mutLBSgeneDB |
Gene summary for PRKCA |
Gene summary |
Basic gene Info. | Gene symbol | PRKCA |
Gene name | protein kinase C, alpha | |
Synonyms | AAG6|PKC-alpha|PKCA|PRKACA | |
Cytomap | UCSC genome browser: 17q22-q23.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002737.2, | |
Description | PKC-Aaging-associated gene 6protein kinase C alpha type | |
Modification date | 20141222 | |
dbXrefs | MIM : 176960 | |
HGNC : HGNC | ||
Ensembl : ENSG00000154229 | ||
HPRD : 01498 | ||
Vega : OTTHUMG00000179533 | ||
Protein | UniProt: P17252 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRKCA | |
BioGPS: 5578 | ||
Pathway | NCI Pathway Interaction Database: PRKCA | |
KEGG: PRKCA | ||
REACTOME: PRKCA | ||
Pathway Commons: PRKCA | ||
Context | iHOP: PRKCA | |
ligand binding site mutation search in PubMed: PRKCA | ||
UCL Cancer Institute: PRKCA | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 10770950 | GO:0035408 | histone H3-T6 phosphorylation | 20228790 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 | GO:0090330 | regulation of platelet aggregation | 12724315 |
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Ligand binding site mutations for PRKCA |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D481 | D481E | COAD | 1 | C115 | D116N | COAD | 1 | N468 | N468K | LUSC | 1 | T134,C132 | D133N | LUSC | 1 | D424 | L425F | SKCM | 1 | C115 | D116N | SKCM | 1 | C151 | G152R | SKCM | 1 | C151 | G152R | STAD | 1 | E387 | R389Q | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PRKCA |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C132 | D133N | -1.0602042 | T134 | D133N | -1.0602042 | C115 | D116N | -1.0189324 | D481 | D481E | -0.93492989 | N468 | N468K | -0.87795264 | D424 | L425F | -0.82919993 | C151 | G152R | -0.55964941 | E387 | R389Q | -0.53304676 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PRKCA from PDB |
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Differential gene expression and gene-gene network for PRKCA |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for PRKCA |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0018800 | Cardiomegaly | 2 | Biomarker |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | Biomarker |
umls:C0021841 | Intestinal Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PRKCA |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical | DB00144 | Phosphatidyl serine | Small molecule | |
Approved|nutraceutical|vet_approved | DB00163 | Vitamin E | Small molecule | |
Approved | DB00675 | Tamoxifen | Small molecule | |
Approved | DB05013 | Ingenol Mebutate | Small molecule | |
Investigational | DB08846 | Ellagic Acid | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PRKCA go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | LW4 | 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-YL]-1H-PYRROLE-2,5-DIONE | 3iw4 | B | E387 D424 N468 D481 | LW4 | 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-YL]-1H-PYRROLE-2,5-DIONE | 3iw4 | A | E387 D481 | LW4 | 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-YL]-1H-PYRROLE-2,5-DIONE | 3iw4 | C | E387 N468 D481 |
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Conservation information for LBS of PRKCA |
Multiple alignments for P17252 in multiple species |
LBS | AA sequence | # species | Species | A366 | TEELYAIKILK | 3 | Homo sapiens, Bos taurus, Mus musculus | A366 | TKELFAIKVLK | 1 | Caenorhabditis elegans | A366 | SEELYAIKILK | 1 | Drosophila melanogaster | A480 | GHIKIADFGMC | 3 | Homo sapiens, Bos taurus, Mus musculus | A480 | GHIKITDFGMC | 1 | Caenorhabditis elegans | A480 | GHVKIADFGMC | 1 | Drosophila melanogaster | C115 | GSPTFCDHCGS | 3 | Homo sapiens, Bos taurus, Mus musculus | C115 | SSPTFCDHCGS | 1 | Caenorhabditis elegans | C115 | AGPTFCDHCGS | 1 | Drosophila melanogaster | C118 | TFCDHCGSLLY | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus | C132 | HQGMKCDTCDM | 3 | Homo sapiens, Bos taurus, Mus musculus | C132 | HQGMKCQSCDT | 1 | Caenorhabditis elegans | C132 | HQGLKCSACDM | 1 | Drosophila melanogaster | C135 | MKCDTCDMNVH | 3 | Homo sapiens, Bos taurus, Mus musculus | C135 | MKCQSCDTNVH | 1 | Caenorhabditis elegans | C135 | LKCSACDMNVH | 1 | Drosophila melanogaster | C143 | NVHKQCVINVP | 2 | Homo sapiens, Bos taurus | C143 | NVHHRCVKNVP | 1 | Caenorhabditis elegans | C143 | NVHARCKENVP | 1 | Drosophila melanogaster | C143 | NVHKQCVINDP | 1 | Mus musculus | C151 | NVPSLCGMDHT | 2 | Homo sapiens, Bos taurus | C151 | NVPNMCGTDNT | 1 | Caenorhabditis elegans | C151 | NVPSLCGCDHT | 1 | Drosophila melanogaster | C151 | NDPSLCGMDHT | 1 | Mus musculus | D424 | YVNGGDLMYHI | 3 | Homo sapiens, Bos taurus, Mus musculus | D424 | FVNGGDLMYQI | 1 | Caenorhabditis elegans | D424 | YVNGGDLMFQI | 1 | Drosophila melanogaster | D467 | RDLKLDNVMLD | 2 | Homo sapiens, Bos taurus | D467 | RDLKLDNVMLE | 1 | Caenorhabditis elegans | D467 | RDLKLDNVLLD | 1 | Drosophila melanogaster | D467 | RDLKLNNVMLN | 1 | Mus musculus | D481 | HIKIADFGMCK | 3 | Homo sapiens, Bos taurus, Mus musculus | D481 | HIKITDFGMCK | 1 | Caenorhabditis elegans | D481 | HVKIADFGMCK | 1 | Drosophila melanogaster | E387 | ECTMVEKRVLA | 3 | Homo sapiens, Bos taurus, Mus musculus | E387 | ECTMTEKRVLA | 1 | Caenorhabditis elegans | E387 | ECTMIEKRVLA | 1 | Drosophila melanogaster | E418 | LYFVMEYVNGG | 3 | Homo sapiens, Bos taurus, Mus musculus | E418 | LYFVMEFVNGG | 1 | Caenorhabditis elegans | E418 | LFFVMEYVNGG | 1 | Drosophila melanogaster | F350 | LGKGSFGKVML | 3 | Homo sapiens, Bos taurus, Mus musculus | F350 | LGKGSFGKVLL | 2 | Caenorhabditis elegans, Drosophila melanogaster | G346 | FLMVLGKGSFG | 3 | Homo sapiens, Bos taurus, Mus musculus | G346 | FLTVLGKGSFG | 1 | Caenorhabditis elegans | G346 | FIKVLGKGSFG | 1 | Drosophila melanogaster | H102 | DPRSKHKFKIH | 3 | Homo sapiens, Bos taurus, Mus musculus | H102 | DPRQQHKWKVQ | 1 | Caenorhabditis elegans | H102 | SPKTQHNFEPF | 1 | Drosophila melanogaster | H140 | CDMNVHKQCVI | 3 | Homo sapiens, Bos taurus, Mus musculus | H140 | CDTNVHHRCVK | 1 | Caenorhabditis elegans | H140 | CDMNVHARCKE | 1 | Drosophila melanogaster | K368 | ELYAIKILKKD | 4 | Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus | K368 | ELFAIKVLKKD | 1 | Caenorhabditis elegans | L345 | NFLMVLGKGSF | 3 | Homo sapiens, Bos taurus, Mus musculus | L345 | NFLTVLGKGSF | 1 | Caenorhabditis elegans | L345 | NFIKVLGKGSF | 1 | Drosophila melanogaster | M417 | RLYFVMEYVNG | 3 | Homo sapiens, Bos taurus, Mus musculus | M417 | RLYFVMEFVNG | 1 | Caenorhabditis elegans | M417 | RLFFVMEYVNG | 1 | Drosophila melanogaster | M470 | KLDNVMLDSEG | 2 | Homo sapiens, Bos taurus | M470 | KLDNVMLERDG | 1 | Caenorhabditis elegans | M470 | KLDNVLLDADG | 1 | Drosophila melanogaster | M470 | KLNNVMLNSEG | 1 | Mus musculus | N468 | DLKLDNVMLDS | 2 | Homo sapiens, Bos taurus | N468 | DLKLDNVMLER | 1 | Caenorhabditis elegans | N468 | DLKLDNVLLDA | 1 | Drosophila melanogaster | N468 | DLKLNNVMLNS | 1 | Mus musculus | T134 | GMKCDTCDMNV | 3 | Homo sapiens, Bos taurus, Mus musculus | T134 | GMKCQSCDTNV | 1 | Caenorhabditis elegans | T134 | GLKCSACDMNV | 1 | Drosophila melanogaster | T401 | KPPFLTQLHSC | 3 | Homo sapiens, Bos taurus, Mus musculus | T401 | KPSFLVALHSC | 1 | Caenorhabditis elegans | T401 | KPPFLVQLHSC | 1 | Drosophila melanogaster | V353 | GSFGKVMLADR | 3 | Homo sapiens, Bos taurus, Mus musculus | V353 | GSFGKVLLGEQ | 1 | Caenorhabditis elegans | V353 | GSFGKVLLAER | 1 | Drosophila melanogaster | V420 | FVMEYVNGGDL | 4 | Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus | V420 | FVMEFVNGGDL | 1 | Caenorhabditis elegans | Y419 | YFVMEYVNGGD | 3 | Homo sapiens, Bos taurus, Mus musculus | Y419 | YFVMEFVNGGD | 1 | Caenorhabditis elegans | Y419 | FFVMEYVNGGD | 1 | Drosophila melanogaster |
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