mutLBSgeneDB |
Gene summary for PRKCH |
![]() |
Basic gene Info. | Gene symbol | PRKCH |
Gene name | protein kinase C, eta | |
Synonyms | PKC-L|PKCL|PRKCL|nPKC-eta | |
Cytomap | UCSC genome browser: 14q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_006255.4, | |
Description | protein kinase C eta type | |
Modification date | 20141207 | |
dbXrefs | MIM : 605437 | |
HGNC : HGNC | ||
Ensembl : ENSG00000027075 | ||
HPRD : 05669 | ||
Vega : OTTHUMG00000152341 | ||
Protein | UniProt: P24723 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRKCH | |
BioGPS: 5583 | ||
Pathway | NCI Pathway Interaction Database: PRKCH | |
KEGG: PRKCH | ||
REACTOME: PRKCH | ||
Pathway Commons: PRKCH | ||
Context | iHOP: PRKCH | |
ligand binding site mutation search in PubMed: PRKCH | ||
UCL Cancer Institute: PRKCH | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
![]() |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for PRKCH |
![]() |
LBS | AAchange of nsSNV | Cancer type | # samples | D497 | F498V | STAD | 1 | V436,E434 | F435S | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for PRKCH |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
![]() ![]() |
![]() |
![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E434 | F435S | -1.6797186 | V436 | F435S | -1.6797186 | D497 | F498V | -0.52568087 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
![]() |
Top |
Differential gene expression and gene-gene network for PRKCH |
![]() |
![]() |
Top |
Top |
Phenotype information for PRKCH |
![]() |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007785 | Cerebral Infarction | 3 | Biomarker, GeneticVariation |
umls:C0028754 | Obesity | 1 | Biomarker |
umls:C0236969 | Substance-Related Disorders | 1 | Biomarker |
![]() |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for PRKCH |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
![]() |
![]() |
![]() |
![]() |
Drug status | DrugBank ID | Name | Type | Drug structure |
![]() |
![]() |
![]() |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 07U | 2-METHYL-N~1~-[3-(PYRIDIN-4-YL)-2,6-NAPHTHYRIDIN-1-YL]PROPANE-1,2-DIAMINE | 3txo | A | E434 V436 D497 |
Top |
Conservation information for LBS of PRKCH |
![]() |
LBS | AA sequence | # species | Species | A382 | TGELYAVKVLK | 2 | Mus musculus, Rattus norvegicus | A382 | TGDLYAVKVLK | 1 | Homo sapiens | D440 | FVNGGDLMFHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D483 | RDLKLDNVLLD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D497 | HCKLADFGMCK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E434 | LFFVMEFVNGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F366 | LGKGSFGKVML | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F644 | EDVSNFDPDFI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K384 | ELYAVKVLKKD | 2 | Mus musculus, Rattus norvegicus | K384 | DLYAVKVLKKD | 1 | Homo sapiens | L486 | KLDNVLLDHEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V369 | GSFGKVMLARI | 2 | Mus musculus, Rattus norvegicus | V369 | GSFGKVMLARV | 1 | Homo sapiens | V436 | FVMEFVNGGDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
![]() |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |