mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for HDAC8

Gene summary

Basic gene Info.	Gene symbol	HDAC8
	Gene name	histone deacetylase 8
	Synonyms	CDLS5\|HD8\|HDACL1\|MRXS6\|RPD3\|WTS
	Cytomap	UCSC genome browser: Xq13
	Type of gene	protein-coding
	RefGenes	NM_001166418.1, NM_001166419.1,NM_001166420.1,NM_001166422.1,NM_001166448.1, NM_018486.2,NR_051952.1,
	Description	histone deacetylase-like 1
	Modification date	20141219
dbXrefs	MIM : 300269
	HGNC : HGNC
	Ensembl : ENSG00000147099
	HPRD : 02227
	Vega : OTTHUMG00000021814
Protein	UniProt: Q9BY41 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HDAC8
	BioGPS: 55869
Pathway	NCI Pathway Interaction Database: HDAC8
	KEGG: HDAC8
	REACTOME: HDAC8
	Pathway Commons: HDAC8
Context	iHOP: HDAC8
	ligand binding site mutation search in PubMed: HDAC8
	UCL Cancer Institute: HDAC8
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for HDAC8

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
L155	L155V	BRCA	1
A309	T311M	BRCA	1
H143,K145	A144G	PRAD	1
H143	H143Y	SKCM	1
T197	T197A	STAD	1
A309	T311M	STAD	1
G222	R223W	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for HDAC8

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
A309	T311M	0.069045278
G222	R223W	-1.1086082
H143	A144G	-0.99551215
K145	A144G	-0.99551215
L155	L155V	-0.76796174
T197	T197A	-0.73578167
H143	H143Y	-0.13668487

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HDAC8 from PDB

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Differential gene expression and gene-gene network for HDAC8

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of HDAC8 and the right PPI network was created from samples without mutations in the LBS of HDAC8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for HDAC8

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C3550903	CORNELIA DE LANGE SYNDROME 5	1	GeneticVariation

Mutation level pathogenic information (ClinVar annotation)

Allele ID	AA change	Clinical significance	Origin	Phenotype IDs
48311	T311M	Pathogenic	Germline	GeneReviews:NBK1104 MedGen:C3550903 OMIM:300882 Orphanet:ORPHA199

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Pharmacological information for HDAC8

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|investigational	DB02546	Vorinostat	Small molecule
Experimental	DB02565	4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide	Small molecule
Experimental	DB02917	N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide	Small molecule
Experimental	DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide	Small molecule
Approved\|investigational	DB06603	Panobinostat	Small molecule
Experimental	DB07350	(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide	Small molecule
Experimental	DB07586	5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE	Small molecule
Experimental	DB08168	7-AMINO-4-METHYL-CHROMEN-2-ONE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HDAC8 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS)	3ewf	A	A309
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS)	3ewf	B	A309
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS)	3ewf	C	A309
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS)	3ewf	D	A309
TSN		TRICHOSTATIN A	1t64	A	H143
TSN		TRICHOSTATIN A	1t64	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	1t67	A	H143
SHH		VORINOSTAT	1t69	A	H143
CRI		5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLICACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE	1vkg	A	H143
CRI		5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLICACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE	1vkg	B	H143
NHB		N-HYDROXY-4-[METHYL-(5-PYRIDIN-2-YLTHIOPHEN-2-YL)SULFONYLAMINO]BENZAMIDE	1w22	A	H143
NHB		N-HYDROXY-4-[METHYL-(5-PYRIDIN-2-YLTHIOPHEN-2-YL)SULFONYLAMINO]BENZAMIDE	1w22	B	H143
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS,MCM)	2v5w	B	H143
V5X		(2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE	2v5x	A	H143
V5X		(2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE	2v5x	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3ew8	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3ezp	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3ezp	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3ezt	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3ezt	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3f06	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3f06	B	H143
AGE		APHA COMPOUND 8	3f07	A	H143
AGE		APHA COMPOUND 8	3f07	B	H143
TSN		TRICHOSTATIN A	3f0r	A	H143
TSN		TRICHOSTATIN A	3f0r	B	H143
TSN		TRICHOSTATIN A	3f0r	C	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz3	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz3	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz4	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz4	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz6	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	3mz7	A	H143
III		Peptide ligand (02G,GLY,CYS,CYS,VAL)	3rqd	A	H143
III		Peptide ligand (02G,GLY,CYS,CYS,VAL)	3rqd	B	H143
0DI		(2R)-2-AMINO-3-(3-CHLOROPHENYL)-1-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PROPAN-1-ONE	3sff	A	H143
1DI		(2R)-2-AMINO-3-(2,4-DICHLOROPHENYL)-1-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPAN-1-ONE	3sfh	A	H143
SHH		VORINOSTAT	4qa0	A	H143
SHH		VORINOSTAT	4qa0	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	4qa1	A	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	4qa1	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	4qa1	C	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	4qa1	D	H143
SHH		VORINOSTAT	4qa2	A	H143
SHH		VORINOSTAT	4qa2	B	H143
TSN		TRICHOSTATIN A	4qa3	A	H143
TSN		TRICHOSTATIN A	4qa3	B	H143
B3N		4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE	4qa4	A	H143
III		Peptide ligand (ACE,ARG,HIS,LYS,LYS)	4qa5	B	H143
L6G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3,17-DITHIA-7,10,14,19,20- PENTAAZATRICYCLO[14.2.1.1~2,5~]ICOSA-1(18),2(20), 16(19)-TRIENE-6,9,13-TRIONE	4rn0	A	H143
L6G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3,17-DITHIA-7,10,14,19,20- PENTAAZATRICYCLO[14.2.1.1~2,5~]ICOSA-1(18),2(20), 16(19)-TRIENE-6,9,13-TRIONE	4rn0	B	H143
L8G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3-THIA-7,10,14,20,21- PENTAAZATRICYCLO[14.3.1.1~2,5~]HENICOSA-1(20),2(21), 16,18-TETRAENE-6,9,13-TRIONE	4rn1	A	H143
L8G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3-THIA-7,10,14,20,21- PENTAAZATRICYCLO[14.3.1.1~2,5~]HENICOSA-1(20),2(21), 16,18-TETRAENE-6,9,13-TRIONE	4rn1	B	H143
L7G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3-THIA-7,10,14,17,21- PENTAAZATRICYCLO[14.3.1.1~2,5~]HENICOSA-1(20),2(21), 16,18-TETRAENE-6,9,13-TRIONE	4rn2	A	H143
L7G		(5R,8S,11S)-5-METHYL-8-(PROPAN-2-YL)-11-[(1E)-4- SULFANYLBUT-1-EN-1-YL]-3-THIA-7,10,14,17,21- PENTAAZATRICYCLO[14.3.1.1~2,5~]HENICOSA-1(20),2(21), 16,18-TETRAENE-6,9,13-TRIONE	4rn2	B	H143
TSN		TRICHOSTATIN A	5d1b	A	H143
TSN		TRICHOSTATIN A	5d1b	B	H143
III		Peptide ligand (ACE,ARG,HIS,ALY,ALY,MCM)	5d1c	B	H143
III		Peptide ligand (ACE,ARG,HIS,ALY,ALY,MCM)	5d1d	A	H143
III		Peptide ligand (GLY,GLY,GLY)	2v5w	B	K145
ACT		ACETATE	3sfh	A	L155
K		POTASSIUM(1+)	1w22	A	T197 G222
K		POTASSIUM(1+)	1w22	B	T197 G222

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Conservation information for LBS of HDAC8

Multiple alignments for Q9BY41 in multiple species

LBS	AA sequence	# species	Species
A309	GGYNLANTARC	5	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A309	GGYHLPNTARC	1	Xenopus tropicalis
A68	SMEEMATFHTD	3	Homo sapiens, Mus musculus, Rattus norvegicus
A68	SIEEMAVFHTD	1	Danio rerio
A68	SMEEMAAFHTD	1	Xenopus tropicalis
A68	SMEEMASFHTD	1	Bos taurus
C153	EASGFCYLNDA	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
C153	EASGSCYVNDA	1	Danio rerio
C275	AGDPMCSFNMT	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D101	YGLGYDCPATE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D101	FGLGYDCPVVE	1	Danio rerio
D101	YGLGYDCPITE	1	Xenopus tropicalis
D147	HHAKKDEASGF	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D147	HHAKKDEASGS	1	Danio rerio
D176	RILYVDLDLHH	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D176	RVLYVDVDLHH	1	Danio rerio
D176	RVLYVDMDLHH	1	Xenopus tropicalis
D178	LYVDLDLHHGD	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D178	LYVDVDLHHGD	1	Danio rerio
D178	LYVDMDLHHGD	1	Xenopus tropicalis
D267	LQLGADTIAGD	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D267	MQLGADTMAGD	1	Danio rerio
D272	DTIAGDPMCSF	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
D272	DTMAGDPMCSF	1	Danio rerio
D87	VSQEGDEDHPD	2	Mus musculus, Rattus norvegicus
D87	VSQEGDDDHPD	1	Homo sapiens
D87	ISQDGDNDDPQ	1	Danio rerio
D87	VSEEGDNDDPE	1	Xenopus tropicalis
D87	VSEDGDDDHPD	1	Bos taurus
D92	DDDHPDSIEYG	2	Homo sapiens, Bos taurus
D92	DEDHPDSIEYG	2	Mus musculus, Rattus norvegicus
D92	DNDDPQSADFG	1	Danio rerio
D92	DNDDPETLEYG	1	Xenopus tropicalis
E148	HAKKDEASGFC	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
E148	HAKKDEASGSC	1	Danio rerio
E95	HPDSIEYGLGY	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E95	DPQSADFGLGY	1	Danio rerio
E95	DPETLEYGLGY	1	Xenopus tropicalis
F152	DEASGFCYLND	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F152	DEASGSCYVND	1	Danio rerio
F189	GVEDAFSFTSK	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F191	EDAFSFTSKVM	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F207	KFSPGFFPGTG	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F208	FSPGFFPGTGD	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
F277	DPMCSFNMTPV	5	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
F277	DPMCSFNMTPQ	1	Xenopus tropicalis
G140	INWSGGWHHAK	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G140	INWAGGWHHAK	1	Danio rerio
G140	INWPGGWHHAK	1	Xenopus tropicalis
G151	KDEASGFCYLN	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G151	KDEASGSCYVN	1	Danio rerio
G182	LDLHHGDGVED	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G182	VDLHHGDGVED	1	Danio rerio
G182	MDLHHGDGVED	1	Xenopus tropicalis
G206	HKFSPGFFPGT	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
G210	PGFFPGTGDVS	3	Homo sapiens, Xenopus tropicalis, Bos taurus
G210	PGFFPGTGDMS	2	Mus musculus, Rattus norvegicus
G210	PGFFPGTGDVT	1	Danio rerio
G220	SDVGLGKGRYY	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G220	TDTGLGKGRWY	1	Danio rerio
G220	SDIGLGKGRYY	1	Xenopus tropicalis
G222	VGLGKGRYYSV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G222	TGLGKGRWYAV	1	Danio rerio
G222	IGLGKGRYYSV	1	Xenopus tropicalis
G303	TLILGGGGYNL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G303	TLLLGGGGYNL	1	Danio rerio
G303	TLILGGGGYHL	1	Xenopus tropicalis
G304	LILGGGGYNLA	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G304	LLLGGGGYNLA	1	Danio rerio
G304	LILGGGGYHLP	1	Xenopus tropicalis
G341	FFTAYGPDYVL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G341	FFTEYGPDYSL	1	Danio rerio
G341	FFTEYGPDYVL	1	Xenopus tropicalis
G97	DSIEYGLGYDC	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G97	QSADFGLGYDC	1	Danio rerio
G97	ETLEYGLGYDC	1	Xenopus tropicalis
H142	WSGGWHHAKKD	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H142	WAGGWHHAKKD	1	Danio rerio
H142	WPGGWHHAKKD	1	Xenopus tropicalis
H143	SGGWHHAKKDE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H143	AGGWHHAKKDE	1	Danio rerio
H143	PGGWHHAKKDE	1	Xenopus tropicalis
H180	VDLDLHHGDGV	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H180	VDVDLHHGDGV	1	Danio rerio
H180	VDMDLHHGDGV	1	Xenopus tropicalis
H181	DLDLHHGDGVE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H181	DVDLHHGDGVE	1	Danio rerio
H181	DMDLHHGDGVE	1	Xenopus tropicalis
H201	MTVSLHKFSPG	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
H71	EMATFHTDAYL	3	Homo sapiens, Mus musculus, Rattus norvegicus
H71	EMAVFHTDSYL	1	Danio rerio
H71	EMAAFHTDSYL	1	Xenopus tropicalis
H71	EMASFHTDAYL	1	Bos taurus
H78	DAYLQHLQKVS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H78	DSYLQHLHKIS	1	Danio rerio
H78	DSYLQHLHKVS	1	Xenopus tropicalis
H90	EGDEDHPDSIE	2	Mus musculus, Rattus norvegicus
H90	EGDDDHPDSIE	1	Homo sapiens
H90	DGDNDDPQSAD	1	Danio rerio
H90	EGDNDDPETLE	1	Xenopus tropicalis
H90	DGDDDHPDSIE	1	Bos taurus
I269	LGADTIAGDPM	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
I269	LGADTMAGDPM	1	Danio rerio
I34	SL-VKVPKRAS	2	Mus musculus, Rattus norvegicus
I34	SL-AKIPKRAS	1	Homo sapiens
I34	SL-SKVPNRAS	1	Danio rerio
I34	NVQSKVPRRAS	1	Xenopus tropicalis
I34	SL-AKVPKRAS	1	Bos taurus
I94	DHPDSIEYGLG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I94	DDPQSADFGLG	1	Danio rerio
I94	DDPETLEYGLG	1	Xenopus tropicalis
K145	GWHHAKKDEAS	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
K221	DVGLGKGRYYS	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K221	DTGLGKGRWYA	1	Danio rerio
K221	DIGLGKGRYYS	1	Xenopus tropicalis
K33	DSL-VKVPKRA	2	Mus musculus, Rattus norvegicus
K33	DSL-AKIPKRA	1	Homo sapiens
K33	DSL-SKVPNRA	1	Danio rerio
K33	DNVQSKVPRRA	1	Xenopus tropicalis
K33	DSL-AKVPKRA	1	Bos taurus
L155	SGFCYLNDAVL	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
L155	SGSCYVNDAVL	1	Danio rerio
L177	ILYVDLDLHHG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L177	VLYVDVDLHHG	1	Danio rerio
L177	VLYVDMDLHHG	1	Xenopus tropicalis
L179	YVDLDLHHGDG	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L179	YVDVDLHHGDG	1	Danio rerio
L179	YVDMDLHHGDG	1	Xenopus tropicalis
L200	VMTVSLHKFSP	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
L308	GGGYNLANTAR	5	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L308	GGGYHLPNTAR	1	Xenopus tropicalis
M196	FTSKVMTVSLH	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
M274	IAGDPMCSFNM	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
M274	MAGDPMCSFNM	1	Danio rerio
N307	GGGGYNLANTA	5	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
N307	GGGGYHLPNTA	1	Xenopus tropicalis
P209	SPGFFPGTGDV	4	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus
P209	SPGFFPGTGDM	2	Mus musculus, Rattus norvegicus
P273	TIAGDPMCSFN	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
P273	TMAGDPMCSFN	1	Danio rerio
P342	FTAYGPDYVLE	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P342	FTEYGPDYSLE	1	Danio rerio
P342	FTEYGPDYVLE	1	Xenopus tropicalis
P35	L-VKVPKRASM	2	Mus musculus, Rattus norvegicus
P35	L-AKIPKRASM	1	Homo sapiens
P35	L-SKVPNRASM	1	Danio rerio
P35	VQSKVPRRASM	1	Xenopus tropicalis
P35	L-AKVPKRASM	1	Bos taurus
R37	VKVPKRASMVH	2	Mus musculus, Rattus norvegicus
R37	AKIPKRASMVH	1	Homo sapiens
R37	SKVPNRASMVH	1	Danio rerio
R37	SKVPRRASMVH	1	Xenopus tropicalis
R37	AKVPKRASMVH	1	Bos taurus
S190	VEDAFSFTSKV	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
S199	KVMTVSLHKFS	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
S226	KGRYYSVNVPI	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S226	KGRWYAVNVPF	1	Danio rerio
S226	KGRYYSVNVPL	1	Xenopus tropicalis
S276	GDPMCSFNMTP	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
T192	DAFSFTSKVMT	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
T197	TSKVMTVSLHK	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
V195	SFTSKVMTVSL	6	Homo sapiens, Danio rerio, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
W141	NWSGGWHHAKK	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W141	NWAGGWHHAKK	1	Danio rerio
W141	NWPGGWHHAKK	1	Xenopus tropicalis
Y100	EYGLGYDCPAT	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y100	DFGLGYDCPVV	1	Danio rerio
Y100	EYGLGYDCPIT	1	Xenopus tropicalis
Y111	EGIFDYAAAIG	3	Homo sapiens, Mus musculus, Rattus norvegicus
Y111	EGIFDYAAAVG	2	Danio rerio, Bos taurus
Y111	EGIYDYAAAVG	1	Xenopus tropicalis
Y154	ASGFCYLNDAV	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
Y154	ASGSCYVNDAV	1	Danio rerio
Y225	GKGRYYSVNVP	5	Homo sapiens, Xenopus tropicalis, Bos taurus, Mus musculus, Rattus norvegicus
Y225	GKGRWYAVNVP	1	Danio rerio
Y306	LGGGGYNLANT	5	Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Y306	LGGGGYHLPNT	1	Xenopus tropicalis