mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DPYSL5
Gene summary
Basic gene Info.Gene symbolDPYSL5
Gene namedihydropyrimidinase-like 5
SynonymsCRAM|CRMP-5|CRMP5|Ulip6
CytomapUCSC genome browser: 2p23.3
Type of geneprotein-coding
RefGenesNM_001253723.1,
NM_001253724.1,NM_020134.3,
DescriptionCRMP3-associated moleculeDRP-5ULIP-6UNC33-like phosphoprotein 6collapsin response mediator protein 5collapsin response mediator protein-5dihydropyrimidinase-related protein 5
Modification date20141222
dbXrefs MIM : 608383
HGNC : HGNC
Ensembl : ENSG00000157851
HPRD : 10522
Vega : OTTHUMG00000097071
ProteinUniProt: Q9BPU6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DPYSL5
BioGPS: 56896
PathwayNCI Pathway Interaction Database: DPYSL5
KEGG: DPYSL5
REACTOME: DPYSL5
Pathway Commons: DPYSL5
ContextiHOP: DPYSL5
ligand binding site mutation search in PubMed: DPYSL5
UCL Cancer Institute: DPYSL5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for DPYSL5

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H290A291VSKCM1
H290A291VSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DPYSL5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H290A291V0.05215465
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DPYSL5 from PDB

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Differential gene expression and gene-gene network for DPYSL5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DPYSL5 and the right PPI network was created from samples without mutations in the LBS of DPYSL5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DPYSL5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DPYSL5
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DPYSL5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4b92AH290
ZNZINC(2+)4b92BH290


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Conservation information for LBS of DPYSL5
Multiple alignments for Q9BPU6 in multiple species
LBSAA sequence# speciesSpecies
D183LHACKDIGAIA1Homo sapiens
D183FHACRDIGAIP1Mus musculus
D183FHACRDFGAIP1Rattus norvegicus
H179LYQVLHACKDI1Homo sapiens
H179LYQVFHACRDI1Mus musculus
H179LYQVFHACRDF1Rattus norvegicus
H282TLTGLHYYHQD3Homo sapiens, Mus musculus, Rattus norvegicus
H285GLHYYHQDWSH3Homo sapiens, Mus musculus, Rattus norvegicus
H290HQDWSHAAAYV3Homo sapiens, Mus musculus, Rattus norvegicus


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