mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PRKACA

Gene summary

Basic gene Info.	Gene symbol	PRKACA
	Gene name	protein kinase, cAMP-dependent, catalytic, alpha
	Synonyms	PKACA
	Cytomap	UCSC genome browser: 19p13.1
	Type of gene	protein-coding
	RefGenes	NM_002730.3, NM_207518.1,
	Description	PKA C-alphacAMP-dependent protein kinase catalytic subunit alphaprotein kinase A catalytic subunit
	Modification date	20141207
dbXrefs	MIM : 601639
	HGNC : HGNC
	Ensembl : ENSG00000072062
	HPRD : 03382
	Vega : OTTHUMG00000182051
Protein	UniProt: P17612 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PRKACA
	BioGPS: 5566
Pathway	NCI Pathway Interaction Database: PRKACA
	KEGG: PRKACA
	REACTOME: PRKACA
	Pathway Commons: PRKACA
Context	iHOP: PRKACA
	ligand binding site mutation search in PubMed: PRKACA
	UCL Cancer Institute: PRKACA
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0018105	peptidyl-serine phosphorylation	10805756
GO:0045667	regulation of osteoblast differentiation	19949837
GO:0061136	regulation of proteasomal protein catabolic process	17565987
GO:0071333	cellular response to glucose stimulus	19949837
GO:2000810	regulation of tight junction assembly	15905176

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Ligand binding site mutations for PRKACA

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
L83	L83P	BRCA	1
T198	W197R	BRCA	1
G235	A234T	COAD	1
R46	R46Q	HNSC	1
V124	V124M	HNSC	1
L83	L83P	HNSC	1
G235	A234S	LUAD	1
T198	W197G	PRAD	1
T198	W197L	SKCM	1
V105	L104F	SKCM	1
P244	P244L	UCEC	1
H143	R145H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PRKACA

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
T198	W197L	0.15774594
L83	L83P	-1.7479261
R46	R46Q	-1.6736073
V105	L104F	-1.3919197
H143	R145H	-1.0409206
V124	V124M	-0.99287518
P244	P244L	-0.76298276
G235	A234S	-0.73977423
T198	W197G	-0.70665854
G235	A234T	-0.62263311
T198	W197R	-0.2445653

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRKACA from PDB

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Differential gene expression and gene-gene network for PRKACA

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PRKACA and the right PPI network was created from samples without mutations in the LBS of PRKACA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PRKACA

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0001624	Adrenal Gland Neoplasms	2	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PRKACA

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB01919	Pentanal	Small molecule
Experimental	DB01940	Balanol Analog 2	Small molecule
Experimental	DB02155	Balanol Analog 8	Small molecule
Experimental	DB02482	Phosphonothreonine	Small molecule
Experimental	DB02611	Balanol Analog 1	Small molecule
Experimental	DB03374	3,5-Diiodotyrosine	Small molecule
Experimental	DB04098	Balanol	Small molecule
Experimental	DB04522	Phosphonoserine	Small molecule
Experimental	DB04530	S,S-(2-Hydroxyethyl)Thiocysteine	Small molecule
Experimental	DB04707	HYDROXYFASUDIL	Small molecule
Experimental	DB06959	(1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE	Small molecule
Experimental	DB06977	(2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE	Small molecule
Experimental	DB07107	(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE	Small molecule
Experimental	DB07124	(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Small molecule
Experimental	DB07204	(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE	Small molecule
Experimental	DB07235	N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE	Small molecule
Experimental	DB07458	3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE	Small molecule
Experimental	DB07583	(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE	Small molecule
Experimental	DB07854	N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE	Small molecule
Experimental	DB07855	(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE	Small molecule
Experimental	DB07856	6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE	Small molecule
Experimental	DB07857	(2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE	Small molecule
Experimental	DB07858	(2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE	Small molecule
Experimental	DB07859	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE	Small molecule
Experimental	DB07860	(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE	Small molecule
Experimental	DB07876	(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE	Small molecule
Experimental	DB07947	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE	Small molecule
Experimental	DB07995	N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE	Small molecule
Experimental	DB07996	1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	Small molecule
Experimental	DB07997	N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE	Small molecule
Experimental	DB08070	2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE	Small molecule
Experimental	DB08073	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Small molecule
Experimental	DB08113	3-pyridin-4-yl-1H-indazole	Small molecule
Experimental	DB08114	5-benzyl-1,3-thiazol-2-amine	Small molecule
Experimental	DB08148	1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine	Small molecule
Experimental	DB08149	1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine	Small molecule
Experimental	DB08150	4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium	Small molecule
Experimental	DB08162	5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE	Small molecule
Experimental	DB08231	MYRISTIC ACID	Small molecule
Experimental	DB08568	(2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE	Small molecule
Experimental	DB08569	3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE	Small molecule
Experimental	DB08756	(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE	Small molecule
Investigational	DB08846	Ellagic Acid	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRKACA go to BioLip

Ligand ID

Ligand short name

Ligand long name

PDB ID

PDB name

mutLBS

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Conservation information for LBS of PRKACA

Multiple alignments for P17612 in multiple species

LBS	AA sequence	# species	Species
A241	YPPFFADQPIQ	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
A241	YTPFYDTTPMK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A241	YPPFYSENPMK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A71	TGNHYAMKILD	2	Homo sapiens, Bos taurus
A71	SGNHYAMKILD	1	Mus musculus
A71	TGNHFAMKILD	1	Canis lupus familiaris
A71	NGRYYAIKVLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A71	NRLYYAIKVLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C200	T-WTLCGTPEY	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
C200	T-WTLCGTPDY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C200	NCCTLCGTPDY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D167	DLIYRDLKPEN	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
D167	NIIYRDLKPEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D167	QIVYRDLKPEN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D185	YIQVTDFGFAK	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
D185	HIKITDFGFAK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D185	HLKIVDFGFAK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D242	PPFFADQPIQI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
D242	TPFYDTTPMKT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D242	PPFYSENPMKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D26	----EDFLKKW	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
D26	----QQLLTSQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D26	VSQLLDLQRRR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D329	DTSNFDDYEEE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
D329	DTSLFDQYPEE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D329	DSSQFDAYADV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E122	LYMVMEYVPGG	3	Homo sapiens, Bos taurus, Canis lupus familiaris
E122	LYMVMEYVAGG	1	Mus musculus
E122	IFMVMDYIEGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E122	LFMVMDFAEGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E128	YVPGGEMFSHL	3	Homo sapiens, Bos taurus, Canis lupus familiaris
E128	YVAGGEMFSHL	1	Mus musculus
E128	YIEGGELFSLL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E128	FAEGGELFSLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E171	RDLKPENLLID	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E171	RDLKPENILLD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E171	RDLKPENLLLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E204	LCGTPEYLAPE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E204	LCGTPDYIAPE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E204	LCGTPDYLAPE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E231	GVLIYEMAAGY	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E231	GVLIYEMLAGY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E231	GILIFEMLAGY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E25	-----EDFLKK	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
E25	-----QQLLTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E25	RVSQLLDLQRR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E45	-LDQFERIKTL	3	Homo sapiens, Bos taurus, Canis lupus familiaris
E45	-LDQFDRIKTL	1	Mus musculus
E45	TLHDFQIMRTL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E45	GIQDFNFLQTL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F130	PGGEMFSHLRR	3	Homo sapiens, Bos taurus, Canis lupus familiaris
F130	EGGELFSLLRK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F130	AGGEMFSHLRR	1	Mus musculus
F188	VTDFGFAKRVK	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
F188	ITDFGFAKEVQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F188	IVDFGFAKRVS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F240	GYPPFFADQPI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
F240	GYTPFYDTTPM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F240	GYPPFYSENPM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F328	GDTSNFDDYEE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
F328	GDTSLFDQYPE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F328	GDSSQFDAYAD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F44	--LDQFERIKT	3	Homo sapiens, Bos taurus, Canis lupus familiaris
F44	--LDQFDRIKT	1	Mus musculus
F44	YTLHDFQIMRT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F44	YGIQDFNFLQT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F55	LGTGSFGRVML	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
F55	LGTGSFGRVHL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G127	EYVPGGEMFSH	3	Homo sapiens, Bos taurus, Canis lupus familiaris
G127	EYVAGGEMFSH	1	Mus musculus
G127	DYIEGGELFSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G127	DFAEGGELFSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G137	HLRRIGRFSEP	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G137	LLRKSQRFPNP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G137	LLRKCHRFPEK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G201	-WTLCGTPEYL	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G201	-WTLCGTPDYI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G201	CCTLCGTPDYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G235	YEMAAGYPPFF	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G235	YEMLAGYTPFY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G235	FEMLAGYPPFY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G51	RIKTLGTGSFG	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G51	IMRTLGTGSFG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G51	FLQTLGTGSFG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G53	KTLGTGSFGRV	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G53	RTLGTGSFGRV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G53	QTLGTGSFGRV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G56	GTGSFGRVMLV	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
G56	GTGSFGRVHLV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H143	RFSEPHARFYA	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
H143	RFPNPVAKFYA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H143	RFPEKVAKFYA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H88	LKQIEHTLNEK	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
H88	MKQVEHTNDER	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H88	MKQIEHTCDER	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I247	DQPIQIYEKIV	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
I247	TTPMKTYEKIL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I247	ENPMKLYENIL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I336	YEEEEIRVSI-	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
I336	YPEEQLDYGIQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I336	YADVATDYGTS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I74	HYAMKILDKQK	3	Homo sapiens, Mus musculus, Bos taurus
I74	HFAMKILDKQK	1	Canis lupus familiaris
I74	YYAIKVLKKQQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I74	YYAIKVLEKKK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K169	IYRDLKPENLL	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
K169	IYRDLKPENIL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K169	VYRDLKPENLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K73	NHYAMKILDKQ	3	Homo sapiens, Mus musculus, Bos taurus
K73	NHFAMKILDKQ	1	Canis lupus familiaris
K73	RYYAIKVLKKQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K73	LYYAIKVLEKK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K84	KVVKLKQIEHT	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
K84	QVVKMKQVEHT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K84	KIVDMKQIEHT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L174	KPENLLIDQQG	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
L174	KPENILLDRNG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L174	KPENLLLDRFG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L199	RT-WTLCGTPE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
L199	VT-WTLCGTPD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L199	SNCCTLCGTPD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L206	GTPEYLAPEII	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
L206	GTPDYIAPEVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L206	GTPDYLAPEII	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L41	H----LDQFER	3	Homo sapiens, Bos taurus, Canis lupus familiaris
L41	Q----LDQFDR	1	Mus musculus
L41	KGKYTLHDFQI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L41	KDRYGIQDFNF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L50	ERIKTLGTGSF	3	Homo sapiens, Bos taurus, Canis lupus familiaris
L50	DRIKTLGTGSF	1	Mus musculus
L50	QIMRTLGTGSF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L50	NFLQTLGTGSF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L75	YAMKILDKQKV	3	Homo sapiens, Mus musculus, Bos taurus
L75	FAMKILDKQKV	1	Canis lupus familiaris
L75	YAIKVLKKQQV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L75	YAIKVLEKKKI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L83	QKVVKLKQIEH	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
L83	QQVVKMKQVEH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L83	KKIVDMKQIEH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M121	NLYMVMEYVPG	3	Homo sapiens, Bos taurus, Canis lupus familiaris
M121	NLYMVMEYVAG	1	Mus musculus
M121	NIFMVMDYIEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M121	NLFMVMDFAEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M59	SFGRVMLVKHK	3	Homo sapiens, Mus musculus, Canis lupus familiaris
M59	SFGRVMLVKHM	1	Bos taurus
M59	SFGRVHLVRSV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M59	SFGRVHLVQSN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N172	DLKPENLLIDQ	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
N172	DLKPENILLDR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N172	DLKPENLLLDR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N327	PGDTSNFDDYE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
N327	IGDTSLFDQYP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N327	MGDSSQFDAYA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P125	VMEYVPGGEMF	3	Homo sapiens, Bos taurus, Canis lupus familiaris
P125	VMEYVAGGEMF	1	Mus musculus
P125	VMDYIEGGELF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P125	VMDFAEGGELF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P170	YRDLKPENLLI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
P170	YRDLKPENILL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P170	YRDLKPENLLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P203	TLCGTPEYLAP	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
P203	TLCGTPDYIAP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P203	TLCGTPDYLAP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P237	MAAGYPPFFAD	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
P237	MLAGYTPFYDT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P237	MLAGYPPFYSE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P244	FFADQPIQIYE	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
P244	FYDTTPMKTYE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P244	FYSENPMKLYE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q182	QQGYIQVTDFG	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Q182	RNGHIKITDFG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q182	RFGHLKIVDFG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q85	VVKLKQIEHTL	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Q85	VVKMKQVEHTN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q85	IVDMKQIEHTC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R134	MFSHLRRIGRF	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
R134	LFSLLRKSQRF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R134	LFSLLRKCHRF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R138	LRRIGRFSEPH	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
R138	LRKSQRFPNPV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R138	LRKCHRFPEKV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R257	VSGKVRFPSHF	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
R257	LQGKVVYPPYF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R257	LEGKVNYPSYF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R46	LDQFERIKTLG	3	Homo sapiens, Bos taurus, Canis lupus familiaris
R46	LDQFDRIKTLG	1	Mus musculus
R46	LHDFQIMRTLG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R46	IQDFNFLQTLG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R57	TGSFGRVMLVK	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
R57	TGSFGRVHLVR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R57	TGSFGRVHLVQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S131	GGEMFSHLRRI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
S131	GGELFSLLRKS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S131	GGELFSLLRKC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S140	RIGRFSEPHAR	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
S140	KSQRFPNPVAK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S140	KCHRFPEKVAK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S54	TLGTGSFGRVM	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
S54	TLGTGSFGRVH	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T184	GYIQVTDFGFA	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
T184	GHIKITDFGFA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T184	GHLKIVDFGFA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T198	GRT-WTLCGTP	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
T198	TVT-WTLCGTP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T198	TSNCCTLCGTP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T202	WTLCGTPEYLA	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
T202	WTLCGTPDYIA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T202	CTLCGTPDYLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T52	IKTLGTGSFGR	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
T52	MRTLGTGSFGR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T52	LQTLGTGSFGR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V105	NFPFLVKLEFS	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
V105	EHPFLIRMWGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V105	QHPFITILWGT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V124	MVMEYVPGGEM	3	Homo sapiens, Bos taurus, Canis lupus familiaris
V124	MVMEYVAGGEM	1	Mus musculus
V124	MVMDYIEGGEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V124	MVMDFAEGGEL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V58	GSFGRVMLVKH	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
V58	GSFGRVHLVRS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V58	GSFGRVHLVQS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V61	GRVMLVKHKET	2	Homo sapiens, Canis lupus familiaris
V61	GRVMLVKHKES	1	Mus musculus
V61	GRVMLVKHMET	1	Bos taurus
V61	GRVHLVRSVHN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V61	GRVHLVQSNHN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y123	YMVMEYVPGGE	3	Homo sapiens, Bos taurus, Canis lupus familiaris
Y123	YMVMEYVAGGE	1	Mus musculus
Y123	FMVMDYIEGGE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y123	FMVMDFAEGGE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y205	CGTPEYLAPEI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Y205	CGTPDYIAPEV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y205	CGTPDYLAPEI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y236	EMAAGYPPFFA	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Y236	EMLAGYTPFYD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y236	EMLAGYPPFYS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y248	QPIQIYEKIVS	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Y248	TPMKTYEKILQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y248	NPMKLYENILE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y331	SNFDDYEEEEI	4	Homo sapiens, Mus musculus, Bos taurus, Canis lupus familiaris
Y331	SLFDQYPEEQL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y331	SQFDAYADVAT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)