mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 5645
Gene summary
Basic gene Info.Gene symbol5645
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt: P07477
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_5645
BioGPS: 5645
PathwayNCI Pathway Interaction Database: 5645
KEGG: 5645
REACTOME: 5645
Pathway Commons: 5645
ContextiHOP: 5645
ligand binding site mutation search in PubMed: 5645
UCL Cancer Institute: 5645
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for 5645

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for 5645
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H46H46L0.08926324
V214G212R-1.0508764
V80E79D-1.0170131
I78E79D-1.0170131
V80E79K-0.91625225
I78E79K-0.91625225
I78I78V-0.76739851
G198G198D-0.71626649
E82G83E-0.6704031
E85E85Q-0.66899115
S215S215F-0.65233759
E85E85K-0.61087741
S195S195L-0.33980397
N77N77K-0.27056667
E85N84I-0.12261288
D194K193M-0.070841121
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 5645 from PDB

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Differential gene expression and gene-gene network for 5645
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 5645 and the right PPI network was created from samples without mutations in the LBS of 5645. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for 5645
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for 5645
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01665ZK-800270Small molecule
ExperimentalDB01705Bis(5-Amidino-Benzimidazolyl)MethaneSmall molecule
ExperimentalDB01725CRA_7806Small molecule
ExperimentalDB01737Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-IsopropylesterSmall molecule
ExperimentalDB01741CRA_17693Small molecule
ExperimentalDB01745N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl EsterSmall molecule
ExperimentalDB01767Hemi-BabimSmall molecule
ExperimentalDB01771CRA_10991Small molecule
ExperimentalDB01805MonoisopropylphosphorylserineSmall molecule
ExperimentalDB01836[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-MethanoneSmall molecule
ExperimentalDB01876Bis(5-Amidino-2-Benzimidazolyl)MethanoneSmall molecule
ExperimentalDB019052-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineSmall molecule
ExperimentalDB019395-Amidino-BenzimidazoleSmall molecule
ExperimentalDB02045AmylamineSmall molecule
ExperimentalDB02063CRA_16847Small molecule
ExperimentalDB02081Bis-BenzamidineSmall molecule
ExperimentalDB02084CRA_17312Small molecule
ExperimentalDB02112Zk-806450Small molecule
ExperimentalDB021932-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineSmall molecule
ExperimentalDB02269[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-AmmoniumSmall molecule
ExperimentalDB022872-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-CarboxamidineSmall molecule
ExperimentalDB02288CRA_9334Small molecule
ExperimentalDB023544-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-BenzamidineSmall molecule
ExperimentalDB02366CRA_10762Small molecule
ExperimentalDB02435AminomethylcyclohexaneSmall molecule
ExperimentalDB024632-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineSmall molecule
ExperimentalDB02464BenzylamineSmall molecule
ExperimentalDB02526CRA_10655Small molecule
ExperimentalDB02665Trans-2-PhenylcyclopropylamineSmall molecule
ExperimentalDB02744RPR131247Small molecule
ExperimentalDB02812(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-PyrrolidinecarboxamideSmall molecule
ExperimentalDB02875CRA_1802Small molecule
ExperimentalDB02989CRA_10972Small molecule
ExperimentalDB03016CRA_1801Small molecule
ExperimentalDB03081Crc200 (Chiron-Behring)Small molecule
ExperimentalDB03127BenzamidineSmall molecule
ExperimentalDB031364-Iodobenzo[B]Thiophene-2-CarboxamidineSmall molecule
ExperimentalDB03159CRA_8696Small molecule
ExperimentalDB03173CRA_10433Small molecule
ExperimentalDB03213Bis(5-Amidino-2-Benzimidazolyl)Methane KetoneSmall molecule
ExperimentalDB032434-FluorobenzylamineSmall molecule
ExperimentalDB03251RWJ-51084Small molecule
ExperimentalDB033371-(2-Amidinophenyl)-3-(Phenoxyphenyl)UreaSmall molecule
ExperimentalDB03373ZK-806711Small molecule
ExperimentalDB033743,5-DiiodotyrosineSmall molecule
ExperimentalDB034171-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic AcidSmall molecule
ExperimentalDB03443Bis(5-Amidino-Benzimidazolyl)Methanone ZincSmall molecule
ExperimentalDB03494CRA_10950Small molecule
ExperimentalDB03555CRA_11092Small molecule
ExperimentalDB03595CRA_9785Small molecule
ExperimentalDB03608DiminazeneSmall molecule
ExperimentalDB03643CRA_1144Small molecule
ExperimentalDB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineSmall molecule
ExperimentalDB03876Thieno[2,3-B]Pyridine-2-CarboxamidineSmall molecule
ExperimentalDB03976PhosphorylisopropaneSmall molecule
ExperimentalDB04008Bis(5-Amidino-Benzimidazolyl)Methane ZincSmall molecule
ExperimentalDB04107[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl EsterSmall molecule
ExperimentalDB04125N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-PiperazineSmall molecule
ExperimentalDB04215CRA_9076Small molecule
ExperimentalDB04238N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic AcidSmall molecule
ExperimentalDB04246CRA_23653Small molecule
ExperimentalDB04269Cyclotheonamide ASmall molecule
ExperimentalDB04301Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone HydrateSmall molecule
ExperimentalDB043114-PhenylbutylamineSmall molecule
ExperimentalDB043252-PhenylethylamineSmall molecule
ExperimentalDB043361-(4-Amidinophenyl)-3-(4-Chlorophenyl)UreaSmall molecule
ExperimentalDB04391Aeruginosin 98-BSmall molecule
ExperimentalDB044103-PhenylpropylamineSmall molecule
ExperimentalDB04424RPR128515Small molecule
ExperimentalDB04432ZK-805623Small molecule
ExperimentalDB044422-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-CarboxamidineSmall molecule
ExperimentalDB04446Benzo[B]Thiophene-2-CarboxamidineSmall molecule
ExperimentalDB04470CRA_10656Small molecule
ExperimentalDB04563CRA_9678Small molecule
ExperimentalDB046544-PIPERIDIN-4-YLBUTANALSmall molecule
ExperimentalDB047902,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitolSmall molecule
ExperimentalDB047912-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOLSmall molecule
ExperimentalDB047922,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLSmall molecule
ExperimentalDB047932-O-(3'-AMIDINOPHENYL)-5-O-(4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLSmall molecule
Approved|withdrawnDB06692AprotininBiotech
ExperimentalDB06840diethyl [(1R)-1,5-diaminopentyl]boronateSmall molecule
ExperimentalDB06845(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB06850(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB06853N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall molecule
ExperimentalDB06858N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall molecule
ExperimentalDB069182-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDESmall molecule
ExperimentalDB069232-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall molecule
ExperimentalDB07088(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB07091(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB07095(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB07131(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideSmall molecule
ExperimentalDB072293-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATESmall molecule
ExperimentalDB073684-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDESmall molecule
ExperimentalDB074915-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acidSmall molecule
ExperimentalDB07985+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATESmall molecule
ExperimentalDB081842-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall molecule
ExperimentalDB082542-NAPHTHALENESULFONIC ACIDSmall molecule
ExperimentalDB084201-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACIDSmall molecule
ExperimentalDB08763[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 5645 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ISPMONOISOPROPYL PHOSPHATE1trnAD194 S195
ISPMONOISOPROPYL PHOSPHATE1trnBD194 S195
0G6PPACK1fxyAS195


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Conservation information for LBS of 5645
Multiple alignments for P07477 in multiple species
LBSAA sequence# speciesSpecies


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