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mutLBSgeneDB |
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| Gene summary for CNDP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | CNDP2 |
| Gene name | CNDP dipeptidase 2 (metallopeptidase M20 family) | |
| Synonyms | CN2|CPGL|HEL-S-13|HsT2298|PEPA | |
| Cytomap | UCSC genome browser: 18q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001168499.1, NM_018235.2, | |
| Description | cytosolic non-specific dipeptidasecytosolic nonspecific dipeptidaseepididymis secretory protein Li 13glutamate carboxypeptidase-like protein 1peptidase A | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 169800 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000133313 | ||
| HPRD : 09893 | ||
| Vega : OTTHUMG00000132853 | ||
| Protein | UniProt: Q96KP4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CNDP2 | |
| BioGPS: 55748 | ||
| Pathway | NCI Pathway Interaction Database: CNDP2 | |
| KEGG: CNDP2 | ||
| REACTOME: CNDP2 | ||
| Pathway Commons: CNDP2 | ||
| Context | iHOP: CNDP2 | |
| ligand binding site mutation search in PubMed: CNDP2 | ||
| UCL Cancer Institute: CNDP2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CNDP2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H99 | H99R | LUAD | 1 | E414 | T412I | SKCM | 1 | E166 | M165V | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CNDP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H99 | H99R | -0.70573953 | E414 | T412I | -0.61403536 | E166 | M165V | -0.59906462 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CNDP2 from PDB |
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| Differential gene expression and gene-gene network for CNDP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CNDP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0011881 | Diabetic Nephropathies | 4 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CNDP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CNDP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MN | MANGANESE(2+) | 4ruh | A | H99 | MN | MANGANESE(2+) | 4ruh | B | H99 E166 | BES | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID | 4ruh | A | H99 E166 E414 | BES | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID | 4ruh | B | H99 E166 E414 |
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| Conservation information for LBS of CNDP2 |
| Multiple alignments for Q96KP4 in multiple species |
| LBS | AA sequence | # species | Species | D132 | GRGSTDDKGPV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D132 | GRGATDDKGPV | 1 | Bos taurus | D132 | GRGVTDDTGPL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D132 | GRGATDDKGPL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D133 | RGSTDDKGPVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D133 | RGATDDKGPVA | 1 | Bos taurus | D133 | RGVTDDTGPLL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D133 | RGATDDKGPLI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D195 | YVCISDNYWLG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D195 | AVCISDNYWLG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D195 | CVCISDTYWLG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E166 | CLEGMEESGSE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E166 | CFEGMEESGSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E166 | CFEGMEEYGSE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E167 | LEGMEESGSEG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E167 | FEGMEESGSLK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E167 | FEGMEEYGSEG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E414 | PDLTREGGSIP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E414 | PDFTREGGSIP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E414 | PDFVREGGSIP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G416 | LTREGGSIPVT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G416 | FTREGGSIPIT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G416 | FVREGGSIPVT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H228 | SDKDLHSGVYG | 3 | Mus musculus, Rattus norvegicus, Bos taurus | H228 | SNKDLHSGVYG | 1 | Homo sapiens | H228 | PSADLHSGIFG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H228 | PSADLHSGVFG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H380 | KVYMGHGGKPW | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H380 | RTELIHDGAYW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H380 | AFNNMHSGSWW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H445 | ADDGAHSQNEK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H445 | GDDGAHSINEK | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H99 | VCIYGHLDVQP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H99 | VLVYGHYDVQP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H99 | VLIYNHFDVQP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I213 | YGLRGICYFFI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I213 | YGLRGCNYYQT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I213 | YGLRGVCYFNI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I418 | REGGSIPVTLT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I418 | REGGSIPITLT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I418 | REGGSIPVTVT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L210 | CITYGLRGICY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L210 | VLTYGLRGCNY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L210 | VLTYGLRGVCY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N196 | VCISDNYWLGK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N196 | VCISDNYWLGT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N196 | VCISDTYWLGT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P419 | EGGSIPVTLTF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P419 | EGGSIPITLTF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P419 | EGGSIPVTVTF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R343 | GKFSIRLVPNM | 2 | Homo sapiens, Bos taurus | R343 | GKFSIRLVPDM | 2 | Mus musculus, Rattus norvegicus | R343 | GKFSIRTVPDM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R343 | GKFSIRTVPNM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S417 | TREGGSIPVTL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S417 | TREGGSIPITL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S417 | VREGGSIPVTV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T330 | GSGAKTVIPRK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T330 | AQGAKTVIPAK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T330 | GSGAKTVIPAK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V231 | DLHSGVYGGSV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V231 | DLHSGIFGGVV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V231 | DLHSGVFGGTV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y197 | CISDNYWLGKN | 3 | Mus musculus, Rattus norvegicus, Bos taurus | Y197 | CISDNYWLGKK | 1 | Homo sapiens | Y197 | CISDNYWLGTK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y197 | CISDTYWLGTK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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