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mutLBSgeneDB |
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| Gene summary for PSMB3 |
 Gene summary |
| Basic gene Info. | Gene symbol | PSMB3 |
| Gene name | proteasome (prosome, macropain) subunit, beta type, 3 | |
| Synonyms | HC10-II | |
| Cytomap | UCSC genome browser: 17q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002795.3, NR_104194.1,NR_104195.1, | |
| Description | proteasome chain 13proteasome component C10-IIproteasome subunit beta type-3proteasome theta chain | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602176 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000277791 | ||
| HPRD : 03709 | ||
| Vega : OTTHUMG00000188503 | ||
| Protein | UniProt: P49720 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PSMB3 | |
| BioGPS: 5691 | ||
| Pathway | NCI Pathway Interaction Database: PSMB3 | |
| KEGG: PSMB3 | ||
| REACTOME: PSMB3 | ||
| Pathway Commons: PSMB3 | ||
| Context | iHOP: PSMB3 | |
| ligand binding site mutation search in PubMed: PSMB3 | ||
| UCL Cancer Institute: PSMB3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PSMB3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C129,I127 | G128S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PSMB3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I127 | G128S | -0.9073104 | C129 | G128S | -0.9073104 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PSMB3 from PDB |
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| Differential gene expression and gene-gene network for PSMB3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PSMB3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PSMB3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00188 | Bortezomib | Small molecule |  |
| Experimental | DB08515 | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PSMB3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 3BV | CARFILZOMIB, BOUND FORM | N-{(2S)-2-[(MORPHOLIN-4-YLACETYL)AMINO]-4- PHENYLBUTANOYL}-L-LEUCYL-N-[(2R,3S,4S)-1,3-DIHYDROXY- 2,6-DIMETHYLHEPTAN-4-YL]-L-PHENYLALANINAMIDE | 4r67 | l | I127 | 3BV | CARFILZOMIB, BOUND FORM | N-{(2S)-2-[(MORPHOLIN-4-YLACETYL)AMINO]-4- PHENYLBUTANOYL}-L-LEUCYL-N-[(2R,3S,4S)-1,3-DIHYDROXY- 2,6-DIMETHYLHEPTAN-4-YL]-L-PHENYLALANINAMIDE | 4r67 | z | I127 | 3BV | CARFILZOMIB, BOUND FORM | N-{(2S)-2-[(MORPHOLIN-4-YLACETYL)AMINO]-4- PHENYLBUTANOYL}-L-LEUCYL-N-[(2R,3S,4S)-1,3-DIHYDROXY- 2,6-DIMETHYLHEPTAN-4-YL]-L-PHENYLALANINAMIDE | 4r67 | J | I127 C129 |
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| Conservation information for LBS of PSMB3 |
| Multiple alignments for P49720 in multiple species |
| LBS | AA sequence | # species | Species | C129 | LDLIGCPMVTD | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | C129 | MDSIGAKELAK | 2 | Arabidopsis thaliana, Arabidopsis thaliana | C129 | MDTIGCVSAPR | 1 | Caenorhabditis elegans | C129 | MDLIGCPNAPD | 1 | Drosophila melanogaster | C129 | MDCIGAKELAK | 1 | Oryza sativa subsp. japonica | C129 | FDLIGCIDEAK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C129 | FDSIGCIDFAE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D125 | FICSLDLIGCP | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | D125 | FICTMDSIGAK | 2 | Arabidopsis thaliana, Arabidopsis thaliana | D125 | YICCMDTIGCV | 1 | Caenorhabditis elegans | D125 | FICNMDLIGCP | 1 | Drosophila melanogaster | D125 | FICTMDCIGAK | 1 | Oryza sativa subsp. japonica | D125 | FIAGFDLIGCI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D125 | FICGFDSIGCI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E106 | GPYYTEPVIAG | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | E106 | GSYFTEPLVAG | 1 | Caenorhabditis elegans | E106 | GPYFIEPVVAG | 1 | Drosophila melanogaster | E106 | GPYFCQPVIAG | 1 | Oryza sativa subsp. japonica | E106 | GPFLCQPVIAG | 1 | Arabidopsis thaliana | E106 | GPYLCQPVIAG | 1 | Arabidopsis thaliana | E106 | GPYFVGPVVAG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E106 | GPYFSFPVVAG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I127 | CSLDLIGCPMV | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | I127 | CTMDSIGAKEL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | I127 | CCMDTIGCVSA | 1 | Caenorhabditis elegans | I127 | CNMDLIGCPNA | 1 | Drosophila melanogaster | I127 | CTMDCIGAKEL | 1 | Oryza sativa subsp. japonica | I127 | AGFDLIGCIDE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I127 | CGFDSIGCIDF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L126 | ICSLDLIGCPM | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | L126 | ICTMDSIGAKE | 2 | Arabidopsis thaliana, Arabidopsis thaliana | L126 | ICCMDTIGCVS | 1 | Caenorhabditis elegans | L126 | ICNMDLIGCPN | 1 | Drosophila melanogaster | L126 | ICTMDCIGAKE | 1 | Oryza sativa subsp. japonica | L126 | IAGFDLIGCID | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L126 | ICGFDSIGCID | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M4 | 11 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Rattus norvegicus, Mus musculus, Bos taurus, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyce | R99 | LLYEKRFGPYY | 4 | Homo sapiens, Rattus norvegicus, Mus musculus, Bos taurus | R99 | LAYQHRFGSYF | 1 | Caenorhabditis elegans | R99 | FLYEHRFGPYF | 1 | Drosophila melanogaster | R99 | LLYEKRFGPYF | 1 | Oryza sativa subsp. japonica | R99 | ILYEKRFGPFL | 1 | Arabidopsis thaliana | R99 | ILYEKRFGPYL | 1 | Arabidopsis thaliana | R99 | SLYERRFGPYF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R99 | TLYEKRFGPYF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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