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mutLBSgeneDB |
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| Gene summary for ACOT13 |
 Gene summary |
| Basic gene Info. | Gene symbol | ACOT13 |
| Gene name | acyl-CoA thioesterase 13 | |
| Synonyms | PNAS-27|THEM2 | |
| Cytomap | UCSC genome browser: 6p22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001160094.1, NM_018473.3, | |
| Description | acyl-coenzyme A thioesterase 13hypothalamus protein HT012thioesterase superfamily member 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615652 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000112304 | ||
| HPRD : 07158 | ||
| Vega : OTTHUMG00000014359 | ||
| Protein | UniProt: Q9NPJ3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACOT13 | |
| BioGPS: 55856 | ||
| Pathway | NCI Pathway Interaction Database: ACOT13 | |
| KEGG: ACOT13 | ||
| REACTOME: ACOT13 | ||
| Pathway Commons: ACOT13 | ||
| Context | iHOP: ACOT13 | |
| ligand binding site mutation search in PubMed: ACOT13 | ||
| UCL Cancer Institute: ACOT13 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0008152 | metabolic process | 16934754 |
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| Ligand binding site mutations for ACOT13 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F115 | F115S | COAD | 1 | G26 | I28N | COAD | 1 | M15 | M15V | HNSC | 1 | K95 | L96I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ACOT13 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F115 | F115S | -1.291514 | M15 | M15V | -0.99535645 | G26 | I28N | -0.89167147 | K95 | L96I | -0.44133464 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ACOT13 from PDB |
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| Differential gene expression and gene-gene network for ACOT13 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ACOT13 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ACOT13 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB08688 | undecan-2-one | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ACOT13 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | COA | COENZYME A | 3f5o | A | F115 | COA | COENZYME A | 3f5o | B | F115 | COA | COENZYME A | 3f5o | C | F115 | COA | COENZYME A | 3f5o | D | F115 | COA | COENZYME A | 3f5o | E | F115 | COA | COENZYME A | 3f5o | F | F115 | COA | COENZYME A | 3f5o | G | F115 | COA | COENZYME A | 3f5o | H | F115 | COA | COENZYME A | 3f5o | D | K95 | COA | COENZYME A | 3f5o | E | K95 | COA | COENZYME A | 3f5o | H | K95 | UOC | UNDECAN-2-ONE | 3f5o | A | M15 | UOC | UNDECAN-2-ONE | 3f5o | H | M15 |
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| Conservation information for LBS of ACOT13 |
| Multiple alignments for Q9NPJ3 in multiple species |
| LBS | AA sequence | # species | Species | A51 | EEHTNAIGTLH | 1 | Homo sapiens | A51 | EQHTNKLGTLH | 1 | Mus musculus | A51 | HQHLNSKGTLH | 1 | Caenorhabditis elegans | F115 | GKTLAFTSVDL | 1 | Homo sapiens | F115 | GKTLAFASVDL | 1 | Mus musculus | F115 | GRTMAFTDCEF | 1 | Caenorhabditis elegans | G110 | HVLKQGKTLAF | 1 | Homo sapiens | G110 | HILKQGKTLAF | 1 | Mus musculus | G110 | HVLKVGRTMAF | 1 | Caenorhabditis elegans | G26 | FERVLGKITLV | 1 | Homo sapiens | G26 | FDRVLEKVTLV | 1 | Mus musculus | G26 | FNRVAEDVYPV | 1 | Caenorhabditis elegans | G81 | ERGAPGVSVDM | 2 | Homo sapiens, Mus musculus | G81 | VKDKGMASVEL | 1 | Caenorhabditis elegans | H137 | RHT-KHLGN-- | 2 | Homo sapiens, Mus musculus | H137 | KHTLAFLPNQP | 1 | Caenorhabditis elegans | I52 | EHTNAIGTLHG | 1 | Homo sapiens | I52 | QHTNKLGTLHG | 1 | Mus musculus | I52 | QHLNSKGTLHG | 1 | Caenorhabditis elegans | K108 | TAHVLKQGKTL | 1 | Homo sapiens | K108 | TAHILKQGKTL | 1 | Mus musculus | K108 | TAHVLKVGRTM | 1 | Caenorhabditis elegans | K111 | VLKQGKTLAFT | 1 | Homo sapiens | K111 | ILKQGKTLAFA | 1 | Mus musculus | K111 | VLKVGRTMAFT | 1 | Caenorhabditis elegans | K136 | GRHT-KHLGN- | 2 | Homo sapiens, Mus musculus | K136 | GKHTLAFLPNQ | 1 | Caenorhabditis elegans | K95 | YMSPAKLGEDI | 1 | Homo sapiens | K95 | YMSPAKIGEEI | 1 | Mus musculus | K95 | YLLPVKVGDVL | 1 | Caenorhabditis elegans | L113 | KQGKTLAFTSV | 1 | Homo sapiens | L113 | KQGKTLAFASV | 1 | Mus musculus | L113 | KVGRTMAFTDC | 1 | Caenorhabditis elegans | L55 | NAIGTLHGGLT | 1 | Homo sapiens | L55 | NKLGTLHGGLT | 1 | Mus musculus | L55 | NSKGTLHGGQT | 1 | Caenorhabditis elegans | L73 | STMALLCTERG | 1 | Homo sapiens | L73 | STMALMCTERG | 1 | Mus musculus | L73 | TARAVGVTVKD | 1 | Caenorhabditis elegans | M15 | EVIKAMTKARN | 1 | Homo sapiens | M15 | EVMKVMFKVPG | 1 | Mus musculus | M15 | EQVRVFNKMKG | 1 | Caenorhabditis elegans | M70 | DNISTMALLCT | 1 | Homo sapiens | M70 | DSISTMALMCT | 1 | Mus musculus | M70 | DVITARAVGVT | 1 | Caenorhabditis elegans | M91 | MNITYMSPAKL | 1 | Homo sapiens | M91 | MNITYMSPAKI | 1 | Mus musculus | M91 | LAVSYLLPVKV | 1 | Caenorhabditis elegans | N50 | EEEHTNAIGTL | 1 | Homo sapiens | N50 | EEQHTNKLGTL | 1 | Mus musculus | N50 | QHQHLNSKGTL | 1 | Caenorhabditis elegans | N66 | ATLVDNISTMA | 1 | Homo sapiens | N66 | ATLVDSISTMA | 1 | Mus musculus | N66 | ATLTDVITARA | 1 | Caenorhabditis elegans | P80 | TERGAPGVSVD | 2 | Homo sapiens, Mus musculus | P80 | TVKDKGMASVE | 1 | Caenorhabditis elegans | P93 | ITYMSPAKLGE | 1 | Homo sapiens | P93 | ITYMSPAKIGE | 1 | Mus musculus | P93 | VSYLLPVKVGD | 1 | Caenorhabditis elegans | S83 | GAPGVSVDMNI | 2 | Homo sapiens, Mus musculus | S83 | DKGMASVELAV | 1 | Caenorhabditis elegans | S92 | NITYMSPAKLG | 1 | Homo sapiens | S92 | NITYMSPAKIG | 1 | Mus musculus | S92 | AVSYLLPVKVG | 1 | Caenorhabditis elegans | T112 | LKQGKTLAFTS | 1 | Homo sapiens | T112 | LKQGKTLAFAS | 1 | Mus musculus | T112 | LKVGRTMAFTD | 1 | Caenorhabditis elegans | T69 | VDNISTMALLC | 1 | Homo sapiens | T69 | VDSISTMALMC | 1 | Mus musculus | T69 | TDVITARAVGV | 1 | Caenorhabditis elegans | V82 | RGAPGVSVDMN | 2 | Homo sapiens, Mus musculus | V82 | KDKGMASVELA | 1 | Caenorhabditis elegans | Y90 | DMNITYMSPAK | 2 | Homo sapiens, Mus musculus | Y90 | ELAVSYLLPVK | 1 | Caenorhabditis elegans |
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