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mutLBSgeneDB |
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| Gene summary for MAPK11 |
 Gene summary |
| Basic gene Info. | Gene symbol | MAPK11 |
| Gene name | mitogen-activated protein kinase 11 | |
| Synonyms | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta | |
| Cytomap | UCSC genome browser: 22q13.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002751.6, NR_110887.1, | |
| Description | MAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602898 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185386 | ||
| HPRD : 04208 | ||
| Vega : OTTHUMG00000150226 | ||
| Protein | UniProt: Q15759 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAPK11 | |
| BioGPS: 5600 | ||
| Pathway | NCI Pathway Interaction Database: MAPK11 | |
| KEGG: MAPK11 | ||
| REACTOME: MAPK11 | ||
| Pathway Commons: MAPK11 | ||
| Context | iHOP: MAPK11 | |
| ligand binding site mutation search in PubMed: MAPK11 | ||
| UCL Cancer Institute: MAPK11 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006950 | response to stress | 8663524 | GO:0035556 | intracellular signal transduction | 8663524 |
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| Ligand binding site mutations for MAPK11 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H148 | R149W | BLCA | 1 | L167 | L167M | LUAD | 1 | V52 | V52M | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MAPK11 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L167 | L167M | -1.6732182 | V52 | V52M | -1.143558 | H148 | R149W | -0.25963597 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MAPK11 from PDB |
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| Differential gene expression and gene-gene network for MAPK11 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MAPK11 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0878544 | Cardiomyopathies | 1 | Therapeutic |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MAPK11 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Investigational | DB05157 | KC706 | Small molecule |  |
| Approved | DB08896 | Regorafenib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MAPK11 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NIL | NILOTINIB | 3gp0 | A | H148 L167 | B45 | 5-(2-CHLORO-4-FLUOROPHENYL)-1-(2,6-DICHLOROPHENYL)-7-[1-(1-METHYLETHYL)PIPERIDIN-4-YL]-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | 3gc8 | A | V52 L167 | B45 | 5-(2-CHLORO-4-FLUOROPHENYL)-1-(2,6-DICHLOROPHENYL)-7-[1-(1-METHYLETHYL)PIPERIDIN-4-YL]-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | 3gc8 | B | V52 L167 | B45 | 5-(2-CHLORO-4-FLUOROPHENYL)-1-(2,6-DICHLOROPHENYL)-7-[1-(1-METHYLETHYL)PIPERIDIN-4-YL]-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | 3gc9 | A | V52 L167 | B45 | 5-(2-CHLORO-4-FLUOROPHENYL)-1-(2,6-DICHLOROPHENYL)-7-[1-(1-METHYLETHYL)PIPERIDIN-4-YL]-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | 3gc9 | B | V52 L167 |
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| Conservation information for LBS of MAPK11 |
| Multiple alignments for Q15759 in multiple species |
| LBS | AA sequence | # species | Species | A111 | TTLMGADLNNI | 2 | Homo sapiens, Mus musculus | A111 | NELMEFDLYRT | 1 | Arabidopsis thaliana | A157 | KPSNVAVNEDC | 2 | Homo sapiens, Mus musculus | A157 | KPSNLLLSTQC | 1 | Arabidopsis thaliana | A34 | PVGSGAYGSVC | 2 | Homo sapiens, Mus musculus | A34 | PIGRGACGIVC | 1 | Arabidopsis thaliana | A51 | LRQKVAVKKLS | 2 | Homo sapiens, Mus musculus | A51 | TNEKVAIKKIT | 1 | Arabidopsis thaliana | D292 | RMLVLDSDQRV | 2 | Homo sapiens, Mus musculus | D292 | KMLTFDPKQRI | 1 | Arabidopsis thaliana | D294 | LVLDSDQRVSA | 2 | Homo sapiens, Mus musculus | D294 | LTFDPKQRISV | 1 | Arabidopsis thaliana | E245 | GTPSPEVLAKI | 2 | Homo sapiens, Mus musculus | E245 | GTPSEEELGSL | 1 | Arabidopsis thaliana | E71 | RRTYRELRLLK | 2 | Homo sapiens, Mus musculus | E71 | KRTLREIKLLR | 1 | Arabidopsis thaliana | G110 | VTTLMGADLNN | 2 | Homo sapiens, Mus musculus | G110 | VNELMEFDLYR | 1 | Arabidopsis thaliana | H148 | SAGIIHRDLKP | 2 | Homo sapiens, Mus musculus | H148 | SANVLHRDLKP | 1 | Arabidopsis thaliana | I84 | KHENVIGLLDV | 2 | Homo sapiens, Mus musculus | I84 | DHENIVAIRDV | 1 | Arabidopsis thaliana | K53 | QKVAVKKLSRP | 2 | Homo sapiens, Mus musculus | K53 | EKVAIKKITQV | 1 | Arabidopsis thaliana | L104 | FSEVYLVTTLM | 2 | Homo sapiens, Mus musculus | L104 | FEDVYIVNELM | 1 | Arabidopsis thaliana | L108 | YLVTTLMGADL | 2 | Homo sapiens, Mus musculus | L108 | YIVNELMEFDL | 1 | Arabidopsis thaliana | L167 | CELRILDFGLA | 2 | Homo sapiens, Mus musculus | L167 | CDLKICDFGLA | 1 | Arabidopsis thaliana | L74 | YRELRLLKHLK | 2 | Homo sapiens, Mus musculus | L74 | LREIKLLRHFD | 1 | Arabidopsis thaliana | L75 | RELRLLKHLKH | 2 | Homo sapiens, Mus musculus | L75 | REIKLLRHFDH | 1 | Arabidopsis thaliana | M109 | LVTTLMGADLN | 2 | Homo sapiens, Mus musculus | M109 | IVNELMEFDLY | 1 | Arabidopsis thaliana | N155 | DLKPSNVAVNE | 2 | Homo sapiens, Mus musculus | N155 | DLKPSNLLLST | 1 | Arabidopsis thaliana | R67 | LIHARRTYREL | 2 | Homo sapiens, Mus musculus | R67 | TIEAKRTLREI | 1 | Arabidopsis thaliana | S154 | RDLKPSNVAVN | 2 | Homo sapiens, Mus musculus | S154 | RDLKPSNLLLS | 1 | Arabidopsis thaliana | T106 | EVYLVTTLMGA | 2 | Homo sapiens, Mus musculus | T106 | DVYIVNELMEF | 1 | Arabidopsis thaliana | T107 | VYLVTTLMGAD | 2 | Homo sapiens, Mus musculus | T107 | VYIVNELMEFD | 1 | Arabidopsis thaliana | V30 | -GLRPVGSGAY | 2 | Homo sapiens, Mus musculus | V30 | PPIRPIGRGAC | 1 | Arabidopsis thaliana | V38 | GAYGSVCSAYD | 2 | Homo sapiens, Mus musculus | V38 | GACGIVCSAVD | 1 | Arabidopsis thaliana | V52 | RQKVAVKKLSR | 2 | Homo sapiens, Mus musculus | V52 | NEKVAIKKITQ | 1 | Arabidopsis thaliana | V83 | LKHENVIGLLD | 2 | Homo sapiens, Mus musculus | V83 | FDHENIVAIRD | 1 | Arabidopsis thaliana | Y35 | VGSGAYGSVCS | 2 | Homo sapiens, Mus musculus | Y35 | IGRGACGIVCS | 1 | Arabidopsis thaliana |
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