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mutLBSgeneDB |
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| Gene summary for PRKCB |
 Gene summary |
| Basic gene Info. | Gene symbol | PRKCB |
| Gene name | protein kinase C, beta | |
| Synonyms | PKC-beta|PKCB|PRKCB1|PRKCB2 | |
| Cytomap | UCSC genome browser: 16p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002738.6, NM_212535.2, | |
| Description | PKC-Bprotein kinase C beta typeprotein kinase C, beta 1 polypeptide | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 176970 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166501 | ||
| HPRD : 01499 | ||
| Vega : OTTHUMG00000131615 | ||
| Protein | UniProt: P05771 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKCB | |
| BioGPS: 5579 | ||
| Pathway | NCI Pathway Interaction Database: PRKCB | |
| KEGG: PRKCB | ||
| REACTOME: PRKCB | ||
| Pathway Commons: PRKCB | ||
| Context | iHOP: PRKCB | |
| ligand binding site mutation search in PubMed: PRKCB | ||
| UCL Cancer Institute: PRKCB | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
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| Ligand binding site mutations for PRKCB |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L348 | L348P | BLCA | 1 | M420 | V419L | BRCA | 1 | A483 | K481N | HNSC | 1 | T404 | T404I | UCEC | 1 | L348 | V347M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRKCB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T404 | T404I | 0.40209939 | A483 | K481N | -1.2518545 | L348 | L348P | -1.1546027 | M420 | V419L | -1.0603306 | L348 | V347M | -0.90217509 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRKCB from PDB |
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| Differential gene expression and gene-gene network for PRKCB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRKCB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0011860 | Diabetes Mellitus, Type 2 | 4 | Biomarker, GeneticVariation |
| umls:C0004352 | Autistic Disorder | 4 | Biomarker, GeneticVariation |
| umls:C0018800 | Cardiomegaly | 2 | Biomarker |
| umls:C0020456 | Hyperglycemia | 2 | Biomarker |
| umls:C0009404 | Colorectal Neoplasms | 1 | Biomarker |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRKCB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical|vet_approved | DB00163 | Vitamin E | Small molecule |  |
| Experimental | DB01738 | O-Phosphoethanolamine | Small molecule |  |
| Investigational | DB08846 | Ellagic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRKCB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PDS | 3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | 2i0e | A | L348 T404 A483 | PDS | 3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | 2i0e | B | L348 T404 M420 A483 |
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| Conservation information for LBS of PRKCB |
| Multiple alignments for P05771 in multiple species |
| LBS | AA sequence | # species | Species | A369 | TDELYAVKILK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A369 | NKKFYAIKVLK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A369 | ADELFAIKILK | 1 | Danio rerio | A369 | TDELYAIKILK | 1 | Xenopus tropicalis | A483 | GHIKIADFGMC | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | A483 | GHIRIADYGLC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D470 | RDLKLDNVMLD | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | D470 | RDLKLDNILLC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D484 | HIKIADFGMCK | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | D484 | HIRIADYGLCK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E421 | LYFVMEYVNGG | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | E421 | VYFVMEYILGG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E421 | LYFVMEYINGG | 1 | Danio rerio | F353 | LGKGSFGKVML | 5 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus | F353 | LGKGNFGKVML | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F353 | LGKGSFGKVIL | 1 | Xenopus tropicalis | G349 | FLMVLGKGSFG | 5 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus | G349 | FLAVLGKGNFG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G349 | FLKVLGKGSFG | 1 | Xenopus tropicalis | L348 | NFLMVLGKGSF | 5 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus, Bos taurus | L348 | TFLAVLGKGNF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L348 | NFLKVLGKGSF | 1 | Xenopus tropicalis | M420 | RLYFVMEYVNG | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | M420 | RVYFVMEYILG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M420 | RLYFVMEYING | 1 | Danio rerio | M473 | KLDNVMLDSEG | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | M473 | KLDNILLCPDG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M473 | KLDNVMLDAEG | 1 | Danio rerio | N471 | DLKLDNVMLDS | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | N471 | DLKLDNILLCP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N471 | DLKLDNVMLDA | 1 | Danio rerio | T404 | --PFLTQLHSC | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | T404 | KHPFLLNLFAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V356 | GSFGKVMLSER | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V356 | GNFGKVMLAEY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V356 | GSFGKVMLAER | 1 | Danio rerio | V356 | GSFGKVILAER | 1 | Xenopus tropicalis | V423 | FVMEYVNGGDL | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | V423 | FVMEYILGGDL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V423 | FVMEYINGGDL | 1 | Danio rerio | Y422 | YFVMEYVNGGD | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | Y422 | YFVMEYILGGD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y422 | YFVMEYINGGD | 1 | Danio rerio |
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