mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAP2K6
Gene summary
Basic gene Info.Gene symbolMAP2K6
Gene namemitogen-activated protein kinase kinase 6
SynonymsMAPKK6|MEK6|MKK6|PRKMK6|SAPKK-3|SAPKK3
CytomapUCSC genome browser: 17q24.3
Type of geneprotein-coding
RefGenesNM_002758.3,
NM_031988.1,
DescriptionMAPK/ERK kinase 6MAPKK 6MEK 6SAPK kinase 3dual specificity mitogen-activated protein kinase kinase 6protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)stress-activated protein kinase kinase 3
Modification date20141222
dbXrefs MIM : 601254
HGNC : HGNC
HPRD : 03155
ProteinUniProt: P52564
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAP2K6
BioGPS: 5608
PathwayNCI Pathway Interaction Database: MAP2K6
KEGG: MAP2K6
REACTOME: MAP2K6
Pathway Commons: MAP2K6
ContextiHOP: MAP2K6
ligand binding site mutation search in PubMed: MAP2K6
UCL Cancer Institute: MAP2K6
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MAP2K6

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K82R83QUCEC2
N184N184DCOAD1
K210K210RSTAD1
D197D197NUCEC1
K138K138TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MAP2K6
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D197D197N-1.3326661
K138K138T-0.72483593
K210K210R-0.65102835
N184N184D-0.64886155
K82R83Q-0.54731131
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAP2K6 from PDB
PDB IDPDB titlePDB structure
3VN9Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

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Differential gene expression and gene-gene network for MAP2K6
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAP2K6 and the right PPI network was created from samples without mutations in the LBS of MAP2K6. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAP2K6
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0009375Colonic Neoplasms1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAP2K6
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAP2K6 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ANK9-{5-O-[(R)-HYDROXY{[(S)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-L-RIBOFURANOSYL}-9H-PURIN-6-AMINE3vn9AK82 K138 N184 D197 K210
MGMAGNESIUM(2+)3vn9AN184 D197


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Conservation information for LBS of MAP2K6
Multiple alignments for P52564 in multiple species
LBSAA sequence# speciesSpecies
A63ELGRGAYGVVE3Homo sapiens, Mus musculus, Bos taurus
A63ELGKGGYGIVE1Caenorhabditis elegans
A80SGQIMAVKRIR2Homo sapiens, Mus musculus
A80SGIIMAVKRIK1Caenorhabditis elegans
A80SEQIMAVKRIR1Bos taurus
C196GQVKMCDFGIS3Homo sapiens, Mus musculus, Bos taurus
C196GQVKICDFGIS1Caenorhabditis elegans
D133CMELMDTSLDK3Homo sapiens, Mus musculus, Bos taurus
D133CMEVMDTSLDK1Caenorhabditis elegans
D137MDTSLDKFYKQ3Homo sapiens, Mus musculus, Bos taurus
D137MDTSLDKFYRH1Caenorhabditis elegans
D179SVIHRDVKPSN3Homo sapiens, Mus musculus, Bos taurus
D179NLIHRDVKPSN1Caenorhabditis elegans
D197QVKMCDFGISG3Homo sapiens, Mus musculus, Bos taurus
D197QVKICDFGISG1Caenorhabditis elegans
E130VWICMELMDTS3Homo sapiens, Mus musculus, Bos taurus
E130VWICMEVMDTS1Caenorhabditis elegans
G60PIVELGRGAYG2Mus musculus, Bos taurus
G60PIMELGRGAYG1Homo sapiens
G60VLEELGKGGYG1Caenorhabditis elegans
K138DTSLDKFYKQV3Homo sapiens, Mus musculus, Bos taurus
K138DTSLDKFYRHA1Caenorhabditis elegans
K181IHRDVKPSNVL3Homo sapiens, Mus musculus, Bos taurus
K181IHRDVKPSNIL1Caenorhabditis elegans
K210VDSVAKTIDAG3Homo sapiens, Mus musculus, Bos taurus
K210TNSMAKTVQAG1Caenorhabditis elegans
K82QIMAVKRIRAT3Homo sapiens, Mus musculus, Bos taurus
K82IIMAVKRIKSS1Caenorhabditis elegans
L131WICMELMDTSL3Homo sapiens, Mus musculus, Bos taurus
L131WICMEVMDTSL1Caenorhabditis elegans
L186KPSNVLINALG2Homo sapiens, Bos taurus
L186KPSNILLNRHG1Caenorhabditis elegans
L186KPSNVLINTLG1Mus musculus
L59EPIVELGRGAY2Mus musculus, Bos taurus
L59EPIMELGRGAY1Homo sapiens
L59VVLEELGKGGY1Caenorhabditis elegans
M129DVWICMELMDT3Homo sapiens, Mus musculus, Bos taurus
M129DVWICMEVMDT1Caenorhabditis elegans
M132ICMELMDTSLD3Homo sapiens, Mus musculus, Bos taurus
M132ICMEVMDTSLD1Caenorhabditis elegans
N184DVKPSNVLINA2Homo sapiens, Bos taurus
N184DVKPSNILLNR1Caenorhabditis elegans
N184DVKPSNVLINT1Mus musculus
S135ELMDTSLDKFY3Homo sapiens, Mus musculus, Bos taurus
S135EVMDTSLDKFY1Caenorhabditis elegans
S183RDVKPSNVLIN3Homo sapiens, Mus musculus, Bos taurus
S183RDVKPSNILLN1Caenorhabditis elegans
T134MELMDTSLDKF3Homo sapiens, Mus musculus, Bos taurus
T134MEVMDTSLDKF1Caenorhabditis elegans
V67GAYGVVEKMRH3Homo sapiens, Mus musculus, Bos taurus
V67GGYGIVEKMQH1Caenorhabditis elegans
Y64LGRGAYGVVEK3Homo sapiens, Mus musculus, Bos taurus
Y64LGKGGYGIVEK1Caenorhabditis elegans


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