mutLBSgeneDB |
Gene summary for ENAH |
![]() |
Basic gene Info. | Gene symbol | ENAH |
Gene name | enabled homolog (Drosophila) | |
Synonyms | ENA|MENA|NDPP1 | |
Cytomap | UCSC genome browser: 1q42.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001008493.1, NM_018212.4, | |
Description | mammalian enabled variant 11amammalian enabled variant panprotein enabled homolog | |
Modification date | 20141222 | |
dbXrefs | MIM : 609061 | |
HGNC : HGNC | ||
Ensembl : ENSG00000154380 | ||
HPRD : 12360 | ||
Vega : OTTHUMG00000037742 | ||
Protein | UniProt: Q8N8S7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ENAH | |
BioGPS: 55740 | ||
Pathway | NCI Pathway Interaction Database: ENAH | |
KEGG: ENAH | ||
REACTOME: ENAH | ||
Pathway Commons: ENAH | ||
Context | iHOP: ENAH | |
ligand binding site mutation search in PubMed: ENAH | ||
UCL Cancer Institute: ENAH | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for ENAH |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
![]() |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | V86 | G88D | SKCM | 1 | R81 | R81Q | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for ENAH |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R81 | R81Q | -1.1432904 | V86 | G88D | -1.062737 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for ENAH |
![]() |
![]() |
Top |
Top |
Phenotype information for ENAH |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0017661 | Glomerulonephritis, IGA | 2 | Biomarker, GeneticVariation |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for ENAH |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 3VH | (3AR,5AS,8S,10AS)-1-[(3S,6R,8AS)-1'-[(2S)-2-ACETAMIDO- 3-(2-CHLOROPHENYL)PROPANOYL]-5-OXIDANYLIDENE-SPIRO[1, 2,3,8A-TETRAHYDROINDOLIZINE-6,2'-PYRROLIDINE]-3- YL]CARBONYL-10-OXIDANYLIDENE-2,3,3A,5A,8,10A- HEXAHYDRODIPYRROLO[3,2-B:3',1'-F]AZEPINE-8-CARBOXYL | 4my6 | A | R81 V86 | 3VH | (3AR,5AS,8S,10AS)-1-[(3S,6R,8AS)-1'-[(2S)-2-ACETAMIDO- 3-(2-CHLOROPHENYL)PROPANOYL]-5-OXIDANYLIDENE-SPIRO[1, 2,3,8A-TETRAHYDROINDOLIZINE-6,2'-PYRROLIDINE]-3- YL]CARBONYL-10-OXIDANYLIDENE-2,3,3A,5A,8,10A- HEXAHYDRODIPYRROLO[3,2-B:3',1'-F]AZEPINE-8-CARBOXYL | 4my6 | B | R81 V86 |
Top |
Conservation information for LBS of ENAH |
![]() |
LBS | AA sequence | # species | Species |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |