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mutLBSgeneDB |
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| Gene summary for PRKCG |
 Gene summary |
| Basic gene Info. | Gene symbol | PRKCG |
| Gene name | protein kinase C, gamma | |
| Synonyms | PKC-gamma|PKCC|PKCG|SCA14 | |
| Cytomap | UCSC genome browser: 19q13.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002739.3, | |
| Description | protein kinase C gamma type | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 176980 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126583 | ||
| HPRD : 01502 | ||
| Vega : OTTHUMG00000064846 | ||
| Protein | UniProt: P05129 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKCG | |
| BioGPS: 5582 | ||
| Pathway | NCI Pathway Interaction Database: PRKCG | |
| KEGG: PRKCG | ||
| REACTOME: PRKCG | ||
| Pathway Commons: PRKCG | ||
| Context | iHOP: PRKCG | |
| ligand binding site mutation search in PubMed: PRKCG | ||
| UCL Cancer Institute: PRKCG | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0016310 | phosphorylation | 15808853 | GO:0031397 | negative regulation of protein ubiquitination | 15808853 | GO:0032425 | positive regulation of mismatch repair | 15808853 | GO:0042177 | negative regulation of protein catabolic process | 15808853 |
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| Ligand binding site mutations for PRKCG |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C77 | E79K | COAD | 2 | R252 | R252H | COAD | 1 | D193 | D193N | COAD | 1 | D193 | P194S | HNSC | 1 | H36 | S35N | LUSC | 1 | D254 | D254N | OV | 1 | D193 | D193N | OV | 1 | D187 | P188L | SKCM | 1 | D193 | D193N | SKCM | 1 | C77 | R76Q | SKCM | 1 | C52 | H51Y | UCEC | 1 | C77 | E79K | UCEC | 1 | D254 | D254N | UCEC | 1 | M186 | M186T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRKCG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D193 | P194S | -1.8727477 | M186 | M186T | -1.5637781 | C77 | R76Q | -1.2067396 | H36 | S35N | -0.94523268 | R252 | R252H | -0.94117538 | D193 | D193N | -0.80173652 | D254 | D254N | -0.72830517 | C77 | E79K | -0.72232518 | D187 | P188L | -0.65433613 | C52 | H51Y | -0.35503636 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRKCG from PDB |
| PDB ID | PDB title | PDB structure | 2E73 | Solution structure of the phorbol esters/diacylglycerol binding domain of protein kinase C gamma |  |
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| Differential gene expression and gene-gene network for PRKCG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRKCG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0087012 | Spinocerebellar Ataxias | 27 | Biomarker, GeneticVariation |
| umls:C1854369 | Spinocerebellar ataxia 14 | 4 | Biomarker, GeneticVariation |
| umls:C0020429 | Hyperalgesia | 1 | Biomarker |
| umls:C3714756 | Intellectual Disability | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRKCG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRKCG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2e73 | A | C52 C77 | CA | CALCIUM(2+) | 2uzp | A | D187 D193 | CA | CALCIUM(2+) | 2uzp | B | D187 D193 | CA | CALCIUM(2+) | 2uzp | C | D187 D193 | ZN | ZINC(2+) | 2e73 | A | H36 | CA | CALCIUM(2+) | 2uzp | A | M186 D187 D254 | CA | CALCIUM(2+) | 2uzp | B | M186 D187 D254 | CA | CALCIUM(2+) | 2uzp | C | M186 D187 D254 | CA | CALCIUM(2+) | 2uzp | A | R252 D254 | CA | CALCIUM(2+) | 2uzp | B | R252 D254 | CA | CALCIUM(2+) | 2uzp | C | R252 D254 |
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| Conservation information for LBS of PRKCG |
| Multiple alignments for P05129 in multiple species |
| LBS | AA sequence | # species | Species | A291 | YNVPVADADNC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C49 | KQPTFCSHCTD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C52 | TFCSHCTDFIW | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C66 | KQGLQCQVCSF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C69 | LQCQVCSFVVH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C77 | VVHRRCHEFVT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C85 | FVTFECPGAGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D187 | NLIPMDPNGLS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D193 | PNGLSDPYVKL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D246 | SVEVWDWDRTS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D248 | EVWDWDRTSRN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D254 | RTSRNDFMGAM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H154 | LCGVDHTERRG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H36 | HEVKSHKFTAR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H74 | CSFVVHRRCHE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M186 | RNLIPMDPNGL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R252 | WDRTSRNDFMG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S251 | DWDRTSRNDFM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T155 | CGVDHTERRGR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W247 | VEVWDWDRTSR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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