mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SAR1A
Gene summary
Basic gene Info.Gene symbolSAR1A
Gene namesecretion associated, Ras related GTPase 1A
SynonymsSAR1|SARA1|Sara|masra2
CytomapUCSC genome browser: 10q22.1
Type of geneprotein-coding
RefGenesNM_001142648.1,
NM_020150.4,
DescriptionCOPII-associated small GTPaseGTP-binding protein SAR1aSAR1 gene homolog ASAR1 homolog ASAR1a gene homolog 1
Modification date20141207
dbXrefs MIM : 607691
HGNC : HGNC
Ensembl : ENSG00000079332
HPRD : 07608
Vega : OTTHUMG00000018400
ProteinUniProt: Q9NR31
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SAR1A
BioGPS: 56681
PathwayNCI Pathway Interaction Database: SAR1A
KEGG: SAR1A
REACTOME: SAR1A
Pathway Commons: SAR1A
ContextiHOP: SAR1A
ligand binding site mutation search in PubMed: SAR1A
UCL Cancer Institute: SAR1A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SAR1A
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L181R183TUCEC1
R138D140YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SAR1A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L181R183T-1.2432374
R138D140Y-0.026724808
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SAR1A from PDB

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Differential gene expression and gene-gene network for SAR1A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SAR1A and the right PPI network was created from samples without mutations in the LBS of SAR1A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SAR1A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SAR1A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SAR1A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GDPGUANOSINE-5'-DIPHOSPHATE2gaoAR138 L181
GDPGUANOSINE-5'-DIPHOSPHATE2gaoBR138 L181


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Conservation information for LBS of SAR1A
Multiple alignments for Q9NR31 in multiple species
LBSAA sequence# speciesSpecies
A36LGLDNAGKTTL8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
D137LGNKIDRTDAI2Homo sapiens, Bos taurus
D137LGNKIDIPYAA1Arabidopsis thaliana
D137LGNKIDSPSAV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D137LGNKIDAPNAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D137LGNKIDAPSAV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D137LGNKIDAPGAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D137LGNKIDHPEAI1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
G37GLDNAGKTTLL8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
K135LILGNKIDRTD2Homo sapiens, Bos taurus
K135LILGNKIDIPY1Arabidopsis thaliana
K135AVLGNKIDSPS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K135VILGNKIDAPN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K135VILGNKIDAPS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K135LILGNKIDAPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K135VILGNKIDHPE1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K38LDNAGKTTLLH8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
L181FMCSVLKRQGY2Homo sapiens, Bos taurus
L181FMCSVVMKSGY2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L181FMCSIVRKMGY1Arabidopsis thaliana
L181FMCSVVMRNGY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L181FMCSVVLRQGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L181FMCSVVMRQGY1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N134ILILGNKIDRT2Homo sapiens, Bos taurus
N134FVILGNKIDAP2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N134FLILGNKIDIP1Arabidopsis thaliana
N134FAVLGNKIDSP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N134FLILGNKIDAP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N134FVILGNKIDHP1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N35FLGLDNAGKTT8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
R138GNKIDRTDAIS2Homo sapiens, Bos taurus
R138GNKIDIPYAAS1Arabidopsis thaliana
R138GNKIDSPSAVS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R138GNKIDAPNAVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R138GNKIDAPSAVS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R138GNKIDAPGAIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R138GNKIDHPEAIS1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
S179EVFMCSVLKRQ2Homo sapiens, Bos taurus
S179ELFMCSVVMKS2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S179EVFMCSIVRKM1Arabidopsis thaliana
S179EVFMCSVVMRN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S179EVFMCSVVLRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S179EVFMCSVVMRQ1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
T39DNAGKTTLLHM8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
T40NAGKTTLLHML8Homo sapiens, Bos taurus, Arabidopsis thaliana, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC
V180VFMCSVLKRQG2Homo sapiens, Bos taurus
V180LFMCSVVMKSG2Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V180VFMCSIVRKMG1Arabidopsis thaliana
V180VFMCSVVMRNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V180VFMCSVVLRQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V180VFMCSVVMRQG1Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)


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