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mutLBSgeneDB |
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| Gene summary for PPP5C |
 Gene summary |
| Basic gene Info. | Gene symbol | PPP5C |
| Gene name | protein phosphatase 5, catalytic subunit | |
| Synonyms | PP5|PPP5|PPT | |
| Cytomap | UCSC genome browser: 19q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001204284.1, NM_006247.3, | |
| Description | PP-Tprotein phosphatase Tserine/threonine-protein phosphatase 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600658 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000011485 | ||
| HPRD : 02805 | ||
| Vega : OTTHUMG00000134287 | ||
| Protein | UniProt: P53041 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PPP5C | |
| BioGPS: 5536 | ||
| Pathway | NCI Pathway Interaction Database: PPP5C | |
| KEGG: PPP5C | ||
| REACTOME: PPP5C | ||
| Pathway Commons: PPP5C | ||
| Context | iHOP: PPP5C | |
| ligand binding site mutation search in PubMed: PPP5C | ||
| UCL Cancer Institute: PPP5C | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PPP5C |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L70 | A71T | COAD | 1 | E428 | E428K | HNSC | 1 | H352 | G354D | STAD | 1 | K97 | G98D | STAD | 1 | F446 | A448T | UCEC | 1 | R400 | R400Q | UCEC | 1 | F39 | F39L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PPP5C |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F39 | F39L | -1.0254207 | R400 | R400Q | -1.0063263 | H352 | G354D | -0.93050693 | K97 | G98D | -0.89264072 | E428 | E428K | -0.85639946 | F446 | A448T | -0.83729037 | L70 | A71T | -0.7826483 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PPP5C from PDB |
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| Differential gene expression and gene-gene network for PPP5C |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PPP5C |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PPP5C |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PPP5C go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ACE,MET,GLU,GLU,VAL,ASP) | 2bug | A | F39 L70 K97 | MN | MANGANESE(2+) | 1s95 | A | H352 | MN | MANGANESE(2+) | 1s95 | B | H352 | MN | MANGANESE(2+) | 1wao | 1 | H352 | MN | MANGANESE(2+) | 1wao | 2 | H352 | MN | MANGANESE(2+) | 1wao | 3 | H352 | MN | MANGANESE(2+) | 1wao | 4 | H352 | MN | MANGANESE(2+) | 3h60 | A | H352 | MN | MANGANESE(2+) | 3h60 | A | H352 | MN | MANGANESE(2+) | 3h60 | B | H352 | MN | MANGANESE(2+) | 3h60 | B | H352 | MN | MANGANESE(2+) | 3h61 | A | H352 | MN | MANGANESE(2+) | 3h61 | D | H352 | MN | MANGANESE(2+) | 3h62 | C | H352 | MN | MANGANESE(2+) | 3h62 | B | H352 | MN | MANGANESE(2+) | 3h63 | A | H352 | MN | MANGANESE(2+) | 3h63 | C | H352 | MN | MANGANESE(2+) | 3h64 | A | H352 | MN | MANGANESE(2+) | 3h64 | D | H352 | ZN | ZINC(2+) | 3h66 | A | H352 | ZN | ZINC(2+) | 3h66 | B | H352 | ZN | ZINC(2+) | 3h67 | A | H352 | ZN | ZINC(2+) | 3h67 | D | H352 | ZN | ZINC(2+) | 3h68 | A | H352 | ZN | ZINC(2+) | 3h68 | D | H352 | ZN | ZINC(2+) | 3h69 | A | H352 | ZN | ZINC(2+) | 3h69 | D | H352 | NHC | CANTHARIDIC ACID | 3h63 | A | H352 R400 E428 F446 | ENL | ENDOTHALL | 3h61 | A | R400 E428 F446 | ENL | ENDOTHALL | 3h61 | D | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h63 | C | R400 E428 F446 | ENL | ENDOTHALL | 3h64 | A | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h67 | A | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h67 | D | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h68 | A | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h68 | D | R400 E428 F446 | ENL | ENDOTHALL | 3h69 | D | R400 E428 F446 | NHC | CANTHARIDIC ACID | 3h62 | C | R400 F446 | NHC | CANTHARIDIC ACID | 3h62 | B | R400 F446 | ENL | ENDOTHALL | 3h64 | D | R400 F446 | ENL | ENDOTHALL | 3h69 | A | R400 F446 |
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| Conservation information for LBS of PPP5C |
| Multiple alignments for P53041 in multiple species |
| LBS | AA sequence | # species | Species | D242 | ITVCGDTHGQF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D242 | ISVCGDTHGQF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D242 | LVICGDTHGQY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D242 | ITVCGDVHGQF | 1 | Arabidopsis thaliana | D271 | YIFNGDFVDRG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D271 | YLFNGDFVDRG | 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana | E428 | IIRSHEVKAEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E428 | IFRSHELRMGG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E428 | VIRSHEVRDQG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E428 | LVRSHEVKDEG | 1 | Arabidopsis thaliana | E76 | AYLRTECYGYA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E76 | AHFKVDNFQSA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E76 | AHLKSEDYGLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E76 | AHTKLEEYGSA | 1 | Arabidopsis thaliana | F39 | QANDYFKAKDY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F39 | EGNVFVKEKHF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F39 | EANKFLKEGHI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F39 | QANEAFKGHKY | 1 | Arabidopsis thaliana | F446 | RCVTVFSAPNY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F446 | KLMTVFSAPNY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F446 | YCITVFSAPNY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F446 | KLITVFSAPNY | 1 | Arabidopsis thaliana | H244 | VCGDTHGQFYD | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | H244 | ICGDTHGQYFD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H244 | VCGDVHGQFYD | 1 | Arabidopsis thaliana | H304 | LLRGNHETDNM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H304 | LNRGNHESDNM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H304 | INRGNHETDDM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H304 | LARGNHESKSM | 1 | Arabidopsis thaliana | H352 | KVLIMHGGLFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H352 | DYLVMHGGLPS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H352 | SYLVVHGGLFS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H352 | KVFVVHGGLFS | 1 | Arabidopsis thaliana | H427 | YIIRSHEVKAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H427 | KIFRSHELRMG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H427 | AVIRSHEVRDQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H427 | LLVRSHEVKDE | 1 | Arabidopsis thaliana | I63 | NPSNAIYYGNR | 2 | Homo sapiens, Rattus norvegicus | I63 | DSTQSIYFSNR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I63 | DSTNAILYSNR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I63 | NPGNAIYYGNR | 1 | Mus musculus | I63 | NSNNAVYWANR | 1 | Arabidopsis thaliana | K32 | RAEELKTQAND | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K32 | KALERKNEGNV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K32 | EALELKNEANK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K32 | RAEEFKSQANE | 1 | Arabidopsis thaliana | K40 | ANDYFKAKDYE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K40 | GNVFVKEKHFL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K40 | ANKFLKEGHIV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K40 | ANEAFKGHKYS | 1 | Arabidopsis thaliana | K97 | DKKYIKGYYRR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K97 | DPKNIKAYHRR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K97 | DPEYAKAYFRR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K97 | DSRYSKGYYRR | 1 | Arabidopsis thaliana | L70 | YGNRSLAYLRT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L70 | FSNRAFAHFKV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L70 | YSNRSLAHLKS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L70 | WANRAFAHTKL | 1 | Arabidopsis thaliana | N303 | HLLRGNHETDN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N303 | FLNRGNHESDN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N303 | FINRGNHETDD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N303 | YLARGNHESKS | 1 | Arabidopsis thaliana | N36 | LKTQANDYFKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N36 | RKNEGNVFVKE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N36 | LKNEANKFLKE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N36 | FKSQANEAFKG | 1 | Arabidopsis thaliana | N67 | AIYYGNRSLAY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N67 | SIYFSNRAFAH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N67 | AILYSNRSLAH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N67 | AVYWANRAFAH | 1 | Arabidopsis thaliana | R101 | IKGYYRRAASN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R101 | IKAYHRRALSC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R101 | AKAYFRRATAH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R101 | SKGYYRRGAAY | 1 | Arabidopsis thaliana | R275 | GDFVDRGSFSV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Arabidopsis thaliana | R275 | GDFVDRGSWSC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R275 | GDFVDRGSWST | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R400 | RSVSKRGVSCQ | 2 | Mus musculus, Rattus norvegicus | R400 | RSISKRGVSCQ | 1 | Homo sapiens | R400 | MGPSQRGLGHA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R400 | RGPSKRGVGLQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R400 | RGPSKRGVGLS | 1 | Arabidopsis thaliana | V429 | IRSHEVKAEGY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V429 | FRSHELRMGGV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V429 | IRSHEVRDQGY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V429 | VRSHEVKDEGY | 1 | Arabidopsis thaliana | Y451 | FSAPNYCDQMG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Arabidopsis thaliana | Y451 | FSAPNYCDSQG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y451 | FSAPNYCDSTG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y95 | ELDKKYIKGYY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y95 | KLDPKNIKAYH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y95 | ECDPEYAKAYF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y95 | EVDSRYSKGYY | 1 | Arabidopsis thaliana |
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