mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPK7
Gene summary
Basic gene Info.Gene symbolMAPK7
Gene namemitogen-activated protein kinase 7
SynonymsBMK1|ERK4|ERK5|PRKM7
CytomapUCSC genome browser: 17p11.2
Type of geneprotein-coding
RefGenesNM_002749.3,
NM_139032.2,NM_139033.2,NM_139034.2,
DescriptionBMK-1BMK1 kinaseERK-5MAP kinase 7MAPK 7big MAP kinase 1extracellular signal-regulated kinase 5extracellular-signal-regulated kinase 5
Modification date20141207
dbXrefs MIM : 602521
HGNC : HGNC
Ensembl : ENSG00000166484
HPRD : 03952
Vega : OTTHUMG00000059587
ProteinUniProt: Q13164
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK7
BioGPS: 5598
PathwayNCI Pathway Interaction Database: MAPK7
KEGG: MAPK7
REACTOME: MAPK7
Pathway Commons: MAPK7
ContextiHOP: MAPK7
ligand binding site mutation search in PubMed: MAPK7
UCL Cancer Institute: MAPK7
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0071560cellular response to transforming growth factor beta stimulus18588859


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Ligand binding site mutations for MAPK7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R98R98QLUAD1
I115A116TSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAPK7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I115A116T-1.2676007
R98R98Q-0.23373768
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPK7 from PDB

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Differential gene expression and gene-gene network for MAPK7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPK7 and the right PPI network was created from samples without mutations in the LBS of MAPK7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAPK7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020429Hyperalgesia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAPK7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPK7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
R4L11-CYCLOPENTYL-2-[[2-METHOXY-4-[4-(4- METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]CARBONYL-PHENYL] AMINO]-5-METHYL-PYRIMIDO[4,5-B][1,4] BENZODIAZEPIN-6-ONE4b99AI115
ANPAMP-PNP4ic7DR98
ANPAMP-PNP4ic7AR98 I115


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Conservation information for LBS of MAPK7
Multiple alignments for Q13164 in multiple species
LBSAA sequence# speciesSpecies
A65TIGNGAYGVVS3Homo sapiens, Mus musculus, Bos taurus
A65PIGRGAYGIVC2Oryza sativa subsp. japonica, Arabidopsis thaliana
A65PIGRGASGIVC1Arabidopsis thaliana
A65EIGHGAYGIVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A65ELGQGAYGIVC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A82QQ--VAIKKIP3Homo sapiens, Mus musculus, Bos taurus
A82EE--VAIKKIG3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
A82EDTTVAIKKVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A82DQEAVAIKKIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D138VYVVLDLMESD3Homo sapiens, Mus musculus, Bos taurus
D138VYIVSELMDTD1Oryza sativa subsp. japonica
D138VYIVYELMDTD1Arabidopsis thaliana
D138VHIVYELMDTD1Arabidopsis thaliana
D138LYLYEELMECD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D138VYIYEELMEAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D200ELKIGDFGMAR3Homo sapiens, Mus musculus, Bos taurus
D200DLKIADFGLAR1Oryza sativa subsp. japonica
D200DLKLGDFGLAR1Arabidopsis thaliana
D200DLKIGDFGLAR1Arabidopsis thaliana
D200QLKICDFGLAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D200ELKICDFGLAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E141VLDLMESDLHQ3Homo sapiens, Mus musculus, Bos taurus
E141VSELMDTDLHQ1Oryza sativa subsp. japonica
E141VYELMDTDLHQ1Arabidopsis thaliana
E141VYELMDTDLHH1Arabidopsis thaliana
E141YEELMECDMHQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E141YEELMEADLNA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G62IIETIGNGAYG3Homo sapiens, Mus musculus, Bos taurus
G62PIRPIGRGAYG1Oryza sativa subsp. japonica
G62PLRPIGRGAYG1Arabidopsis thaliana
G62PLRPIGRGASG1Arabidopsis thaliana
G62LIKEIGHGAYG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G62VVKELGQGAYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G64ETIGNGAYGVV3Homo sapiens, Mus musculus, Bos taurus
G64RPIGRGAYGIV2Oryza sativa subsp. japonica, Arabidopsis thaliana
G64RPIGRGASGIV1Arabidopsis thaliana
G64KEIGHGAYGIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G64KELGQGAYGIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I115-HDNIIAIKDI3Homo sapiens, Mus musculus, Bos taurus
I115-HENIIAIKDI1Oryza sativa subsp. japonica
I115-HENVIAVKDI1Arabidopsis thaliana
I115-HDNVIAIIDI1Arabidopsis thaliana
I115GHKNITCLYDM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I115NHRNITCIYD-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I61EIIETIGNGAY3Homo sapiens, Mus musculus, Bos taurus
I61PPIRPIGRGAY1Oryza sativa subsp. japonica
I61PPLRPIGRGAY1Arabidopsis thaliana
I61PPLRPIGRGAS1Arabidopsis thaliana
I61QLIKEIGHGAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I61KVVKELGQGAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K84--VAIKKIPNA3Homo sapiens, Mus musculus, Bos taurus
K84--VAIKKIGNA3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K84TTVAIKKVTNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K84EAVAIKKITNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L137SVYVVLDLMES3Homo sapiens, Mus musculus, Bos taurus
L137DVYIVSELMDT1Oryza sativa subsp. japonica
L137DVYIVYELMDT1Arabidopsis thaliana
L137DVHIVYELMDT1Arabidopsis thaliana
L137GLYLYEELMEC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L137EVYIYEELMEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L189KPSNLLVNENC3Homo sapiens, Mus musculus, Bos taurus
L189KPSNLLLNANC2Arabidopsis thaliana, Arabidopsis thaliana
L189KPGNLLVNADC2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L189KPSNLFLNANC1Oryza sativa subsp. japonica
M140VVLDLMESDLH3Homo sapiens, Mus musculus, Bos taurus
M140IVYELMDTDLH2Arabidopsis thaliana, Arabidopsis thaliana
M140IVSELMDTDLH1Oryza sativa subsp. japonica
M140LYEELMECDMH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M140IYEELMEADLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N63IETIGNGAYGV3Homo sapiens, Mus musculus, Bos taurus
N63IRPIGRGAYGI1Oryza sativa subsp. japonica
N63LRPIGRGAYGI1Arabidopsis thaliana
N63LRPIGRGASGI1Arabidopsis thaliana
N63IKEIGHGAYGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N63VKELGQGAYGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q146ESDLHQIIHSS3Homo sapiens, Mus musculus, Bos taurus
Q146DTDLHQIIRSN2Oryza sativa subsp. japonica, Arabidopsis thaliana
Q146DTDLHHIIRSN1Arabidopsis thaliana
Q146ECDMHQIIKSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q146EADLNAIIKSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R98VTNAKRTLREL3Homo sapiens, Mus musculus, Bos taurus
R98IIDAKRTLREI2Arabidopsis thaliana, Arabidopsis thaliana
R98HIDAKRTLREI1Oryza sativa subsp. japonica
R98TLLCKRSLREL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R98SILTKRALREI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S142LDLMESDLHQI3Homo sapiens, Mus musculus, Bos taurus
S142SELMDTDLHQI1Oryza sativa subsp. japonica
S142YELMDTDLHQI1Arabidopsis thaliana
S142YELMDTDLHHI1Arabidopsis thaliana
S142EELMECDMHQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S142EELMEADLNAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S186RDLKPSNLLVN3Homo sapiens, Mus musculus, Bos taurus
S186RDLKPSNLLLN2Arabidopsis thaliana, Arabidopsis thaliana
S186RDLKPGNLLVN2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S186RDLKPSNLFLN1Oryza sativa subsp. japonica
V69GAYGVVSSARR3Homo sapiens, Mus musculus, Bos taurus
V69GAYGIVCAAVN1Oryza sativa subsp. japonica
V69GAYGIVCAATN1Arabidopsis thaliana
V69GASGIVCAAWN1Arabidopsis thaliana
V69GAYGIVCSARF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V69GAYGIVCAARN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y66IGNGAYGVVSS3Homo sapiens, Mus musculus, Bos taurus
Y66IGRGAYGIVCA2Oryza sativa subsp. japonica, Arabidopsis thaliana
Y66IGRGASGIVCA1Arabidopsis thaliana
Y66IGHGAYGIVCS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y66LGQGAYGIVCA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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