mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for MAPK7

Gene summary

Basic gene Info.	Gene symbol	MAPK7
	Gene name	mitogen-activated protein kinase 7
	Synonyms	BMK1\|ERK4\|ERK5\|PRKM7
	Cytomap	UCSC genome browser: 17p11.2
	Type of gene	protein-coding
	RefGenes	NM_002749.3, NM_139032.2,NM_139033.2,NM_139034.2,
	Description	BMK-1BMK1 kinaseERK-5MAP kinase 7MAPK 7big MAP kinase 1extracellular signal-regulated kinase 5extracellular-signal-regulated kinase 5
	Modification date	20141207
dbXrefs	MIM : 602521
	HGNC : HGNC
	Ensembl : ENSG00000166484
	HPRD : 03952
	Vega : OTTHUMG00000059587
Protein	UniProt: Q13164 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MAPK7
	BioGPS: 5598
Pathway	NCI Pathway Interaction Database: MAPK7
	KEGG: MAPK7
	REACTOME: MAPK7
	Pathway Commons: MAPK7
Context	iHOP: MAPK7
	ligand binding site mutation search in PubMed: MAPK7
	UCL Cancer Institute: MAPK7
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0071560	cellular response to transforming growth factor beta stimulus	18588859

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Ligand binding site mutations for MAPK7

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R98	R98Q	LUAD	1
I115	A116T	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for MAPK7

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
I115	A116T	-1.2676007
R98	R98Q	-0.23373768

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPK7 from PDB

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Differential gene expression and gene-gene network for MAPK7

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of MAPK7 and the right PPI network was created from samples without mutations in the LBS of MAPK7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for MAPK7

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0020429	Hyperalgesia	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for MAPK7

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPK7 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
R4L		11-CYCLOPENTYL-2-[[2-METHOXY-4-[4-(4- METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]CARBONYL-PHENYL] AMINO]-5-METHYL-PYRIMIDO[4,5-B][1,4] BENZODIAZEPIN-6-ONE	4b99	A	I115
ANP		AMP-PNP	4ic7	D	R98
ANP		AMP-PNP	4ic7	A	R98 I115

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Conservation information for LBS of MAPK7

Multiple alignments for Q13164 in multiple species

LBS	AA sequence	# species	Species
A65	TIGNGAYGVVS	3	Homo sapiens, Mus musculus, Bos taurus
A65	PIGRGAYGIVC	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
A65	PIGRGASGIVC	1	Arabidopsis thaliana
A65	EIGHGAYGIVC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A65	ELGQGAYGIVC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A82	QQ--VAIKKIP	3	Homo sapiens, Mus musculus, Bos taurus
A82	EE--VAIKKIG	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
A82	EDTTVAIKKVT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A82	DQEAVAIKKIT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D138	VYVVLDLMESD	3	Homo sapiens, Mus musculus, Bos taurus
D138	VYIVSELMDTD	1	Oryza sativa subsp. japonica
D138	VYIVYELMDTD	1	Arabidopsis thaliana
D138	VHIVYELMDTD	1	Arabidopsis thaliana
D138	LYLYEELMECD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D138	VYIYEELMEAD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D200	ELKIGDFGMAR	3	Homo sapiens, Mus musculus, Bos taurus
D200	DLKIADFGLAR	1	Oryza sativa subsp. japonica
D200	DLKLGDFGLAR	1	Arabidopsis thaliana
D200	DLKIGDFGLAR	1	Arabidopsis thaliana
D200	QLKICDFGLAR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D200	ELKICDFGLAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E141	VLDLMESDLHQ	3	Homo sapiens, Mus musculus, Bos taurus
E141	VSELMDTDLHQ	1	Oryza sativa subsp. japonica
E141	VYELMDTDLHQ	1	Arabidopsis thaliana
E141	VYELMDTDLHH	1	Arabidopsis thaliana
E141	YEELMECDMHQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E141	YEELMEADLNA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G62	IIETIGNGAYG	3	Homo sapiens, Mus musculus, Bos taurus
G62	PIRPIGRGAYG	1	Oryza sativa subsp. japonica
G62	PLRPIGRGAYG	1	Arabidopsis thaliana
G62	PLRPIGRGASG	1	Arabidopsis thaliana
G62	LIKEIGHGAYG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G62	VVKELGQGAYG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G64	ETIGNGAYGVV	3	Homo sapiens, Mus musculus, Bos taurus
G64	RPIGRGAYGIV	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
G64	RPIGRGASGIV	1	Arabidopsis thaliana
G64	KEIGHGAYGIV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G64	KELGQGAYGIV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I115	-HDNIIAIKDI	3	Homo sapiens, Mus musculus, Bos taurus
I115	-HENIIAIKDI	1	Oryza sativa subsp. japonica
I115	-HENVIAVKDI	1	Arabidopsis thaliana
I115	-HDNVIAIIDI	1	Arabidopsis thaliana
I115	GHKNITCLYDM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I115	NHRNITCIYD-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I61	EIIETIGNGAY	3	Homo sapiens, Mus musculus, Bos taurus
I61	PPIRPIGRGAY	1	Oryza sativa subsp. japonica
I61	PPLRPIGRGAY	1	Arabidopsis thaliana
I61	PPLRPIGRGAS	1	Arabidopsis thaliana
I61	QLIKEIGHGAY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I61	KVVKELGQGAY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K84	--VAIKKIPNA	3	Homo sapiens, Mus musculus, Bos taurus
K84	--VAIKKIGNA	3	Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
K84	TTVAIKKVTNV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K84	EAVAIKKITNV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L137	SVYVVLDLMES	3	Homo sapiens, Mus musculus, Bos taurus
L137	DVYIVSELMDT	1	Oryza sativa subsp. japonica
L137	DVYIVYELMDT	1	Arabidopsis thaliana
L137	DVHIVYELMDT	1	Arabidopsis thaliana
L137	GLYLYEELMEC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L137	EVYIYEELMEA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L189	KPSNLLVNENC	3	Homo sapiens, Mus musculus, Bos taurus
L189	KPSNLLLNANC	2	Arabidopsis thaliana, Arabidopsis thaliana
L189	KPGNLLVNADC	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L189	KPSNLFLNANC	1	Oryza sativa subsp. japonica
M140	VVLDLMESDLH	3	Homo sapiens, Mus musculus, Bos taurus
M140	IVYELMDTDLH	2	Arabidopsis thaliana, Arabidopsis thaliana
M140	IVSELMDTDLH	1	Oryza sativa subsp. japonica
M140	LYEELMECDMH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M140	IYEELMEADLN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N63	IETIGNGAYGV	3	Homo sapiens, Mus musculus, Bos taurus
N63	IRPIGRGAYGI	1	Oryza sativa subsp. japonica
N63	LRPIGRGAYGI	1	Arabidopsis thaliana
N63	LRPIGRGASGI	1	Arabidopsis thaliana
N63	IKEIGHGAYGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N63	VKELGQGAYGI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q146	ESDLHQIIHSS	3	Homo sapiens, Mus musculus, Bos taurus
Q146	DTDLHQIIRSN	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
Q146	DTDLHHIIRSN	1	Arabidopsis thaliana
Q146	ECDMHQIIKSG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q146	EADLNAIIKSG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R98	VTNAKRTLREL	3	Homo sapiens, Mus musculus, Bos taurus
R98	IIDAKRTLREI	2	Arabidopsis thaliana, Arabidopsis thaliana
R98	HIDAKRTLREI	1	Oryza sativa subsp. japonica
R98	TLLCKRSLREL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R98	SILTKRALREI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S142	LDLMESDLHQI	3	Homo sapiens, Mus musculus, Bos taurus
S142	SELMDTDLHQI	1	Oryza sativa subsp. japonica
S142	YELMDTDLHQI	1	Arabidopsis thaliana
S142	YELMDTDLHHI	1	Arabidopsis thaliana
S142	EELMECDMHQI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S142	EELMEADLNAI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S186	RDLKPSNLLVN	3	Homo sapiens, Mus musculus, Bos taurus
S186	RDLKPSNLLLN	2	Arabidopsis thaliana, Arabidopsis thaliana
S186	RDLKPGNLLVN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S186	RDLKPSNLFLN	1	Oryza sativa subsp. japonica
V69	GAYGVVSSARR	3	Homo sapiens, Mus musculus, Bos taurus
V69	GAYGIVCAAVN	1	Oryza sativa subsp. japonica
V69	GAYGIVCAATN	1	Arabidopsis thaliana
V69	GASGIVCAAWN	1	Arabidopsis thaliana
V69	GAYGIVCSARF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V69	GAYGIVCAARN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y66	IGNGAYGVVSS	3	Homo sapiens, Mus musculus, Bos taurus
Y66	IGRGAYGIVCA	2	Oryza sativa subsp. japonica, Arabidopsis thaliana
Y66	IGRGASGIVCA	1	Arabidopsis thaliana
Y66	IGHGAYGIVCS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y66	LGQGAYGIVCA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)