mutLBSgeneDB |
Gene summary for PRSS3 |
Gene summary |
Basic gene Info. | Gene symbol | PRSS3 |
Gene name | protease, serine, 3 | |
Synonyms | MTG|PRSS4|T9|TRY3|TRY4 | |
Cytomap | UCSC genome browser: 9p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001197097.2, NM_001197098.1,NM_002771.3,NM_007343.3, | |
Description | brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsin-3trypsinogen 4trypsinogen 5trypsinogen IV | |
Modification date | 20141207 | |
dbXrefs | MIM : 613578 | |
HGNC : HGNC | ||
Ensembl : ENSG00000010438 | ||
HPRD : 06685 | ||
Vega : OTTHUMG00000019798 | ||
Protein | UniProt: P35030 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRSS3 | |
BioGPS: 5646 | ||
Pathway | NCI Pathway Interaction Database: PRSS3 | |
KEGG: PRSS3 | ||
REACTOME: PRSS3 | ||
Pathway Commons: PRSS3 | ||
Context | iHOP: PRSS3 | |
ligand binding site mutation search in PubMed: PRSS3 | ||
UCL Cancer Institute: PRSS3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 6698368 | GO:0031638 | zymogen activation | 6698368 |
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Ligand binding site mutations for PRSS3 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Q254 | D255Y | COAD | 1 | S257 | T256I | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PRSS3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PRSS3 from PDB |
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Differential gene expression and gene-gene network for PRSS3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for PRSS3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0005695 | Urinary Bladder Neoplasms | 1 | Biomarker, PostTranslationalModification |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PRSS3 |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB02308 | 4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium | Small molecule | |
Experimental | DB02541 | 4-Hydroxybutan-1-Aminium | Small molecule | |
Experimental | DB02585 | 4-(Hydroxymethyl)Benzamidine | Small molecule | |
Experimental | DB03127 | Benzamidine | Small molecule | |
Experimental | DB03129 | [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine | Small molecule | |
Experimental | DB03637 | Guanidine-3-Propanol | Small molecule | |
Experimental | DB04109 | [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine | Small molecule | |
Experimental | DB04369 | 1,3,2-Dioxaborolan-2-Ol | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PRSS3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of PRSS3 |
Multiple alignments for P35030 in multiple species |
LBS | AA sequence | # species | Species |
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