mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ACOT13
Gene summary
Basic gene Info.Gene symbolACOT13
Gene nameacyl-CoA thioesterase 13
SynonymsPNAS-27|THEM2
CytomapUCSC genome browser: 6p22.3
Type of geneprotein-coding
RefGenesNM_001160094.1,
NM_018473.3,
Descriptionacyl-coenzyme A thioesterase 13hypothalamus protein HT012thioesterase superfamily member 2
Modification date20141207
dbXrefs MIM : 615652
HGNC : HGNC
Ensembl : ENSG00000112304
HPRD : 07158
Vega : OTTHUMG00000014359
ProteinUniProt: Q9NPJ3
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACOT13
BioGPS: 55856
PathwayNCI Pathway Interaction Database: ACOT13
KEGG: ACOT13
REACTOME: ACOT13
Pathway Commons: ACOT13
ContextiHOP: ACOT13
ligand binding site mutation search in PubMed: ACOT13
UCL Cancer Institute: ACOT13
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0008152metabolic process16934754


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Ligand binding site mutations for ACOT13

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F115F115SCOAD1
G26I28NCOAD1
M15M15VHNSC1
K95L96IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ACOT13
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F115F115S-1.291514
M15M15V-0.99535645
G26I28N-0.89167147
K95L96I-0.44133464
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ACOT13 from PDB

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Differential gene expression and gene-gene network for ACOT13
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ACOT13 and the right PPI network was created from samples without mutations in the LBS of ACOT13. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ACOT13
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ACOT13
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB08688undecan-2-oneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ACOT13 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
COACOENZYME A3f5oAF115
COACOENZYME A3f5oBF115
COACOENZYME A3f5oCF115
COACOENZYME A3f5oDF115
COACOENZYME A3f5oEF115
COACOENZYME A3f5oFF115
COACOENZYME A3f5oGF115
COACOENZYME A3f5oHF115
COACOENZYME A3f5oDK95
COACOENZYME A3f5oEK95
COACOENZYME A3f5oHK95
UOCUNDECAN-2-ONE3f5oAM15
UOCUNDECAN-2-ONE3f5oHM15


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Conservation information for LBS of ACOT13
Multiple alignments for Q9NPJ3 in multiple species
LBSAA sequence# speciesSpecies
A51EEHTNAIGTLH1Homo sapiens
A51EQHTNKLGTLH1Mus musculus
A51HQHLNSKGTLH1Caenorhabditis elegans
F115GKTLAFTSVDL1Homo sapiens
F115GKTLAFASVDL1Mus musculus
F115GRTMAFTDCEF1Caenorhabditis elegans
G110HVLKQGKTLAF1Homo sapiens
G110HILKQGKTLAF1Mus musculus
G110HVLKVGRTMAF1Caenorhabditis elegans
G26FERVLGKITLV1Homo sapiens
G26FDRVLEKVTLV1Mus musculus
G26FNRVAEDVYPV1Caenorhabditis elegans
G81ERGAPGVSVDM2Homo sapiens, Mus musculus
G81VKDKGMASVEL1Caenorhabditis elegans
H137RHT-KHLGN--2Homo sapiens, Mus musculus
H137KHTLAFLPNQP1Caenorhabditis elegans
I52EHTNAIGTLHG1Homo sapiens
I52QHTNKLGTLHG1Mus musculus
I52QHLNSKGTLHG1Caenorhabditis elegans
K108TAHVLKQGKTL1Homo sapiens
K108TAHILKQGKTL1Mus musculus
K108TAHVLKVGRTM1Caenorhabditis elegans
K111VLKQGKTLAFT1Homo sapiens
K111ILKQGKTLAFA1Mus musculus
K111VLKVGRTMAFT1Caenorhabditis elegans
K136GRHT-KHLGN-2Homo sapiens, Mus musculus
K136GKHTLAFLPNQ1Caenorhabditis elegans
K95YMSPAKLGEDI1Homo sapiens
K95YMSPAKIGEEI1Mus musculus
K95YLLPVKVGDVL1Caenorhabditis elegans
L113KQGKTLAFTSV1Homo sapiens
L113KQGKTLAFASV1Mus musculus
L113KVGRTMAFTDC1Caenorhabditis elegans
L55NAIGTLHGGLT1Homo sapiens
L55NKLGTLHGGLT1Mus musculus
L55NSKGTLHGGQT1Caenorhabditis elegans
L73STMALLCTERG1Homo sapiens
L73STMALMCTERG1Mus musculus
L73TARAVGVTVKD1Caenorhabditis elegans
M15EVIKAMTKARN1Homo sapiens
M15EVMKVMFKVPG1Mus musculus
M15EQVRVFNKMKG1Caenorhabditis elegans
M70DNISTMALLCT1Homo sapiens
M70DSISTMALMCT1Mus musculus
M70DVITARAVGVT1Caenorhabditis elegans
M91MNITYMSPAKL1Homo sapiens
M91MNITYMSPAKI1Mus musculus
M91LAVSYLLPVKV1Caenorhabditis elegans
N50EEEHTNAIGTL1Homo sapiens
N50EEQHTNKLGTL1Mus musculus
N50QHQHLNSKGTL1Caenorhabditis elegans
N66ATLVDNISTMA1Homo sapiens
N66ATLVDSISTMA1Mus musculus
N66ATLTDVITARA1Caenorhabditis elegans
P80TERGAPGVSVD2Homo sapiens, Mus musculus
P80TVKDKGMASVE1Caenorhabditis elegans
P93ITYMSPAKLGE1Homo sapiens
P93ITYMSPAKIGE1Mus musculus
P93VSYLLPVKVGD1Caenorhabditis elegans
S83GAPGVSVDMNI2Homo sapiens, Mus musculus
S83DKGMASVELAV1Caenorhabditis elegans
S92NITYMSPAKLG1Homo sapiens
S92NITYMSPAKIG1Mus musculus
S92AVSYLLPVKVG1Caenorhabditis elegans
T112LKQGKTLAFTS1Homo sapiens
T112LKQGKTLAFAS1Mus musculus
T112LKVGRTMAFTD1Caenorhabditis elegans
T69VDNISTMALLC1Homo sapiens
T69VDSISTMALMC1Mus musculus
T69TDVITARAVGV1Caenorhabditis elegans
V82RGAPGVSVDMN2Homo sapiens, Mus musculus
V82KDKGMASVELA1Caenorhabditis elegans
Y90DMNITYMSPAK2Homo sapiens, Mus musculus
Y90ELAVSYLLPVK1Caenorhabditis elegans


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