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mutLBSgeneDB |
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| Gene summary for PSMB5 |
 Gene summary |
| Basic gene Info. | Gene symbol | PSMB5 |
| Gene name | proteasome (prosome, macropain) subunit, beta type, 5 | |
| Synonyms | LMPX|MB1|X | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001130725.1, NM_001144932.2,NM_002797.4, | |
| Description | PSX large multifunctional protease Xmacropain epsilon chainmulticatalytic endopeptidase complex epsilon chainproteasome beta 5 subunitproteasome catalytic subunit 3proteasome chain 6proteasome epsilon chainproteasome subunit MB1proteasome subunit | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600306 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100804 | ||
| HPRD : 02629 | ||
| Vega : OTTHUMG00000028713 | ||
| Protein | UniProt: P28074 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PSMB5 | |
| BioGPS: 5693 | ||
| Pathway | NCI Pathway Interaction Database: PSMB5 | |
| KEGG: PSMB5 | ||
| REACTOME: PSMB5 | ||
| Pathway Commons: PSMB5 | ||
| Context | iHOP: PSMB5 | |
| ligand binding site mutation search in PubMed: PSMB5 | ||
| UCL Cancer Institute: PSMB5 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PSMB5 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R78 | D76H | BLCA | 1 | A108 | A108T | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PSMB5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R78 | D76H | -0.48879072 | A108 | A108T | -0.053020152 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PSMB5 from PDB |
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| Differential gene expression and gene-gene network for PSMB5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PSMB5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PSMB5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00188 | Bortezomib | Small molecule |  |
| Experimental | DB08515 | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Small molecule |  |
| Approved | DB08889 | Carfilzomib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PSMB5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PSMB5 |
| Multiple alignments for P28074 in multiple species |
| LBS | AA sequence | # species | Species | A105 | LLGTMAGGAAD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A105 | MLGTMAGGAAD | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A108 | TMAGGAADCSF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A108 | TMAGGAADCQF | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A79 | AADSRATAGAY | 3 | Homo sapiens, Mus musculus, Bos taurus | A79 | AADSRASMGGY | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A79 | AADSRATAGPY | 1 | Rattus norvegicus | A81 | DSRATAGAYIA | 3 | Homo sapiens, Mus musculus, Bos taurus | A81 | DSRASMGGYIS | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A81 | DSRATAGPYIA | 1 | Rattus norvegicus | A86 | AGAYIASQTVK | 3 | Homo sapiens, Mus musculus, Bos taurus | A86 | MGGYISSQSVK | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A86 | AGPYIASQTVK | 1 | Rattus norvegicus | G106 | LGTMAGGAADC | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana | G107 | GTMAGGAADCS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G107 | GTMAGGAADCQ | 2 | Arabidopsis thaliana, Arabidopsis thaliana | K92 | SQTVKKVIEIN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K92 | SQSVKKIIEIN | 2 | Arabidopsis thaliana, Arabidopsis thaliana | M104 | YLLGTMAGGAA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M104 | YMLGTMAGGAA | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R78 | VAADSRATAGA | 3 | Homo sapiens, Mus musculus, Bos taurus | R78 | VAADSRASMGG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R78 | VAADSRATAGP | 1 | Rattus norvegicus | S189 | TFSVGSGSVYA | 2 | Homo sapiens, Bos taurus | S189 | AFSVGSGSVYA | 2 | Mus musculus, Rattus norvegicus | S189 | RFSVGSGSPYA | 2 | Arabidopsis thaliana, Arabidopsis thaliana | T60 | ---HGTTTLAF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T60 | KHAKGTTTLAF | 1 | Arabidopsis thaliana | T60 | KPAKGTTTLAF | 1 | Arabidopsis thaliana | T80 | ADSRATAGAYI | 3 | Homo sapiens, Mus musculus, Bos taurus | T80 | ADSRASMGGYI | 2 | Arabidopsis thaliana, Arabidopsis thaliana | T80 | ADSRATAGPYI | 1 | Rattus norvegicus | Y228 | TYRDAYSGGAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y228 | TFRDGASGGVA | 2 | Arabidopsis thaliana, Arabidopsis thaliana | Y228 | TYRDAYSGGSV | 1 | Bos taurus |
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