mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAP2K1
Gene summary
Basic gene Info.Gene symbolMAP2K1
Gene namemitogen-activated protein kinase kinase 1
SynonymsCFC3|MAPKK1|MEK1|MKK1|PRKMK1
CytomapUCSC genome browser: 15q22.1-q22.33
Type of geneprotein-coding
RefGenesNM_002755.3,
DescriptionERK activator kinase 1MAPK/ERK kinase 1MAPKK 1MEK 1dual specificity mitogen-activated protein kinase kinase 1protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Modification date20141219
dbXrefs MIM : 176872
HGNC : HGNC
HPRD : 01469
ProteinUniProt: Q02750
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAP2K1
BioGPS: 5604
PathwayNCI Pathway Interaction Database: MAP2K1
KEGG: MAP2K1
REACTOME: MAP2K1
Pathway Commons: MAP2K1
ContextiHOP: MAP2K1
ligand binding site mutation search in PubMed: MAP2K1
UCL Cancer Institute: MAP2K1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000187activation of MAPK activity10644344
GO:0008285negative regulation of cell proliferation9765203
GO:0071902positive regulation of protein serine/threonine kinase activity8388392


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Ligand binding site mutations for MAP2K1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R234L235HBLCA1
S150S150FCOAD1
V127V127MCOAD1
D66D67NCOAD1
H119C121SLUAD1
D190,K192V191FLUAD1
A95,K97R96KLUSC1
G225V224MSTAD1
H119C121SSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAP2K1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S150S150F0.12236247
K97R96K-1.44934
A95R96K-1.44934
H119C121S-1.4244039
R234L235H-1.4126238
K192V191F-1.2811874
D190V191F-1.2811874
D66D67N-1.17849
G225V224M-0.98355801
V127V127M-0.85857775
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAP2K1 from PDB

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Differential gene expression and gene-gene network for MAP2K1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAP2K1 and the right PPI network was created from samples without mutations in the LBS of MAP2K1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAP2K1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0025202Melanoma17AlteredExpression, Biomarker, GeneticVariation
umls:C1275081Cardiofaciocutaneous syndrome15Biomarker, GeneticVariation
umls:C0028326Noonan Syndrome6Biomarker, GeneticVariation
umls:C3809006CARDIOFACIOCUTANEOUS SYNDROME 32GeneticVariation
umls:C0152013Adenocarcinoma of lung2Biomarker
umls:C0587248Costello Syndrome2Biomarker
umls:C0023443Leukemia, Hairy Cell1Biomarker
umls:C0007786Brain Ischemia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
49251D67NPathogenicGermlineMedGen:C3809006
OMIM:615279
Orphanet:ORPHA1340
MedGen:CN166718
MedGen:CN207091

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Pharmacological information for MAP2K1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02152K-252aSmall molecule
ExperimentalDB031155-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]BenzamideSmall molecule
ApprovedDB05239CobimetinibSmall molecule
ApprovedDB06616BosutinibSmall molecule
ExperimentalDB06892(5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamideSmall molecule
ExperimentalDB070462-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamideSmall molecule
ExperimentalDB07101N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideSmall molecule
ExperimentalDB08130N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamineSmall molecule
ExperimentalDB082082-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDESmall molecule
ApprovedDB08911TrametinibSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAP2K1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
92P1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID3zlsAA95
MT8(1R)-1-HYDROXY-1-METHYL-2,3,6,7-TETRAHYDRO- 1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE3zlwAA95
YSO3-AMINO-1H-INDAZOLE-4-CARBONITRILE3zlyAA95
22T7-CHLORANYL-6-[(3S)-PYRROLIDIN-3-YL]OXY-2H- ISOQUINOLIN-1-ONE3zm4AA95
4W5ETHYL 2H-INDAZOLE-5-CARBOXYLATE5bx0AA95
KSAK-252A3eqfAA95 K97
ADPADP3eqiAA95 K97 S150
ANPAMP-PNP3slsAA95 K97 S150 D190 K192
ANPAMP-PNP3slsBA95 K97 S150 D190 K192
ANPAMP-PNP4lmnAA95 K97 S150 D190 K192
ATPATP1s9jAA95 K97 S150 K192
ATPATP3dv3AA95 K97 S150 K192
ATPATP3dy7AA95 K97 S150 K192
ATPATP3e8nAA95 K97 S150 K192
ATPATP3eqbAA95 K97 S150 K192
ADPADP3eqgAA95 K97 S150 K192
ADPADP3eqhAA95 K97 S150 K192
ADPADP3mblAA95 K97 S150 K192
ANPAMP-PNP3ornAA95 K97 S150 K192
ATPATP3os3AA95 K97 S150 K192
ATPATP3pp1AA95 K97 S150 K192
ATPATP3v01AA95 K97 S150 K192
ATPATP3v04AA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4an2AA95 K97 S150 K192
ATPATP4an3AA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4an9AA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4anbAA95 K97 S150 K192
ADPADP4arkAA95 K97 S150 K192
ATPATP3vvhAA95 K97 S150 K192
ATPATP3vvhBA95 K97 S150 K192
ATPATP3vvhCA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4mneAA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4mneDA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4mneEA95 K97 S150 K192
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4mneHA95 K97 S150 K192
ANPAMP-PNP4u7zAA95 K97 S150 K192
ANPAMP-PNP4u80AA95 K97 S150 K192
ANPAMP-PNP4u81AA95 K97 S150 K192
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3eqcAA95 K97 S150 K192 G225
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3eqdAA95 K97 S150 K192 G225
AGSADENOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE3w8qAA95 K97 V127 S150
ATPATP2p55AA95 K97 V127 S150 K192
5EZ7-CHORO-6-(PYRROLIDIN-3-YLMETHOXY)-2H- ISOQUINOLIN-1-ONE3zlxAA95 S150
MGMAGNESIUM(2+)3eqfAD190
CACALCIUM(2+)3eqcAD66
CACALCIUM(2+)3eqdAD66
CACALCIUM(2+)3eqfAD66
CACALCIUM(2+)3eqgAD66
CACALCIUM(2+)3eqhAD66
CACALCIUM(2+)3eqiAD66
5737-FLUORO-3-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-{[(2S)-2- HYDROXYPROPYL]OXY}FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4mneHH119
MGMAGNESIUM(2+)1s9jAK97
MGMAGNESIUM(2+)3eqbAK97
MGMAGNESIUM(2+)3mblAK97
MGMAGNESIUM(2+)3slsAK97
MGMAGNESIUM(2+)3slsBK97
MGMAGNESIUM(2+)3v01AK97
MGMAGNESIUM(2+)3v04AK97
MGMAGNESIUM(2+)4mneAK97
BBM5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE1s9jAK97 V127
MRA2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE2p55AK97 V127
MEK3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-(2-HYDROXYETHOXY)-5-[(2-HYDROXYETHOXY)METHYL]BENZAMIDE3dv3AK97 V127
1CX(5S)-4,5-DIFLUORO-6-[(2-FLUORO-4-IODOPHENYL)IMINO]-N-(2-HYDROXYETHOXY)CYCLOHEXA-1,3-DIENE-1-CARBOXAMIDE3dy7AK97 V127
LUGN-(5-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]PHENYL}-1,3,4-OXADIAZOL-2-YL)ETHANE-1,2-DIAMINE3eqbAK97 V127
3BM2-[(2-CHLORO-4-IODOPHENYL)AMINO]-N-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3,4-DIFLUOROBENZAMIDE3eqcAK97 V127
4BMN-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE3eqgAK97 V127
LSG5-ACETYL-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-(2-HYDROXYETHOXY)-1-METHYL-1H-PYRROLE-3-CARBOXAMIDE3mblAK97 V127
3OR3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-(2-HYDROXYETHOXY)-5-[(3-OXO-1,2-OXAZINAN-2-YL)METHYL]BENZAMIDE3ornAK97 V127
IZG3-[(2R)-2,3-DIHYDROXYPROPYL]-6-FLUORO-5-[(2-FLUORO-4-IODOPHENYL)AMINO]-8-METHYLPYRIDO[2,3-D]PYRIMIDINE-4,7(3H,8H)-DIONE3pp1AK97 V127
77D2-[(2-FLUORO-4-IODOPHENYL)AMINO]-5,5-DIMETHYL-8-OXO-N-[(3R)-PIPERIDIN-3-YL]-5,6,7,8-TETRAHYDRO-4H-THIENO[2,3-C]AZEPINE-3-CARBOXAMIDE3slsAK97 V127
77D2-[(2-FLUORO-4-IODOPHENYL)AMINO]-5,5-DIMETHYL-8-OXO-N-[(3R)-PIPERIDIN-3-YL]-5,6,7,8-TETRAHYDRO-4H-THIENO[2,3-C]AZEPINE-3-CARBOXAMIDE3slsBK97 V127
3V0N-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3-[(2-FLUORO-4-IODOPHENYL)AMINO]FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE3v01AK97 V127
V044-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-(2-HYDROXYETHOXY)-1H-INDAZOLE-5-CARBOXAMIDE3v04AK97 V127
5Y0N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2- FLUORO-4-IODOPHENYL)AMINO]BENZAMIDEN-[(2S)-2,3-BIS(OXIDANYL)PROPOXY]-3,4- BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL) AMINO]BENZAMIDE4an3AK97 V127
4BMN-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE3vvhAK97 V127
4BMN-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE3vvhBK97 V127
4BMN-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE3vvhCK97 V127
5737-FLUORO-3-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-{[(2S)-2- HYDROXYPROPYL]OXY}FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4mneAK97 V127
5737-FLUORO-3-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-{[(2S)-2- HYDROXYPROPYL]OXY}FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4mneDK97 V127
5737-FLUORO-3-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-{[(2S)-2- HYDROXYPROPYL]OXY}FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4mneEK97 V127
5737-FLUORO-3-[(2-FLUORO-4-IODOPHENYL)AMINO]-N-{[(2S)-2- HYDROXYPROPYL]OXY}FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4mneHK97 V127
3EW5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2- HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE4u7zAK97 V127
3EX3-[(4-CYCLOPROPYL-2-FLUOROPHENYL)AMINO]-N-(2- HYDROXYETHOXY)FURO[3,2-C]PYRIDINE-2-CARBOXAMIDE4u80AK97 V127
3EY8-[(4-CYCLOPROPYL-2-FLUOROPHENYL)AMINO]-N-(2- HYDROXYETHOXY)IMIDAZO[1,5-A]PYRIDINE-7-CARBOXAMIDE4u81AK97 V127
VRAN-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[(2S)-2,3-DIHYDROXYPROPYL]CYCLOPROPANESULFONAMIDE3e8nAK97 V127 D190
5BM(2Z)-BIS{AMINO[(2-AMINOPHENYL)SULFANYL]METHYLIDENE}BUTANEDINITRILE3eqhAK97 V127 D190
2P7[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4- IODANYL-PHENYL)AMINO]PHENYL]-(3-OXIDANYLAZETIDIN-1- YL)METHANONE4an9AK97 V127 D190
YQY[3-(AMINOMETHYL)-3-OXIDANYL-AZETIDIN-1-YL]- [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL- PHENYL)AMINO]PHENYL]METHANONE4anbAK97 V127 D190
M3K2-([3R-3,4-DIHYDROXYBUTYL]OXY)-4-FLUORO-6- [(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE4arkAK97 V127 D190
EUI[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL) AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2- YL]AZETIDIN-1-YL]METHANONE4lmnAK97 V127 D190
EUI[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4- IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)- PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE4an2AK97 V127 D190 G225
3OS2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)-5-{[(2-HYDROXYETHOXY)IMINO]METHYL}BENZAMIDE3os3AK97 V127 R234


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Conservation information for LBS of MAP2K1
Multiple alignments for Q02750 in multiple species
LBSAA sequence# speciesSpecies
A76ISELGAGNGGV4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
A76IKVIGKGSSGN1Arabidopsis thaliana
A76VKVIGKGSSGV1Arabidopsis thaliana
A76VRHLGEGNGGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A76EGELGHGNGGV1Caenorhabditis elegans
A76LGELGSGNGGV1Drosophila melanogaster
A95SGLVMARKLIH4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
A95TQQFFALKVIQ1Arabidopsis thaliana
A95TGQFFALKVIQ1Arabidopsis thaliana
A95-NIFMARKTVY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A95TGVIMARKLVH1Caenorhabditis elegans
A95THLIMARKLIH1Drosophila melanogaster
C207GEIKLCDFGVS6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Pan troglodytes, Rattus norvegicus, Mus musculus
C207GEVKITDFGVS2Arabidopsis thaliana, Arabidopsis thaliana
C207GEIKICDFGVS1Drosophila melanogaster
D152DGGSLDQVLKK4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
D152DGGSLADLLKK1Arabidopsis thaliana
D152DGGSLADFLKS1Arabidopsis thaliana
D152DCGSLDAILRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D152DGLSLDIVLKK1Caenorhabditis elegans
D152DGGSLDLILKR1Drosophila melanogaster
D190KIMHRDVKPSN3Homo sapiens, Rattus norvegicus, Mus musculus
D190HIIHRDLKPSN2Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D190RIIHRDLKPSN1Arabidopsis thaliana
D190KILHRDVKPSN1Caenorhabditis elegans
D190AIIHRDVKPSN1Drosophila melanogaster
D190KIMHRDVQPSN1Pan troglodytes
D208EIKLCDFGVSG6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Pan troglodytes, Rattus norvegicus, Mus musculus
D208EVKITDFGVSK1Arabidopsis thaliana
D208EVKITDFGVST1Arabidopsis thaliana
D208EIKICDFGVSG1Drosophila melanogaster
D65VGELKDDDFEK4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
D65DNQLSLADLEV1Arabidopsis thaliana
D65DDQLSLSDLDM1Arabidopsis thaliana
D65ISDLDNSSLEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D65IKELSEDMLQT1Caenorhabditis elegans
D65IGELSDEDLEK1Drosophila melanogaster
D66GELKDDDFEKI4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
D66NQLSLADLEVI1Arabidopsis thaliana
D66DQLSLSDLDMV1Arabidopsis thaliana
D66SDLDNSSLEVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D66KELSEDMLQTE1Caenorhabditis elegans
D66GELSDEDLEKL1Drosophila melanogaster
E144ISICMEHMDGG4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
E144VSIILEFMDGG1Arabidopsis thaliana
E144ISLILEYMDGG1Arabidopsis thaliana
E144ISLCMEYMDCG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E144ISICMEYMDGL1Caenorhabditis elegans
E144ISICMEYMDGG1Drosophila melanogaster
F209IKLCDFGVSGQ4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
F209VKITDFGVSKI1Arabidopsis thaliana
F209VKITDFGVSTV1Arabidopsis thaliana
F209IKLCDFGVSGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F209IKLCDFGVSGM1Caenorhabditis elegans
F209IKICDFGVSGQ1Drosophila melanogaster
G128SPYIVGFYGAF5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Pan troglodytes, Rattus norvegicus, Mus musculus
G128CPYLVSCYQSF1Arabidopsis thaliana
G128CPNLVTSYQSF1Arabidopsis thaliana
G128SPFIVGFYGAF1Caenorhabditis elegans
G128FPHIVGFYGAF1Drosophila melanogaster
G149EHMDGGSLDQV4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G149EFMDGGSLADL1Arabidopsis thaliana
G149EYMDGGSLADF1Arabidopsis thaliana
G149EYMDCGSLDAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G149EYMDGLSLDIV1Caenorhabditis elegans
G149EYMDGGSLDLI1Drosophila melanogaster
G210KLCDFGVSGQL4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G210KITDFGVSKIL1Arabidopsis thaliana
G210KITDFGVSTVM1Arabidopsis thaliana
G210KLCDFGVSGEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G210KLCDFGVSGML1Caenorhabditis elegans
G210KICDFGVSGQL1Drosophila melanogaster
G225ANSFVGTRSYM6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
G225ANSFVGTYPYM1Arabidopsis thaliana
G225ANTFVGTYNYM1Arabidopsis thaliana
G225AQTFVGTSTYM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G75KISELGAGNGG4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G75VIKVIGKGSSG1Arabidopsis thaliana
G75MVKVIGKGSSG1Arabidopsis thaliana
G75VVRHLGEGNGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G75TEGELGHGNGG1Caenorhabditis elegans
G75KLGELGSGNGG1Drosophila melanogaster
G77SELGAGNGGVV4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G77KVIGKGSSGNV1Arabidopsis thaliana
G77KVIGKGSSGVV1Arabidopsis thaliana
G77RHLGEGNGGAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G77GELGHGNGGVV1Caenorhabditis elegans
G77GELGSGNGGVV1Drosophila melanogaster
G79LGAGNGGVVFK4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G79IGKGSSGNVQL1Arabidopsis thaliana
G79IGKGSSGVVQL1Arabidopsis thaliana
G79LGEGNGGAVSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G79LGHGNGGVVNK1Caenorhabditis elegans
G79LGSGNGGVVMK1Drosophila melanogaster
G80GAGNGGVVFKV4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
G80GKGSSGNVQLV1Arabidopsis thaliana
G80GKGSSGVVQLV1Arabidopsis thaliana
G80GEGNGGAVSLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G80GHGNGGVVNKC1Caenorhabditis elegans
G80GSGNGGVVMKV1Drosophila melanogaster
H119ELQVLHECNSP4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
H119ELRINLSSQCP1Arabidopsis thaliana
H119ELKINQSSQCP1Arabidopsis thaliana
H119ELGVLHHCRSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H119ELAVLHKCNSP1Caenorhabditis elegans
H119ELKVLHECNFP1Drosophila melanogaster
H145SICMEHMDGGS4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
H145SIILEFMDGGS1Arabidopsis thaliana
H145SLILEYMDGGS1Arabidopsis thaliana
H145SLCMEYMDCGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H145SICMEYMDGLS1Caenorhabditis elegans
H145SICMEYMDGGS1Drosophila melanogaster
H188KHKIMHRDVKP3Homo sapiens, Rattus norvegicus, Mus musculus
H188ERRIIHRDLKP1Arabidopsis thaliana
H188DRHIIHRDLKP1Arabidopsis thaliana
H188VLHIIHRDLKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H188EIKILHRDVKP1Caenorhabditis elegans
H188NHAIIHRDVKP1Drosophila melanogaster
H188KHKIMHRDVQP1Pan troglodytes
H87VFKVSHKPSGL4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
H87VQLVKHKLTQQ1Arabidopsis thaliana
H87VQLVQHKWTGQ1Arabidopsis thaliana
H87VSLVKHR--NI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H87VNKCVHRKTGV1Caenorhabditis elegans
H87VMKVRHTHTHL1Drosophila melanogaster
I141DGEISICMEHM4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
I141NGLVSIILEFM1Arabidopsis thaliana
I141NGAISLILEYM1Arabidopsis thaliana
I141KNNISLCMEYM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I141NNDISICMEYM1Caenorhabditis elegans
I141DGEISICMEYM1Drosophila melanogaster
I216VSGQLID--SM5Homo sapiens, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
I216VSKILTSTSSL1Arabidopsis thaliana
I216VSTVMTNTAGL1Arabidopsis thaliana
I216VSGELVN--SV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I216VSGMLID--SM1Caenorhabditis elegans
I99MARKLIHLEIK4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
I99FALKVIQLNTE1Arabidopsis thaliana
I99FALKVIQLNID1Arabidopsis thaliana
I99MARKTVYVGSD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I99MARKLVHLEIK1Caenorhabditis elegans
I99MARKLIHLEVK1Drosophila melanogaster
K192MHRDVKPSNIL3Homo sapiens, Rattus norvegicus, Mus musculus
K192IHRDLKPSNLL2Arabidopsis thaliana, Arabidopsis thaliana
K192IHRDLKPSNVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K192LHRDVKPSNML1Caenorhabditis elegans
K192IHRDVKPSNIL1Drosophila melanogaster
K192MHRDVQPSNIL1Pan troglodytes
K97LVMARKLIHLE4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
K97QFFALKVIQLN2Arabidopsis thaliana, Arabidopsis thaliana
K97IFMARKTVYVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K97VIMARKLVHLE1Caenorhabditis elegans
K97LIMARKLIHLE1Drosophila melanogaster
L115QIIRELQVLHE4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
L115AISQELRINLS1Arabidopsis thaliana
L115AIAQELKINQS1Arabidopsis thaliana
L115QILRELGVLHH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L115QIVKELAVLHK1Caenorhabditis elegans
L115QILRELKVLHE1Drosophila melanogaster
L118RELQVLHECNS4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
L118QELRINLSSQC1Arabidopsis thaliana
L118QELKINQSSQC1Arabidopsis thaliana
L118RELGVLHHCRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L118KELAVLHKCNS1Caenorhabditis elegans
L118RELKVLHECNF1Drosophila melanogaster
L197KPSNILVNSRG3Homo sapiens, Rattus norvegicus, Mus musculus
L197KPSNLLINHRG2Arabidopsis thaliana, Arabidopsis thaliana
L197KPSNVVVNSRG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L197KPSNMLVNSNG1Caenorhabditis elegans
L197KPSNILVNSSG1Drosophila melanogaster
L197QPSNILVNSRG1Pan troglodytes
L215GVSGQLID--S5Homo sapiens, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
L215GVSKILTSTSS1Arabidopsis thaliana
L215GVSTVMTNTAG1Arabidopsis thaliana
L215GVSGELVN--S1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L215GVSGMLID--S1Caenorhabditis elegans
L74EKISELGAGNG4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
L74EVIKVIGKGSS1Arabidopsis thaliana
L74DMVKVIGKGSS1Arabidopsis thaliana
L74EVVRHLGEGNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L74QTEGELGHGNG1Caenorhabditis elegans
L74EKLGELGSGNG1Drosophila melanogaster
L92HKPSGLVMARK4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
L92HKLTQQFFALK1Arabidopsis thaliana
L92HKWTGQFFALK1Arabidopsis thaliana
L92HR--NIFMARK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L92HRKTGVIMARK1Caenorhabditis elegans
L92HTHTHLIMARK1Drosophila melanogaster
M143EISICMEHMDG4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
M143LVSIILEFMDG1Arabidopsis thaliana
M143AISLILEYMDG1Arabidopsis thaliana
M143NISLCMEYMDC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M143DISICMEYMDG1Caenorhabditis elegans
M143EISICMEYMDG1Drosophila melanogaster
M146ICMEHMDGGSL4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
M146IILEFMDGGSL1Arabidopsis thaliana
M146LILEYMDGGSL1Arabidopsis thaliana
M146LCMEYMDCGSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M146ICMEYMDGLSL1Caenorhabditis elegans
M146ICMEYMDGGSL1Drosophila melanogaster
M219ID--SMANSFV6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
M219TSTSSLANSFV1Arabidopsis thaliana
M219TNTAGLANTFV1Arabidopsis thaliana
M219VN--SVAQTFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M94PSGLVMARKLI4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
M94LTQQFFALKVI1Arabidopsis thaliana
M94WTGQFFALKVI1Arabidopsis thaliana
M94--NIFMARKTV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M94KTGVIMARKLV1Caenorhabditis elegans
M94HTHLIMARKLI1Drosophila melanogaster
N195DVKPSNILVNS4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
N195DLKPSNLLINH2Arabidopsis thaliana, Arabidopsis thaliana
N195DLKPSNVVVNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N195DVKPSNMLVNS1Caenorhabditis elegans
N195DVQPSNILVNS1Pan troglodytes
N221--SMANSFVGT6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
N221TSSLANSFVGT1Arabidopsis thaliana
N221TAGLANTFVGT1Arabidopsis thaliana
N221--SVAQTFVGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N78ELGAGNGGVVF4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
N78VIGKGSSGNVQ1Arabidopsis thaliana
N78VIGKGSSGVVQ1Arabidopsis thaliana
N78HLGEGNGGAVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N78ELGHGNGGVVN1Caenorhabditis elegans
N78ELGSGNGGVVM1Drosophila melanogaster
Q153GGSLDQVLKKA4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
Q153GGSLADLLKKV1Arabidopsis thaliana
Q153GGSLADFLKSV1Arabidopsis thaliana
Q153CGSLDAILREG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q153GLSLDIVLKKV1Caenorhabditis elegans
Q153GGSLDLILKRA1Drosophila melanogaster
R189HKIMHRDVKPS3Homo sapiens, Rattus norvegicus, Mus musculus
R189RRIIHRDLKPS1Arabidopsis thaliana
R189RHIIHRDLKPS1Arabidopsis thaliana
R189LHIIHRDLKPS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R189IKILHRDVKPS1Caenorhabditis elegans
R189HAIIHRDVKPS1Drosophila melanogaster
R189HKIMHRDVQPS1Pan troglodytes
R234YMSPERLQGTH4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
R234YMSPERISGSL1Arabidopsis thaliana
R234YMSPERIVGNK1Arabidopsis thaliana
R234YMSPERIRGGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R234YMAPERLTGSH1Caenorhabditis elegans
R234YMSPERFQGTH1Pan troglodytes
S150HMDGGSLDQVL4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
S150FMDGGSLADLL1Arabidopsis thaliana
S150YMDGGSLADFL1Arabidopsis thaliana
S150YMDCGSLDAIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S150YMDGLSLDIVL1Caenorhabditis elegans
S150YMDGGSLDLIL1Drosophila melanogaster
S194RDVKPSNILVN4Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus
S194RDLKPSNLLIN2Arabidopsis thaliana, Arabidopsis thaliana
S194RDLKPSNVVVN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S194RDVKPSNMLVN1Caenorhabditis elegans
S194RDVQPSNILVN1Pan troglodytes
S212CDFGVSGQLID5Homo sapiens, Drosophila melanogaster, Pan troglodytes, Rattus norvegicus, Mus musculus
S212TDFGVSKILTS1Arabidopsis thaliana
S212TDFGVSTVMTN1Arabidopsis thaliana
S212CDFGVSGELVN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S212CDFGVSGMLID1Caenorhabditis elegans
V127NSPYIVGFYGA4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
V127QCPYLVSCYQS1Arabidopsis thaliana
V127QCPNLVTSYQS1Arabidopsis thaliana
V127RSPYIVGFYGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V127NSPFIVGFYGA1Caenorhabditis elegans
V127NFPHIVGFYGA1Drosophila melanogaster
V211LCDFGVSGQLI4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
V211ITDFGVSKILT1Arabidopsis thaliana
V211ITDFGVSTVMT1Arabidopsis thaliana
V211LCDFGVSGELV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V211LCDFGVSGMLI1Caenorhabditis elegans
V211ICDFGVSGQLI1Drosophila melanogaster
V82GNGGVVFKVSH4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
V82GSSGNVQLVKH1Arabidopsis thaliana
V82GSSGVVQLVQH1Arabidopsis thaliana
V82GNGGAVSLVKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V82GNGGVVNKCVH1Caenorhabditis elegans
V82GNGGVVMKVRH1Drosophila melanogaster
Y130YIVGFYGAFYS4Homo sapiens, Pan troglodytes, Rattus norvegicus, Mus musculus
Y130YLVSCYQSFYH1Arabidopsis thaliana
Y130NLVTSYQSFYD1Arabidopsis thaliana
Y130YIVGFYGAFQY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y130FIVGFYGAFVD1Caenorhabditis elegans
Y130HIVGFYGAFYS1Drosophila melanogaster


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