mutLBSgeneDB |
Gene summary for KLK6 |
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Basic gene Info. | Gene symbol | KLK6 |
Gene name | kallikrein-related peptidase 6 | |
Synonyms | Bssp|Klk7|PRSS18|PRSS9|SP59|hK6 | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001012964.1, NM_001012965.1,NM_002774.3,NM_001012966.1, | |
Description | kallikrein-6neurosinprotease Mserine protease 18serine protease 9zyme | |
Modification date | 20141207 | |
dbXrefs | MIM : 602652 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167755 | ||
HPRD : 04037 | ||
Vega : OTTHUMG00000183098 | ||
Protein | UniProt: Q92876 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLK6 | |
BioGPS: 5653 | ||
Pathway | NCI Pathway Interaction Database: KLK6 | |
KEGG: KLK6 | ||
REACTOME: KLK6 | ||
Pathway Commons: KLK6 | ||
Context | iHOP: KLK6 | |
ligand binding site mutation search in PubMed: KLK6 | ||
UCL Cancer Institute: KLK6 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 |
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Ligand binding site mutations for KLK6 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | V211 | G209D | KIRC | 1 | H62 | A61G | LUSC | 1 | C218,I216 | P217H | LUSC | 1 | F151 | P152S | SKCM | 1 | L45 | H44R | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KLK6 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F151 | P152S | -1.7197944 | H62 | A61G | -1.6386328 | I216 | P217H | -1.5822956 | C218 | P217H | -1.5822956 | V211 | G209D | -0.80880333 | L45 | H44R | -0.5478289 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for KLK6 |
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Phenotype information for KLK6 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KLK6 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB03127 | Benzamidine | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 0HL | 4-{[(3R)-3-{[(7-METHOXYNAPHTHALEN-2-YL) SULFONYL](THIOPHEN-3-YLMETHYL)AMINO}-2-OXOPYRROLIDIN- 1-YL]METHYL}THIOPHENE-2-CARBOXIMIDAMIDE | 3vfe | A | F151 |
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Conservation information for LBS of KLK6 |
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LBS | AA sequence | # species | Species |
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