mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PSMB6
Gene summary
Basic gene Info.Gene symbolPSMB6
Gene nameproteasome (prosome, macropain) subunit, beta type, 6
CytomapUCSC genome browser: 17p13
Type of geneprotein-coding
DescriptionPSY large multifunctional protease Ymacropain delta chainmulticatalytic endopeptidase complex delta chainproteasome catalytic subunit 1proteasome delta chainproteasome subunit Yproteasome subunit beta type-6proteasome subunit delta
Modification date20141207
dbXrefs MIM : 600307
Ensembl : ENSG00000142507
HPRD : 02630
Vega : OTTHUMG00000090777
ProteinUniProt: P28072
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PSMB6
BioGPS: 5694
PathwayNCI Pathway Interaction Database: PSMB6
Pathway Commons: PSMB6
ContextiHOP: PSMB6
ligand binding site mutation search in PubMed: PSMB6
UCL Cancer Institute: PSMB6
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PSMB6

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PSMB6
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PSMB6 from PDB

Differential gene expression and gene-gene network for PSMB6
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PSMB6 and the right PPI network was created from samples without mutations in the LBS of PSMB6. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PSMB6
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PSMB6
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00188BortezomibSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PSMB6 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PSMB6
Multiple alignments for P28072 in multiple species
LBSAA sequence# speciesSpecies
A61TGSYIANRVTD3Homo sapiens, Mus musculus, Bos taurus
A61TGAYIANRVTD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A61MGAYIANRVTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A83CRSGSAADTQA4Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A83CRSGSAADTQT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G81FCCRSGSAADT3Homo sapiens, Mus musculus, Bos taurus
G81WCCRSGSAADT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K67NRVTDKLTPIH3Homo sapiens, Mus musculus, Bos taurus
K67NRVTDKLTRVH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K67NRVTDKLTQLT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M129YREDLMAGIII3Homo sapiens, Mus musculus, Bos taurus
M129NKDNLTAGIIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M129NKNMLSAGLIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R53LGADSRTTTGS3Homo sapiens, Mus musculus, Bos taurus
R53LGADSRTTTGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R53LAADSRTTMGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S164FAIGGSGSSYI3Homo sapiens, Mus musculus, Bos taurus
S164YAIAGSGSTFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S164LAIGGSGSAFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S203MERDGSSGGVI3Homo sapiens, Mus musculus, Bos taurus
S203IKWDGSSGGVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S203MERDGSSGGTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S82CCRSGSAADTQ5Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T35EVSTGTTIMAV3Homo sapiens, Mus musculus, Bos taurus
T35EVSLGTSIMAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T35EIRMGTTITAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T54GADSRTTTGSY3Homo sapiens, Mus musculus, Bos taurus
T54GADSRTTTGAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T54AADSRTTMGAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T55ADSRTTTGSYI3Homo sapiens, Mus musculus, Bos taurus
T55ADSRTTTGAYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T55ADSRTTMGAYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T56DSRTTTGSYIA3Homo sapiens, Mus musculus, Bos taurus
T56DSRTTTGAYIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T56DSRTTMGAYIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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