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mutLBSgeneDB |
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| Gene summary for PSMB6 |
 Gene summary |
| Basic gene Info. | Gene symbol | PSMB6 |
| Gene name | proteasome (prosome, macropain) subunit, beta type, 6 | |
| Synonyms | DELTA|LMPY|Y | |
| Cytomap | UCSC genome browser: 17p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001270481.1, NM_002798.2, | |
| Description | PSY large multifunctional protease Ymacropain delta chainmulticatalytic endopeptidase complex delta chainproteasome catalytic subunit 1proteasome delta chainproteasome subunit Yproteasome subunit beta type-6proteasome subunit delta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600307 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000142507 | ||
| HPRD : 02630 | ||
| Vega : OTTHUMG00000090777 | ||
| Protein | UniProt: P28072 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PSMB6 | |
| BioGPS: 5694 | ||
| Pathway | NCI Pathway Interaction Database: PSMB6 | |
| KEGG: PSMB6 | ||
| REACTOME: PSMB6 | ||
| Pathway Commons: PSMB6 | ||
| Context | iHOP: PSMB6 | |
| ligand binding site mutation search in PubMed: PSMB6 | ||
| UCL Cancer Institute: PSMB6 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PSMB6 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A61 | N62K | BLCA | 1 | R53 | S52F | BRCA | 1 | A61 | Y59H | HNSC | 1 | G81 | R79C | STAD | 1 | A61 | R63Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PSMB6 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A61 | N62K | -0.99785635 | A61 | R63Q | -0.93806763 | G81 | R79C | -0.8846711 | A61 | Y59H | -0.66297495 | R53 | S52F | -0.30794281 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PSMB6 from PDB |
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| Differential gene expression and gene-gene network for PSMB6 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PSMB6 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PSMB6 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00188 | Bortezomib | Small molecule |  |
| Experimental | DB08515 | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PSMB6 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PSMB6 |
| Multiple alignments for P28072 in multiple species |
| LBS | AA sequence | # species | Species | A61 | TGSYIANRVTD | 3 | Homo sapiens, Mus musculus, Bos taurus | A61 | TGAYIANRVTD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A61 | MGAYIANRVTD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A83 | CRSGSAADTQA | 4 | Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A83 | CRSGSAADTQT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G81 | FCCRSGSAADT | 3 | Homo sapiens, Mus musculus, Bos taurus | G81 | WCCRSGSAADT | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K67 | NRVTDKLTPIH | 3 | Homo sapiens, Mus musculus, Bos taurus | K67 | NRVTDKLTRVH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K67 | NRVTDKLTQLT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M129 | YREDLMAGIII | 3 | Homo sapiens, Mus musculus, Bos taurus | M129 | NKDNLTAGIIV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M129 | NKNMLSAGLIV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R53 | LGADSRTTTGS | 3 | Homo sapiens, Mus musculus, Bos taurus | R53 | LGADSRTTTGA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R53 | LAADSRTTMGA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S164 | FAIGGSGSSYI | 3 | Homo sapiens, Mus musculus, Bos taurus | S164 | YAIAGSGSTFI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S164 | LAIGGSGSAFI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S203 | MERDGSSGGVI | 3 | Homo sapiens, Mus musculus, Bos taurus | S203 | IKWDGSSGGVI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S203 | MERDGSSGGTI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S82 | CCRSGSAADTQ | 5 | Homo sapiens, Mus musculus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T35 | EVSTGTTIMAV | 3 | Homo sapiens, Mus musculus, Bos taurus | T35 | EVSLGTSIMAV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T35 | EIRMGTTITAL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T54 | GADSRTTTGSY | 3 | Homo sapiens, Mus musculus, Bos taurus | T54 | GADSRTTTGAY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T54 | AADSRTTMGAY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T55 | ADSRTTTGSYI | 3 | Homo sapiens, Mus musculus, Bos taurus | T55 | ADSRTTTGAYI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T55 | ADSRTTMGAYI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T56 | DSRTTTGSYIA | 3 | Homo sapiens, Mus musculus, Bos taurus | T56 | DSRTTTGAYIA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T56 | DSRTTMGAYIA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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