mutLBSgeneDB |
Gene summary for PRMT8 |
Gene summary |
Basic gene Info. | Gene symbol | PRMT8 |
Gene name | protein arginine methyltransferase 8 | |
Synonyms | HRMT1L3|HRMT1L4 | |
Cytomap | UCSC genome browser: 12p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001256537.1, NR_046301.1,NM_001256536.1,NM_019854.4, | |
Description | HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4protein arginine N-methyltransferase 4protein arginine N-methyltransferase 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610086 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111218 | ||
HPRD : 11029 | ||
Vega : OTTHUMG00000128493 | ||
Protein | UniProt: Q9NR22 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRMT8 | |
BioGPS: 56341 | ||
Pathway | NCI Pathway Interaction Database: PRMT8 | |
KEGG: PRMT8 | ||
REACTOME: PRMT8 | ||
Pathway Commons: PRMT8 | ||
Context | iHOP: PRMT8 | |
ligand binding site mutation search in PubMed: PRMT8 | ||
UCL Cancer Institute: PRMT8 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0016571 | histone methylation | 16051612 | GO:0018216 | peptidyl-arginine methylation | 16051612 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | 16051612 | GO:0034969 | histone arginine methylation | 16051612 |
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Ligand binding site mutations for PRMT8 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H86 | G84V | GBM | 1 | E141 | G139R | KIRC | 1 | G119 | G119A | OV | 1 | T199 | V200M | SKCM | 1 | G167 | G167D | SKCM | 1 | R95 | R95W | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PRMT8 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R95 | R95W | 0.020867735 | G119 | G119A | -1.086458 | T199 | V200M | -0.98320978 | G167 | G167D | -0.83531851 | E141 | G139R | -0.39272659 | H86 | G84V | -0.27044022 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PRMT8 from PDB |
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Differential gene expression and gene-gene network for PRMT8 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for PRMT8 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PRMT8 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PRMT8 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4x41 | A | H86 R95 G119 E141 G167 T199 |
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Conservation information for LBS of PRMT8 |
Multiple alignments for Q9NR22 in multiple species |
LBS | AA sequence | # species | Species |
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