mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAP2K7
Gene summary
Basic gene Info.Gene symbolMAP2K7
Gene namemitogen-activated protein kinase kinase 7
CytomapUCSC genome browser: 19p13.3-p13.2
Type of geneprotein-coding
DescriptionJNK-activating kinase 2MAP kinase kinase 7MAPK/ERK kinase 7SAPK kinase 4c-Jun N-terminal kinase kinase 2dual specificity mitogen-activated protein kinase kinase 7stress-activated protein kinase kinase 4
Modification date20141207
dbXrefs MIM : 603014
Ensembl : ENSG00000076984
Vega : OTTHUMG00000137368
ProteinUniProt: O14733
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAP2K7
BioGPS: 5609
PathwayNCI Pathway Interaction Database: MAP2K7
Pathway Commons: MAP2K7
ContextiHOP: MAP2K7
ligand binding site mutation search in PubMed: MAP2K7
UCL Cancer Institute: MAP2K7
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006970response to osmotic stress9535930
GO:0009408response to heat9535930
GO:0009411response to UV9535930
GO:0034612response to tumor necrosis factor9535930
GO:0051403stress-activated MAPK cascade9535930

Ligand binding site mutations for MAP2K7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MAP2K7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAP2K7 from PDB

Differential gene expression and gene-gene network for MAP2K7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAP2K7 and the right PPI network was created from samples without mutations in the LBS of MAP2K7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MAP2K7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms3AlteredExpression, Biomarker
umls:C0024121Lung Neoplasms2AlteredExpression, Biomarker
umls:C0018801Heart Failure1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0032927Precancerous Conditions1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MAP2K7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAP2K7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of MAP2K7
Multiple alignments for O14733 in multiple species
LBSAA sequence# speciesSpecies
C202ELMGTCAEKLK3Homo sapiens, Mus musculus, Rattus norvegicus
C202ECMATCLDRLL1Caenorhabditis elegans
C202ELMSMCFDKLL1Drosophila melanogaster
E197VFIAMELMGTC3Homo sapiens, Mus musculus, Rattus norvegicus
E197VRVCMECMATC1Caenorhabditis elegans
E197VWICMELMSMC1Drosophila melanogaster
G127NLGEMGSGTCG3Homo sapiens, Mus musculus, Rattus norvegicus
G127FVEDIGHGSCG1Caenorhabditis elegans
G127HLGDLGNGTSG1Drosophila melanogaster
G129GEMGSGTCGQV3Homo sapiens, Mus musculus, Rattus norvegicus
G129EDIGHGSCGTV1Caenorhabditis elegans
G129GDLGNGTSGNV1Drosophila melanogaster
K149HIIAVKQMRRS2Mus musculus, Rattus norvegicus
K149HVIAVKQMRRS1Homo sapiens
K149-IMAVKTMPRT1Caenorhabditis elegans
K149TIIAVKQMRRT1Drosophila melanogaster
K205GTCAEKLKKRM3Homo sapiens, Mus musculus, Rattus norvegicus
K205ATCLDRLLIRI1Caenorhabditis elegans
K205SMCFDKLLKLS1Drosophila melanogaster
L250KPSNILLDERG3Homo sapiens, Mus musculus, Rattus norvegicus
L250KPSNILLDWSG1Caenorhabditis elegans
L250KPSNILIDERG1Drosophila melanogaster
M126ENLGEMGSGTC3Homo sapiens, Mus musculus, Rattus norvegicus
M126QFVEDIGHGSC1Caenorhabditis elegans
M126KHLGDLGNGTS1Drosophila melanogaster
M196DVFIAMELMGT3Homo sapiens, Mus musculus, Rattus norvegicus
M196DVRVCMECMAT1Caenorhabditis elegans
M196DVWICMELMSM1Drosophila melanogaster
M199IAMELMGTCAE3Homo sapiens, Mus musculus, Rattus norvegicus
M199VCMECMATCLD1Caenorhabditis elegans
M199ICMELMSMCFD1Drosophila melanogaster
S247RDVKPSNILLD4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
S247RDVKPSNILID1Drosophila melanogaster
T130EMGSGTCGQVW3Homo sapiens, Mus musculus, Rattus norvegicus
T130DIGHGSCGTVT1Caenorhabditis elegans
T130DLGNGTSGNVV1Drosophila melanogaster

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