mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPK3
Gene summary
Basic gene Info.Gene symbolMAPK3
Gene namemitogen-activated protein kinase 3
SynonymsERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK
CytomapUCSC genome browser: 16p11.2
Type of geneprotein-coding
RefGenesNM_001040056.2,
NM_001109891.1,NM_002746.2,
DescriptionMAP kinase isoform p44MAPK 1extracellular signal-regulated kinase 1extracellular signal-related kinase 1insulin-stimulated MAP2 kinasemicrotubule-associated protein 2 kinase
Modification date20141222
dbXrefs MIM : 601795
HGNC : HGNC
Ensembl : ENSG00000102882
HPRD : 03479
Vega : OTTHUMG00000132149
ProteinUniProt: P27361
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK3
BioGPS: 5595
PathwayNCI Pathway Interaction Database: MAPK3
KEGG: MAPK3
REACTOME: MAPK3
Pathway Commons: MAPK3
ContextiHOP: MAPK3
ligand binding site mutation search in PubMed: MAPK3
UCL Cancer Institute: MAPK3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation7687743
GO:0006975DNA damage induced protein phosphorylation17560175
GO:0016310phosphorylation15950189
GO:0038083peptidyl-tyrosine autophosphorylation8388392
GO:0070849response to epidermal growth factor18794356


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Ligand binding site mutations for MAPK3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V56S58LCOAD2
C183I182NBLCA1
R84R84HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAPK3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
V56S58L0.34150954
C183I182N-1.457657
R84R84H-0.50561626
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPK3 from PDB
PDB IDPDB titlePDB structure
3FHRHigh resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3 (MK3)-inhibitor complex

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Differential gene expression and gene-gene network for MAPK3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPK3 and the right PPI network was created from samples without mutations in the LBS of MAPK3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAPK3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027627Neoplasm Metastasis16AlteredExpression, Biomarker, PostTranslationalModification
umls:C0007137Carcinoma, Squamous Cell7AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0878544Cardiomyopathies4Biomarker, Therapeutic
umls:C0919267Ovarian Neoplasms3AlteredExpression, Biomarker
umls:C0038356Stomach Neoplasms3AlteredExpression, Biomarker, PostTranslationalModification
umls:C0024121Lung Neoplasms3Biomarker
umls:C0333641Atrophy1Biomarker
umls:C0007786Brain Ischemia1Biomarker
umls:C0236736Cocaine-Related Disorders1Biomarker
umls:C0017639Gliosis1Biomarker
umls:C0018671Head and Neck Neoplasms1Biomarker
umls:C0020429Hyperalgesia1Biomarker
umls:C0020564Hypertrophy1Biomarker
umls:C0021361Infertility, Female1Biomarker
umls:C0022665Kidney Neoplasms1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0027746Nerve Degeneration1Biomarker
umls:C0155862Pneumonia, Pneumococcal1Biomarker
umls:C0034531Radiation Injuries, Experimental1Therapeutic
umls:C0243026Sepsis1Biomarker
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAPK3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00605SulindacSmall molecule
Approved|investigationalDB01169Arsenic trioxideSmall molecule
ExperimentalDB02733PurvalanolSmall molecule
ExperimentalDB046045-iodotubercidinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPK3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
38Z(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN- 1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE4qtbAR84 C183
5ID5-IODOTUBERCIDIN2zoqBV56
5ID5-IODOTUBERCIDIN2zoqAV56 C183
38Z(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN- 1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE4qtbBV56 R84 C183


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Conservation information for LBS of MAPK3
Multiple alignments for P27361 in multiple species
LBSAA sequence# speciesSpecies
A52YIGEGAYGMVS3Homo sapiens, Mus musculus, Rattus norvegicus
A52PIGRGAYGIVC2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
A52PIGRGAYGVVC2Arabidopsis thaliana, Arabidopsis thaliana
A52LLGEGAYGVVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A52LIGQGAYGVVC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A69RKTRVAIKKIS3Homo sapiens, Mus musculus, Rattus norvegicus
A69TNEKVAIKKIH2Oryza sativa subsp. japonica, Arabidopsis thaliana
A69TNEKVAIKKIN1Oryza sativa subsp. japonica
A69SNERVAIKKIH1Arabidopsis thaliana
A69TGEIVAIKKIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A69SGLKVAVKKIH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C183CDLKICDFGLA7Homo sapiens, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
C183CDLKVCDFGLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C183CDLKVADFGLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D123VYLVYELMDTD4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D123VYIVQDLMETD3Homo sapiens, Mus musculus, Rattus norvegicus
D123VYIIQELMQTD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D123VYIVQELMETD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D128ELMDTDLHQII4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
D128DLMETDLYKLL3Homo sapiens, Mus musculus, Rattus norvegicus
D128ELMQTDLHRVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D128ELMETDLYRVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D184DLKICDFGLAR7Homo sapiens, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
D184DLKVCDFGLAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D184DLKVADFGLAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E126VYELMDTDLHQ4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E126VQDLMETDLYK3Homo sapiens, Mus musculus, Rattus norvegicus
E126IQELMQTDLHR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E126VQELMETDLYR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E50LQYIGEGAYGM3Homo sapiens, Mus musculus, Rattus norvegicus
E50IKPIGRGAYGI2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E50IKPIGRGAYGV2Arabidopsis thaliana, Arabidopsis thaliana
E50KSLLGEGAYGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E50INLIGQGAYGV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E88LRTLRELKLLR4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
E88QRTLREIQILL3Homo sapiens, Mus musculus, Rattus norvegicus
E88LRTLREIKILK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E88LRTLREIKLLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G186KICDFGLARI-3Homo sapiens, Mus musculus, Rattus norvegicus
G186KICDFGLART-3Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana
G186KICDFGLARA-1Arabidopsis thaliana
G186KVCDFGLARII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G186KVADFGLARS-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I48TQLQYIGEGAY3Homo sapiens, Mus musculus, Rattus norvegicus
I48VPIKPIGRGAY3Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana
I48MPIKPIGRGAY1Arabidopsis thaliana
I48QLKSLLGEGAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I48EMINLIGQGAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I73VAIKKISP-FE3Homo sapiens, Mus musculus, Rattus norvegicus
I73VAIKKINNVFD1Oryza sativa subsp. japonica
I73VAIKKIHNVFD1Oryza sativa subsp. japonica
I73VAIKKIHNVYE1Arabidopsis thaliana
I73VAIKKIHNVFE1Arabidopsis thaliana
I73VAIKKIEP-FD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I73VAVKKIHP-FN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K131ETDLYKLLKS-3Homo sapiens, Mus musculus, Rattus norvegicus
K131DTDLHQIIKSS3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K131DTDLHQIIKSP1Oryza sativa subsp. japonica
K131QTDLHRVIST-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K131ETDLYRVIRS-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K71TRVAIKKISP-3Homo sapiens, Mus musculus, Rattus norvegicus
K71EKVAIKKIHNV2Oryza sativa subsp. japonica, Arabidopsis thaliana
K71EKVAIKKINNV1Oryza sativa subsp. japonica
K71ERVAIKKIHNV1Arabidopsis thaliana
K71EIVAIKKIEP-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K71LKVAVKKIHP-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L173KPGNLLVNANC4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
L173KPSNLLINTTC3Homo sapiens, Mus musculus, Rattus norvegicus
L173KPSNLLINSNC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L173KPSNLLLNANC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M125LVYELMDTDLH4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
M125IVQDLMETDLY3Homo sapiens, Mus musculus, Rattus norvegicus
M125IIQELMQTDLH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M125IVQELMETDLY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q122DVYLVYELMDT4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
Q122DVYIVQDLMET3Homo sapiens, Mus musculus, Rattus norvegicus
Q122EVYIIQELMQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q122DVYIVQELMET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R84QTYCQRTLREI3Homo sapiens, Mus musculus, Rattus norvegicus
R84RVDALRTLREL2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R84RIDALRTLREL2Arabidopsis thaliana, Arabidopsis thaliana
R84PLFALRTLREI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R84PVFCLRTLREI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S170RDLKPSNLLIN4Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S170RDLKPGNLLVN4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
S170RDLKPSNLLLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T127YELMDTDLHQI4Oryza sativa subsp. japonica, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
T127QDLMETDLYKL3Homo sapiens, Mus musculus, Rattus norvegicus
T127QELMQTDLHRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T127QELMETDLYRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T85TYCQRTLREIQ3Homo sapiens, Mus musculus, Rattus norvegicus
T85VDALRTLRELK2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T85IDALRTLRELK2Arabidopsis thaliana, Arabidopsis thaliana
T85LFALRTLREIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T85VFCLRTLREIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V56GAYGMVSSAYD3Homo sapiens, Mus musculus, Rattus norvegicus
V56GAYGIVCSSIN2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V56GAYGVVCSSVN2Arabidopsis thaliana, Arabidopsis thaliana
V56GAYGVVCSATH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V56GAYGVVCAALH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y53IGEGAYGMVSS3Homo sapiens, Mus musculus, Rattus norvegicus
Y53IGRGAYGIVCS2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Y53IGRGAYGVVCS2Arabidopsis thaliana, Arabidopsis thaliana
Y53LGEGAYGVVCS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y53IGQGAYGVVCA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y81FEHQTYCQRTL3Homo sapiens, Mus musculus, Rattus norvegicus
Y81FDNRVDALRTL2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Y81YENRIDALRTL1Arabidopsis thaliana
Y81FENRIDALRTL1Arabidopsis thaliana
Y81FDKPLFALRTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y81FNHPVFCLRTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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