mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRKAA2
Gene summary
Basic gene Info.Gene symbolPRKAA2
Gene nameprotein kinase, AMP-activated, alpha 2 catalytic subunit
SynonymsAMPK|AMPK2|AMPKa2|PRKAA
CytomapUCSC genome browser: 1p31
Type of geneprotein-coding
RefGenesNM_006252.3,
Description5'-AMP-activated protein kinase catalytic subunit alpha-25'-AMP-activated protein kinase, catalytic alpha-2 chainACACA kinaseAMP-activated protein kinase alpha-2 subunit variant 2AMP-activated protein kinase alpha-2 subunit variant 3AMPK alpha 2AMPK
Modification date20141207
dbXrefs MIM : 600497
HGNC : HGNC
Ensembl : ENSG00000162409
HPRD : 02735
Vega : OTTHUMG00000008282
ProteinUniProt: P54646
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRKAA2
BioGPS: 5563
PathwayNCI Pathway Interaction Database: PRKAA2
KEGG: PRKAA2
REACTOME: PRKAA2
Pathway Commons: PRKAA2
ContextiHOP: PRKAA2
ligand binding site mutation search in PubMed: PRKAA2
UCL Cancer Institute: PRKAA2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PRKAA2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D157G159VBRCA1
I46I46LCOAD1
M164S165LLUAD1
A43V42LSTAD1
K45K45RUCEC1
D88D88YUCEC1
D157G159RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PRKAA2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K45K45R0.25822213
I46I46L-0.82797244
D88D88Y-0.64546626
D157G159R-0.57167502
M164S165L-0.56909726
D157G159V-0.4907839
A43V42L-0.44987973
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRKAA2 from PDB

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Differential gene expression and gene-gene network for PRKAA2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRKAA2 and the right PPI network was created from samples without mutations in the LBS of PRKAA2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PRKAA2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0878544Cardiomyopathies2Biomarker
umls:C0018800Cardiomegaly1Therapeutic
umls:C0271650Glucose Intolerance1Biomarker
umls:C0021655Insulin Resistance1Biomarker
umls:C0038454Stroke1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PRKAA2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRKAA2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STUSTAUROSPORINE4cfeAA43 D157
STUSTAUROSPORINE4cfeCA43 D157
STUSTAUROSPORINE4cffAA43 K45 D157
STUSTAUROSPORINE4cffCA43 K45 D157
TAKDORSOMORPHIN3aqvAA43 K45 M164
9925-[[6-CHLORANYL-5-(1-METHYLINDOL-5-YL)-1H- BENZIMIDAZOL-2-YL]OXY]-2-METHYL-BENZOIC ACID4cfeAI46 D88
9925-[[6-CHLORANYL-5-(1-METHYLINDOL-5-YL)-1H- BENZIMIDAZOL-2-YL]OXY]-2-METHYL-BENZOIC ACID4cfeCI46 D88
C1V3-[4-(2-HYDROXYPHENYL)PHENYL]-4-OXIDANYL-6- OXIDANYLIDENE-7H-THIENO[2,3-B]PYRIDINE-5- CARBONITRILE4cffAI46 D88
C1V3-[4-(2-HYDROXYPHENYL)PHENYL]-4-OXIDANYL-6- OXIDANYLIDENE-7H-THIENO[2,3-B]PYRIDINE-5- CARBONITRILE4cffCI46 D88


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Conservation information for LBS of PRKAA2
Multiple alignments for P54646 in multiple species
LBSAA sequence# speciesSpecies
A43TGHKVAVKILN3Homo sapiens, Mus musculus, Rattus norvegicus
A43TQYKVAVKILN1Caenorhabditis elegans
A43TGQKVALKIIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A43TQQKVALKFIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D103GGELFDYICKH3Homo sapiens, Mus musculus, Rattus norvegicus
D103GGELFDYIVKH1Caenorhabditis elegans
D103GNELFDYIVQR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D103GGELFDYIVEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D157NAKIADFGLSN3Homo sapiens, Mus musculus, Rattus norvegicus
D157NVKIADFGLSN3Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D88ISTPTDFFMVM3Homo sapiens, Mus musculus, Rattus norvegicus
D88ISTPSDIFMIM1Caenorhabditis elegans
D88IKSKDEIIMVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D88ITTPTDIVMVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E100YVSGGELFDYI3Homo sapiens, Mus musculus, Rattus norvegicus
E100HVSGGELFDYI1Caenorhabditis elegans
E100Y-AGNELFDYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E100Y-AGGELFDYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E143RDLKPENVLLD3Homo sapiens, Mus musculus, Rattus norvegicus
E143RDLKPENLLLD3Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E94FFMVMEYVSGG3Homo sapiens, Mus musculus, Rattus norvegicus
E94IFMIMEHVSGG1Caenorhabditis elegans
E94IIMVIEY-AGN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E94IVMVIEY-AGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F90TPTDFFMVMEY3Homo sapiens, Mus musculus, Rattus norvegicus
F90TPSDIFMIMEH1Caenorhabditis elegans
F90SKDEIIMVIEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F90TPTDIVMVIEY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G19GHYVLGDTLGV3Homo sapiens, Mus musculus, Rattus norvegicus
G19GHYILKETLGV1Caenorhabditis elegans
G19GNYQIVKTLGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G19GPYIIRETLGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G23LGDTLGVGTFG3Homo sapiens, Mus musculus, Rattus norvegicus
G23LKETLGVGTFG1Caenorhabditis elegans
G23IVKTLGEGSFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G23IRETLGEGSFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G25DTLGVGTFGKV3Homo sapiens, Mus musculus, Rattus norvegicus
G25ETLGVGTFGKV1Caenorhabditis elegans
G25KTLGEGSFGKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G25ETLGEGSFGKV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G28GVGTFGKVKIG3Homo sapiens, Mus musculus, Rattus norvegicus
G28GEGSFGKVKLA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G28GVGTFGKVKVG1Caenorhabditis elegans
G98MEYVSGGELFD3Homo sapiens, Mus musculus, Rattus norvegicus
G98MEHVSGGELFD1Caenorhabditis elegans
G98IEY-AGNELFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G98IEY-AGGELFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G99EYVSGGELFDY3Homo sapiens, Mus musculus, Rattus norvegicus
G99EHVSGGELFDY1Caenorhabditis elegans
G99EY-AGNELFDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G99EY-AGGELFDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I46KVAVKILNRQK4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
I46KVALKIINKKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I46KVALKFISRQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K29VGTFGKVKIGE3Homo sapiens, Mus musculus, Rattus norvegicus
K29VGTFGKVKVGI1Caenorhabditis elegans
K29EGSFGKVKLAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K29EGSFGKVKLAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K31TFGKVKIGEHQ3Homo sapiens, Mus musculus, Rattus norvegicus
K31TFGKVKVGIHE1Caenorhabditis elegans
K31SFGKVKLAYHT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K31SFGKVKLATHY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K45HKVAVKILNRQ3Homo sapiens, Mus musculus, Rattus norvegicus
K45YKVAVKILNRQ1Caenorhabditis elegans
K45QKVALKIINKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K45QKVALKFISRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L146KPENVLLDAQM2Mus musculus, Rattus norvegicus
L146KPENVLLDAHM1Homo sapiens
L146KPENLLLDEQN1Caenorhabditis elegans
L146KPENLLLDEHL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L146KPENLLLDDNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L18IGHYVLGDTLG3Homo sapiens, Mus musculus, Rattus norvegicus
L18IGHYILKETLG1Caenorhabditis elegans
L18IGNYQIVKTLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L18IGPYIIRETLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L22VLGDTLGVGTF3Homo sapiens, Mus musculus, Rattus norvegicus
L22ILKETLGVGTF1Caenorhabditis elegans
L22QIVKTLGEGSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L22IIRETLGEGSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M164GLSNMMSDGEF3Homo sapiens, Mus musculus, Rattus norvegicus
M164GLSNIMTDGNF2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M164GLSNIMTDGDF1Caenorhabditis elegans
M93DFFMVMEYVSG3Homo sapiens, Mus musculus, Rattus norvegicus
M93DIFMIMEHVSG1Caenorhabditis elegans
M93EIIMVIEY-AG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M93DIVMVIEY-AG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N144DLKPENVLLDA3Homo sapiens, Mus musculus, Rattus norvegicus
N144DLKPENLLLDE2Caenorhabditis elegans, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N144DLKPENLLLDD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N48AVKILNRQKIR3Homo sapiens, Mus musculus, Rattus norvegicus
N48AVKILNRQKIK1Caenorhabditis elegans
N48ALKIINKKVLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N48ALKFISRQLLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S97VMEYVSGGELF3Homo sapiens, Mus musculus, Rattus norvegicus
S97IMEHVSGGELF1Caenorhabditis elegans
S97VIEY-AGNELF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S97VIEY-AGGELF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V11KHDGRV-----3Homo sapiens, Mus musculus, Rattus norvegicus
V11SPGGETSTKQQ1Caenorhabditis elegans
V11LADGA------1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V11LPPEAISKR--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V24GDTLGVGTFGK3Homo sapiens, Mus musculus, Rattus norvegicus
V24KETLGVGTFGK1Caenorhabditis elegans
V24VKTLGEGSFGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V24RETLGEGSFGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V30GTFGKVKIGEH3Homo sapiens, Mus musculus, Rattus norvegicus
V30GTFGKVKVGIH1Caenorhabditis elegans
V30GSFGKVKLAYH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V30GSFGKVKLATH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V96MVMEYVSGGEL3Homo sapiens, Mus musculus, Rattus norvegicus
V96MIMEHVSGGEL1Caenorhabditis elegans
V96MVIEY-AGNEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V96MVIEY-AGGEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y95FMVMEYVSGGE3Homo sapiens, Mus musculus, Rattus norvegicus
Y95FMIMEHVSGGE1Caenorhabditis elegans
Y95IMVIEY-AGNE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y95VMVIEY-AGGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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