mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRKCH
Gene summary
Basic gene Info.Gene symbolPRKCH
Gene nameprotein kinase C, eta
SynonymsPKC-L|PKCL|PRKCL|nPKC-eta
CytomapUCSC genome browser: 14q23.1
Type of geneprotein-coding
RefGenesNM_006255.4,
Descriptionprotein kinase C eta type
Modification date20141207
dbXrefs MIM : 605437
HGNC : HGNC
Ensembl : ENSG00000027075
HPRD : 05669
Vega : OTTHUMG00000152341
ProteinUniProt: P24723
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRKCH
BioGPS: 5583
PathwayNCI Pathway Interaction Database: PRKCH
KEGG: PRKCH
REACTOME: PRKCH
Pathway Commons: PRKCH
ContextiHOP: PRKCH
ligand binding site mutation search in PubMed: PRKCH
UCL Cancer Institute: PRKCH
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for PRKCH

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D497F498VSTAD1
V436,E434F435SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for PRKCH
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E434F435S-1.6797186
V436F435S-1.6797186
D497F498V-0.52568087
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRKCH from PDB

Top
Differential gene expression and gene-gene network for PRKCH
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRKCH and the right PPI network was created from samples without mutations in the LBS of PRKCH. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for PRKCH
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007785Cerebral Infarction3Biomarker, GeneticVariation
umls:C0028754Obesity1Biomarker
umls:C0236969Substance-Related Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for PRKCH
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRKCH go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
07U2-METHYL-N~1~-[3-(PYRIDIN-4-YL)-2,6-NAPHTHYRIDIN-1-YL]PROPANE-1,2-DIAMINE3txoAE434 V436 D497


Top
Conservation information for LBS of PRKCH
Multiple alignments for P24723 in multiple species
LBSAA sequence# speciesSpecies
A382TGELYAVKVLK2Mus musculus, Rattus norvegicus
A382TGDLYAVKVLK1Homo sapiens
D440FVNGGDLMFHI3Homo sapiens, Mus musculus, Rattus norvegicus
D483RDLKLDNVLLD3Homo sapiens, Mus musculus, Rattus norvegicus
D497HCKLADFGMCK3Homo sapiens, Mus musculus, Rattus norvegicus
E434LFFVMEFVNGG3Homo sapiens, Mus musculus, Rattus norvegicus
F366LGKGSFGKVML3Homo sapiens, Mus musculus, Rattus norvegicus
F644EDVSNFDPDFI3Homo sapiens, Mus musculus, Rattus norvegicus
K384ELYAVKVLKKD2Mus musculus, Rattus norvegicus
K384DLYAVKVLKKD1Homo sapiens
L486KLDNVLLDHEG3Homo sapiens, Mus musculus, Rattus norvegicus
V369GSFGKVMLARI2Mus musculus, Rattus norvegicus
V369GSFGKVMLARV1Homo sapiens
V436FVMEFVNGGDL3Homo sapiens, Mus musculus, Rattus norvegicus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas