mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRKCI
Gene summary
Basic gene Info.Gene symbolPRKCI
Gene nameprotein kinase C, iota
SynonymsDXS1179E|PKCI|nPKC-iota
CytomapUCSC genome browser: 3q26.3
Type of geneprotein-coding
RefGenesNM_002740.5,
DescriptionPRKC-lambda/iotaaPKC-lambda/iotaatypical protein kinase C-lambda/iotaprotein kinase C iota type
Modification date20141222
dbXrefs MIM : 600539
HGNC : HGNC
Ensembl : ENSG00000163558
HPRD : 02105
Vega : OTTHUMG00000150214
ProteinUniProt: P41743
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRKCI
BioGPS: 5584
PathwayNCI Pathway Interaction Database: PRKCI
KEGG: PRKCI
REACTOME: PRKCI
Pathway Commons: PRKCI
ContextiHOP: PRKCI
ligand binding site mutation search in PubMed: PRKCI
UCL Cancer Institute: PRKCI
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation8226978
GO:0043524negative regulation of neuron apoptotic process10467349
GO:0051092positive regulation of NF-kappaB transcription factor activity10467349


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Ligand binding site mutations for PRKCI

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D382N383IHNSC1
D396D396ELUAD1
V268,A266K267NLUSC1
K283,A281M282ILUSC1
V335N336KOV1
V316L315FSKCM1
G338G338RSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PRKCI
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D382N383I0.013932155
V316L315F-1.4615595
K283M282I-1.2142967
A281M282I-1.2142967
D396D396E-0.85774611
V335N336K-0.76232065
G338G338R-0.56530658
A266K267N-0.49626736
V268K267N-0.49626736
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRKCI from PDB

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Differential gene expression and gene-gene network for PRKCI
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRKCI and the right PPI network was created from samples without mutations in the LBS of PRKCI. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PRKCI
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PRKCI
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB03777Rbt205 InhibitorSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRKCI go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PRKCI
Multiple alignments for P41743 in multiple species
LBSAA sequence# speciesSpecies
A266GRGSYAKVLLV4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
A266GRGSYAKVVQA1Caenorhabditis elegans
A266GRGSYAKVLMV1Drosophila melanogaster
A281TDRIYAMKVVK3Homo sapiens, Mus musculus, Rattus norvegicus
A281TRQIYAIKIIK1Caenorhabditis elegans
A281TRRIYAMKVIK1Drosophila melanogaster
A281TERIYAMKVVK1Danio rerio
D339YVNGGDLMFHM4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
D339FVPGGDLMFHM1Caenorhabditis elegans
D339FVRGGDLMYHM1Drosophila melanogaster
D382RDLKLDNVLLD5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
D382RDLKLDNVLID1Caenorhabditis elegans
D396HIKLTDYGMCK6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
E333LFFVIEYVNGG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
E333LFFVIEFVPGG1Caenorhabditis elegans
E333LFFVIEFVRGG1Drosophila melanogaster
F552FGLDNFDSQFT3Homo sapiens, Mus musculus, Rattus norvegicus
F552RDLTHFDHQFT1Caenorhabditis elegans
F552RDLANFPPEFT1Drosophila melanogaster
F552FGLDNFDAQFT1Danio rerio
G261LLRVIGRGSYA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G261LLTVIGRGSYA1Caenorhabditis elegans
G261LIRVIGRGSYA1Drosophila melanogaster
G263RVIGRGSYAKV5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
G263TVIGRGSYAKV1Caenorhabditis elegans
G338EYVNGGDLMFH4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G338EFVPGGDLMFH1Caenorhabditis elegans
G338EFVRGGDLMYH1Drosophila melanogaster
I260DLLRVIGRGSY4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
I260RLLTVIGRGSY1Caenorhabditis elegans
I260ELIRVIGRGSY1Drosophila melanogaster
I332RLFFVIEYVNG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
I332RLFFVIEFVPG1Caenorhabditis elegans
I332RLFFVIEFVRG1Drosophila melanogaster
K283RIYAMKVVKKE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
K283QIYAIKIIKKE1Caenorhabditis elegans
K283RIYAMKVIKKA1Drosophila melanogaster
L385KLDNVLLDSEG4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L385KLDNVLIDAEG1Caenorhabditis elegans
L385KLDNVLLDHEG1Drosophila melanogaster
R262LRVIGRGSYAK4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
R262LTVIGRGSYAK1Caenorhabditis elegans
R262IRVIGRGSYAK1Drosophila melanogaster
S264VIGRGSYAKVL5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
S264VIGRGSYAKVV1Caenorhabditis elegans
T395GHIKLTDYGMC6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
V268GSYAKVLLVRL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
V268GSYAKVVQAEH1Caenorhabditis elegans
V268GSYAKVLMVEL1Drosophila melanogaster
V316NHPFLVGLHSC5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
V316NYPFLVGLHSC1Caenorhabditis elegans
V335FVIEYVNGGDL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
V335FVIEFVPGGDL1Caenorhabditis elegans
V335FVIEFVRGGDL1Drosophila melanogaster
Y265IGRGSYAKVLL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Y265IGRGSYAKVVQ1Caenorhabditis elegans
Y265IGRGSYAKVLM1Drosophila melanogaster
Y334FFVIEYVNGGD4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Y334FFVIEFVPGGD1Caenorhabditis elegans
Y334FFVIEFVRGGD1Drosophila melanogaster


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