mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPK8
Gene summary
Basic gene Info.Gene symbolMAPK8
Gene namemitogen-activated protein kinase 8
SynonymsJNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c
CytomapUCSC genome browser: 10q11.22
Type of geneprotein-coding
RefGenesNM_001278547.1,
NM_001278548.1,NM_002750.3,NM_139046.2,NM_139049.2,
DescriptionJUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activated protein kinase 1c
Modification date20141222
dbXrefs MIM : 601158
HGNC : HGNC
Ensembl : ENSG00000107643
HPRD : 03100
Vega : OTTHUMG00000018172
ProteinUniProt: P45983
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK8
BioGPS: 5599
PathwayNCI Pathway Interaction Database: MAPK8
KEGG: MAPK8
REACTOME: MAPK8
Pathway Commons: MAPK8
ContextiHOP: MAPK8
ligand binding site mutation search in PubMed: MAPK8
UCL Cancer Institute: MAPK8
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007254JNK cascade8654373
GO:0007258JUN phosphorylation14967141
GO:0009411response to UV14967141
GO:0018105peptidyl-serine phosphorylation15850461
GO:0018107peptidyl-threonine phosphorylation21095239
GO:0032091negative regulation of protein binding21095239
GO:0032880regulation of protein localization20027304
GO:0043066negative regulation of apoptotic process14967141
GO:0071222cellular response to lipopolysaccharide23776175


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Ligand binding site mutations for MAPK8

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R150R150WBRCA1
T183T183MCOAD1
I231I231VCOAD1
N114,C116L115ICOAD1
G38G38RCOAD1
Q120Q120HCOAD1
Q120Q120RCOAD1
T183T183ACOAD1
A42A42TCOAD1
L57L57QGBM1
R189R189SLUAD1
R150H149YLUSC1
R189R189CLUSC1
R189R189LLUSC1
L198L198FOV1
M121M121ISKCM1
G199G199DSTAD1
D112D112YSTAD1
K30,I32P31LUCEC1
T183T183MUCEC1
N114,C116L115IUCEC1
R189R189HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAPK8
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I231I231V-1.5458807
G199G199D-1.3439762
R189R189S-1.3195766
R189R189H-1.3190246
L57L57Q-1.276512
Q120Q120H-1.0765183
T183T183A-1.0658336
R189R189C-1.0629107
L198L198F-0.86001966
K30P31L-0.85651148
I32P31L-0.85651148
Q120Q120R-0.70431562
R189R189L-0.69429185
N114L115I-0.63221664
C116L115I-0.63221664
T183T183M-0.61098271
M121M121I-0.54380495
A42A42T-0.36363921
R150H149Y-0.30401708
D112D112Y-0.2629978
R150R150W-0.25963597
G38G38R-0.18765111
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPK8 from PDB

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Differential gene expression and gene-gene network for MAPK8
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPK8 and the right PPI network was created from samples without mutations in the LBS of MAPK8. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAPK8
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0035126Reperfusion Injury2Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0011615Dermatitis, Atopic1Biomarker
umls:C0162557Liver Failure, Acute1Biomarker
umls:C0032927Precancerous Conditions1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAPK8
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB017822,6-Dihydroanthra/1,9-Cd/Pyrazol-6-OneSmall molecule
ExperimentalDB072186-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONESmall molecule
ExperimentalDB072682-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDESmall molecule
ExperimentalDB07272N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDESmall molecule
ExperimentalDB072765-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDESmall molecule
ExperimentalDB078452-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPK8 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU)2gmxBD112
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU)2g01AD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)2h96AD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)2h96BD112 M121
IIIPeptide ligand (ARG,PRO,SER,ARG,ASP,HIS,LEU,TYR,LEU,PRO,LEU,GLU)2xrwAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3o17BD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3o2mAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3o2mBD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vugAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vuhAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vuiAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vukAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vulAD112 M121
IIIPeptide ligand (ARG,PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vumAD112 M121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU)4e73AD112 M121
IIIPeptide ligand (PRO,ARG,PRO,THR,LEU,GLN,LEU,PRO,LEU,ALA)4ux9AD112 M121
IIIPeptide ligand (PRO,THR,LEU,GLN,LEU,PRO,LEU,ALA)4ux9BD112 M121
IIIPeptide ligand (GLN,ARG,PRO,ARG,PRO,THR,LEU,GLN,LEU,PRO,LEU,ALA)4ux9CD112 M121
73Q6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE2g01BD112 N114
8592-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE2no3AD112 N114
SO4SULFATE3vugAG38 L57
SO4SULFATE3vuhAG38 L57
SO4SULFATE3vuiAG38 L57
8935-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE2h96AI32 A42 D112
8935-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE2h96BI32 A42 D112 N114
0NRMETHYL 3-(4-{[(1R,2S,3S,5S,7S)-5- AMINOTRICYCLO[3.3.1.1~3,7~]DEC-2-YL]CARBAMOYL}BENZYL)- 4-OXO-1-PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-2- CARBOXYLATE4e73AI32 A42 D112 N114
877N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE2gmxAI32 D112
CFK3-(CARBAMOYLAMINO)-5-PHENYLTHIOPHENE-2-CARBOXAMIDE3pzeAI32 D112
8592-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE2no3BI32 D112 N114
GS72-FLUORO-6-{[2-({2-METHOXY-4-[(METHYLSULFONYL)METHYL]PHENYL}AMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL]AMINO}BENZAMIDE3eljAI32 D112 N114
MYUQUERCETAGETIN3v3vAI32 D112 N114
38Z(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN- 1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE4qtdAI32 D112 N114 C116 Q120
1V5N-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-[(TRANS-4- HYDROXYCYCLOHEXYL)AMINO]IMIDAZO[1,2-A]QUINOXALINE-8- CARBOXAMIDE4l7fAI32 G38 L57 D112 N114
73Q6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE2g01AI32 N114
ANPAMP-PNP2xrwAI32 N114
ANPAMP-PNP2xs0AI32 N114
ANPAMP-PNP4ux9AI32 N114
ANPAMP-PNP4ux9BI32 N114
ANPAMP-PNP4ux9CI32 N114
ANPAMP-PNP4ux9DI32 N114
877N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE2gmxBK30 I32 D112 N114
46AN-BUTYL-4,6-DIMETHYL-N-{[2'-(2H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL}PYRIMIDIN-2-AMINE3o2mAL198 G199 I231
46AN-BUTYL-4,6-DIMETHYL-N-{[2'-(2H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL}PYRIMIDIN-2-AMINE3o2mBL198 G199 I231
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU)2g01BM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)2gmxAM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)2no3AM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)2no3BM121
IIIPeptide ligand (ARG,PRO,SER,ARG,ASP,HIS,LEU,TYR,LEU,PRO,LEU,GLU)2xs0AM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3o17AM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3v3vAM121
IIIPeptide ligand (PRO,LYS,ARG,PRO,THR,THR,LEU,ASN,LEU,PHE)3vudAM121
IIIPeptide ligand (GLN,LEU,PRO,LEU)4ux9DM121
SO4SULFATE3vuiAR150
SO4SULFATE3vuhAR150 T183
SO4SULFATE3vukAR150 T183
SO4SULFATE3vudAR189
SO4SULFATE3vugAR189
SO4SULFATE3vukAR189


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Conservation information for LBS of MAPK8
Multiple alignments for P45983 in multiple species
LBSAA sequence# speciesSpecies
A113MELMDANLCQV4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
A36PIGSGAQGIVC3Homo sapiens, Drosophila melanogaster, Mus musculus
A36LIGSGAQGIVC1Caenorhabditis elegans
A42QGIVCAAYDAI2Homo sapiens, Mus musculus
A42QGIVCSAFDTV1Caenorhabditis elegans
A42QGIVCAAYDTI1Drosophila melanogaster
A53LERNVAIKKLS2Homo sapiens, Mus musculus
A53RNEQVAIKKLS1Caenorhabditis elegans
A53TQQNVAIKKLS1Drosophila melanogaster
C116MDANLCQVIQM4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
C163VVKSDCTLKIL2Homo sapiens, Mus musculus
C163VVRSDCTLKIL1Caenorhabditis elegans
C163VVKADCTLKIL1Drosophila melanogaster
D112VMELMDANLCQ4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
D162IVVKSDCTLKI2Homo sapiens, Mus musculus
D162IVVRSDCTLKI1Caenorhabditis elegans
D162IVVKADCTLKI1Drosophila melanogaster
D169TLKILDFGLAR4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
D326INVWYDPSEAE2Homo sapiens, Mus musculus
D326VNVWFDEIEVY1Caenorhabditis elegans
D326INVWYDAEEVD1Drosophila melanogaster
E109VYIVMELMDAN2Homo sapiens, Mus musculus
E109LYIVMELMDAN1Caenorhabditis elegans
E109VYLVMELMDAN1Drosophila melanogaster
E126MELDHERMSYL2Homo sapiens, Mus musculus
E126MDLDHERLSYL1Caenorhabditis elegans
E126MDLDHDRMSYL1Drosophila melanogaster
E329WYDPSEAEAPP2Homo sapiens, Mus musculus
E329WFDEIEVYAPP1Caenorhabditis elegans
E329WYDAEEVDAPA1Drosophila melanogaster
E73KRAYRELVLMK2Homo sapiens, Mus musculus
E73KRAYRELKLMS1Caenorhabditis elegans
E73KRAYREFKLMK1Drosophila melanogaster
G199PEVILGMGYKE3Homo sapiens, Caenorhabditis elegans, Mus musculus
G199PEVILGMGYTE1Drosophila melanogaster
G33NLKPIGSGAQG2Homo sapiens, Mus musculus
G33NLRLIGSGAQG1Caenorhabditis elegans
G33NLRPIGSGAQG1Drosophila melanogaster
G35KPIGSGAQGIV2Homo sapiens, Mus musculus
G35RLIGSGAQGIV1Caenorhabditis elegans
G35RPIGSGAQGIV1Drosophila melanogaster
G38GSGAQGIVCAA3Homo sapiens, Drosophila melanogaster, Mus musculus
G38GSGAQGIVCSA1Caenorhabditis elegans
H286PADSEHN-KLK2Homo sapiens, Mus musculus
H286PMTADSS-RLT1Caenorhabditis elegans
H286PNDNNQNSRRK1Drosophila melanogaster
H66FQNQTHAKRAY2Homo sapiens, Mus musculus
H66FQNVTHAKRAY2Caenorhabditis elegans, Drosophila melanogaster
I197RAPEVILGMGY4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
I231PGRDYIDQWNK2Homo sapiens, Mus musculus
I231PGGDHIDQWTR1Caenorhabditis elegans
I231PGTDHIDQWNK1Drosophila melanogaster
I32QNLKPIGSGAQ2Homo sapiens, Mus musculus
I32QNLRLIGSGAQ1Caenorhabditis elegans
I32INLRPIGSGAQ1Drosophila melanogaster
I39SGAQGIVCAAY3Homo sapiens, Drosophila melanogaster, Mus musculus
I39SGAQGIVCSAF1Caenorhabditis elegans
I86NHKNIIGLLNV2Homo sapiens, Mus musculus
I86NHKNIIGILNC1Caenorhabditis elegans
I86NHKNIIGLLNA1Drosophila melanogaster
K153IHRDLKPSNIV4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
K160SNIVVKSDCTL2Homo sapiens, Mus musculus
K160SNIVVRSDCTL1Caenorhabditis elegans
K160SNIVVKADCTL1Drosophila melanogaster
K288SEHN-KLKASQ2Homo sapiens, Mus musculus
K288ADSS-RLTGAQ1Caenorhabditis elegans
K288NNQNSRRKASD1Drosophila melanogaster
K30RYQNLKPIGSG2Homo sapiens, Mus musculus
K30RYQNLRLIGSG1Caenorhabditis elegans
K30RYINLRPIGSG1Drosophila melanogaster
K55RNVAIKKLSRP2Homo sapiens, Mus musculus
K55EQVAIKKLSRP1Caenorhabditis elegans
K55QNVAIKKLSRP1Drosophila melanogaster
K56NVAIKKLSRPF3Homo sapiens, Drosophila melanogaster, Mus musculus
K56QVAIKKLSRPF1Caenorhabditis elegans
K68NQTHAKRAYRE2Homo sapiens, Mus musculus
K68NVTHAKRAYRE2Caenorhabditis elegans, Drosophila melanogaster
K83KCVNHKNIIGL2Homo sapiens, Mus musculus
K83SLVNHKNIIGI1Caenorhabditis elegans
K83KLVNHKNIIGL1Drosophila melanogaster
L110YIVMELMDANL3Homo sapiens, Caenorhabditis elegans, Mus musculus
L110YLVMELMDANL1Drosophila melanogaster
L123VIQMELDHERM2Homo sapiens, Mus musculus
L123VIQMDLDHERL1Caenorhabditis elegans
L123VIQMDLDHDRM1Drosophila melanogaster
L168CTLKILDFGLA4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
L198APEVILGMGYK3Homo sapiens, Caenorhabditis elegans, Mus musculus
L198APEVILGMGYT1Drosophila melanogaster
L289EHN-KLKASQA2Homo sapiens, Mus musculus
L289DSS-RLTGAQA1Caenorhabditis elegans
L289NQNSRRKASDA1Drosophila melanogaster
L57VAIKKLSRPFQ4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
M108DVYIVMELMDA2Homo sapiens, Mus musculus
M108DLYIVMELMDA1Caenorhabditis elegans
M108DVYLVMELMDA1Drosophila melanogaster
M111IVMELMDANLC3Homo sapiens, Caenorhabditis elegans, Mus musculus
M111LVMELMDANLC1Drosophila melanogaster
M121CQVIQMELDHE2Homo sapiens, Mus musculus
M121CQVIQMDLDHE1Caenorhabditis elegans
M121CQVIQMDLDHD1Drosophila melanogaster
N114ELMDANLCQVI4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
N156DLKPSNIVVKS2Homo sapiens, Mus musculus
N156DLKPSNIVVRS1Caenorhabditis elegans
N156DLKPSNIVVKA1Drosophila melanogaster
P327NVWYDPSEAEA2Homo sapiens, Mus musculus
P327NVWFDEIEVYA1Caenorhabditis elegans
P327NVWYDAEEVDA1Drosophila melanogaster
Q117DANLCQVIQME2Homo sapiens, Mus musculus
Q117DANLCQVIQMD2Caenorhabditis elegans, Drosophila melanogaster
Q120LCQVIQMELDH2Homo sapiens, Mus musculus
Q120LCQVIQMDLDH2Caenorhabditis elegans, Drosophila melanogaster
Q253FMKKLQPTVRT2Homo sapiens, Mus musculus
Q253FLERLQPTVRN1Caenorhabditis elegans
Q253FMQRLQPTVRN1Drosophila melanogaster
Q37IGSGAQGIVCA3Homo sapiens, Drosophila melanogaster, Mus musculus
Q37IGSGAQGIVCS1Caenorhabditis elegans
R127ELDHERMSYLL2Homo sapiens, Mus musculus
R127DLDHERLSYLL1Caenorhabditis elegans
R127DLDHDRMSYLL1Drosophila melanogaster
R150AGIIHRDLKPS4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
R174DFGLARTAGTS2Homo sapiens, Mus musculus
R174DFGLARTAIEA1Caenorhabditis elegans
R174DFGLARTAGTT1Drosophila melanogaster
R189PYVVTRYYRAP4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
R192VTRYYRAPEVI4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
R69QTHAKRAYREL2Homo sapiens, Mus musculus
R69VTHAKRAYREL1Caenorhabditis elegans
R69VTHAKRAYREF1Drosophila melanogaster
R72AKRAYRELVLM2Homo sapiens, Mus musculus
R72AKRAYRELKLM1Caenorhabditis elegans
R72AKRAYREFKLM1Drosophila melanogaster
S155RDLKPSNIVVK3Homo sapiens, Drosophila melanogaster, Mus musculus
S155RDLKPSNIVVR1Caenorhabditis elegans
S161NIVVKSDCTLK2Homo sapiens, Mus musculus
S161NIVVRSDCTLK1Caenorhabditis elegans
S161NIVVKADCTLK1Drosophila melanogaster
S34LKPIGSGAQGI2Homo sapiens, Mus musculus
S34LRLIGSGAQGI1Caenorhabditis elegans
S34LRPIGSGAQGI1Drosophila melanogaster
S58AIKKLSRPFQN4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
T183TSFMMTPYVVT2Homo sapiens, Mus musculus
T183EAFMMTPYVVT1Caenorhabditis elegans
T183TTFMMTPYVVT1Drosophila melanogaster
T188TPYVVTRYYRA4Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus
V118ANLCQVIQMEL2Homo sapiens, Mus musculus
V118ANLCQVIQMDL2Caenorhabditis elegans, Drosophila melanogaster
V158KPSNIVVKSDC2Homo sapiens, Mus musculus
V158KPSNIVVRSDC1Caenorhabditis elegans
V158KPSNIVVKADC1Drosophila melanogaster
V159PSNIVVKSDCT2Homo sapiens, Mus musculus
V159PSNIVVRSDCT1Caenorhabditis elegans
V159PSNIVVKADCT1Drosophila melanogaster
V323HPYINVWYDPS2Homo sapiens, Mus musculus
V323HPYVNVWFDEI1Caenorhabditis elegans
V323HEYINVWYDAE1Drosophila melanogaster
V40GAQGIVCAAYD3Homo sapiens, Drosophila melanogaster, Mus musculus
V40GAQGIVCSAFD1Caenorhabditis elegans
W324PYINVWYDPSE2Homo sapiens, Mus musculus
W324PYVNVWFDEIE1Caenorhabditis elegans
W324EYINVWYDAEE1Drosophila melanogaster
Y130HERMSYLLYQM2Homo sapiens, Mus musculus
Y130HERLSYLLYQM1Caenorhabditis elegans
Y130HDRMSYLLYQM1Drosophila melanogaster
Y133MSYLLYQMLCG3Homo sapiens, Drosophila melanogaster, Mus musculus
Y133LSYLLYQMLCG1Caenorhabditis elegans
Y230FPGRDYIDQWN2Homo sapiens, Mus musculus
Y230FPGGDHIDQWT1Caenorhabditis elegans
Y230FPGTDHIDQWN1Drosophila melanogaster
Y259PTVRTYVENRP2Homo sapiens, Mus musculus
Y259PTVRNYVENRP2Caenorhabditis elegans, Drosophila melanogaster


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