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mutLBSgeneDB |
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| Gene summary for MAP2K7 |
 Gene summary |
| Basic gene Info. | Gene symbol | MAP2K7 |
| Gene name | mitogen-activated protein kinase kinase 7 | |
| Synonyms | JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 | |
| Cytomap | UCSC genome browser: 19p13.3-p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001297555.1, NM_001297556.1,NM_145185.3, | |
| Description | JNK-activating kinase 2MAP kinase kinase 7MAPK/ERK kinase 7SAPK kinase 4c-Jun N-terminal kinase kinase 2dual specificity mitogen-activated protein kinase kinase 7stress-activated protein kinase kinase 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603014 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000076984 | ||
| Vega : OTTHUMG00000137368 | ||
| Protein | UniProt: O14733 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MAP2K7 | |
| BioGPS: 5609 | ||
| Pathway | NCI Pathway Interaction Database: MAP2K7 | |
| KEGG: MAP2K7 | ||
| REACTOME: MAP2K7 | ||
| Pathway Commons: MAP2K7 | ||
| Context | iHOP: MAP2K7 | |
| ligand binding site mutation search in PubMed: MAP2K7 | ||
| UCL Cancer Institute: MAP2K7 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006970 | response to osmotic stress | 9535930 | GO:0009408 | response to heat | 9535930 | GO:0009411 | response to UV | 9535930 | GO:0034612 | response to tumor necrosis factor | 9535930 | GO:0051403 | stress-activated MAPK cascade | 9535930 |
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| Ligand binding site mutations for MAP2K7 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S247 | N248S | COAD | 1 | G129 | G129D | LUAD | 1 | G129 | G129S | STAD | 1 | E197 | E197D | STAD | 1 | T130 | G132S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MAP2K7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T130 | G132S | -0.88953864 | E197 | E197D | -0.65276383 | S247 | N248S | -0.18168097 | G129 | G129D | -0.083376763 | G129 | G129S | -0.02472176 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MAP2K7 from PDB |
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| Differential gene expression and gene-gene network for MAP2K7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MAP2K7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 3 | AlteredExpression, Biomarker |
| umls:C0024121 | Lung Neoplasms | 2 | AlteredExpression, Biomarker |
| umls:C0016059 | Fibrosis | 1 | Biomarker |
| umls:C0018801 | Heart Failure | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0032927 | Precancerous Conditions | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MAP2K7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MAP2K7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of MAP2K7 |
| Multiple alignments for O14733 in multiple species |
| LBS | AA sequence | # species | Species | C202 | ELMGTCAEKLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C202 | ECMATCLDRLL | 1 | Caenorhabditis elegans | C202 | ELMSMCFDKLL | 1 | Drosophila melanogaster | E197 | VFIAMELMGTC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E197 | VRVCMECMATC | 1 | Caenorhabditis elegans | E197 | VWICMELMSMC | 1 | Drosophila melanogaster | G127 | NLGEMGSGTCG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G127 | FVEDIGHGSCG | 1 | Caenorhabditis elegans | G127 | HLGDLGNGTSG | 1 | Drosophila melanogaster | G129 | GEMGSGTCGQV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G129 | EDIGHGSCGTV | 1 | Caenorhabditis elegans | G129 | GDLGNGTSGNV | 1 | Drosophila melanogaster | K149 | HIIAVKQMRRS | 2 | Mus musculus, Rattus norvegicus | K149 | HVIAVKQMRRS | 1 | Homo sapiens | K149 | -IMAVKTMPRT | 1 | Caenorhabditis elegans | K149 | TIIAVKQMRRT | 1 | Drosophila melanogaster | K205 | GTCAEKLKKRM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K205 | ATCLDRLLIRI | 1 | Caenorhabditis elegans | K205 | SMCFDKLLKLS | 1 | Drosophila melanogaster | L250 | KPSNILLDERG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L250 | KPSNILLDWSG | 1 | Caenorhabditis elegans | L250 | KPSNILIDERG | 1 | Drosophila melanogaster | M126 | ENLGEMGSGTC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M126 | QFVEDIGHGSC | 1 | Caenorhabditis elegans | M126 | KHLGDLGNGTS | 1 | Drosophila melanogaster | M196 | DVFIAMELMGT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M196 | DVRVCMECMAT | 1 | Caenorhabditis elegans | M196 | DVWICMELMSM | 1 | Drosophila melanogaster | M199 | IAMELMGTCAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M199 | VCMECMATCLD | 1 | Caenorhabditis elegans | M199 | ICMELMSMCFD | 1 | Drosophila melanogaster | S247 | RDVKPSNILLD | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus | S247 | RDVKPSNILID | 1 | Drosophila melanogaster | T130 | EMGSGTCGQVW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T130 | DIGHGSCGTVT | 1 | Caenorhabditis elegans | T130 | DLGNGTSGNVV | 1 | Drosophila melanogaster |
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