|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for PREP |
 Gene summary |
| Basic gene Info. | Gene symbol | PREP |
| Gene name | prolyl endopeptidase | |
| Synonyms | PE|PEP | |
| Cytomap | UCSC genome browser: 6q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002726.4, | |
| Description | dJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600400 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000085377 | ||
| HPRD : 02673 | ||
| Vega : OTTHUMG00000015297 | ||
| Protein | UniProt: P48147 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PREP | |
| BioGPS: 5550 | ||
| Pathway | NCI Pathway Interaction Database: PREP | |
| KEGG: PREP | ||
| REACTOME: PREP | ||
| Pathway Commons: PREP | ||
| Context | iHOP: PREP | |
| ligand binding site mutation search in PubMed: PREP | ||
| UCL Cancer Institute: PREP | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for PREP |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C255 | P257S | BLCA | 1 | V580 | G579R | COAD | 1 | I591 | T590N | KIRC | 1 | R643 | R643C | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for PREP |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R643 | R643C | -1.5001876 | C255 | P257S | -1.2657262 | I591 | T590N | -1.1531993 | V580 | G579R | -0.029934283 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PREP from PDB |
| Top |
| Differential gene expression and gene-gene network for PREP |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for PREP |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0002622 | Amnesia | 1 | Biomarker |
| umls:C0002624 | Amnesia, Retrograde | 1 | Biomarker |
| umls:C0242656 | Disease Progression | 1 | Biomarker |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for PREP |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01684 | 1-Hydroxy-1-Thio-Glycerol | Small molecule |  |
| Experimental | DB01769 | Double Oxidized Cysteine | Small molecule |  |
| Experimental | DB03382 | S-Oxy Cysteine | Small molecule |  |
| Experimental | DB03535 | Z-Pro-Prolinal | Small molecule |  |
| Experimental | DB03864 | Monothioglycerol | Small molecule |  |
| Experimental | DB07148 | (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one | Small molecule |  |
| Experimental | DB08738 | 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one | Small molecule |  |
| Experimental | DB08739 | 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of PREP go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 552 | (6S)-1-CHLORO-3-[(4-FLUOROBENZYL)OXY]-6-(PYRROLIDIN-1-YLCARBONYL)PYRROLO[1,2-A]PYRAZIN-4(6H)-ONE | 3ddu | A | C255 V580 I591 R643 |
| Top |
| Conservation information for LBS of PREP |
| Multiple alignments for P48147 in multiple species |
| LBS | AA sequence | # species | Species | C255 | SIREGCDPVNR | 2 | Homo sapiens, Bos taurus | C255 | SIWEGCDPVNR | 2 | Mus musculus, Rattus norvegicus | F173 | LERVKFSCMAW | 2 | Homo sapiens, Bos taurus | F173 | LERVKFTCMAW | 2 | Mus musculus, Rattus norvegicus | F476 | YGYGGFNISIT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G254 | LSIREGCDPVN | 2 | Homo sapiens, Bos taurus | G254 | LSIWEGCDPVN | 2 | Mus musculus, Rattus norvegicus | I591 | FHKYTIGHAWT | 2 | Homo sapiens, Bos taurus | I591 | FHKFTIGHAWT | 2 | Mus musculus, Rattus norvegicus | M235 | DEPKWMGGAEL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R252 | VLLSIREGCDP | 2 | Homo sapiens, Bos taurus | R252 | VLLSIWEGCDP | 2 | Mus musculus, Rattus norvegicus | R643 | ADHDDRVVPLH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S554 | TINGGSNGGLL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V580 | IAQVGVMDMLK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V644 | DHDDRVVPLHS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W595 | TIGHAWTTDYG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y599 | AWTTDYGCSDS | 2 | Homo sapiens, Rattus norvegicus | Y599 | AWTTDYGCSDN | 1 | Bos taurus | Y599 | AWTTDYGCSDT | 1 | Mus musculus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |