNSA | 1 | Rattus norvegicus | Q61 | ADLGAQYITCT | 2 | Homo sapiens, Rattus norvegicus | Q61 | ADLGAQYITCS | 1 | Mus musculus | R131 | VYFRHRVTQIN | 1 | Homo sapiens | R131 | VSLKHCVTQIH | 1 | Mus musculus | R131 | VFLRQCVTQIN | 1 | Rattus norvegicus | R42 | EDSGGRMTTAC | 1 | Homo sapiens | R42 | GDIGGRMITAS | 1 | Mus musculus | R42 | GDIGGRMTTAN | 1 | Rattus norvegicus | S291 | QKWRHSQVTNA | 1 | Homo sapiens | S291 | HKWTYSQVTSS | 1 | Mus musculus | S291 | WKWRYSQVTNS | 1 | Rattus norvegicus | S322 | DGFTQSNFDGC | 1 | Homo sapiens | S322 | DGFTHSNFNGC | 1 | Mus musculus | S322 | ----------- | 1 | Rattus norvegicus | T12 | VGAGLTGSLCA | 2 | Mus musculus, Rattus norvegicus | T12 | VGAGMTGSLCA | 1 | Homo sapiens | V132 | YFRHRVTQINL | 1 | Homo sapiens | V132 | SLKHCVTQIHL | 1 | Mus musculus | V132 | FLRQCVTQINL | 1 | Rattus norvegicus | V7 | AQVLIVGAGMT | 1 | Homo sapiens | V7 | SRVLVVGAGLT | 1 | Mus musculus | V7 | FRVLVVGAGLT | 1 | Rattus norvegicus | W288 | TKCQKWRHSQV | 1 | Homo sapiens | W288 | TICHKWTYSQV | 1 | Mus musculus | W288 | TKCWKWRYSQV | 1 | Rattus norvegicus | Y62 | DLGAQYITCTP | 2 | Homo sapiens, Rattus norvegicus | Y62 | DLGAQYITCSP | 1 | Mus musculus |
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