mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PPP3R1

Gene summary

Basic gene Info.	Gene symbol	PPP3R1
	Gene name	protein phosphatase 3, regulatory subunit B, alpha
	Synonyms	CALNB1\|CNB\|CNB1
	Cytomap	UCSC genome browser: 2p15
	Type of gene	protein-coding
	RefGenes	NM_000945.3,
	Description	calcineurin B, type I (19kDa)calcineurin subunit B type 1protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I
	Modification date	20141222
dbXrefs	MIM : 601302
	HGNC : HGNC
	Ensembl : ENSG00000221823
	HPRD : 03195
	Vega : OTTHUMG00000129561
Protein	UniProt: P63098 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PPP3R1
	BioGPS: 5534
Pathway	NCI Pathway Interaction Database: PPP3R1
	KEGG: PPP3R1
	REACTOME: PPP3R1
	Pathway Commons: PPP3R1
Context	iHOP: PPP3R1
	ligand binding site mutation search in PubMed: PPP3R1
	UCL Cancer Institute: PPP3R1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0033173	calcineurin-NFAT signaling cascade	22688515
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	22688515
GO:0051533	positive regulation of NFAT protein import into nucleus	22688515

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Ligand binding site mutations for PPP3R1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
V120	G121E	BRCA	1
D100	D100G	COAD	1
D63	D63N	COAD	1
Y106	Y106C	KIRC	1
D100	I98V	LUAD	1
S39	V40L	LUAD	1
G36	G36C	LUAD	1
D63	I61M	LUAD	1
D100	Y99C	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PPP3R1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
D63	I61M	-1.3916683
D100	Y99C	-1.390299
Y106	Y106C	-1.1110928
D100	I98V	-0.99586586
D100	D100G	-0.88247479
D63	D63N	-0.72712193
S39	V40L	-0.15347678
V120	G121E	-0.13449128
G36	G36C	-0.08471828

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPP3R1 from PDB

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Differential gene expression and gene-gene network for PPP3R1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PPP3R1 and the right PPI network was created from samples without mutations in the LBS of PPP3R1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PPP3R1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0149721	Hypertrophy, Left Ventricular	3	Biomarker, GeneticVariation
umls:C0151744	Myocardial Ischemia	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PPP3R1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Investigational	DB04906	ISA247	Small molecule
Experimental	DB08231	MYRISTIC ACID	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPP3R1 go to BioLip

Ligand ID

Ligand short name

Ligand long name

PDB ID

PDB name

mutLBS

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Conservation information for LBS of PPP3R1

Multiple alignments for P63098 in multiple species

LBS	AA sequence	# species	Species
D100	AFRIYDMDKDG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D100	AFRIYDMDNDG	2	Drosophila melanogaster, Drosophila melanogaster
D100	AFKIYDIDKDG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D100	AFKIYDIDRDG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D100	AFRIYDIDKDG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D102	RIYDMDKDGYI	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D102	RIYDMDNDGYI	2	Drosophila melanogaster, Drosophila melanogaster
D102	KIYDIDRDGYI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D102	RIYDIDKDGYI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D102	KIYDIDKDGFI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D102	KIYDIDKDGYI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D104	YDMDKDGYISN	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D104	YDMDNDGYISN	2	Drosophila melanogaster, Drosophila melanogaster
D104	YDIDKDGYISN	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D104	YDIDRDGYISN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D104	YDIDKDGFISN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D141	TIINADKDGDG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D141	TIMENDVDGDG	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D141	TIGFADKDEDG	1	Drosophila melanogaster
D141	TICFADKDEDG	1	Drosophila melanogaster
D141	TIMEVDKDRDG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D141	TIVENDSDGDG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D143	INADKDGDGRI	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D143	MENDVDGDGKL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D143	GFADKDEDGKI	1	Drosophila melanogaster
D143	CFADKDEDGKI	1	Drosophila melanogaster
D143	MEVDKDRDGKI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D143	VENDSDGDGRL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D145	ADKDGDGRISF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D145	ADKDEDGKISF	2	Drosophila melanogaster, Drosophila melanogaster
D145	NDVDGDGKLSF	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D145	VDKDRDGKISF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D145	NDSDGDGRLSF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D31	RFKKLDLDNSG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D31	RFRKLDLDNSG	2	Drosophila melanogaster, Drosophila melanogaster
D31	RFMKLDRDSSG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D31	RFIKIDANQSG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D31	RFMKLDKDSSG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D33	KKLDLDNSGSL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D33	RKLDLDNSGAL	2	Drosophila melanogaster, Drosophila melanogaster
D33	MKLDRDSSGSI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D33	IKIDANQSGSI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D33	MKLDKDSSGSI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D63	VIDIFDTDGNG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D63	VIDIFDADGNG	2	Drosophila melanogaster, Drosophila melanogaster
D63	IMEVFDADNSG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D63	LFSVVDEDGGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D63	IIEVFDEDNSG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D65	DIFDTDGNGEV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D65	DIFDADGNGEV	2	Drosophila melanogaster, Drosophila melanogaster
D65	EVFDADNSGDV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D65	SVVDEDGGGDV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D65	EVFDEDNSGDV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D71	GNGEVDFKEFI	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
D71	NSGDVDFQEFI	3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D71	GGGDVDFQEFI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E111	YISNGELFQVL	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
E111	YISNGELFIVL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E111	YISNGELYLVL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E111	FISNGELFIVL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E152	RISFEEFCAVV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E152	KISFDEFCSVV	2	Drosophila melanogaster, Drosophila melanogaster
E152	KISFEEFKDIV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E152	KLSFEEFKKAA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E152	RLSFEEFKNAI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E152	KLSFEEFKSAV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E42	SLSVEEFMSLP	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E42	SIDKNEFMSIP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E42	ALSVDEFMSLP	1	Drosophila melanogaster
E42	ALSIDEFMSLP	1	Drosophila melanogaster
E42	SIDRNEFLSIP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E42	SIDKTEFMSIP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E69	TDGNGEVDFKE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E69	ADGNGEVDFKE	2	Drosophila melanogaster, Drosophila melanogaster
E69	ADNSGDVDFQE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E69	EDGGGDVDFQE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E69	EDNSGDVDFQE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E74	EVDFKEFIEGV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E74	EVDFKEFIQGV	2	Drosophila melanogaster, Drosophila melanogaster
E74	DVDFQEFINSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E74	DVDFQEFITSL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E74	DVDFQEFITGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E74	DVDFQEFISGL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G36	DLDNSGSLSVE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G36	DRDSSGSIDKN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G36	DLDNSGALSVD	1	Drosophila melanogaster
G36	DLDNSGALSID	1	Drosophila melanogaster
G36	DANQSGSIDRN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G36	DKDSSGSIDKT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I148	DGDGRISFEEF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I148	DEDGKISFDEF	2	Drosophila melanogaster, Drosophila melanogaster
I148	DGDGKLSFEEF	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I148	DRDGKISFEEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I148	DGDGRLSFEEF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L124	MVGNNLKDTQL	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
L124	MVGTNLREDQL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L124	MVGTNLEDEQL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L124	MVGSNLDDEQL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L124	MVGNNLEDEQL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M101	FRIYDMDKDGY	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M101	FRIYDMDNDGY	2	Drosophila melanogaster, Drosophila melanogaster
M101	FKIYDIDRDGY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M101	FRIYDIDKDGY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M101	FKIYDIDKDGF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M101	FKIYDIDKDGY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M119	QVLKMMVGNNL	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
M119	LVLKMMVGTNL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M119	IVLKIMVGTNL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M119	IVLKIMVGSNL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M119	IVLKIMVGNNL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N123	MMVGNNLKDTQ	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
N123	MMVGTNLREDQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N123	IMVGTNLEDEQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N123	IMVGSNLDDEQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N123	IMVGNNLEDEQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N67	FDTDGNGEVDF	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N67	FDADGNGEVDF	2	Drosophila melanogaster, Drosophila melanogaster
N67	FDADNSGDVDF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N67	VDEDGGGDVDF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N67	FDEDNSGDVDF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R147	KDGDGRISFEE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R147	KDEDGKISFDE	2	Drosophila melanogaster, Drosophila melanogaster
R147	VDGDGKLSFEE	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R147	KDRDGKISFEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R147	SDGDGRLSFEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S149	GDGRISFEEFC	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S149	EDGKISFDEFC	2	Drosophila melanogaster, Drosophila melanogaster
S149	GDGKLSFEEFK	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S149	RDGKISFEEFK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S149	GDGRLSFEEFK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S35	LDLDNSGSLSV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S35	LDRDSSGSIDK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S35	LDLDNSGALSV	1	Drosophila melanogaster
S35	LDLDNSGALSI	1	Drosophila melanogaster
S35	IDANQSGSIDR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S35	LDKDSSGSIDK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S37	LDNSGSLSVEE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S37	RDSSGSIDKNE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S37	LDNSGALSVDE	1	Drosophila melanogaster
S37	LDNSGALSIDE	1	Drosophila melanogaster
S37	ANQSGSIDRNE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S37	KDSSGSIDKTE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S39	NSGSLSVEEFM	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S39	SSGSIDKNEFM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S39	NSGALSVDEFM	1	Drosophila melanogaster
S39	NSGALSIDEFM	1	Drosophila melanogaster
S39	QSGSIDRNEFL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S39	SSGSIDKTEFM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V120	VLKMMVGNNLK	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
V120	VLKMMVGTNLR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V120	VLKIMVGTNLE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V120	VLKIMVGSNLD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V120	VLKIMVGNNLE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V70	DGNGEVDFKEF	6	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
V70	DNSGDVDFQEF	3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V70	DGGGDVDFQEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y106	MDKDGYISNGE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y106	MDNDGYISNGE	2	Drosophila melanogaster, Drosophila melanogaster
Y106	IDKDGYISNGE	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y106	IDRDGYISNGE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y106	IDKDGFISNGE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)