|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for ADCY10 |
 Gene summary |
| Basic gene Info. | Gene symbol | ADCY10 |
| Gene name | adenylate cyclase 10 (soluble) | |
| Synonyms | HCA2|SAC|SACI|Sacy|hsAC | |
| Cytomap | UCSC genome browser: 1q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001167749.2, NM_001297772.1,NM_018417.5, | |
| Description | 3',5'-cyclic AMP synthetaseAH-related proteinATP pyrophosphate-lyaseadenylate cyclase type 10germ cell soluble adenylyl cyclasetesticular soluble adenylyl cyclase (SAC) | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 605205 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143199 | ||
| HPRD : 05549 | ||
| Vega : OTTHUMG00000034573 | ||
| Protein | UniProt: Q96PN6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADCY10 | |
| BioGPS: 55811 | ||
| Pathway | NCI Pathway Interaction Database: ADCY10 | |
| KEGG: ADCY10 | ||
| REACTOME: ADCY10 | ||
| Pathway Commons: ADCY10 | ||
| Context | iHOP: ADCY10 | |
| ligand binding site mutation search in PubMed: ADCY10 | ||
| UCL Cancer Institute: ADCY10 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for ADCY10 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V172 | V172M | HNSC | 1 | I74 | L75P | LUAD | 1 | S49 | S49A | LUAD | 1 | A97 | A97V | LUSC | 1 | Q283 | Q283H | LUSC | 1 | G408 | G408C | OV | 1 | R250 | L248I | SKCM | 1 | F96 | F96C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for ADCY10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S49 | S49A | -1.3798766 | F96 | F96C | -1.1971279 | I74 | L75P | -1.1186485 | V172 | V172M | -0.9103083 | G408 | G408C | -0.75074619 | R250 | L248I | -0.69963254 | A97 | A97V | -0.23814118 | Q283 | Q283H | -0.18511574 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ADCY10 from PDB |
| Top |
| Differential gene expression and gene-gene network for ADCY10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for ADCY10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for ADCY10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of ADCY10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CMP | 3',5'-CYCLIC AMP | 4clp | A | A97 | CMP | 3',5'-CYCLIC AMP | 4clt | A | A97 | 1VE | (4-AZANYL-1,2,5-OXADIAZOL-3-YL)-[3-(1H-BENZIMIDAZOL-2- YLMETHOXY)PHENYL]METHANONE | 4oya | A | A97 | 1VJ | ETHYL 2-[3-[(4-AZANYL-1,2,5-OXADIAZOL-3-YL) CARBONYL]PHENOXY]ETHANOATE | 4oyb | A | A97 | 1VK | (4-AZANYL-1,2,5-OXADIAZOL-3-YL)-PHENYL-METHANONE | 4oyi | A | A97 | 1ZC | (4-AZANYL-1,2,5-OXADIAZOL-3-YL)-(3-METHOXYPHENYL) METHANONE | 4oym | A | A97 | 1WC | 4-(2-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE | 4oyo | A | A97 | BZ2 | COUMARILIC ACID | 4oyp | A | A97 | 1Z6 | 4-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE | 4oz2 | A | A97 | 1Z8 | 4-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE | 4oz3 | A | A97 V172 | 4DS | 4,4'-DIISOTHIOCYANO-2,2'-STILBENEDISULFONIC ACID | 4clz | A | F96 A97 | 1WC | 4-(2-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE | 4oyo | A | G408 | 4DS | 4,4'-DIISOTHIOCYANO-2,2'-STILBENEDISULFONIC ACID | 4clz | A | I74 | 4DS | 4,4'-DIISOTHIOCYANO-2,2'-STILBENEDISULFONIC ACID | 4clz | A | R250 Q283 | POP | DIPHOSPHATE(2-) | 4cls | A | S49 | POP | DIPHOSPHATE(2-) | 4clt | A | S49 | POP | DIPHOSPHATE(2-) | 4clu | A | S49 | POP | DIPHOSPHATE(2-) | 4ust | A | S49 | POP | DIPHOSPHATE(2-) | 4usv | A | S49 | APC | ALPHA,BETA-METHYLENE ATP | 4clk | A | S49 A97 | APC | ALPHA,BETA-METHYLENE ATP | 4clw | A | S49 A97 | APC | ALPHA,BETA-METHYLENE ATP | 4cm0 | A | S49 A97 | APC | ALPHA,BETA-METHYLENE ATP | 4oyx | A | S49 A97 | APC | ALPHA,BETA-METHYLENE ATP | 4usu | A | S49 A97 | ATP | ATP | 4usw | A | S49 A97 | BCT | HYDROGENCARBONATE | 4cll | A | V172 | 1WC | 4-(2-CHLOROPHENYL)-5-METHYL-1H-PYRAZOLE | 4oyo | A | V172 | BCT | HYDROGENCARBONATE | 4oyz | A | V172 |
| Top |
| Conservation information for LBS of ADCY10 |
| Multiple alignments for Q96PN6 in multiple species |
| LBS | AA sequence | # species | Species | A100 | KFAGDALLALW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A18 | IVKIAAHLPDL | 2 | Mus musculus, Rattus norvegicus | A18 | IVRIAAHLPDL | 1 | Homo sapiens | A252 | NFLRLACMLES | 2 | Mus musculus, Rattus norvegicus | A252 | NLLRLACTLKP | 1 | Homo sapiens | A415 | KVNIAARMMMY | 2 | Mus musculus, Rattus norvegicus | A415 | KVNLAARMMMY | 1 | Homo sapiens | A97 | DILKFAGDALL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C253 | FLRLACMLESD | 2 | Mus musculus, Rattus norvegicus | C253 | LLRLACTLKPD | 1 | Homo sapiens | D10 | RQELQDRAIVK | 2 | Mus musculus, Rattus norvegicus | D10 | KEEFQDWPIVR | 1 | Homo sapiens | D339 | KVFMFDKGCSF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D47 | VLMFVDISGFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D99 | LKFAGDALLAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E203 | DRSMIEIERIP | 2 | Mus musculus, Rattus norvegicus | E203 | DRSMIEIESVP | 1 | Homo sapiens | E205 | SMIEIERIPDQ | 2 | Mus musculus, Rattus norvegicus | E205 | SMIEIESVPDQ | 1 | Homo sapiens | F296 | PVTIVFVNLMF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F336 | QINKVFMFDKG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F338 | NKVFMFDKGCS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F45 | DGVLMFVDISG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F51 | VDISGFTAMTE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F58 | AMTEKFSTAMY | 2 | Mus musculus, Rattus norvegicus | F58 | AMTEKFSSAMY | 1 | Homo sapiens | F8 | ARRQELQDRAI | 2 | Mus musculus, Rattus norvegicus | F8 | TPKEEFQDWPI | 1 | Homo sapiens | F96 | GDILKFAGDAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G408 | EYTVIGQKVNI | 2 | Mus musculus, Rattus norvegicus | G408 | EYTVIGQKVNL | 1 | Homo sapiens | G452 | KKVMKGVADPG | 2 | Mus musculus, Rattus norvegicus | G452 | KKVMKGVADSG | 1 | Homo sapiens | G50 | FVDISGFTAMT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G98 | ILKFAGDALLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H78 | EILNYYISAIV | 2 | Mus musculus, Rattus norvegicus | H78 | EILNYHISAIV | 1 | Homo sapiens | I202 | CDRSMIEIERI | 2 | Mus musculus, Rattus norvegicus | I202 | CDRSMIEIESV | 1 | Homo sapiens | I204 | RSMIEIERIPD | 2 | Mus musculus, Rattus norvegicus | I204 | RSMIEIESVPD | 1 | Homo sapiens | I277 | IILKQIDDKQL | 2 | Mus musculus, Rattus norvegicus | I277 | SILKQIDNKQL | 1 | Homo sapiens | I407 | HEYTVIGQKVN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I48 | LMFVDISGFTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I74 | EQLVEILNYYI | 2 | Mus musculus, Rattus norvegicus | I74 | EQLVEILNYHI | 1 | Homo sapiens | K144 | LDIRVKIGLAA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K340 | VFMFDKGCSFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K57 | TAMTEKFSTAM | 2 | Mus musculus, Rattus norvegicus | K57 | TAMTEKFSSAM | 1 | Homo sapiens | K95 | GGDILKFAGDA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L101 | FAGDALLALWK | 2 | Mus musculus, Rattus norvegicus | L101 | FAGDALLALWR | 1 | Homo sapiens | L102 | AGDALLALWKV | 2 | Mus musculus, Rattus norvegicus | L102 | AGDALLALWRV | 1 | Homo sapiens | L166 | TRNYFLVIGQA | 2 | Mus musculus, Rattus norvegicus | L166 | THSHFLVIGQA | 1 | Homo sapiens | L345 | KGCSFLCVFGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L94 | FGGDILKFAGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M337 | INKVFMFDKGC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M418 | IAARMMMYYPG | 2 | Mus musculus, Rattus norvegicus | M418 | LAARMMMYYPG | 1 | Homo sapiens | M419 | AARMMMYYPGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M54 | SGFTAMTEKFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M62 | KFSTAMYMDRG | 2 | Mus musculus, Rattus norvegicus | M62 | KFSSAMYMDRG | 1 | Homo sapiens | N279 | LKQIDDKQLRG | 2 | Mus musculus, Rattus norvegicus | N279 | LKQIDNKQLQG | 1 | Homo sapiens | N412 | IGQKVNIAARM | 2 | Mus musculus, Rattus norvegicus | N412 | IGQKVNLAARM | 1 | Homo sapiens | Q179 | DVRLAQNMAQM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q276 | EIILKQIDDKQ | 2 | Mus musculus, Rattus norvegicus | Q276 | ESILKQIDNKQ | 1 | Homo sapiens | Q281 | QIDDKQLRGYL | 2 | Mus musculus, Rattus norvegicus | Q281 | QIDNKQLQGYL | 1 | Homo sapiens | Q283 | DDKQLRGYLSE | 2 | Mus musculus, Rattus norvegicus | Q283 | DNKQLQGYLSE | 1 | Homo sapiens | R15 | DRAIVKIAAHL | 2 | Mus musculus, Rattus norvegicus | R15 | DWPIVRIAAHL | 1 | Homo sapiens | R176 | AVDDVRLAQNM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R199 | WQLCDRSMIEI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R250 | HKNFLRLACML | 2 | Mus musculus, Rattus norvegicus | R250 | HKNLLRLACTL | 1 | Homo sapiens | R416 | VNIAARMMMYY | 2 | Mus musculus, Rattus norvegicus | R416 | VNLAARMMMYY | 1 | Homo sapiens | S206 | MIEIERIPDQR | 2 | Mus musculus, Rattus norvegicus | S206 | MIEIESVPDQR | 1 | Homo sapiens | S343 | FDKGCSFLCVF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S49 | MFVDISGFTAM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T399 | GIVGHTVRHEY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T405 | VRHEYTVIGQK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T52 | DISGFTAMTEK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V14 | QDRAIVKIAAH | 2 | Mus musculus, Rattus norvegicus | V14 | QDWPIVRIAAH | 1 | Homo sapiens | V167 | RNYFLVIGQAV | 2 | Mus musculus, Rattus norvegicus | V167 | HSHFLVIGQAV | 1 | Homo sapiens | V172 | VIGQAVDDVRL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V335 | GQINKVFMFDK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V400 | IVGHTVRHEYT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V406 | RHEYTVIGQKV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V411 | VIGQKVNIAAR | 2 | Mus musculus, Rattus norvegicus | V411 | VIGQKVNLAAR | 1 | Homo sapiens | W194 | LSPNCWQLCDR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y420 | ARMMMYYPGIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y63 | FSTAMYMDRGA | 2 | Mus musculus, Rattus norvegicus | Y63 | FSSAMYMDRGA | 1 | Homo sapiens |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |