mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MIOX
Gene summary
Basic gene Info.Gene symbolMIOX
Gene namemyo-inositol oxygenase
CytomapUCSC genome browser: 22q13.3
Type of geneprotein-coding
DescriptionMI oxygenasealdehyde reductase (aldose reductase) like 6aldehyde reductase-like 6inositol oxygenasekidney-specific protein 32renal-specific oxidoreductase
Modification date20141207
dbXrefs MIM : 606774
HPRD : 12443
ProteinUniProt: Q9UGB7
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MIOX
BioGPS: 55586
PathwayNCI Pathway Interaction Database: MIOX
Pathway Commons: MIOX
ContextiHOP: MIOX
ligand binding site mutation search in PubMed: MIOX
UCL Cancer Institute: MIOX
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0019310inositol catabolic process18364358

Ligand binding site mutations for MIOX
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MIOX
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MIOX from PDB

Differential gene expression and gene-gene network for MIOX
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MIOX and the right PPI network was created from samples without mutations in the LBS of MIOX. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MIOX
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MIOX
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MIOX go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of MIOX
Multiple alignments for Q9UGB7 in multiple species
LBSAA sequence# speciesSpecies
C235DYRQLCSQQDL2Mus musculus, Rattus norvegicus
C235DYQQLCSQQDL1Homo sapiens
C235AYKHLMNNEDR1Arabidopsis thaliana
C235AYMHLMNDEDK1Oryza sativa subsp. japonica
C235DYMHLCNEKDQ1Danio rerio
C235DYQQLCNEQDL1Bos taurus
D124VGLLHDLGKVL2Homo sapiens, Bos taurus
D124TGLIHDLGKVL2Arabidopsis thaliana, Oryza sativa subsp. japonica
D124VGLIHDVGKVM1Danio rerio
D124VGLLHDLGKIM1Mus musculus
D124VGLLHDLGKIL1Rattus norvegicus
D142WAVVGDTFPVG5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
D142WSVVGDTFPVG1Oryza sativa subsp. japonica
D142WAVVGDTYPVG1Danio rerio
G141QWAVVGDTFPV5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
G141QWSVVGDTFPV1Oryza sativa subsp. japonica
G141QWAVVGDTYPV1Danio rerio
H123LVGLLHDLGKV2Homo sapiens, Bos taurus
H123LTGLIHDLGKV2Arabidopsis thaliana, Oryza sativa subsp. japonica
H123LVGLLHDLGKI2Mus musculus, Rattus norvegicus
H123LVGLIHDVGKV1Danio rerio
H194LMSWGHDEYLY3Danio rerio, Mus musculus, Rattus norvegicus
H194LMSWGHDEYMY2Homo sapiens, Bos taurus
H194LMSWGHDDYMY2Arabidopsis thaliana, Oryza sativa subsp. japonica
H220YMIRFHSFYPW3Homo sapiens, Danio rerio, Mus musculus
H220FIIRYHSFYAL1Arabidopsis thaliana
H220FIIRYHSFYPL1Oryza sativa subsp. japonica
H220YIIRFHSFYPW1Bos taurus
H220YMVRFHSFYPW1Rattus norvegicus
H98FPNSFHAFQTA5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
H98EPQIEHLLQTA1Arabidopsis thaliana
H98MPQIEHLLQTA1Oryza sativa subsp. japonica
K127LHDLGKVL--A2Homo sapiens, Bos taurus
K127IHDLGKVLLHS1Arabidopsis thaliana
K127IHDLGKVLLHP1Oryza sativa subsp. japonica
K127IHDVGKVM--A1Danio rerio
K127LHDLGKIM--A1Mus musculus
K127LHDLGKIL--A1Rattus norvegicus
L240CSQQDLDMLPW2Mus musculus, Rattus norvegicus
L240CSQQDLAMLPW1Homo sapiens
L240MNNEDRENMKW1Arabidopsis thaliana
L240MNDEDKENLKW1Oryza sativa subsp. japonica
L240CNEKDQQMLPW1Danio rerio
L240CNEQDLAMLPW1Bos taurus
Q232TGGDYRQLCSQ2Mus musculus, Rattus norvegicus
Q232TGRDYQQLCSQ1Homo sapiens
Q232KSEAYKHLMNN1Arabidopsis thaliana
Q232KHGAYMHLMND1Oryza sativa subsp. japonica
Q232SNGDYMHLCNE1Danio rerio
Q232KFGDYQQLCNE1Bos taurus
R229PWHTGGDYRQL2Mus musculus, Rattus norvegicus
R229PWHTGRDYQQL1Homo sapiens
R229ALHKSEAYKHL1Arabidopsis thaliana
R229PLHKHGAYMHL1Oryza sativa subsp. japonica
R229PWHSNGDYMHL1Danio rerio
R229PWHKFGDYQQL1Bos taurus
S221MIRFHSFYPWH3Homo sapiens, Danio rerio, Mus musculus
S221IIRYHSFYALH1Arabidopsis thaliana
S221IIRYHSFYPLH1Oryza sativa subsp. japonica
S221IIRFHSFYPWH1Bos taurus
S221MVRFHSFYPWH1Rattus norvegicus
S236YRQLCSQQDLD2Mus musculus, Rattus norvegicus
S236YQQLCSQQDLA1Homo sapiens
S236YKHLMNNEDRE1Arabidopsis thaliana
S236YMHLMNDEDKE1Oryza sativa subsp. japonica
S236YMHLCNEKDQQ1Danio rerio
S236YQQLCNEQDLA1Bos taurus
V140PQWAVVGDTFP5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
V140PQWSVVGDTFP1Oryza sativa subsp. japonica
V140PQWAVVGDTYP1Danio rerio
W225HSFYPWHTGGD2Mus musculus, Rattus norvegicus
W225HSFYPWHTGRD1Homo sapiens
W225HSFYALHKSEA1Arabidopsis thaliana
W225HSFYPLHKHGA1Oryza sativa subsp. japonica
W225HSFYPWHSNGD1Danio rerio
W225HSFYPWHKFGD1Bos taurus

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