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mutLBSgeneDB |
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| Gene summary for PRKCI |
 Gene summary |
| Basic gene Info. | Gene symbol | PRKCI |
| Gene name | protein kinase C, iota | |
| Synonyms | DXS1179E|PKCI|nPKC-iota | |
| Cytomap | UCSC genome browser: 3q26.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002740.5, | |
| Description | PRKC-lambda/iotaaPKC-lambda/iotaatypical protein kinase C-lambda/iotaprotein kinase C iota type | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600539 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163558 | ||
| HPRD : 02105 | ||
| Vega : OTTHUMG00000150214 | ||
| Protein | UniProt: P41743 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKCI | |
| BioGPS: 5584 | ||
| Pathway | NCI Pathway Interaction Database: PRKCI | |
| KEGG: PRKCI | ||
| REACTOME: PRKCI | ||
| Pathway Commons: PRKCI | ||
| Context | iHOP: PRKCI | |
| ligand binding site mutation search in PubMed: PRKCI | ||
| UCL Cancer Institute: PRKCI | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 8226978 | GO:0043524 | negative regulation of neuron apoptotic process | 10467349 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10467349 |
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| Ligand binding site mutations for PRKCI |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D382 | N383I | HNSC | 1 | D396 | D396E | LUAD | 1 | V268,A266 | K267N | LUSC | 1 | K283,A281 | M282I | LUSC | 1 | V335 | N336K | OV | 1 | V316 | L315F | SKCM | 1 | G338 | G338R | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRKCI |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D382 | N383I | 0.013932155 | V316 | L315F | -1.4615595 | K283 | M282I | -1.2142967 | A281 | M282I | -1.2142967 | D396 | D396E | -0.85774611 | V335 | N336K | -0.76232065 | G338 | G338R | -0.56530658 | A266 | K267N | -0.49626736 | V268 | K267N | -0.49626736 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRKCI from PDB |
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| Differential gene expression and gene-gene network for PRKCI |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRKCI |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRKCI |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB03777 | Rbt205 Inhibitor | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRKCI go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PRKCI |
| Multiple alignments for P41743 in multiple species |
| LBS | AA sequence | # species | Species | A266 | GRGSYAKVLLV | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | A266 | GRGSYAKVVQA | 1 | Caenorhabditis elegans | A266 | GRGSYAKVLMV | 1 | Drosophila melanogaster | A281 | TDRIYAMKVVK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A281 | TRQIYAIKIIK | 1 | Caenorhabditis elegans | A281 | TRRIYAMKVIK | 1 | Drosophila melanogaster | A281 | TERIYAMKVVK | 1 | Danio rerio | D339 | YVNGGDLMFHM | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | D339 | FVPGGDLMFHM | 1 | Caenorhabditis elegans | D339 | FVRGGDLMYHM | 1 | Drosophila melanogaster | D382 | RDLKLDNVLLD | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | D382 | RDLKLDNVLID | 1 | Caenorhabditis elegans | D396 | HIKLTDYGMCK | 6 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | E333 | LFFVIEYVNGG | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | E333 | LFFVIEFVPGG | 1 | Caenorhabditis elegans | E333 | LFFVIEFVRGG | 1 | Drosophila melanogaster | F552 | FGLDNFDSQFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F552 | RDLTHFDHQFT | 1 | Caenorhabditis elegans | F552 | RDLANFPPEFT | 1 | Drosophila melanogaster | F552 | FGLDNFDAQFT | 1 | Danio rerio | G261 | LLRVIGRGSYA | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | G261 | LLTVIGRGSYA | 1 | Caenorhabditis elegans | G261 | LIRVIGRGSYA | 1 | Drosophila melanogaster | G263 | RVIGRGSYAKV | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | G263 | TVIGRGSYAKV | 1 | Caenorhabditis elegans | G338 | EYVNGGDLMFH | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | G338 | EFVPGGDLMFH | 1 | Caenorhabditis elegans | G338 | EFVRGGDLMYH | 1 | Drosophila melanogaster | I260 | DLLRVIGRGSY | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | I260 | RLLTVIGRGSY | 1 | Caenorhabditis elegans | I260 | ELIRVIGRGSY | 1 | Drosophila melanogaster | I332 | RLFFVIEYVNG | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | I332 | RLFFVIEFVPG | 1 | Caenorhabditis elegans | I332 | RLFFVIEFVRG | 1 | Drosophila melanogaster | K283 | RIYAMKVVKKE | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | K283 | QIYAIKIIKKE | 1 | Caenorhabditis elegans | K283 | RIYAMKVIKKA | 1 | Drosophila melanogaster | L385 | KLDNVLLDSEG | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | L385 | KLDNVLIDAEG | 1 | Caenorhabditis elegans | L385 | KLDNVLLDHEG | 1 | Drosophila melanogaster | R262 | LRVIGRGSYAK | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | R262 | LTVIGRGSYAK | 1 | Caenorhabditis elegans | R262 | IRVIGRGSYAK | 1 | Drosophila melanogaster | S264 | VIGRGSYAKVL | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | S264 | VIGRGSYAKVV | 1 | Caenorhabditis elegans | T395 | GHIKLTDYGMC | 6 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | V268 | GSYAKVLLVRL | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | V268 | GSYAKVVQAEH | 1 | Caenorhabditis elegans | V268 | GSYAKVLMVEL | 1 | Drosophila melanogaster | V316 | NHPFLVGLHSC | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | V316 | NYPFLVGLHSC | 1 | Caenorhabditis elegans | V335 | FVIEYVNGGDL | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | V335 | FVIEFVPGGDL | 1 | Caenorhabditis elegans | V335 | FVIEFVRGGDL | 1 | Drosophila melanogaster | Y265 | IGRGSYAKVLL | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | Y265 | IGRGSYAKVVQ | 1 | Caenorhabditis elegans | Y265 | IGRGSYAKVLM | 1 | Drosophila melanogaster | Y334 | FFVIEYVNGGD | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | Y334 | FFVIEFVPGGD | 1 | Caenorhabditis elegans | Y334 | FFVIEFVRGGD | 1 | Drosophila melanogaster |
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