mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PRKG1
Gene summary
Basic gene Info.Gene symbolPRKG1
Gene nameprotein kinase, cGMP-dependent, type I
Synonyms1|AAT8|PKG|PRKG1B|PRKGR1B|cGK|cGK 1|cGK1|cGKI|cGKI-BETA|cGKI-alpha
CytomapUCSC genome browser: 10q11.2
Type of geneprotein-coding
RefGenesNM_001098512.2,
NM_006258.3,
DescriptioncGMP-dependent protein kinase 1protein kinase, cGMP-dependent, regulatory, type I, beta
Modification date20141207
dbXrefs MIM : 176894
HGNC : HGNC
Ensembl : ENSG00000185532
HPRD : 08910
Vega : OTTHUMG00000018248
ProteinUniProt: Q13976
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRKG1
BioGPS: 5592
PathwayNCI Pathway Interaction Database: PRKG1
KEGG: PRKG1
REACTOME: PRKG1
Pathway Commons: PRKG1
ContextiHOP: PRKG1
ligand binding site mutation search in PubMed: PRKG1
UCL Cancer Institute: PRKG1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PRKG1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V268V268ICOAD1
E214E214DCOAD1
V181K182NCOAD1
T283T283ACOAD1
T283L284SCOAD1
E211E211GLUAD1
M160M160ILUSC1
V181K182ELUSC1
T283T283SUCEC1
R282R282KUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PRKG1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V181K182E0.22535367
E211E211G-1.4045429
T283L284S-1.3876361
T283T283S-1.0248499
T283T283A-0.98039613
R282R282K-0.60847503
E214E214D-0.4894866
V268V268I-0.41939983
M160M160I-0.34557045
V181K182N-0.25878413
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PRKG1 from PDB

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Differential gene expression and gene-gene network for PRKG1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PRKG1 and the right PPI network was created from samples without mutations in the LBS of PRKG1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PRKG1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3809513AORTIC ANEURYSM, FAMILIAL THORACIC 81GeneticVariation
umls:C0236733Amphetamine-Related Disorders1Biomarker
umls:C0020542Hypertension, Pulmonary1Biomarker
umls:C0032927Precancerous Conditions1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PRKG1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PRKG1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PRKG1
Multiple alignments for Q13976 in multiple species
LBSAA sequence# speciesSpecies
A170VFGELAILYNC3Homo sapiens, Mus musculus, Bos taurus
A179NCTRTATVKTL3Homo sapiens, Mus musculus, Bos taurus
A294WFGEKALQGED3Homo sapiens, Mus musculus, Bos taurus
A303EDVRTANVIAA3Homo sapiens, Mus musculus, Bos taurus
A335DVSNKAYEDAE3Homo sapiens, Mus musculus, Bos taurus
C158EGVKLCTMGPG3Homo sapiens, Mus musculus, Bos taurus
E168GKVFGELAILY3Homo sapiens, Mus musculus, Bos taurus
E211LIKHTEYMEFL3Homo sapiens, Mus musculus, Bos taurus
E214HTEYMEFLKSV3Homo sapiens, Mus musculus, Bos taurus
E292GDWFGEKALQG3Homo sapiens, Mus musculus, Bos taurus
F166GPGKVFGELAI3Homo sapiens, Mus musculus, Bos taurus
F215TEYMEFLKSVP3Homo sapiens, Mus musculus, Bos taurus
F290GKGDWFGEKAL3Homo sapiens, Mus musculus, Bos taurus
G167PGKVFGELAIL3Homo sapiens, Mus musculus, Bos taurus
G291KGDWFGEKALQ3Homo sapiens, Mus musculus, Bos taurus
I249NGEYIIRQGAR3Homo sapiens, Mus musculus, Bos taurus
K293DWFGEKALQGE3Homo sapiens, Mus musculus, Bos taurus
L157KEGVKLCTMGP3Homo sapiens, Mus musculus, Bos taurus
L169KVFGELAILYN3Homo sapiens, Mus musculus, Bos taurus
L172GELAILYNCTR3Homo sapiens, Mus musculus, Bos taurus
L281EDPVFLRTLGK3Homo sapiens, Mus musculus, Bos taurus
M160VKLCTMGPGKV3Homo sapiens, Mus musculus, Bos taurus
N174LAILYNCTRTA3Homo sapiens, Mus musculus, Bos taurus
R177LYNCTRTATVK3Homo sapiens, Mus musculus, Bos taurus
R282DPVFLRTLGKG3Homo sapiens, Mus musculus, Bos taurus
R301QGEDVRTANVI3Homo sapiens, Mus musculus, Bos taurus
T178YNCTRTATVKT3Homo sapiens, Mus musculus, Bos taurus
T283PVFLRTLGKGD3Homo sapiens, Mus musculus, Bos taurus
T302GEDVRTANVIA3Homo sapiens, Mus musculus, Bos taurus
V150DGKVEVTKEGV3Homo sapiens, Mus musculus, Bos taurus
V181TRTATVKTLVN3Homo sapiens, Mus musculus, Bos taurus
V268KGTVNVTREDS1Homo sapiens
V268KGQVNVTREDS1Mus musculus
V268KGKVNVTREDS1Bos taurus
V305VRTANVIAAEA3Homo sapiens, Mus musculus, Bos taurus
V331GGLDDVSNKAY3Homo sapiens, Mus musculus, Bos taurus
Y71AEPQTYRSFHD3Homo sapiens, Mus musculus, Bos taurus


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