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mutLBSgeneDB |
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| Gene summary for PKN1 |
 Gene summary |
| Basic gene Info. | Gene symbol | PKN1 |
| Gene name | protein kinase N1 | |
| Synonyms | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 | |
| Cytomap | UCSC genome browser: 19p13.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002741.3, NM_213560.1, | |
| Description | protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaprotein-kinase C-related kinase 1serine-threonine kinase Nserine-threonine protein kinase Nserine/threonine protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601032 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123143 | ||
| HPRD : 03019 | ||
| Vega : OTTHUMG00000039611 | ||
| Protein | UniProt: Q16512 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PKN1 | |
| BioGPS: 5585 | ||
| Pathway | NCI Pathway Interaction Database: PKN1 | |
| KEGG: PKN1 | ||
| REACTOME: PKN1 | ||
| Pathway Commons: PKN1 | ||
| Context | iHOP: PKN1 | |
| ligand binding site mutation search in PubMed: PKN1 | ||
| UCL Cancer Institute: PKN1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12514133 | GO:0006468 | protein phosphorylation | 17332740 | GO:0035407 | histone H3-T11 phosphorylation | 18066052 |
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| Ligand binding site mutations for PKN1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M695 | F693L | LUSC | 1 | K644 | L646V | LUSC | 1 | M695 | F693S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PKN1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K644 | L646V | -1.6713779 | M695 | F693S | -1.0742936 | M695 | F693L | -0.51136249 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PKN1 from PDB |
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| Differential gene expression and gene-gene network for PKN1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PKN1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PKN1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PKN1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PKN1 |
| Multiple alignments for Q16512 in multiple species |
| LBS | AA sequence | # species | Species | A642 | SGELFAIKALK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A757 | GYVKIADFGLC | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D702 | YSAGGDLMLHI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D744 | RDLKLDNLLLD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | D758 | YVKIADFGLCK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E696 | VCFVMEYSAGG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F626 | LGRGHFGKVLL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F904 | TDVSNFDEEFT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G622 | FLAVLGRGHFG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G624 | AVLGRGHFGKV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G627 | GRGHFGKVLLS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G701 | EYSAGGDLMLH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K628 | RGHFGKVLLSE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K644 | ELFAIKALKKG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L621 | KFLAVLGRGHF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L747 | KLDNLLLDTEG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M695 | HVCFVMEYSAG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N745 | DLKLDNLLLDT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R623 | LAVLGRGHFGK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S698 | FVMEYSAGGDL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V629 | GHFGKVLLSEF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V679 | GHPFLVNLFGC | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | Y697 | CFVMEYSAGGD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus |
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