|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for MIOX |
 Gene summary |
| Basic gene Info. | Gene symbol | MIOX |
| Gene name | myo-inositol oxygenase | |
| Synonyms | ALDRL6 | |
| Cytomap | UCSC genome browser: 22q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017584.5, | |
| Description | MI oxygenasealdehyde reductase (aldose reductase) like 6aldehyde reductase-like 6inositol oxygenasekidney-specific protein 32renal-specific oxidoreductase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606774 | |
| HGNC : HGNC | ||
| HPRD : 12443 | ||
| Protein | UniProt: Q9UGB7 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MIOX | |
| BioGPS: 55586 | ||
| Pathway | NCI Pathway Interaction Database: MIOX | |
| KEGG: MIOX | ||
| REACTOME: MIOX | ||
| Pathway Commons: MIOX | ||
| Context | iHOP: MIOX | |
| ligand binding site mutation search in PubMed: MIOX | ||
| UCL Cancer Institute: MIOX | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0019310 | inositol catabolic process | 18364358 |
| Top |
| Ligand binding site mutations for MIOX |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C235 | C235R | COAD | 1 | D142 | T143I | SKCM | 1 | V140 | V140I | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for MIOX |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V140 | V140I | 0.16936319 | C235 | C235R | -0.61400368 | D142 | T143I | -0.49417627 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MIOX from PDB |
| Top |
| Differential gene expression and gene-gene network for MIOX |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for MIOX |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for MIOX |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of MIOX go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CYS | CYSTEINE | 2ibn | A | C235 | CYS | CYSTEINE | 2ibn | B | C235 | I1N | (2S,3R,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXANONE | 2ibn | A | V140 D142 | I1N | (2S,3R,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXANONE | 2ibn | B | V140 D142 |
| Top |
| Conservation information for LBS of MIOX |
| Multiple alignments for Q9UGB7 in multiple species |
| LBS | AA sequence | # species | Species | C235 | DYRQLCSQQDL | 2 | Mus musculus, Rattus norvegicus | C235 | DYQQLCSQQDL | 1 | Homo sapiens | C235 | AYKHLMNNEDR | 1 | Arabidopsis thaliana | C235 | AYMHLMNDEDK | 1 | Oryza sativa subsp. japonica | C235 | DYMHLCNEKDQ | 1 | Danio rerio | C235 | DYQQLCNEQDL | 1 | Bos taurus | D124 | VGLLHDLGKVL | 2 | Homo sapiens, Bos taurus | D124 | TGLIHDLGKVL | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | D124 | VGLIHDVGKVM | 1 | Danio rerio | D124 | VGLLHDLGKIM | 1 | Mus musculus | D124 | VGLLHDLGKIL | 1 | Rattus norvegicus | D142 | WAVVGDTFPVG | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | D142 | WSVVGDTFPVG | 1 | Oryza sativa subsp. japonica | D142 | WAVVGDTYPVG | 1 | Danio rerio | G141 | QWAVVGDTFPV | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | G141 | QWSVVGDTFPV | 1 | Oryza sativa subsp. japonica | G141 | QWAVVGDTYPV | 1 | Danio rerio | H123 | LVGLLHDLGKV | 2 | Homo sapiens, Bos taurus | H123 | LTGLIHDLGKV | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | H123 | LVGLLHDLGKI | 2 | Mus musculus, Rattus norvegicus | H123 | LVGLIHDVGKV | 1 | Danio rerio | H194 | LMSWGHDEYLY | 3 | Danio rerio, Mus musculus, Rattus norvegicus | H194 | LMSWGHDEYMY | 2 | Homo sapiens, Bos taurus | H194 | LMSWGHDDYMY | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | H220 | YMIRFHSFYPW | 3 | Homo sapiens, Danio rerio, Mus musculus | H220 | FIIRYHSFYAL | 1 | Arabidopsis thaliana | H220 | FIIRYHSFYPL | 1 | Oryza sativa subsp. japonica | H220 | YIIRFHSFYPW | 1 | Bos taurus | H220 | YMVRFHSFYPW | 1 | Rattus norvegicus | H98 | FPNSFHAFQTA | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | H98 | EPQIEHLLQTA | 1 | Arabidopsis thaliana | H98 | MPQIEHLLQTA | 1 | Oryza sativa subsp. japonica | K127 | LHDLGKVL--A | 2 | Homo sapiens, Bos taurus | K127 | IHDLGKVLLHS | 1 | Arabidopsis thaliana | K127 | IHDLGKVLLHP | 1 | Oryza sativa subsp. japonica | K127 | IHDVGKVM--A | 1 | Danio rerio | K127 | LHDLGKIM--A | 1 | Mus musculus | K127 | LHDLGKIL--A | 1 | Rattus norvegicus | L240 | CSQQDLDMLPW | 2 | Mus musculus, Rattus norvegicus | L240 | CSQQDLAMLPW | 1 | Homo sapiens | L240 | MNNEDRENMKW | 1 | Arabidopsis thaliana | L240 | MNDEDKENLKW | 1 | Oryza sativa subsp. japonica | L240 | CNEKDQQMLPW | 1 | Danio rerio | L240 | CNEQDLAMLPW | 1 | Bos taurus | Q232 | TGGDYRQLCSQ | 2 | Mus musculus, Rattus norvegicus | Q232 | TGRDYQQLCSQ | 1 | Homo sapiens | Q232 | KSEAYKHLMNN | 1 | Arabidopsis thaliana | Q232 | KHGAYMHLMND | 1 | Oryza sativa subsp. japonica | Q232 | SNGDYMHLCNE | 1 | Danio rerio | Q232 | KFGDYQQLCNE | 1 | Bos taurus | R229 | PWHTGGDYRQL | 2 | Mus musculus, Rattus norvegicus | R229 | PWHTGRDYQQL | 1 | Homo sapiens | R229 | ALHKSEAYKHL | 1 | Arabidopsis thaliana | R229 | PLHKHGAYMHL | 1 | Oryza sativa subsp. japonica | R229 | PWHSNGDYMHL | 1 | Danio rerio | R229 | PWHKFGDYQQL | 1 | Bos taurus | S221 | MIRFHSFYPWH | 3 | Homo sapiens, Danio rerio, Mus musculus | S221 | IIRYHSFYALH | 1 | Arabidopsis thaliana | S221 | IIRYHSFYPLH | 1 | Oryza sativa subsp. japonica | S221 | IIRFHSFYPWH | 1 | Bos taurus | S221 | MVRFHSFYPWH | 1 | Rattus norvegicus | S236 | YRQLCSQQDLD | 2 | Mus musculus, Rattus norvegicus | S236 | YQQLCSQQDLA | 1 | Homo sapiens | S236 | YKHLMNNEDRE | 1 | Arabidopsis thaliana | S236 | YMHLMNDEDKE | 1 | Oryza sativa subsp. japonica | S236 | YMHLCNEKDQQ | 1 | Danio rerio | S236 | YQQLCNEQDLA | 1 | Bos taurus | V140 | PQWAVVGDTFP | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | V140 | PQWSVVGDTFP | 1 | Oryza sativa subsp. japonica | V140 | PQWAVVGDTYP | 1 | Danio rerio | W225 | HSFYPWHTGGD | 2 | Mus musculus, Rattus norvegicus | W225 | HSFYPWHTGRD | 1 | Homo sapiens | W225 | HSFYALHKSEA | 1 | Arabidopsis thaliana | W225 | HSFYPLHKHGA | 1 | Oryza sativa subsp. japonica | W225 | HSFYPWHSNGD | 1 | Danio rerio | W225 | HSFYPWHKFGD | 1 | Bos taurus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |